| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malcolm Begg, Fong-Ming Mo, László Offertaler, Sándor Bátkai, Pál Pacher, Raj K Razdan, David M Lovinger, George Kuno. G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12952947. |
the cannabinoid analog "abnormal cannabidiol" (abn-cbd) causes endothelium-dependent vasodilation in rat isolated mesenteric arteries through a g protein-coupled receptor distinct from cb1 or cb2. |
2003-12-24 |
2023-08-12 |
human |
| Kirsten R Müller-Vah. Cannabinoids reduce symptoms of Tourette's syndrome. Expert opinion on pharmacotherapy. vol 4. issue 10. 2003-12-18. PMID:14521482. |
at present, it remains unclear whether herbal cannabis, different natural or synthetic cannabinoid cb1-receptor agonists or agents that interfere with the inactivation of endocannabinoids, may have the best adverse effect profile in ts. |
2003-12-18 |
2023-08-12 |
Not clear |
| B Park, H M Gibbons, M D Mitchell, M Glass. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 5. 2003-12-10. PMID:12744923. |
synthetic cannabinoids, the psychoactive components of the cannabis sativa (marijuana) and their endogenous counterparts, act through two g protein-coupled receptors, cb1 and cb2. |
2003-12-10 |
2023-08-12 |
human |
| B Park, H M Gibbons, M D Mitchell, M Glass. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 5. 2003-12-10. PMID:12744923. |
this is consistent with a placental site of action of endocannabinoids and cannabis being responsible, at least in part, for the poor outcomes associated with cannabis consumption and pathology in the endocannabinoid system during pregnancy. |
2003-12-10 |
2023-08-12 |
human |
| Shih-Fang Fan, Stephen Yazull. Biphasic modulation of voltage-dependent currents of retinal cones by cannabinoid CB1 receptor agonist WIN 55212-2. Visual neuroscience. vol 20. issue 2. 2003-11-28. PMID:12916739. |
thus, neuronal excitability appears to be affected by cannabinoids at the first synapse of the visual pathway and could account for some of the visual effects of marijuana. |
2003-11-28 |
2023-08-12 |
Not clear |
| Thomas W Klein, Cathy Newton, Kellie Larsen, Lily Lu, Izabella Perkins, Liang Nong, Herman Friedma. The cannabinoid system and immune modulation. Journal of leukocyte biology. vol 74. issue 4. 2003-11-18. PMID:12960289. |
studies on the effects of marijuana smoking have evolved into the discovery and description of the endocannabinoid system. |
2003-11-18 |
2023-08-12 |
Not clear |
| Manuel Guzmá. Cannabinoids: potential anticancer agents. Nature reviews. Cancer. vol 3. issue 10. 2003-11-04. PMID:14570037. |
cannabinoids - the active components of cannabis sativa and their derivatives - exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. |
2003-11-04 |
2023-08-12 |
Not clear |
| Jenny L Wiley, Billy R Marti. Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505690. |
delta(9)-tetrahydrocannabinol (delta(9)-thc), the primary psychoactive constituent of marijuana (cannabis sativa), is known to bind to two cannabinoid receptors: cb(1) receptors, located primarily in the brain, and cb(2) receptors, located primarily in the periphery. |
2003-08-22 |
2023-08-12 |
mouse |
| Herbert Schuel, Lani J Burkman, Jack Lippes, Kent Crickard, Ellyn Forester, Daniele Piomelli, Andrea Giuffrid. N-Acylethanolamines in human reproductive fluids. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505702. |
collectively, these findings suggest that naes in human reproductive fluids may help regulate multiple physiological and pathological processes in the reproductive system, and imply that exogenous cannabinoids delivered by marijuana smoke might impact these processes. |
2003-08-22 |
2023-08-12 |
human |
| Herbert Schuel, Lani J Burkman, Jack Lippes, Kent Crickard, Ellyn Forester, Daniele Piomelli, Andrea Giuffrid. N-Acylethanolamines in human reproductive fluids. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505702. |
