| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Howard M Lazarus, Jill Denning, Stephen Wring, Michelle Palacios, Sidra Hoffman, Katelyn Crizer, Watiri Kamau-Kelley, William Symonds, Jeremy Feldma. A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2). Pulmonary circulation. vol 12. issue 2. 2022-07-07. PMID:35795492. |
tryptophan hydroxylase 1 (tph1) is the rate-limiting enzyme for biosynthesis of serotonin and is upregulated in pah arterial endothelial cells, supporting tph1 inhibition to treat pah. |
2022-07-07 |
2023-08-14 |
human |
| Howard M Lazarus, Jill Denning, Stephen Wring, Michelle Palacios, Sidra Hoffman, Katelyn Crizer, Watiri Kamau-Kelley, William Symonds, Jeremy Feldma. A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2). Pulmonary circulation. vol 12. issue 2. 2022-07-07. PMID:35795492. |
rodatristat ethyl, a prodrug for rodatristat, a potent, peripheral inhibitor of tph1, has demonstrated efficacy in monocrotaline and sugen hypoxia nonclinical models of pah and robust dose-dependent reductions of 5-hydroxyindoleacetic acid, the major metabolite of serotonin in plasma and urine of healthy human subjects. |
2022-07-07 |
2023-08-14 |
human |
| Suvarna H Pagire, Haushabhau S Pagire, Kun-Young Park, Eun Jung Bae, Kwang-Eun Kim, Minhee Kim, Jihyeon Yoon, Saravanan Parameswaran, Jun-Ho Choi, Sungmi Park, Jae-Han Jeon, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jae Myoung Suh, Jin Hee Ah. Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684355. |
because serotonin cannot cross the blood-brain barrier (bbb), we focused on identifying new tryptophan hydroxylase type i (tph1) inhibitors that act only in peripheral tissues for treating obesity and fatty liver disease without affecting the central nervous system. |
2022-06-10 |
2023-08-14 |
Not clear |
| Giulia Sbrini, Sabrina I Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R Homberg, Francesca Calabres. Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563331. |
while the tph2 isoform is responsible for the production of serotonin in the brain, tph1 is expressed in peripheral organs. |
2022-05-14 |
2023-08-13 |
rat |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
additionally, tph1's impact on serotonin synthesis production throughout the body will be discussed with regards to its involvement in neuropsychiatric disorders similar to tph2. |
2022-05-13 |
2023-08-13 |
Not clear |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
tph1 is predominantly expressed during the late developmental stages in the brain and is synthesizing serotonin throughout the body. |
2022-05-13 |
2023-08-13 |
Not clear |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
although tph1 is particularly responsible for serotonin synthesis in enterochromaffin cells, mammary glands, lungs, and the pancreas, it is also found in the brain's pineal gland. |
2022-05-13 |
2023-08-13 |
Not clear |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
tph1 shows a greater affinity for tryptophan, an amino acid used in the production of serotonin, and has a stronger enzymatic activity than tph2 for a developing brain stem. |
2022-05-13 |
2023-08-13 |
Not clear |
| Huawei Li, Peng Wang, Yunping Zhou, Fei Zhao, Xue Gao, Chunfeng Wu, Tianxia Wu, Liping Jiang, Dianliang Zhan. Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats. Genes, brain, and behavior. 2022-05-10. PMID:35535862. |
cums intervention significantly increased the levels of 5-ht and tph1 in the colon and decreased the level of scl6a4. |
2022-05-10 |
2023-08-13 |
rat |
| ZhiFei Zhang, Wei Du, WenYi Liu, Braden T Wong, HuiLing Zhen. Increasing serotonin concentrations alter calcium metabolism in periparturient dairy goats. Journal of animal science. 2022-03-02. PMID:35235945. |
serotonin (5-hydroxytryphtamine, 5-ht), the product of 5-hydroxy-l-tryptophan (5-htp) catalysed by tryptophan hydroxylase 1 (tph1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal. |
2022-03-02 |
2023-08-13 |
Not clear |
| Katsunori Nonogak. The Regulatory Role of the Central and Peripheral Serotonin Network on Feeding Signals in Metabolic Diseases. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163521. |
nutritional, pharmacologic, or genetic inhibition of peripheral 5-ht synthesis via tryptophan hydroxylase 1 (tph1) decreases hepatic fgf21 expression and plasma fgf21 levels in mice. |
