| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinglong Yang, Bin Liu, Hao Shen, Shimei Li, Quanzhen Zhao, Ran An, Fayun Hu, Hui Ren, Yanming Xu, Zhong X. Prevalence of restless legs syndrome in Parkinson's disease: a systematic review and meta-analysis of observational studies. Sleep medicine. vol 43. 2019-09-19. PMID:29482811. |
restless legs syndrome (rls) and parkinson's disease (pd) are common neurological disorders that respond to dopaminergic therapy. |
2019-09-19 |
2023-08-13 |
Not clear |
| Juliane Winkelmann, Richard P Allen, Birgit Högl, Yuichi Inoue, Wolfgang Oertel, Aaro V Salminen, John W Winkelman, Claudia Trenkwalder, Cristina Sampai. Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017) Movement disorders : official journal of the Movement Disorder Society. vol 33. issue 7. 2019-08-26. PMID:29756335. |
restless legs syndrome augmentation has been identified as a significant long-term treatment complication for pramipexole more than pregabalin and possibly for all dopaminergic agents more than α2δ ligands. |
2019-08-26 |
2023-08-13 |
human |
| Maren de Moraes E Silva, Cezar Henrique Lorenzi, Blenda Barreto Schneider, Catherine Enk Fischer Seidel, Isabela Salomé, Viktor Cleto Morais Gianini, Renata Ramina Pessoa, Pilar Bueno Siqueira Mercer, Maria Carolina Zavagna Wit. Restless legs syndrome in Parkinson's disease and increased cardiovascular risk. Arquivos de neuro-psiquiatria. vol 76. issue 11. 2019-06-10. PMID:30570015. |
restless legs syndrome (rls) is a disorder commonly found in patients with parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. |
2019-06-10 |
2023-08-13 |
Not clear |
| Giovanni Rizzo, Giuseppe Plazz. Neuroimaging Applications in Restless Legs Syndrome. International review of neurobiology. vol 143. 2019-05-21. PMID:30473197. |
in summary, neuroimaging findings in restless legs syndrome support the presence of reduction of brain iron content, of dysfunction of mesolimbic and nigrostriatal dopaminergic pathways, and of abnormalities at level of limbic/nociceptive and sensorimotor networks. |
2019-05-21 |
2023-08-13 |
Not clear |
| Chun-Ni Guo, Wen-Jia Yang, Shi-Qin Zhan, Xi-Fei Yang, Michael C Chen, Patrick M Fuller, Jun L. Targeted disruption of supraspinal motor circuitry reveals a distributed network underlying Restless Legs Syndrome (RLS)-like movements in the rat. Scientific reports. vol 7. issue 1. 2019-04-23. PMID:28852150. |
in this study we uncovered, through targeted ablation, a potential role for corticospinal, cerebello-rubro-spinal, and hypothalamic a11 dopaminergic systems in the development of restless legs syndrome (rls)-like movements during sleep. |
2019-04-23 |
2023-08-13 |
human |
| S Chenini, I Arnulf, C Charley Monaca, I Ghoraye. French consensus: Pharmacoresistant restless legs syndrome. Revue neurologique. vol 174. issue 7-8. 2018-12-17. PMID:30075957. |
dopaminergic agonists, α2δ ligands and opioids are, as single-drug therapy, the first line treatment for restless legs syndrome (rls/willis-ekbom disease). |
2018-12-17 |
2023-08-13 |
Not clear |
| Diego Garcia-Borreguero, Irene Cano-Pumarega, Rafael Maruland. Management of treatment failure in restless legs syndrome (Willis-Ekbom disease). Sleep medicine reviews. vol 41. 2018-12-11. PMID:29602660. |
dopaminergic drugs have been widely used over the last decades for the treatment of restless legs syndrome (rls)/willis-ekbom disease (wed). |
2018-12-11 |
2023-08-13 |
Not clear |
| Baris Metin, Sinem Zeynep Metin, Aysegul Gunduz, Burc Cagri Poyraz, Mine Ozmen, Gunes Kiziltan, Meral E Kizilta. Brainstem reflexes are hyperactive in patients with drug-induced akathisia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 38. issue 9. 2018-07-30. PMID:28681310. |
we recently showed nociceptive flexor reflex was altered in akathisia as compared to restless legs syndrome and therefore, these findings may indicate co-involvement of pathways other than dopaminergic ones. |
2018-07-30 |
2023-08-13 |
human |
| Elisabeth Ruppert, Marc Bataillard, Izzie Jacques Namer, Laurent Tatu, Aurélien Hacquard, Laurence Hugueny, Jeffrey Hubbard, Ulker Kilic-Huck, Valérie Wolff, Patrice Bourgi. Hyperdopaminergism in lenticulostriate stroke-related restless legs syndrome: an imaging study. Sleep medicine. vol 30. 2018-07-25. PMID:28215236. |
the pathophysiology of restless legs syndrome (rls) involves a dopaminergic dysregulation that remains poorly understood, with controversial data from the literature. |
2018-07-25 |
2023-08-13 |
Not clear |
| Yuan-Yang Lai, Yu-Hsuan Cheng, Kung-Chiao Hsieh, Darian Nguyen, Keng-Tee Chew, Lalini Ramanathan, Jerome M Siege. Motor hyperactivity of the iron-deficient rat - an animal model of restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 32. issue 12. 2018-07-19. PMID:28843017. |
dopaminergic drugs are commonly used to treat restless legs syndrome. |