this study has potential medical and public policy ramifications because of the incidence of marijuana abuse by adolescents and adults in our society, previously documented reproductive effects of marijuana, and the ongoing debate about medicinal use of marijuana and cannabinoids. |
2003-08-22 |
2023-08-12 |
human |
| Alexander F Hoffman, Murat Oz, Tara Caulder, Carl R Lupic. Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832502. |
the rewarding properties of the psychoactive constituents of marijuana, termed "cannabinoids," may reflect actions on synaptic transmission in the nucleus accumbens (nac). |
2003-08-05 |
2023-08-12 |
rat |
| Alexander F Hoffman, Murat Oz, Tara Caulder, Carl R Lupic. Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832502. |
because humans often use marijuana for prolonged periods, we examined the impact of long-term cannabinoid exposure on synaptic processes in an animal model. |
2003-08-05 |
2023-08-12 |
rat |
| Alexander F Hoffman, Murat Oz, Tara Caulder, Carl R Lupic. Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832502. |
these data demonstrate that long-term exposure to the active ingredient of marijuana blocks synaptic plasticity in the nac and reduces the sensitivity of gabaergic and glutamatergic synapses to both cannabinoids and opioids. |
2003-08-05 |
2023-08-12 |
rat |
| Tamas F Freund, Istvan Katona, Daniele Piomell. Role of endogenous cannabinoids in synaptic signaling. Physiological reviews. vol 83. issue 3. 2003-08-01. PMID:12843414. |
in addition, the behavioral effects of exogenous cannabinoids such as delta-9-tetrahydrocannabinol, the major active compound of hashish and marijuana, await explanation at the cellular and network levels. |
2003-08-01 |
2023-08-12 |
Not clear |
| Albert D Fraser, David Wort. Urinary excretion profiles of 11-nor-9-carboxy-Delta9-tetrahydrocannabinol: a Delta9-THC-COOH to creatinine ratio study #2. Forensic science international. vol 133. issue 1-2. 2003-07-29. PMID:12742686. |
the objective of the present study was to determine whether creatinine corrected urine specimens positive for cannabinoids could differentiate new marijuana use from the excretion of residual delta(9)-thc-cooh in chronic users of marijuana based on the huestis 0.5 ratio. |
2003-07-29 |
2023-08-12 |
human |
| Demetris P Papahatjis, Spyros P Nikas, Thanos Andreou, Alexandros Makriyanni. Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic & medicinal chemistry letters. vol 12. issue 24. 2003-07-16. PMID:12443781. |
1',1'-cyclopropyl side chain substituents enhance the affinities of delta(8)-tetrahydrocannabinol and respective cannabidiol analogues for the cb1 and cb2 cannabinoid receptors. |
2003-07-16 |
2023-08-12 |
Not clear |
| Allyn C Howlet. The cannabinoid receptors. Prostaglandins & other lipid mediators. vol 68-69. 2003-07-10. PMID:12432948. |
cannabinoid receptors were named because they have affinity for the agonist delta9-tetrahydrocannabinol (delta9-thc), a ligand found in organic extracts from cannabis sativa. |
2003-07-10 |
2023-08-12 |
Not clear |
| Giovanni Diana, Massimo Pieri, Giovanni Valentin. Effects of Win 55,212-2 on hippocampal CA1 long-term potentiation in experiments controlled for basal glutamatergic synaptic transmission. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398912. |
cannabinoids, the active components of marijuana, are presumed to affect memory by an action on long-term potentiation. |
2003-07-08 |
2023-08-12 |
Not clear |
| Declan Walsh, Kristine A Nelson, Fade Aziz Mahmou. Established and potential therapeutic applications of cannabinoids in oncology. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. vol 11. issue 3. 2003-06-12. PMID:12618922. |
cannabinoids are the active compounds extracted from cannabis. |
2003-06-12 |
2023-08-12 |
Not clear |
| Franjo Grotenherme. Pharmacokinetics and pharmacodynamics of cannabinoids. Clinical pharmacokinetics. vol 42. issue 4. 2003-06-11. PMID:12648025. |
however, its acid metabolite thc-cooh, the non-psychotropic cannabidiol (cbd), several cannabinoid analogues and newly discovered modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. |
2003-06-11 |
2023-08-12 |
Not clear |