2022-02-15 |
2023-08-13 |
mouse |
| Katsunori Nonogak. The Regulatory Role of the Central and Peripheral Serotonin Network on Feeding Signals in Metabolic Diseases. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163521. |
increased energy intake via a high-fat diet and/or high-carbohydrate diet can upregulate gut-derived 5-ht synthesis via tph1. |
2022-02-15 |
2023-08-13 |
mouse |
| Joanna Smardz, Helena Martynowicz, Anna Wojakowska, Joanna Wezgowiec, Cyprian Olchowy, Dariusz Danel, Grzegorz Mazur, Mieszko Wieckiewic. Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway? Clinical oral investigations. 2021-12-09. PMID:34882257. |
this exploratory research aimed to evaluate the levels of tryptophan hydroxylase 1 (tph1) and aromatic l-amino acid decarboxylase (ddc), which play an important role in the serotonin synthesis pathway, in individuals with sleep bruxism (sb) diagnosed using audio-video polysomnography (vpsg) and compare them with that of individuals not presenting with sb. |
2021-12-09 |
2023-08-13 |
Not clear |
| Yihang Kevin Pan, Greg Jensen, Steve F Perr. Disruption of tph1 genes demonstrates the importance of serotonin in regulating ventilation in larval zebrafish (Danio rerio). Respiratory physiology & neurobiology. vol 285. 2021-11-26. PMID:33271304. |
disruption of tph1 genes demonstrates the importance of serotonin in regulating ventilation in larval zebrafish (danio rerio). |
2021-11-26 |
2023-08-13 |
zebrafish |
| Enrica Saponara, Rong Chen, Theresia Reding, Richard Zuellig, Darren C Henstridge, Rolf Graf, Sabrina Sond. Single or combined ablation of peripheral serotonin and p21 limit adipose tissue expansion and metabolic alterations in early adulthood in mice fed a normocaloric diet. PloS one. vol 16. issue 8. 2021-11-23. PMID:34379673. |
at the molecular level, this was associated with an increase in adipose tissue tryptophan hydroxylase 1 (tph1) transcripts, the key enzyme responsible for the synthesis of peripheral serotonin. |
2021-11-23 |
2023-08-13 |
mouse |
| Wu-Dang Lu, Man-Li Wu, Jun-Xia Zhang, Ting-Ting Huang, Shuai-Shuai Du, Yong-Xiao Ca. The effect of sodium carboxymethyl starch with high degree of substitution on defecation. PloS one. vol 16. issue 9. 2021-11-22. PMID:34478474. |
5-hydroxytryptamine (5-ht) and tryptophan hydroxylase 1 (tph1) were measured by elisa. |
2021-11-22 |
2023-08-13 |
mouse |
| Wu-Dang Lu, Man-Li Wu, Jun-Xia Zhang, Ting-Ting Huang, Shuai-Shuai Du, Yong-Xiao Ca. The effect of sodium carboxymethyl starch with high degree of substitution on defecation. PloS one. vol 16. issue 9. 2021-11-22. PMID:34478474. |
the contents of water, acetic acid, propionic acid and n-butyrate in feces, tph1 in colon and 5-ht in serum of rats were increased. |
2021-11-22 |
2023-08-13 |
mouse |
| Wu-Dang Lu, Man-Li Wu, Jun-Xia Zhang, Ting-Ting Huang, Shuai-Shuai Du, Yong-Xiao Ca. The effect of sodium carboxymethyl starch with high degree of substitution on defecation. PloS one. vol 16. issue 9. 2021-11-22. PMID:34478474. |
the mechanism may be related to the regulation of alloprevotella and lactobacillus in colon, the increase of short-chain fatty acids, and the promotion of the synthesis of tph1 and 5-ht. |
2021-11-22 |
2023-08-13 |
mouse |
| S L Field, M G Marrero, B Dado-Senn, A L Skibiel, P M Ramos, T L Scheffler, J Laport. Peripheral serotonin regulates glucose and insulin metabolism in Holstein dairy calves. Domestic animal endocrinology. vol 74. 2021-11-19. PMID:32739765. |
the liver and pancreas of preweaned calves express serotonin factors (ie, tph1, sert, and cell surface receptors), indicating their ability to synthesize, uptake, and respond to serotonin. |
2021-11-19 |
2023-08-13 |
Not clear |
| Jessica Romero-Reyes, Edgar Ricardo Vázquez-Martínez, Daniel Bahena-Alvarez, Jessica López-Jiménez, Anayansi Molina-Hernández, Ignacio Camacho-Arroyo, Néstor Fabián Día. Differential localization of serotoninergic system elements in human amniotic epithelial cells†. Biology of reproduction. vol 105. issue 2. 2021-11-18. PMID:34057176. |
we found the expression of tryptophan hydroxylase type 1 (tph1), type 2 (tph2), serotonin transporter (sert), monoamine oxidase-a (maoa), as well as htr1d and htr7 receptors at mrna level in amnion tissue as well in haec. |
2021-11-18 |
2023-08-13 |
human |