| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asena Gülçiçek, Elif Şanlı, Gülçin Benbir Şenel, Derya Karadeniz, Özlem Timirci-Kahraman, Cem İsmail Küçükali, Erdem Tüzü. Patients with restless legs syndrome exhibit reduced serum colony-stimulating factor-1, humanin-like 3 and 10 levels. Acta neurologica Belgica. 2024-04-17. PMID:38630326. |
the main pathophysiological mechanisms in restless legs syndrome (rls) are known as genetic predisposition, brain iron deficiency, and dopaminergic dysfunction. |
2024-04-17 |
2024-04-19 |
Not clear |
| Ying-Sheng Li, Wei-Chih Yeh, Chung-Yao Hs. Association of low serum ferritin levels with augmentation in patients with restless legs syndrome: A systematic review and meta-analysis. Sleep medicine. vol 112. 2023-10-25. PMID:37879259. |
augmentation of restless legs syndrome (rls) is an iatrogenic side effect induced by dopaminergic agents, and it is a major cause of therapeutic failure. |
2023-10-25 |
2023-11-08 |
Not clear |
| Arthur S Walters, Yuqing Li, Brian B Koo, William G Ondo, Leonard B Weinstock, David Champion, Lawrence B Afrin, Elias G Karroum, Kanika Bagai, Karen Spruy. Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome. Brain : a journal of neurology. 2023-08-26. PMID:37633259. |
restless legs syndrome (rls) is responsive to opioid, dopaminergic, and iron-based treatments. |
2023-08-26 |
2023-09-07 |
mouse |
| Amanda Scanga, Anne-Louise Lafontaine, Marta Kaminsk. An overview of the effects of levodopa and dopaminergic agonists on sleep disorders in Parkinson's disease. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 2023-01-30. PMID:36716191. |
we provide an overview of the effects of levodopa and dopaminergic agonists on sleep architecture, insomnia, excessive daytime sleepiness, sleep-disordered breathing, rapid eye movement sleep behavior disorder, and restless legs syndrome in pd. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yasin Abanoz, Yeşim Gülen Abanoz, Ayşegül Gündüz, Derya Karadeniz, Meral Erdemir Kızılta. Long Latency Trigemino-cervical Reflex in Restless Legs Syndrome. The International journal of neuroscience. 2022-12-19. PMID:36533413. |
if the inhibitory response in tcc is likely dopaminergic, we hypothesized that tcr, which has never been evaluated in restless legs syndrome (rls) patients before, would be also abnormal. |
2022-12-19 |
2023-08-14 |
Not clear |
| Szymon Suwała, Jakub Rzeszuto, Rafał Glonek, Magdalena Krintus, Roman Juni. Is Restless Legs Syndrome De Facto Thyroid Disease? Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289762. |
while a primary role in the pathogenesis of restless legs syndrome (rls) has been attributed to dysfunction of the dopaminergic system and impaired iron metabolism (particularly in the central nervous system), it has been hypothesized that an imbalance between thyroid hormones and dopaminergic activity may be the starting point for all aspects of rls. |
2022-10-27 |
2023-08-14 |
human |
| Milca Abda Morais, Beatriz Silva Franco, Alessandro Spencer Souza Holanda, Laís Angélica de Paula Simino, Alana Carolina Costa Veras, Marcio Alberto Torsoni, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteve. Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome. Journal of sleep research. 2022-09-02. PMID:36053904. |
the pathophysiology of the restless legs syndrome (rls) is related to dopaminergic dysfunction, reduced iron and variations in gene expression, such as the protein tyrosine phosphatase receptor type delta gene (ptprd). |
2022-09-02 |
2023-08-14 |
rat |
| b' ChristopherJ Earley, Byron C Jones, Sergi Ferr\\xc3\\xa. Brain-iron deficiency models of restless legs syndrome. Experimental neurology. 2022-07-02. PMID:35779614.' |
restless legs syndrome (rls) is a common sensorimotor disorder for which two main pathological elements are fairly well accepted: brain iron deficiency (bid) and an altered dopaminergic system. |
2022-07-02 |
2023-08-14 |
mouse |
| Zoé Mazurie, Willy Mayo, Imad Ghoraye. Attention-deficit/hyperactivity and obsessive-compulsive symptoms in adult patients with primary restless legs syndrome. Applied neuropsychology. Adult. 2022-04-06. PMID:35382650. |
this putative association, possibly reflecting a shared brain iron homeostasis and dopaminergic dysfunction, supports the hypothesis of a neurodevelopmental component in restless legs syndrome pathogenesis. |
2022-04-06 |
2023-08-13 |
human |
| Beatrice Heim, Philipp Ellmerer, Ambra Stefani, Melanie Bergmann, Elisabeth Brandauer, Klaus Seppi, Birgit Högl, Atbin Djamshidia. Factors associated with augmentation in patients with Restless Legs Syndrome. European journal of neurology. 2021-12-19. PMID:34923723. |
