| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Wu, Yi Li, Bo Xia. DISC1-related signaling pathways in adult neurogenesis of the hippocampus. Gene. vol 518. issue 2. 2013-04-30. PMID:23353011. |
in this review, we present several signaling pathways discussed in recent research, such as the akt signaling pathway, gaba signaling pathway, gsk3β signaling pathway, wnt signaling pathway, and nmda-r signaling pathway. |
2013-04-30 |
2023-08-12 |
Not clear |
| Laurie P Sutton, Walter J Rushlo. The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3. The international journal of neuropsychopharmacology. vol 15. issue 7. 2012-12-11. PMID:21777508. |
the dopamine d2 receptor (d2dr) regulates akt and may also target the wnt pathway, two signalling cascades that inhibit glycogen synthase kinase-3 (gsk-3). |
2012-12-11 |
2023-08-12 |
rat |
| Laurie P Sutton, Walter J Rushlo. The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3. The international journal of neuropsychopharmacology. vol 15. issue 7. 2012-12-11. PMID:21777508. |
however, altering dvl-3 levels resulted in changes in akt and the wnt pathway similar to what was observed following raclopride or quinpirole treatment. |
2012-12-11 |
2023-08-12 |
rat |
| Jane Palsgaard, Brice Emanuelli, Jonathon N Winnay, Grzegorz Sumara, Gerard Karsenty, C Ronald Kah. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22337886. |
we find that wnt stimulation leads to phosphorylation of insulin signaling key mediators, including akt, gsk3β, and erk1/2, although with a lower fold stimulation and slower time course than observed for insulin. |
2012-06-06 |
2023-08-12 |
Not clear |
| Shashi Rajput, Mahitosh Manda. Antitumor promoting potential of selected phytochemicals derived from spices: a review. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 21. issue 2. 2012-05-07. PMID:21876437. |
however, the in-vitro and in-vivo studies in the last few decades have demonstrated that some phytochemicals derived from 'natural products' such as fruits, vegetables and certain spices, referred to as chemopreventive agents, including capsaicin, trans-anethole, thymoquinone, diosgenin, allicin, can not only reduce the risk of acquiring specific cancer but also have been shown to suppress cancer cell proliferation, inhibit growth factor signaling pathways, induce apoptosis, inhibit nuclear factor-κb, ap-1, akt, mapk, wnt, notch, p53, ar, er, and jak-stat, etc., activation pathways, inhibit angiogenesis, suppress the expression of antiapoptotic proteins, and inhibit cyclooxygenase-2. |
2012-05-07 |
2023-08-12 |
Not clear |
| L P Sutton, W J Rushlo. The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling. Neuroscience. vol 199. 2012-04-06. PMID:22001305. |
consequently, the current study examined the effects of antipsychotics (haloperidol and clozapine), mood stabilizers (lithium and valproic acid), and antidepressants (imipramine and fluoxetine) on gsk-3, as well as akt and wnt in the prefrontal cortex and striatum. |
2012-04-06 |
2023-08-12 |
rat |
| Miroslav Zavoral, Petra Minarikova, Filip Zavada, Cyril Salek, Marek Minari. Molecular biology of pancreatic cancer. World journal of gastroenterology. vol 17. issue 24. 2011-10-27. PMID:21734801. |
the most characteristic aberrations (somatic point mutations and allelic losses) affect oncogenes and tumor-suppressor genes within ras, akt and wnt signaling, and have a key role in transcription and proliferation, as well as systems that regulate the cell cycle (smad/dpc, cdkn2a/p16) and apoptosis (tp53). |
2011-10-27 |
2023-08-12 |
Not clear |
| Laurie P Sutton, Walter J Rushlo. Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268. Journal of neurochemistry. vol 117. issue 6. 2011-08-03. PMID:21477044. |
regulation of akt and wnt signaling by the group ii metabotropic glutamate receptor antagonist ly341495 and agonist ly379268. |
2011-08-03 |
2023-08-12 |
Not clear |
| Laurie P Sutton, Walter J Rushlo. Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268. Journal of neurochemistry. vol 117. issue 6. 2011-08-03. PMID:21477044. |
the current study examined whether mglu(2/3) regulates akt (protein kinase b) and wnt (wingless/int-1) signaling, two cascades associated with schizophrenia and modified by antipsychotics. |
2011-08-03 |
2023-08-12 |
Not clear |
| Fabio Bozzi, Andrea Ferrari, Tiziana Negri, Elena Conca, Da Riva Luca, Marco Losa, Paola Casieri, Marta Orsenigo, Andrea Lampis, Cristina Meazza, Michela Casanova, Marco A Pierotti, Elena Tamborini, Silvana Pilott. Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. Translational oncology. vol 1. issue 2. 2011-07-14. PMID:18633459. |
seventeen cases of pediatric ss showing the syt-ssx fusion transcript were screened immunohistochemically, biochemically, molecularly, and cytogenetically (depending on the available material) to investigate any expression/activation of epidermal growth factor receptor, platelet-derived growth factor receptor alpha (pdgfralpha), pdgfrbeta, akt, and deregulated wnt pathway. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jürgen Knobloch, David Jungck, Andrea Koc. Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis? Current molecular pharmacology. vol 4. issue 1. 2011-04-22. PMID:20958261. |
