| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenxiang Gao, T John Winhusen, Maria Gorenflo, Udi E Ghitza, Pamela B Davis, David C Kaelber, Rong X. Repurposing ketamine to treat cocaine use disorder: Integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration, and mechanism of action analyses. Addiction (Abingdon, England). 2023-02-15. PMID:36792381. |
cocaine use disorder (cud) is a significant public health issue for which there is no food and drug administration (fda) approved medication. |
2023-02-15 |
2023-08-14 |
Not clear |
| Michal M Graczyk, Barbara J Sahakian, Trevor W Robbins, Karen D Ersch. Genotype-by-diagnosis interaction influences self-control in human cocaine addiction. Translational psychiatry. vol 13. issue 1. 2023-02-11. PMID:36774338. |
patients with cocaine use disorder (cud, n = 79) and healthy unrelated participants with no history of drug abuse (n = 54) completed the stop-signal task. |
2023-02-11 |
2023-08-14 |
human |
| Philipp Mews, Ashley M Cunningham, Joseph Scarpa, Aarthi Ramakrishnan, Emily M Hicks, Sarah Bolnick, Susanna Garamszegi, Li Shen, Deborah C Mash, Eric J Nestle. Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models. Science advances. vol 9. issue 6. 2023-02-10. PMID:36763659. |
cocaine use disorder (cud) is an intractable syndrome, and rising overdose death rates represent a substantial public health crisis that exacts tremendous personal and financial costs on patients and society. |
2023-02-10 |
2023-08-14 |
mouse |
| Philipp Mews, Ashley M Cunningham, Joseph Scarpa, Aarthi Ramakrishnan, Emily M Hicks, Sarah Bolnick, Susanna Garamszegi, Li Shen, Deborah C Mash, Eric J Nestle. Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models. Science advances. vol 9. issue 6. 2023-02-10. PMID:36763659. |
integration of comprehensive transcriptomic datasets from mouse cocaine self-administration models revealed evolutionarily conserved gene networks in cud that implicate especially d1 medium spiny neurons as drivers of cocaine-induced plasticity. |
2023-02-10 |
2023-08-14 |
mouse |
| Christina R Merritt, Ashley E Smith, Kamil Khanipov, George Golovko, Kelly T Dineley, Noelle C Anastasio, Kathryn A Cunningha. Heightened cocaine-seeking in male rats associates with a distinct transcriptomic profile in the medial prefrontal cortex. Frontiers in pharmacology. vol 13. 2023-01-02. PMID:36588704. |
drug overdose deaths involving cocaine have skyrocketed, an outcome attributable in part to the lack of fda-approved medications for the treatment of cocaine use disorder (cud), highlighting the need to identify new pharmacotherapeutic targets. |
2023-01-02 |
2023-08-14 |
rat |
| Hui Xu, Cheng Xu, Chenguang Gu. Cocaine use disorder is associated with widespread surface-based alterations of the basal ganglia. Journal of psychiatric research. vol 158. 2022-12-29. PMID:36580868. |
cocaine use disorder (cud) is closely associated with brain structure alterations, which are mainly analyzed using voxel-based morphometric and traditional volumetric methods with certain limitations. |
2022-12-29 |
2023-08-14 |
Not clear |
| Hui Xu, Cheng Xu, Chenguang Gu. Cocaine use disorder is associated with widespread surface-based alterations of the basal ganglia. Journal of psychiatric research. vol 158. 2022-12-29. PMID:36580868. |
this study conducted vertex-wise shape analysis to examine the effects of cocaine use on surface-based alterations of the basal ganglia in cud. |
2022-12-29 |
2023-08-14 |
Not clear |
| Hui Xu, Cheng Xu, Chenguang Gu. Cocaine use disorder is associated with widespread surface-based alterations of the basal ganglia. Journal of psychiatric research. vol 158. 2022-12-29. PMID:36580868. |
related to hcs, cud individuals showed regional surface atrophy of the left medial anterior thalamus, right medial posterior thalamus, and right dorsal anterior caudate, which were found to exhibit more significant surface atrophy in cud individuals with onset age of cocaine use below 18. |
2022-12-29 |
2023-08-14 |
Not clear |
| Hui Xu, Cheng Xu, Chenguang Gu. Cocaine use disorder is associated with widespread surface-based alterations of the basal ganglia. Journal of psychiatric research. vol 158. 2022-12-29. PMID:36580868. |
furthermore, surface-based alteration of the right dorsal anterior caudate was significantly associated with years of cocaine use and the onset age of cocaine use in cud individuals. |
2022-12-29 |
2023-08-14 |
Not clear |
| Hui Xu, Cheng Xu, Chenguang Gu. Cocaine use disorder is associated with widespread surface-based alterations of the basal ganglia. Journal of psychiatric research. vol 158. 2022-12-29. PMID:36580868. |
furthermore, both cud individuals with onset age of cocaine use below 18 and cud individuals with onset age of cocaine use above 18 showed similar significant relationship patterns between regional surface alteration of right dorsal anterior caudate and the onset age of cocaine use. |