augmentation is a paradoxical reaction mainly to dopaminergic medication in patients with restless legs syndrome (rls), but the exact pathomechanism remains unclear. |
2021-12-19 |
2023-08-13 |
Not clear |
| Maria P Mogavero, Domenico M Mezzapesa, Mariantonietta Savarese, Lourdes M DelRosso, Giuseppe Lanza, Raffaele Ferr. Morphological analysis of the brain subcortical gray structures in restless legs syndrome. Sleep medicine. vol 88. 2021-12-07. PMID:34740168. |
although several studies have shown the involvement of specific structures of the central nervous system, the dopaminergic system, and iron metabolism in restless legs syndrome (rls), the exact location and extent of its anatomical substrate is not yet known. |
2021-12-07 |
2023-08-13 |
Not clear |
| Xiao-Ying Zhu, Hong-Ming Wang, Ting-Ting Wu, Te Liu, Ya-Jing Chen, Xuan Li, Tian-Jiao Chen, Ye Liu, Xiao-Jin Zhang, Xi-Xi Wang, Yue Zhang, William G Ondo, Yun-Cheng W. SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome. Parkinsonism & related disorders. vol 81. 2021-10-29. PMID:33035800. |
brain iron disequilibrium and dopaminergic dysfunction are key pathophysiological features of restless legs syndrome (rls). |
2021-10-29 |
2023-08-13 |
Not clear |
| Lucile Cathiard, Valerie Fraulob, Daniel D Lam, Miguel Torres, Juliane Winkelmann, Wojciech Kręże. Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome. Journal of sleep research. vol 30. issue 5. 2021-10-21. PMID:34008292. |
investigation of dopaminergic signalling in meis homeobox 1 (meis1) deficient mice as an animal model of restless legs syndrome. |
2021-10-21 |
2023-08-13 |
mouse |
| Beatriz Franco, Diego Silva Mota, Paulo Daubian-Nosé, Natália de Almeida Rodrigues, Laís Angélica de Paula Simino, Thaís de Fante, Rosangela Maria Neves Bezerra, Fúlvia de Barros Manchado Gobatto, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteve. Iron deficiency in pregnancy: Influence on sleep, behavior, and molecular markers of adult male offspring. Journal of neuroscience research. 2021-10-15. PMID:34651324. |
iron restriction during pregnancy can lead to iron deficiency and changes in the dopaminergic system in the adulthood of offspring, and restless legs syndrome (rls) is closely related to these changes. |
2021-10-15 |
2023-08-13 |
rat |
| Ferda Ilgen Uslu, Ervanur Demir, Eray Metin Güler, Abdürahim Koçyiği. Circulating levels of cytokines are increased in restless legs syndrome. Sleep & breathing = Schlaf & Atmung. vol 25. issue 3. 2021-08-23. PMID:33083922. |
restless legs syndrome [rls] is known as a disease of iron and dopaminergic dysregulation but inflammatory processes might also have a role in the pathogenesis. |
2021-08-23 |
2023-08-13 |
human |
| Sergi Ferré, Xavier Guitart, César Quiroz, William Rea, Celia García-Malo, Diego Garcia-Borreguero, Richard P Allen, Christopher J Earle. Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. Sleep medicine clinics. vol 16. issue 2. 2021-07-13. PMID:33985651. |
akathisia and restless legs syndrome: solving the dopaminergic paradox. |
2021-07-13 |
2023-08-13 |
Not clear |
| Laura M Botta P, Samantha S Anguizola E, Andrea Castro-Villacañas, Diego Garcia-Borreguer. Restless Legs Syndrome: Challenges to Treatment. Sleep medicine clinics. vol 16. issue 2. 2021-07-13. PMID:33985652. |
for a long time, dopaminergic treatment (dt) was the medication for restless legs syndrome. |
2021-07-13 |
2023-08-13 |
Not clear |
| Richard P Allen, Christopher J Earley, Byron C Jones, Erica L Unge. Iron-deficiency and dopaminergic treatment effects on RLS-Like behaviors of an animal model with the brain iron deficiency pattern of the restless legs syndrome. Sleep medicine. vol 71. 2021-06-21. PMID:32094092. |
iron-deficiency and dopaminergic treatment effects on rls-like behaviors of an animal model with the brain iron deficiency pattern of the restless legs syndrome. |
2021-06-21 |
2023-08-13 |
Not clear |
| William G Ondo, Titilayo Olubaj. Exploratory cross-over, trial of augmented RLS with the dopamine receptor 1/5 antagonist ecopipam D1/D5 antagonist ecopipam for augmented RLS. The International journal of neuroscience. 2021-05-10. PMID:33066723. |
restless legs syndrome (rls) is a common condition that initially responds dramatically to dopaminergic therapy. |
2021-05-10 |
2023-08-13 |
Not clear |
| Shangru Lyu, Atbin Doroodchi, Hong Xing, Yi Sheng, Mark P DeAndrade, Youfeng Yang, Tracy L Johnson, Stefan Clemens, Fumiaki Yokoi, Michael A Miller, Rui Xiao, Yuqing L. BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome. Brain structure & function. vol 225. issue 6. 2021-03-24. PMID:32468214. |
btbd9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome. |
2021-03-24 |
2023-08-13 |
mouse |