| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anton N M Schoffelmeer, Benjamin Drukarch, Taco J De Vries, François Hogenboom, Dustin Schetters, Tommy Patti. Insulin modulates cocaine-sensitive monoamine transporter function and impulsive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 4. 2011-03-30. PMID:21273413. |
whereas insulin reduced electrically evoked exocytotic [(3)h]dopamine release in nucleus accumbens slices, the hormone potentiated the release-enhancing effect of cocaine thereon. |
2011-03-30 |
2023-08-12 |
rat |
| A Tomillero, M A Mora. Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology. vol 32. issue 5. 2010-12-16. PMID:20664824. |
[¹¹c]rac; (18)f-fluoromisonidazole; 89-12; 9-[¹⁸f]fluoropropyl-(+)-dihydrotetrabenazine; adalimumab, adecatumumab, admva, adxs-11-001, aflibercept, agatolimod sodium, ags-004, alglucosidase alfa, aliskiren fumarate, alvocidib hydrochloride, amg-108, amg-853, apixaban, aripiprazole, armodafinil, atazanavir sulfate, atomoxetine hydrochloride; bevacizumab, biomatrix flex drug eluting stent, biphasic insulin aspart, bortezomib, bosentan; caspofungin acetate, cediranib, cetuximab, chimerivax-dengue, choriogonadotropin alfa, cinacalcet hydrochloride, cizolirtine citrate, clofarabine, cocaine conjugate vaccine, cx-717; darbepoetin alfa, dasatinib, decitabine, denosumab, desvenlafaxine succinate, dexamethasone sodium phosphate, dienogest, diphencyprone, doripenem, dtap-hepb-ipv, dutasteride; e-7010, ecallantide, ecstasy, eicosapentaenoic acid/docosahexaenoic acid, emtricitabine, enfuvirtide, erlotinib hydrochloride, eszopiclone, etonogestrel/ethinyl estradiol, etoricoxib, everolimus, everolimus-eluting coronary stent evt-201, ezetimibe, ezetimibe/simvastatin; ferumoxytol, fesoterodine fumavate, figitumumab, filgrastim, fingolimod hydrochloride, fluticasone furoate, fluval p, fluzone, fondaparinux sodium, fulvestrant, fungichromin; gamma-hydroxybutyrate sodium, gefitinib, ghb-01l1, gly-230, gsk-1349572; hib-mency-tt, hib-tt, hpv-6/11/16/18, hydrocodone bitartrate; ic-51, icatibant acetate, imatinib mesylate, immunoglobulin intravenous (human), indetanib, influenza a (h1n1) 2009 monovalent vaccine, inhalable human insulin, insulin glargine, insulin glulisine, interferon-beta, ispinesib mesylate, ixabepilone; laromustine, latanoprost/timolol maleate, l-citrulline, lenalidomide, lexatumumab, linezolid, lopinavir/ritonavir, lutropin alfa; mapatumumab, mdx-066, mdx-1388, mepolizumab, methoxy polyethylene glycol-epoetin-beta, metreleptin, micafungin sodium, mometasone furoate/oxymetazoline hydrochloride, mx-dng1, mycophenolic acid sodium salt; nabiximols, natalizumab, nemonoxacin, norelgestromin/ethinyl estradiol; oblimersen sodium, ocriplasmin, olmesartan medoxomil, omacetaxine mepesuccinate; paclitaxel-eluting stent, pagoclone, paliperidone, panitumumab, pazopanib hydrochloride, pcv7, pegaptanib octasodium, peginterferon alfa-2a, peginterferon alfa-2b/ ribavirin, pegvisomant, pemetrexed disodium, perifosine, pimecrolimus, pitavastatin calcium, plerixafor hydrochloride, plitidepsin, posaconazole, pregabalin, progesterone capriate; raltegravir potassium, ramucirumab, ranelic acid distrontium salt, rasburicase, recombinant bet v1, recombinant human insulin, rhfsh, rolofylline, romidepsin, romiplostim, rosuvastatin calcium; sapacitabine, sevelamer carbonate, sinecatechins, sirolimus-eluting stent, sitagliptin phosphate monohydrate, sn-29244, sorafenib, sugammadex sodium, sunitinib malate; tadalafil, tafenoquine, talnetant, tanezumab, tapentadol hydrochloride, tasocitinib citrate, technosphere/insulin, telcagepant, tenofovir disoproxil fumarate, teriparatide, ticagrelor, tigecycline, tiotropium bromide, tipifarnib, tocilizumab, ts-041; ulipristal acetate, urtoxazumab, ustekinumab; vandetanib, varenicline tartrate, vicriviroc, voriconazole, vorinostat, vrc-hivadv014-00-vp, vrc-hivdna016-00-vp; zoledronic acid monohydrate. |
2010-12-16 |
2023-08-12 |
human |
| Miriam Granado, Cristina García-Cáceres, Laura M Frago, Jesús Argente, Julie A Chowe. The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status. Endocrinology. vol 151. issue 5. 2010-06-08. PMID:20219977. |
