| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Sullivan, R Simmon. Fenfluramine for treatment-resistant epilepsy in Dravet syndrome and other genetically mediated epilepsies. Drugs of today (Barcelona, Spain : 1998). vol 57. issue 7. 2021-07-19. PMID:34268532. |
the potential antiseizure effects of fenfluramine were first identified in patients with photosensitive epilepsy in the 1980s but it was not rigorously explored as a treatment option until 30 years later. |
2021-07-19 |
2023-08-13 |
Not clear |
| J Sullivan, R Simmon. Fenfluramine for treatment-resistant epilepsy in Dravet syndrome and other genetically mediated epilepsies. Drugs of today (Barcelona, Spain : 1998). vol 57. issue 7. 2021-07-19. PMID:34268532. |
here we provide a comprehensive review of the preclinical and clinical activity of fenfluramine, a recently approved drug for treatment of epilepsy in patients with dravet syndrome. |
2021-07-19 |
2023-08-13 |
Not clear |
| J Sullivan, R Simmon. Fenfluramine for treatment-resistant epilepsy in Dravet syndrome and other genetically mediated epilepsies. Drugs of today (Barcelona, Spain : 1998). vol 57. issue 7. 2021-07-19. PMID:34268532. |
fenfluramine for treatment-resistant epilepsy in dravet syndrome and other genetically mediated epilepsies. |
2021-07-19 |
2023-08-13 |
Not clear |
| Joseph Sullivan, M Scott Perry, James W Wheless, Bradley Galer, Arnold Gammaiton. Fenfluramine responder analyses and numbers needed to treat: Translating epilepsy trial data into clinical practice. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 31. 2021-06-14. PMID:33540241. |
fenfluramine responder analyses and numbers needed to treat: translating epilepsy trial data into clinical practice. |
2021-06-14 |
2023-08-13 |
Not clear |
| Catherine Chiro. Stiripentol for the treatment of seizures associated with Dravet syndrome. Expert review of neurotherapeutics. vol 19. issue 4. 2020-08-10. PMID:30900478. |
therapeutic options recently grew in this rare and severe early-onset epilepsy with the approval of stiripentol and cannabidiol in 2018 in the us and the positive trials just completed with fenfluramine. |
2020-08-10 |
2023-08-13 |
Not clear |
| Meir Bialer, Helen Cross, Ulrike B S Hedrich, Lieven Lagae, Holger Lerche, Tobias Loddenkempe. Novel treatment approaches and pediatric research networks in status epilepticus. Epilepsy & behavior : E&B. vol 101. issue Pt B. 2020-08-05. PMID:31708430. |
the five contributions concern: genetic variations in na + channel genes and their importance in status epilepticus; the european reference network for rare and complex epilepsies epicare; the north american pediatric status epilepticus research group (pserg); fenfluramine as a potential therapy for status epilepticus' and the valproate derivatives, valnoctamide and sec-butylpropylacetamide (spd), as potential therapies for status epilepticus. |
2020-08-05 |
2023-08-13 |
Not clear |
| Leonardo B Silenieks, Nicole K Carroll, Annalise Van Niekerk, Emily Van Niekerk, Colleen Taylor, Neil Upton, Guy A Higgin. Evaluation of Selective 5-HT ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:31082204. |
evaluation of selective 5-ht the 5-ht releaser/reuptake inhibitor fenfluramine has been recently reported to provide benefit as an adjunctive treatment for dravet and lennox-gastaut syndromes, two types of severe childhood epilepsy. |
2020-06-11 |
2023-08-13 |
Not clear |
| Lieven Lagae, Joseph Sullivan, Kelly Knupp, Linda Laux, Tilman Polster, Marina Nikanorova, Orrin Devinsky, J Helen Cross, Renzo Guerrini, Dinesh Talwar, Ian Miller, Gail Farfel, Bradley S Galer, Arnold Gammaitoni, Arun Mistry, Glenn Morrison, Michael Lock, Anupam Agarwal, Wyman W Lai, Berten Ceuleman. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Lancet (London, England). vol 394. issue 10216. 2020-01-29. PMID:31862249. |
fenfluramine has been reported to have antiseizure activity in observational studies of photosensitive epilepsy and dravet syndrome. |
2020-01-29 |
2023-08-13 |
Not clear |
| Krista Eschbach, Kelly G Knup. Stiripentol for the treatment of seizures in Dravet syndrome. Expert review of clinical pharmacology. vol 12. issue 5. 2019-05-16. PMID:31017478. |
