| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huimei Wei, Elise C Maul, Annet Kyomuhangi, Shawn Park, Maddilynn L Mutchler, Chang-Guo Zhan, Fang Zhen. Effects of Fentanyl-Laced Cocaine on Circulating Ghrelin, Insulin, and Glucose Levels in Rats. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076960. |
additionally, based on the insulin data obtained in this study, the insulin level was always downregulated significantly and considerably, implying that the fentanyl and cocaine polydrug might have a stronger cardiovascular toxicity to the patients with insulin resistance and diabetes. |
2025-03-13 |
2025-03-15 |
rat |
| Huimei Wei, Elise C Maul, Annet Kyomuhangi, Shawn Park, Maddilynn L Mutchler, Chang-Guo Zhan, Fang Zhen. Effects of Fentanyl-Laced Cocaine on Circulating Ghrelin, Insulin, and Glucose Levels in Rats. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076960. |
as ghrelin plays an important role in drug reward and can also influence insulin, this study aimed to assess responses of the circulating ghrelin, insulin, and glucose levels to the combined use of fentanyl and cocaine (a polydrug) in rats by performing combined animal behavioral experiments and biochemical analysis. |
2025-03-13 |
2025-03-15 |
rat |
| Huimei Wei, Elise C Maul, Annet Kyomuhangi, Shawn Park, Maddilynn L Mutchler, Chang-Guo Zhan, Fang Zhen. Effects of Fentanyl-Laced Cocaine on Circulating Ghrelin, Insulin, and Glucose Levels in Rats. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076960. |
effects of fentanyl-laced cocaine on circulating ghrelin, insulin, and glucose levels in rats. |
2025-03-13 |
2025-03-15 |
rat |
| Huimei Wei, Elise C Maul, Annet Kyomuhangi, Shawn Park, Maddilynn L Mutchler, Chang-Guo Zhan, Fang Zhen. Effects of Fentanyl-Laced Cocaine on Circulating Ghrelin, Insulin, and Glucose Levels in Rats. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076960. |
the experimental data consistently revealed that the fentanyl and cocaine co-use can significantly elevate both the acyl-ghrelin and desacyl-ghrelin levels and significantly decrease the insulin level without significant effects on the glucose level. |
2025-03-13 |
2025-03-15 |
rat |
| Kayvan Khoramipour, Maryam Hossein Rezaei, Elham Madadizadeh, Mahdieh Sadat Hosseini, Zahra Soltani, Janis Schierbauer, Othmar Mose. High Intensity Interval Training can Ameliorate Hypothalamic Appetite Regulation in Male Rats with Type 2 Diabetes: The Role of Leptin. Cellular and molecular neurobiology. 2023-10-12. PMID:37828299. |
homeostatic model assessment for insulin resistance (homa-ir), serum levels of insulin (ins) and lep (leps) as well as hypothalamic expression of lep receptors (lep-r), janus kinase 2 (jak-2), signal transducer and activator of transcription 3 (stat-3), neuropeptide y (npy), agouti-related protein (agrp), pro-opiomelanocortin cocaine (pomc), amphetamine-related transcript (cart), suppressor of cytokine signaling (socs3), forkhead box protein o1 (foxo1) were assessed. |
2023-10-12 |
2023-10-15 |
rat |
| Brittany S Bruggeman, Martha Campbell-Thompson, Stephanie L Filipp, Matthew J Gurka, Mark A Atkinson, Desmond A Schatz, Laura M Jacobse. Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies. Frontiers in endocrinology. vol 12. 2021-12-16. PMID:34912300. |
alcohol and/or cocaine use in type 1 diabetes organ donors increases exocrine pancreas pathology and islet amyloid deposition but does not affect insulitis or insulin positivity. |
2021-12-16 |
2023-08-13 |
human |
| Prashant Nasa, Sandeep Chaudhary, Pavan Kumar Shrivastava, Aanchal Sing. Euglycemic diabetic ketoacidosis: A missed diagnosis. World journal of diabetes. vol 12. issue 5. 2021-05-18. PMID:33995841. |