cocaine amphetamine-related transcript mrna levels were also reduced in diabetic rats, with ghrp-6 inducing a further decrease (p < 0.03) and insulin an increase. |
2010-06-08 |
2023-08-12 |
rat |
| A Tomillero, M A Mora. Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology. vol 32. issue 1. 2010-06-08. PMID:20383346. |
(-)-epigallocatechin gallate, abafungin, ace-031, adapalene/benzoyl peroxide, ae-37, aflibercept, ags-003, albiglutide, alemtuzumab, aliskiren fumarate, alt-801, an-2728, anacetrapib, api, aprepitant, arq-197, ascorbic acid, atazanavir sulfate, atn-224, avi-4658, azacitidine, azelnidipine; belinostat, bevacizumab, bi-2536, biphasic insulin aspart, bortezomib, bovine lactoferrin, bryostatin 1, budesonide/formoterol fumarate; cac10, canfosfamide hydrochloride, cediranib, clofarabine, cocaine conjugate vaccine; darbepoetin alfa, dasatinib, denosumab, disomotide, doripenem, dovitinib lactate, dronedarone hydrochloride, drospirenone/estradiol, dutasteride; ecogramostim, entinostat, enzastaurin hydrochloride, erlotinib hydrochloride, everolimus, exenatide, ezetimibe, ezetimibe/simvastatin; fampridine, fenretinide lxs, ffr-factor viia, fingolimod hydrochloride, frovatriptan; gefitinib, gimatecan, gp-2/gm-csf; iloperidone, imatinib mesylate, indibulin, ipilimumab, ivabradine hydrochloride; lactobacillus rhamnosus, lapatinib ditosylate, lc-07, lenalidomide, linifanib, liposomal doxorubicin, liposomal vincristine, litenimod, lutein; m-118, mdx-1401, medi-528, midostaurin, miglustat, mk-0657; natalizumab, nesiritide, ngr-tnf, niacin/simvastatin; obatoclax mesylate, olaparib, omacetaxine mepesuccinate; paclitaxel nanoparticles, paclitaxel-eluting stent, palonosetron hydrochloride, pazopanib hydrochloride, pegfilgrastim, pemetrexed disodium, per.c-flu, perifosine, pf-02341066, pimecrolimus, pitrakinra, plerixafor hydrochloride, posaconazole; rasburicase, recombinant human relaxin h2, reot3d, retaspimycin hydrochloride, riferminogene pecaplasmid, rindopepimut, romiplostim, ronacaleret hydrochloride, rosuvastatin calcium, rotigotine; sagopilone, salp-fcd10, sar-245409, sch-697243, selumetinib, sirolimus-eluting stent, sir-spheres, sitagliptin phosphate monohydrate, sitaxentan sodium, sorafenib, sunitinib malate; tadalafil, tandutinib, tasimelteon, temsirolimus, teriparatide, tiotropium bromide, tiv, trabectedin, tremelimumab, tru-016; vadimezan, val8-glp-1(7-37)oh, vandetanib, vernakalant hydrochloride, voreloxin, voriconazole, vorinostat, yttrium 90 (90y) ibritumomab tiuxetan; zeaxanthin, ziprasidone hydrochloride, zosuquidar trihydrochloride. |
2010-06-08 |
2023-08-12 |
human |
| D Rott, D D Langleben, I Elma. Cocaine decreases plasma insulin concentrations in non-diabetic subjects: a randomized double-blind study. Diabetic medicine : a journal of the British Diabetic Association. vol 25. issue 4. 2008-07-16. PMID:18346162. |
cocaine decreases plasma insulin concentrations in non-diabetic subjects: a randomized double-blind study. |
2008-07-16 |
2023-08-12 |
human |
| Y Wei, J M Williams, C Dipace, U Sung, J A Javitch, A Galli, C Saunder. Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism. Molecular pharmacology. vol 71. issue 3. 2007-03-22. PMID:17164407. |
thus, amph, but not cocaine, decreases akt activity through a camkii-dependent pathway, thereby providing a novel mechanism by which amph regulates insulin signaling and dat trafficking. |
2007-03-22 |
2023-08-12 |
Not clear |
| Philippe Hantson, Thierry Dupre. The value of morphological neuroimaging after acute exposure to toxic substances. Toxicological reviews. vol 25. issue 2. 2007-02-01. PMID:16958556. |
this article selectively reviews the main radiological changes observed on ct/magnetic resonance (mr) neuroimages after 'acute exposure' to industrial products (methanol [methyl alcohol], ethylene glycol), environmental agents (cyanide, carbon monoxide), pharmaceuticals (insulin, valproic acid) and illicit substances (heroin, cocaine). |
