| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cassidy Delaney, Laurie Sherlock, Susan Fisher, Joanne Maltzahn, Clyde Wright, Eva Nozik-Grayc. Serotonin 2A receptor inhibition protects against the development of pulmonary hypertension and pulmonary vascular remodeling in neonatal mice. American journal of physiology. Lung cellular and molecular physiology. vol 314. issue 5. 2019-01-09. PMID:29345193. |
following treatment with bleomycin, pulmonary expression of the rate-limiting enzyme of 5-ht synthesis, tryptophan hydroxylase-1 (tph1), was significantly increased. |
2019-01-09 |
2023-08-13 |
mouse |
| Harvey J Kliman, Sarah B Quaratella, Alessandra C Setaro, Erin C Siegman, Zarrin T Subha, Reshef Tal, Kristin M Milano, Theodore L Stec. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology. vol 159. issue 4. 2018-11-27. PMID:29381782. |
we used immunocytochemistry to gauge 5-ht, its biosynthetic enzyme tryptophan hydroxylase 1 (tph1); an importer (serotonin transporter, 5-htt/sert/slc6a); other transporters [p-glycoprotein 1 (p-gp/abcb1), oct3/slc22a3, and gap junction connexin-43]; and the 5-ht degradative enzyme monoamine oxidase a (maoa) in sections of placentas. |
2018-11-27 |
2023-08-13 |
mouse |
| Harvey J Kliman, Sarah B Quaratella, Alessandra C Setaro, Erin C Siegman, Zarrin T Subha, Reshef Tal, Kristin M Milano, Theodore L Stec. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology. vol 159. issue 4. 2018-11-27. PMID:29381782. |
in humans, 5-ht was faintly stained only in first-trimester trophoblasts, whereas tph1 was not seen at any stage. |
2018-11-27 |
2023-08-13 |
mouse |
| Jingyao Zhang, Ruixia Cui, Yang Feng, Weiman Gao, Jianbin Bi, Zeyu Li, Chang Li. Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments. Mediators of inflammation. vol 2018. 2018-10-01. PMID:29849496. |
serotonin exhibits accelerated bleomycin-induced pulmonary fibrosis through tph1 knockout mouse experiments. |
2018-10-01 |
2023-08-13 |
mouse |
| Jingyao Zhang, Ruixia Cui, Yang Feng, Weiman Gao, Jianbin Bi, Zeyu Li, Chang Li. Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments. Mediators of inflammation. vol 2018. 2018-10-01. PMID:29849496. |
the aim of this study was to investigate the role of 5-ht in bleomycin- (blm-) induced pulmonary fibrosis through wild-type c57bl/6 (wt) and tph1 knockout (ko) mouse experiments. |
2018-10-01 |
2023-08-13 |
mouse |
| W J Zang, H Li, Z F Zhang, R QuZhen, Y Z CuoMu, D K Zhang, J Luo, J J Loor, H L Zhen. Serotonin induces parathyroid hormone-related protein in goat mammary gland. Journal of animal science. vol 96. issue 3. 2018-09-18. PMID:29617866. |
by knocking down tryptophan hydroxylase-1 (tph1) or adding 5-hydroxytryptophan (5-htp) to decrease or increase the levels of 5-ht in gmec, we observed that 5-htp increased pthrp expression in a dose-dependent manner and sitph1 decreased pthrp protein expression. |
2018-09-18 |
2023-08-13 |
Not clear |
| Takeshi Chiba, Tomoji Maeda, Kenzo Kud. [Endogenous Serotonin and Milk Production Regulation in the Mammary Gland]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 138. issue 6. 2018-08-03. PMID:29863055. |
during lactation, mammary epithelial cells activate 5-ht synthesis by tryptophan hydroxylase 1 (tph1). |
2018-08-03 |
2023-08-13 |
mouse |
| Takeshi Chiba, Tomoji Maeda, Kenzo Kud. [Endogenous Serotonin and Milk Production Regulation in the Mammary Gland]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 138. issue 6. 2018-08-03. PMID:29863055. |
tph1 catalyzes the rate-limiting step in 5-ht biosynthesis within mammary glands. |
2018-08-03 |
2023-08-13 |
mouse |
| Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielse. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatric genetics. vol 27. issue 5. 2018-07-27. PMID:28590957. |
genetic moderation of cocaine subjective effects by variation in the tph1, tph2, and slc6a4 serotonin genes. |
2018-07-27 |
2023-08-13 |
Not clear |
| Si-Yu Tao, Cong-Rui Xiao, Jing Wang, Shu-Jing Zhang, Yu-Shan Gao, Fang-Yuan Mu, Yi-Cheng Wang, Xing-Li Ya. [Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 2. 2018-05-31. PMID:28948742. |
[effects of baldrinal of valeriana jatamansi on expression of crf, tph1 mrna and 5-ht in rats with irritable bowel syndrome]. |
2018-05-31 |
2023-08-13 |
rat |
| Si-Yu Tao, Cong-Rui Xiao, Jing Wang, Shu-Jing Zhang, Yu-Shan Gao, Fang-Yuan Mu, Yi-Cheng Wang, Xing-Li Ya. [Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 2. 2018-05-31. PMID:28948742. |
this study aimed to investigate the effects of baldrinal of valeriana jatamansi on the expression of corticotropin releasing factor (crf) and tryptophan hydroxylase 1 (tph1) mrna and levels of 5-hydroxytryptamine (5-ht) in colon of rats with irritable bowel syndrome (ibs), and to explain its therapeutic mechanism on ibs through 5-ht pathway. |