finally, we discuss the paradox that the embryonic molecular pathology induced by thalidomide suggests this drug as a candidate for therapeutic application in idiopathic pulmonary fibrosis (ipf), a chronic and fatal lung disease characterized by downregulation of bmp signaling, increased wnt and akt activity, and apoptosis resistance. |
2011-04-22 |
2023-08-12 |
Not clear |
| G Martinez, R U de Iong. The lens epithelium in ocular health and disease. The international journal of biochemistry & cell biology. vol 42. issue 12. 2011-04-01. PMID:20883819. |
recent data indicate that normal epithelial phenotype is regulated by several key signalling systems, including receptor tyrosine kinase receptors acting via the mapk and akt pathways, wnt, notch as well as extracellular matrix cues and possibly the sal-warts-hippo pathway. |
2011-04-01 |
2023-08-12 |
Not clear |
| Mei Zhang, Rachel L Atkinson, Jeffrey M Rose. Selective targeting of radiation-resistant tumor-initiating cells. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133717. |
finally, pharmacological inhibition of the akt pathway in both mammospheres and syngeneic mice bearing tumors was shown to inhibit canonical wnt signaling as well as the repair of dna damage selectively in tics, sensitizing them to ionizing radiation treatment. |
2010-04-05 |
2023-08-12 |
mouse |
| Feijun Luo, David G Brooks, Hongtao Ye, Rifat Hamoudi, George Poulogiannis, Charles E Patek, Douglas J Winton, Mark J Arend. Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways. International journal of experimental pathology. vol 90. issue 5. 2009-12-14. PMID:19765110. |
k-ras(asp12) increased activation of mapk and akt signalling pathway targets phospho-extracellular signal-regulated kinase (perk) and pakt, and increased relative expression levels of wnt pathway targets vascular endothelial growth factor (vegf), gastrin, cyclo-oxygenase 2 (cox2) and t-cell lymphoma invasion and metastasis 1 (tiam1) in k-ras(asp12)/cre/apc(min/+) adenomas compared with that of apc(min/+) adenomas, although other wnt signalling pathway target genes such as peroxisome proliferator-activated receptor delta (ppard), matrix metalloproteinase 7 (mmp7), protein phosphatase 1 alpha (pp1a) and c-myc remained unchanged. |
2009-12-14 |
2023-08-12 |
mouse |
| Fazlul H Sarkar, Yiwei Li, Zhiwei Wang, Dejuan Kon. Cellular signaling perturbation by natural products. Cellular signalling. vol 21. issue 11. 2009-11-06. PMID:19298854. |
by regulating multiple important cellular signaling pathways including nf-kappab, akt, mapk, wnt, notch, p53, ar, er, etc, these natural products are known to activate cell death signals and induce apoptosis in pre-cancerous or cancer cells without affecting normal cells. |
2009-11-06 |
2023-08-12 |
human |
| Laurie P Sutton, Dariush Honardoust, Joanne Mouyal, Nagalingam Rajakumar, Walter J Rushlo. Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17472703. |
protein kinase b (akt), glycogen synthase kinase-3 (gsk-3) and members of the wnt signal transduction pathway were recently found to be altered in schizophrenia and targeted by antipsychotic drugs. |
2007-07-30 |
2023-08-12 |
rat |
| Veerle A M van de Schans, Susanne W M van den Borne, Agnieszka E Strzelecka, Ben J A Janssen, Jos L J van der Velden, Ramon C J Langen, Antony Wynshaw-Boris, Jos F M Smits, W Matthijs Blankesteij. Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 49. issue 3. 2007-03-06. PMID:17210832. |
in conclusion, we have demonstrated that interruption of wnt signaling in the mice lacking the dvl-1 gene attenuates the onset of pressure overload-induced cardiac hypertrophy through mechanisms involving glycogen synthase kinase-3beta and akt. |
2007-03-06 |
2023-08-12 |
mouse |
| Zhao Zhong Chong, Faqi Li, Kenneth Maies. Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. Brain research. Brain research reviews. vol 49. issue 1. 2005-08-17. PMID:15960984. |
recent work has identified novel pathways, such as the wnt pathway and the serine-threonine kinase akt, as central modulators that oversee cellular apoptosis and the formation of neurofibrillary tangles through their downstream substrates that include glycogen synthase kinase-3beta, bad, and bcl-xl. |
2005-08-17 |
2023-08-12 |
Not clear |
| Zhao Zhong Chong, Faqi Li, Kenneth Maies. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Progress in neurobiology. vol 75. issue 3. 2005-07-29. PMID:15882775. |
current work has identified exciting pathways, such as the wnt pathway and the serine-threonine kinase akt, as central modulators that oversee cellular apoptosis and their downstream substrates that include forkhead transcription factors, glycogen synthase kinase-3beta, mitochondrial dysfunction, bad, and bcl-x(l). |
2005-07-29 |
2023-08-12 |
Not clear |