the approval comes at a time of other treatment options also receiving approval (cannabidiol) and several products in ongoing studies (fenfluramine, tak-935) providing additional treatment options and hope on the horizon for those impacted by this severe epilepsy syndrome. |
2019-05-16 |
2023-08-13 |
Not clear |
| An-Sofie Schoonjans, Fabienne Marchau, Bernard P Paelinck, Lieven Lagae, Arnold Gammaitoni, Milka Pringsheim, Martin G Keane, Berten Ceuleman. Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population. Current medical research and opinion. vol 33. issue 10. 2018-03-19. PMID:28704161. |
fenfluramine is currently in development for treatment of ds, based on reports in the 1980s and 1990s of its anti-epileptic activity in pediatric patients with intractable epilepsy. |
2018-03-19 |
2023-08-13 |
Not clear |
| Basanagoud Mudigoudar, Sarah Weatherspoon, James W Wheles. Emerging Antiepileptic Drugs for Severe Pediatric Epilepsies. Seminars in pediatric neurology. vol 23. issue 2. 2018-01-26. PMID:27544474. |
this article reports the clinical trial data and personal experience in treating the severe epilepsies of childhood with the recently food and drug administration-approved new antiepileptic drugs (vigabatrin, rufinamide, perampanel, and clobazam) and those in clinical trials (cannabidiol, stiripentol, and fenfluramine). |
2018-01-26 |
2023-08-13 |
Not clear |
| Gaetano Zaccara, Dieter Schmid. Do traditional anti-seizure drugs have a future? A review of potential anti-seizure drugs in clinical development. Pharmacological research. vol 104. 2016-12-13. PMID:26689774. |
they include candidates with mechanisms of action similar to those of marketed aeds (allopregnanolone, brivaracetam, ganaxolone, ica-105665, ns1209, selurampanel); those with new mechanisms of action (beprodon, vx-765); compounds repurposed for the treatment of epilepsy (biperiden, bumetanide, fenfluramine, melatonin, nalutozan, pitolisant, quinidine, valnoctamide, verapamil); and finally candidates with currently unknown mechanisms of action (jnj-26489112, ucb0942, ykp3089 (cenobamate). |
2016-12-13 |
2023-08-13 |
Not clear |
| An-Sofie Schoonjans, Lieven Lagae, Berten Ceuleman. Low-dose fenfluramine in the treatment of neurologic disorders: experience in Dravet syndrome. Therapeutic advances in neurological disorders. vol 8. issue 6. 2015-11-25. PMID:26600876. |
in march 2002, a belgian royal decree was issued permitting further study of fenfluramine in pediatric patients with intractable epilepsy. |
2015-11-25 |
2023-08-13 |
Not clear |
| K Gentsch, U Heinemann, B Schmitz, J Beh. Fenfluramine blocks low-Mg2+-induced epileptiform activity in rat entorhinal cortex. Epilepsia. vol 41. issue 8. 2000-09-05. PMID:10961615. |
considering that the ec receives a strong serotonergic projection from the raphe nuclei and expresses a high density of serotonin (5-ht) receptors, the effect of the 5-ht-releasing drug fenfluramine (ffa) on epileptiform activity generated in the ec was investigated in an in vitro model of epilepsy. |
2000-09-05 |
2023-08-12 |
rat |
| M Boel, P Casae. Add-on therapy of fenfluramine in intractable self-induced epilepsy. Neuropediatrics. vol 27. issue 4. 1997-02-27. PMID:8892363. |
eleven institutionalized children (7 girls, 4 boys) with refractory epilepsy received fenfluramine as add-on therapy. |
1997-02-27 |
2023-08-12 |
Not clear |
| M Boel, P Casae. Add-on therapy of fenfluramine in intractable self-induced epilepsy. Neuropediatrics. vol 27. issue 4. 1997-02-27. PMID:8892363. |
add-on therapy of fenfluramine in intractable self-induced epilepsy. |
1997-02-27 |
2023-08-12 |
Not clear |
| J Aicardi, H Gastau. Treatment of self-induced photosensitive epilepsy with fenfluramine. The New England journal of medicine. vol 313. issue 22. 1985-12-16. PMID:3932858. |
treatment of self-induced photosensitive epilepsy with fenfluramine. |
1985-12-16 |
2023-08-11 |
Not clear |
| D L Davidson, C Mawdsley, C Campbell, J F Munr. Fenfluramine withdrawal and epilepsy. Postgraduate medical journal. vol 51 Suppl 1. 1976-05-10. PMID:1219675. |
fenfluramine withdrawal and epilepsy. |
1976-05-10 |
2023-08-11 |
Not clear |