2018-05-31 |
2023-08-13 |
rat |
| Si-Yu Tao, Cong-Rui Xiao, Jing Wang, Shu-Jing Zhang, Yu-Shan Gao, Fang-Yuan Mu, Yi-Cheng Wang, Xing-Li Ya. [Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 2. 2018-05-31. PMID:28948742. |
crf expression was detected by ihc-p; tph1 mrna expression was detected by using rt-pcr and the 5-ht level was measured by high performance liquid chromatography(hplc). |
2018-05-31 |
2023-08-13 |
rat |
| Si-Yu Tao, Cong-Rui Xiao, Jing Wang, Shu-Jing Zhang, Yu-Shan Gao, Fang-Yuan Mu, Yi-Cheng Wang, Xing-Li Ya. [Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 2. 2018-05-31. PMID:28948742. |
the results indicated that the method of chronic stress with acute restrain stress method and independent feeding could lead to the increase in expressions of crf and tph1 mrna and levels of 5-ht in ibs rats(p<0.05). |
2018-05-31 |
2023-08-13 |
rat |
| Si-Yu Tao, Cong-Rui Xiao, Jing Wang, Shu-Jing Zhang, Yu-Shan Gao, Fang-Yuan Mu, Yi-Cheng Wang, Xing-Li Ya. [Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 2. 2018-05-31. PMID:28948742. |
the expressions of crf, tph1 mrna and 5-ht in baldrinal groups were significantly lower than those in model group(p<0.05). |
2018-05-31 |
2023-08-13 |
rat |
| Si-Yu Tao, Cong-Rui Xiao, Jing Wang, Shu-Jing Zhang, Yu-Shan Gao, Fang-Yuan Mu, Yi-Cheng Wang, Xing-Li Ya. [Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 2. 2018-05-31. PMID:28948742. |
the experimental results showed that ibs could result in increase in the expressions of crf, tph1 mrna and levels of 5-ht, and the baldrinal of v. jatamansi could improve the symptoms of ibs by reducing the expressions of crf, tph1 mrna and levels of 5-ht in colon of rats. |
2018-05-31 |
2023-08-13 |
rat |
| D A Nikishin, N M Alyoshina, Y B Shmukle. Synthesis and Membrane Transport of Serotonin in the Developing Ovarian Follicle of Mouse. Doklady. Biochemistry and biophysics. vol 478. issue 1. 2018-04-09. PMID:29536299. |
using rt-pcr, we showed the presence of tph1 mrna in follicular cells and tph2 mrna in oocytes isolated from primary multilayer ovarian follicles of mouse and the absence of ddc expression, which indicates that serotonin cannot be synthesized in a developing ovarian follicle. |
2018-04-09 |
2023-08-13 |
mouse |
| Maurizio Pompili, Giovanna Gentile, Catia Scassellati, Cristian Bonvicini, Marco Innamorati, Denise Erbuto, Franco Montebovi, Giuseppe Ducci, Alberto Forte, Eleonora De Pisa, Stefano Ferracuti, Gianluca Serafini, Vincenzo De Luca, Mario Amore, Maurizio Simmaco, Paolo Girard. Genetic association analysis of serotonin and signal transduction pathways in suicide attempters from an Italian sample of psychiatric patients. Neuroscience letters. vol 656. 2018-04-05. PMID:28716530. |
we aimed to investigate functional polymorphisms in eight genes (serotonin transporter, slc6a4; receptors, 5htr1a, 1b, 5htr2a; tryptophan hydroxylase, tph1, tph2; monoamine oxidase, maoa and g protein subunit beta 3, gnb3) to investigate their predictive value for suicide. |
2018-04-05 |
2023-08-13 |
Not clear |
| William D Gwynne, Robin M Hallett, Adele Girgis-Gabardo, Bojana Bojovic, Anna Dvorkin-Gheva, Craig Aarts, Kay Dias, Anita Bane, John A Hassel. Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts. Oncotarget. vol 8. issue 19. 2018-03-05. PMID:28404880. |
notably, inhibitors of tryptophan hydroxylase 1 (tph1), required for 5-ht biosynthesis in select non-neuronal cells, the serotonin reuptake transporter (sert) and several 5-ht receptors compromised btic activity as assessed by functional sphere-forming assays. |
2018-03-05 |
2023-08-13 |
mouse |
| William D Gwynne, Robin M Hallett, Adele Girgis-Gabardo, Bojana Bojovic, Anna Dvorkin-Gheva, Craig Aarts, Kay Dias, Anita Bane, John A Hassel. Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts. Oncotarget. vol 8. issue 19. 2018-03-05. PMID:28404880. |
consistent with these findings, human breast tumor cells express tph1, 5-ht and sert independent of their molecular or clinical subtype. |
2018-03-05 |
2023-08-13 |
mouse |
| Yunshuang Yue, Yuming Guo, Ying Yan. Effects of dietary L-tryptophan supplementation on intestinal response to chronic unpredictable stress in broilers. Amino acids. vol 49. issue 7. 2018-02-23. PMID:28487998. |
feed intake, body weight gain, plasma corticosterone and 5-hydroxytryptamine (5-ht), intestinal permeability, mucosal secretory iga (siga), and mrna levels for tryptophan hydroxylase 1 (tph1), il-1β, il-6, tnf-α, il-10, protein abundance for claudin-1, occludin, and zo-1 were determined. |
2018-02-23 |
2023-08-13 |
Not clear |