the other causes of euglycemic dka include pregnancy, fasting, bariatric surgery, gastroparesis, insulin pump failure, cocaine intoxication, chronic liver disease and glycogen storage disease. |
2021-05-18 |
2023-08-13 |
Not clear |
| Leonid Barski, Tamar Eshkoli, Evgenia Brandstaetter, Alan Jotkowit. Euglycemic diabetic ketoacidosis. European journal of internal medicine. vol 63. 2020-07-08. PMID:30910328. |
other causes associated with eu-dka include pregnancy, decreased caloric intake, heavy alcohol use, insulin use prior to hospital admission, cocaine abuse, pancreatitis, sepsis, chronic liver disease and liver cirrhosis. |
2020-07-08 |
2023-08-13 |
Not clear |
| Lindsay Naef, Lauren Seabrook, Jeff Hsiao, Calvin Li, Stephanie L Borglan. Insulin in the ventral tegmental area reduces cocaine-evoked dopamine in the nucleus accumbens in vivo. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:30471157. |
finally, intra-vta or intranasal insulin decreased locomotor responses to cocaine, an effect blocked by an intra-vta administered insulin receptor antagonist. |
2020-06-30 |
2023-08-13 |
Not clear |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
this study evaluated the effects of adx on icv (lateral ventricle) injection of insulin-induced changes on food intake, mrna expression of hypothalamic neuropeptides (insulin receptor (insr), proopiomelanocortin, cocaine and amphetamine-regulated transcript (cart), agouti-related protein, neuropeptide y (npy) in the arcuate nucleus of the hypothalamus (arc), corticotrophin-releasing factor in the paraventricular nucleus of the hypothalamus) and hypothalamic protein content of insulin signaling-related molecules (insulin receptor substrate (irs) 1, protein kinase b (akt), extracellular-signal-regulated kinase (erk1/2), c-jun n-terminal kinase (jnk), protein tyrosine phosphatase-1b (ptp1b) and t cell protein tyrosine phosphatase (tcptp)) compared with sham animals, adx increased the hypothalamic content of pjnk/jnk, ptp1b and tcptp, as well as decreased mrna expression of insr, and corticosterone (b) treatment reversed these effects. |
2020-04-06 |
2023-08-13 |
rat |
| Zhi-Bing You, Bin Wang, Eliot L Gardner, Roy A Wis. Cocaine and cocaine expectancy increase growth hormone, ghrelin, GLP-1, IGF-1, adiponectin, and corticosterone while decreasing leptin, insulin, GIP, and prolactin. Pharmacology, biochemistry, and behavior. vol 176. 2020-02-25. PMID:30414405. |
cocaine and cocaine expectancy increase growth hormone, ghrelin, glp-1, igf-1, adiponectin, and corticosterone while decreasing leptin, insulin, gip, and prolactin. |
2020-02-25 |
2023-08-13 |
rat |
| Evelyn H Schlenke. Sexual dimorphism of cardiopulmonary regulation in the arcuate nucleus of the hypothalamus. Respiratory physiology & neurobiology. vol 245. 2018-07-23. PMID:27756648. |
importantly, the anh exhibits structural and functional sexually dimorphic characteristics and contains numerous neuroactive substances and receptors including leptin, neuropeptide y, glutamate, acetylcholine, endorphins, orexin, kisspeptin, insulin, agouti-related protein, cocaine and amphetamine-regulated transcript, dopamine, somatostatin, components of renin-angiotensin system and gamma amino butyric acid that modulate physiological functions. |
2018-07-23 |
2023-08-13 |
Not clear |
| Sofia Bouhlal, Kayla N Ellefsen, Mikela B Sheskier, Erick Singley, Sandrine Pirard, David A Gorelick, Marilyn A Huestis, Lorenzo Leggi. Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses. Drug and alcohol dependence. vol 180. 2018-04-25. PMID:28881319. |
acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide yy and relationships with cardiorespiratory and subjective responses. |