2022-12-29 |
2023-08-14 |
Not clear |
| Hui Xu, Cheng Xu, Chenguang Gu. Cocaine use disorder is associated with widespread surface-based alterations of the basal ganglia. Journal of psychiatric research. vol 158. 2022-12-29. PMID:36580868. |
these findings shed light on the effect of cocaine use on basal ganglia, help us understand the neural basis of cocaine dependence, and further provide effective interventions for cud. |
2022-12-29 |
2023-08-14 |
Not clear |
| Omeed Rahimi, Jianjing Cao, Jenny Lam, Steven R Childers, Rana Rais, Linda J Porrino, Amy Newman, Michael A Nade. The Journal of pharmacology and experimental therapeutics. 2022-12-12. PMID:36507847. |
while there are no fda-approved treatments for cocaine use disorder (cud), several modafinil analogs have demonstrated promise in reducing cocaine self-administration and reinstatement in rats. |
2022-12-12 |
2023-08-14 |
rat |
| Angela Sanna, Valentina Bini, Paola Badas, Giorgio Corona, Gabriele Sanna, Lara Marcasciano, Maria Chiara De Vivo, Marco Dian. Role of maintenance treatment on long-term efficacy of bilateral iTBS of the prefrontal cortex in treatment-seeking cocaine addicts: A retrospective analysis. Frontiers in psychiatry. vol 13. 2022-11-25. PMID:36424992. |
this study explores the long-term outcome of bilateral intermittent theta-burst stimulation (itbs) of the prefrontal cortex (pfc) in cocaine use disorder (cud) and the possible influence of maintenance treatment in improving abstinence and decreasing do rates. |
2022-11-25 |
2023-08-14 |
Not clear |
| Augusto Martins Lucas Bittencourt, Bárbara Luiza Belmonte da Silveira, Lucca Pizzato Tondo, Leonardo Melo Rothmann, Alexandre Rosa Franco, Pedro Eugenio Mazzucchi Santana Ferreira, Thiago Wendt Viola, Rodrigo Grassi-Oliveir. Cingulate cortical thickness in cocaine use disorder: mediation effect between early life stress and cocaine consumption. Acta neuropsychiatrica. 2022-11-23. PMID:36416534. |
early-life stress (els) is an important moderator of cocaine use disorder (cud). |
2022-11-23 |
2023-08-14 |
Not clear |
| Joanna Jastrzębska, Małgorzata Frankowska, Irena Smaga, Magdalena Hubalewska-Mazgaj, Agata Suder, Renata Pieniążek, Edmund Przegaliński, Małgorzata Fili. Evaluation of the 5-HT Pharmacological reports : PR. 2022-11-14. PMID:36374478. |
evaluation of the 5-ht epidemiological data indicate a high rate of comorbidity of depression and cocaine use disorder (cud). |
2022-11-14 |
2023-08-14 |
Not clear |
| Pierre-Olivier Gaudreault, Sarah G King, Pias Malaker, Nelly Alia-Klein, Rita Z Goldstei. Whole-brain white matter abnormalities in human cocaine and heroin use disorders: association with craving, recency, and cumulative use. Molecular psychiatry. 2022-11-12. PMID:36369361. |
our study assessed whole-brain wm integrity in three subgroups of individuals addicted to drugs, encompassing those with cocaine (cud) or heroin (hud) use disorder, compared to healthy controls (ctl). |
2022-11-12 |
2023-08-14 |
human |
| Verica Milivojevic, Lily Charron, Nia Fogelman, Gretchen Hermes, Rajita Sinh. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules. vol 12. issue 11. 2022-11-11. PMID:36358943. |
this study tested whether potentiation of the neuroactive steroid system with the precursor pregnenolone (preg) affects stress- and cue-induced cocaine craving, anxiety and autonomic response in individuals with cocaine use disorder (cud). |
2022-11-11 |
2023-08-14 |
human |
| Verica Milivojevic, Lily Charron, Nia Fogelman, Gretchen Hermes, Rajita Sinh. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules. vol 12. issue 11. 2022-11-11. PMID:36358943. |
findings indicate that pregnenolone decreases stress- and cocaine cue-provoked craving and anxiety and reduces stress-induced autonomic arousal in individuals with cud. |
2022-11-11 |
2023-08-14 |
human |
| Elise E DeVito, James Poling, Theresa Babuscio, Charla Nich, Kathleen M Carroll, Mehmet Sofuogl. Modafinil Does Not Reduce Cocaine Use in Methadone-Maintained Individuals. Drug and alcohol dependence reports. vol 2. 2022-10-31. PMID:36310662. |
there are no approved medications for the treatment of cocaine use disorder (cud). |
2022-10-31 |
2023-08-14 |
Not clear |
| Sarah A Schoenrock, Leona Gagnon, Ashley Olson, Michael Leonardo, Vivek M Philip, Hao He, Laura G Reinholdt, Stacey J Sukoff Rizzo, James D Jentsch, Elissa J Chesler, Lisa M Tarantin. The collaborative cross strains and their founders vary widely in cocaine-induced behavioral sensitization. Frontiers in behavioral neuroscience. vol 16. 2022-10-24. PMID:36275853. |
despite the prevalence of cocaine use disorder (cud) and the personal and societal problems it presents, there are currently no approved pharmaceutical treatments. |
2022-10-24 |
2023-08-14 |
mouse |