2007-02-01 |
2023-08-12 |
Not clear |
| C Antzelevitch, J M Fis. Therapy for the Brugada syndrome. Handbook of experimental pharmacology. issue 171. 2006-04-27. PMID:16610350. |
the syndrome may also be unmasked or precipitated by a febrile state, vagotonic agents, alpha-adrenergic agonists, beta-adrenergic blockers, tricyclic or tetracyclic antidepressants, a combination of glucose and insulin, and hypokalemia, as well as by alcohol and cocaine toxicity. |
2006-04-27 |
2023-08-12 |
Not clear |
| Charles Antzelevitch, Pedro Brugada, Martin Borggrefe, Josep Brugada, Ramon Brugada, Domenico Corrado, Ihor Gussak, Herve LeMarec, Koonlawee Nademanee, Andres Ricardo Perez Riera, Wataru Shimizu, Eric Schulze-Bahr, Hanno Tan, Arthur Wild. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. vol 111. issue 5. 2005-11-14. PMID:15655131. |
the ecg manifestations of brugada syndrome are often dynamic or concealed and may be unmasked or modulated by sodium channel blockers, a febrile state, vagotonic agents, alpha-adrenergic agonists, beta-adrenergic blockers, tricyclic or tetracyclic antidepressants, a combination of glucose and insulin, hypo- and hyperkalemia, hypercalcemia, and alcohol and cocaine toxicity. |
2005-11-14 |
2023-08-12 |
Not clear |
| Charles Antzelevitch, Pedro Brugada, Martin Borggrefe, Josep Brugada, Ramon Brugada, Domenico Corrado, Ihor Gussak, Herve LeMarec, Koonlawee Nademanee, Andres Ricardo Perez Riera, Wataru Shimizu, Eric Schulze-Bahr, Hanno Tan, Arthur Wild. Brugada syndrome: report of the second consensus conference. Heart rhythm. vol 2. issue 4. 2005-06-13. PMID:15898165. |
the ecg manifestations of brugada syndrome are often dynamic or concealed and may be unmasked or modulated by sodium channel blockers, a febrile state, vagotonic agents, alpha-adrenergic agonists, beta-adrenergic blockers, tricyclic or tetracyclic antidepressants, a combination of glucose and insulin, hypo- and hyperkalemia, hypercalcemia, and alcohol and cocaine toxicity. |
2005-06-13 |
2023-08-12 |
Not clear |
| Wen-Chih Lee, Jin-Jong Chen, Desmond D Hunt, Chien-Wen Hou, Yu-Chiang Lai, Fang-Ching Lin, Chung-Yu Chen, Ching-Hung Lin, Yi-Hung Liao, Chia-Hua Ku. Effects of hiking at altitude on body composition and insulin sensitivity in recovering drug addicts. Preventive medicine. vol 39. issue 4. 2005-04-18. PMID:15351533. |
in the current study individuals with a history of drug abuse (users of heroin, cocaine, or amphetamine) displayed a 13-100% increase in body weight (self-reported) and exhibited a trend toward insulin resistance. |
2005-04-18 |
2023-08-12 |
human |
| Harold E Bay. Current and investigational antiobesity agents and obesity therapeutic treatment targets. Obesity research. vol 12. issue 8. 2004-10-28. PMID:15340100. |
investigational antiobesity agents consist of 1) central nervous system agents that affect neurotransmitters or neural ion channels, including antidepressants (bupropion), selective serotonin 2c receptor agonists, antiseizure agents (topiramate, zonisamide), some dopamine antagonists, and cannabinoid-1 receptor antagonists (rimonabant); 2) leptin/insulin/central nervous system pathway agents, including leptin analogues, leptin transport and/or leptin receptor promoters, ciliary neurotrophic factor (axokine), neuropeptide y and agouti-related peptide antagonists, proopiomelanocortin and cocaine and amphetamine regulated transcript promoters, alpha-melanocyte-stimulating hormone analogues, melanocortin-4 receptor agonists, and agents that affect insulin metabolism/activity, which include protein-tyrosine phosphatase-1b inhibitors, peroxisome proliferator activated receptor-gamma receptor antagonists, short-acting bromocriptine (ergoset), somatostatin agonists (octreotide), and adiponectin; 3) gastrointestinal-neural pathway agents, including those that increase cholecystokinin activity, increase glucagon-like peptide-1 activity (extendin 4, liraglutide, dipeptidyl peptidase iv inhibitors), and increase protein yy3-36 activity and those that decrease ghrelin activity, as well as amylin analogues (pramlintide); 4) agents that may increase resting metabolic rate ("selective" beta-3 stimulators/agonist, uncoupling protein homologues, and thyroid receptor agonists); and 5) other more diverse agents, including melanin concentrating hormone antagonists, phytostanol analogues, functional oils, p57, amylase inhibitors, growth hormone fragments, synthetic analogues of dehydroepiandrosterone sulfate, antagonists of adipocyte 11b-hydroxysteroid dehydrogenase type 1 activity, corticotropin-releasing hormone agonists, inhibitors of fatty acid synthesis, carboxypeptidase inhibitors, indanones/indanols, aminosterols, and other gastrointestinal lipase inhibitors (atl962). |
2004-10-28 |
2023-08-12 |
Not clear |
| Z Liu, Y Wang, W Zhao, J Ding, Z Mei, L Guo, D Cui, J Fe. Peptide derived from insulin with regulatory activity of dopamine transporter. Neuropharmacology. vol 41. issue 4. 2001-11-01. PMID:11543766. |
so insulin is proposed as a kind of neuropeptide precursor in the brain and insulin-derived peptides may be involved in the process of regulating the da system, and these peptides may be developed into new medicines for disorders concerning the da system such as parkinson's disease and cocaine addiction. |
2001-11-01 |
2023-08-12 |
rat |
| A L García-Villalón, N Fernández, L Monge, M A Martínez, B Gómez, G Diégue. Insulin effects on the sympathetic contraction of rabbit ear arteries. General pharmacology. vol 34. issue 4. 2001-06-21. PMID:11282215. |
this inhibitory effect of insulin was not significantly modified by removing the endothelium, or by treatment with n(w)-nitro-l-arginine (l-na, 10(-4) m), meclofenamate (10(-5) m), ouabain (10(-6) m), or cocaine (10(-5) m). |
2001-06-21 |
2023-08-12 |
rabbit |
| T Shimosawa, K Ando, T Fujit. Effect of insulin on norepinephrine overflow at peripheral sympathetic nerve endings in young spontaneously hypertensive rats. American journal of hypertension. vol 9. issue 11. 1997-02-18. PMID:8931838. |
cocaine and ouabain completely blocked the effect of insulin in all four groups. |
1997-02-18 |
2023-08-12 |
rat |
| L P Sandstrom, S N Penningto. Embryonic growth inhibition induced by cocaine is associated with the suppression of ornithine decarboxylase activity. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 202. issue 4. 1993-04-22. PMID:8456117. |
in cultured embryonic tissue, cocaine exposure inhibits the ability of a known trophic factor (insulin) to induce growth and also blocks the associated increase in odc activity. |
1993-04-22 |
2023-08-12 |
chicken |
| L P Sandstrom, S N Penningto. Embryonic growth inhibition induced by cocaine is associated with the suppression of ornithine decarboxylase activity. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 202. issue 4. 1993-04-22. PMID:8456117. |
preliminary data suggest that cocaine hinders the binding of insulin to embryonic cells. |
1993-04-22 |
2023-08-12 |
chicken |
| J R Owiny, D Sadowsky, M T Jones, T J Reimers, P W Nathaniels. Effect of maternal cocaine administration on maternal and fetal glucose, lactate, and insulin in sheep. Obstetrics and gynecology. vol 77. issue 6. 1991-06-20. PMID:2030865. |
there were no significant changes in maternal or fetal plasma insulin concentrations after vehicle or cocaine administration. |
1991-06-20 |
2023-08-11 |
Not clear |
| J R Owiny, D Sadowsky, M T Jones, T J Reimers, P W Nathaniels. Effect of maternal cocaine administration on maternal and fetal glucose, lactate, and insulin in sheep. Obstetrics and gynecology. vol 77. issue 6. 1991-06-20. PMID:2030865. |
effect of maternal cocaine administration on maternal and fetal glucose, lactate, and insulin in sheep. |
1991-06-20 |
2023-08-11 |
Not clear |
| E J Harris, K L Mancheste. The effects of potassium ions and denervation on protein synthesis and the transport of amino acids in muscle. The Biochemical journal. vol 101. issue 1. 1967-09-12. PMID:4382008. |
the stimulation of incorporation by insulin was unaffected by changes in k(+) or in the presence of cocaine and mepyramine. |
1967-09-12 |
2023-08-11 |
rat |