2018-04-25 |
2023-08-13 |
Not clear |
| Milene Moehlecke, Luis Henrique Canani, Lucas Oliveira Junqueira E Silva, Manoel Roberto Maciel Trindade, Rogerio Friedman, Cristiane Bauermann Leitã. Determinants of body weight regulation in humans. Archives of endocrinology and metabolism. vol 60. issue 2. 2017-05-02. PMID:26910628. |
in this review, we examine the role of systemic mediators such as leptin, ghrelin and insulin, which act in the central nervous system by activating or inhibiting neuropeptide y, agouti-related peptide protein, melanocortin, transcript related to cocaine and amphetamine, and others. |
2017-05-02 |
2023-08-13 |
human |
| Asma Abu-Abed Abdin, Muhammad Hamza, Muhammad S Khan, Awab Ahme. Euglycemic Diabetic Ketoacidosis in a Patient with Cocaine Intoxication. Case reports in critical care. vol 2016. 2016-08-31. PMID:27579186. |
we describe an interesting case of euglycemic dka in a middle-aged diabetic female presenting with elevated anion gap metabolic acidosis, with near-normal blood glucose, in the settings of noncompliance to insulin and cocaine abuse. |
2016-08-31 |
2023-08-13 |
Not clear |
| Asma Abu-Abed Abdin, Muhammad Hamza, Muhammad S Khan, Awab Ahme. Euglycemic Diabetic Ketoacidosis in a Patient with Cocaine Intoxication. Case reports in critical care. vol 2016. 2016-08-31. PMID:27579186. |
this case highlights complex physiological interplay between type-1 diabetes, noncompliance to insulin, and cocaine abuse leading to dka, with starvation physiology causing development of euglycemic dka. |
2016-08-31 |
2023-08-13 |
Not clear |
| Qian Zhao, Jing Hou, Bo Chen, Xue Shao, Ruiming Zhu, Qian Bu, Hui Gu, Yan Li, Baolai Zhang, Changman Du, Dengqi Fu, Jueying Kong, Li Luo, Hailei Long, Hongyu Li, Yi Deng, Yinglan Zhao, Xiaobo Ce. Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. Neurobiology of disease. vol 82. 2016-08-19. PMID:26054440. |
prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor ii epigenetic regulation. |
2016-08-19 |
2023-08-13 |
Not clear |
| Andrés Ricardo Pérez Riera, Li Zhang, Augusto Hiroshi Uchida, Edgardo Schapachnik, Sergio Dubner, Celso Ferreir. The management of Brugada syndrome patients. Cardiology journal. vol 14. issue 1. 2012-10-02. PMID:18651443. |
the syndrome may also be unmasked or precipitated by a febrile state, vagotonic agents, alpha-adrenergic agonists, beta-adrenergic blockers, tricyclic or tetracyclic antidepressants, a combination of glucose and insulin and hypokalaemia, as well as by alcohol and cocaine toxicity. |
2012-10-02 |
2023-08-12 |
Not clear |
| Anton N M Schoffelmeer, Benjamin Drukarch, Taco J De Vries, François Hogenboom, Dustin Schetters, Tommy Patti. Insulin modulates cocaine-sensitive monoamine transporter function and impulsive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 4. 2011-03-30. PMID:21273413. |
intracranial administration of insulin in the nucleus accumbens alone reduced premature responses in the five-choice serial reaction time task and enhanced the stimulatory effect of peripheral cocaine administration on impulsivity, resembling the observed neurochemical effects of the hormone. |
2011-03-30 |
2023-08-12 |
rat |
| Anton N M Schoffelmeer, Benjamin Drukarch, Taco J De Vries, François Hogenboom, Dustin Schetters, Tommy Patti. Insulin modulates cocaine-sensitive monoamine transporter function and impulsive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 4. 2011-03-30. PMID:21273413. |
in this respect, we examined the effects of insulin on exocytotic monoamine release and the efficacy of the monoamine transporter blocker cocaine in rat nucleus accumbens. |
2011-03-30 |
2023-08-12 |
rat |