2018-07-19 |
2023-08-13 |
rat |
| I H Iftikhar, L Alghothani, L M Trott. Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis. European journal of neurology. vol 24. issue 12. 2018-06-06. PMID:28888061. |
to synthesize evidence from available randomized controlled trials (rct) to compare the efficacies of dopaminergic drugs (pramipexole, ropinirole and rotigotine) and α-2-δ ligands (gabapentin enacarbil and pregabalin) for the treatment of restless legs syndrome (rls). |
2018-06-06 |
2023-08-13 |
human |
| Michael Kurin, Klaus Bielefeldt, David J Levintha. Prevalence of Nausea and Vomiting in Adults Using Ropinirole: A Systematic Review and Meta-Analysis. Digestive diseases and sciences. vol 63. issue 3. 2018-05-18. PMID:29383607. |
dopaminergic agonists have been associated with these symptoms, but their impact in patients without parkinson's disease, such as those with restless legs syndrome (rls), is not well characterized. |
2018-05-18 |
2023-08-13 |
Not clear |
| Hidechika Ozawa, Tsuyoshi Yamaguchi, Shinsuke Hamaguchi, Shigeki Yamaguchi, Shuichi Ued. Three Types of A11 Neurons Project to the Rat Spinal Cord. Neurochemical research. vol 42. issue 8. 2018-04-19. PMID:28303496. |
the a11 dopaminergic cell group is the only group among the a8-a16 dopaminergic cell groups that includes neurons innervating the spinal cord, and a decrease in dopaminergic transmission at the spinal cord is thought to contribute to the pathogenesis of restless legs syndrome. |
2018-04-19 |
2023-08-13 |
rat |
| Eva Schaeffer, Daniela Ber. Dopaminergic Therapies for Non-motor Symptoms in Parkinson's Disease. CNS drugs. vol 31. issue 7. 2018-04-12. PMID:28643183. |
while there is for example profound evidence for the effectiveness of dopaminergic medication for the treatment of restless legs syndrome and sleep fragmentation, evidence for an improvement of rapid eye movement sleep behavior disorder is lacking. |
2018-04-12 |
2023-08-13 |
Not clear |
| b' Christopher J Earley, George R Uhl, Stefan Clemens, Sergi Ferr\\xc3\\xa. Connectome and molecular pharmacological differences in the dopaminergic system in restless legs syndrome (RLS): plastic changes and neuroadaptations that may contribute to augmentation. Sleep medicine. vol 31. 2018-03-05. PMID:27539027.' |
connectome and molecular pharmacological differences in the dopaminergic system in restless legs syndrome (rls): plastic changes and neuroadaptations that may contribute to augmentation. |
2018-03-05 |
2023-08-13 |
Not clear |
| Sergi Ferré, Christopher Earley, Seema Gulyani, Diego Garcia-Borreguer. In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine. Sleep medicine. vol 31. 2018-03-05. PMID:27899234. |
in search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine. |
2018-03-05 |
2023-08-13 |
Not clear |
| Sergi Ferré, Christopher Earley, Seema Gulyani, Diego Garcia-Borreguer. In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine. Sleep medicine. vol 31. 2018-03-05. PMID:27899234. |
dopaminergic drugs have been used as the first-line treatment for restless legs syndrome (rls) for many years and are considered to be, at least over the short-term, effective and safe. |
2018-03-05 |
2023-08-13 |
Not clear |
| Asli Koskderelioglu, Tuncay Kusbeci, Ozge Yilmaz Kusbeci, Muhtesem Gedizliogl. Optic nerve head, retinal nerve fiber layer and macular thickness analysis in restless legs syndrome. Parkinsonism & related disorders. vol 31. 2018-02-06. PMID:27524286. |
hypothetically, restless legs syndrome (rls) may have an underlying dopaminergic mechanism and a probable relation to pd is assumed. |
2018-02-06 |
2023-08-13 |
human |
| Wolfgang H Oertel, Yngve Hallström, Gerda M Saletu-Zyhlarz, Michael Hopp, Björn Bosse, Claudia Trenkwalde. Sleep and Quality of Life Under Prolonged Release Oxycodone/Naloxone for Severe Restless Legs Syndrome: An Analysis of Secondary Efficacy Variables of a Double-Blind, Randomized, Placebo-Controlled Study with an Open-Label Extension. CNS drugs. vol 30. issue 8. 2018-01-08. PMID:27401882. |
the aim was to assess the effects of prolonged release oxycodone/naloxone (oxn pr) on sleep and quality of life (qol) in patients with severe restless legs syndrome (rls) refractory to first-line dopaminergic rls treatment. |
2018-01-08 |
2023-08-13 |
Not clear |
| Beatrice Heim, Marie-Theres Pertl, Ambra Stefani, Margarete Delazer, Anna Heidbreder, Laura Zamarian, Elisabeth Brandauer, Klaus Seppi, Birgit Högl, Werner Poewe, Atbin Djamshidia. Haste makes waste: Decision making in patients with restless legs syndrome with and without augmentation. PloS one. vol 12. issue 4. 2017-09-01. PMID:28380045. |
to investigate decision making in patients with primary restless legs syndrome (rls) with and without augmentation treated with dopaminergic medication. |
2017-09-01 |
2023-08-13 |
Not clear |