| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Vieira-Coelho, V L Teixeira, J T Guimarães, M P Serrão, P Soares-da-Silv. Caco-2 cells in culture synthesize and degrade dopamine and 5-hydroxytryptamine: a comparison with rat jejunal epithelial cells. Life sciences. vol 64. issue 1. 1999-03-02. PMID:10027744. |
to explore the usefulness of caco-2 cells in the study of intestinal dopaminergic and 5-hydroxytryptaminergic physiology, we have undertaken the study of aromatic l-amino acid decarboxylase (aadc), catechol-o-methyltransferase (comt) and type a and b monoamine oxidase (mao-a and mao-b) activities in these cells using specific substrates. |
1999-03-02 |
2023-08-12 |
rat |
| H M Ruottinen, J O Rinne, V J Oikonen, J R Bergman, M T Haaparanta, O H Solin, U H Ruotsalainen, U K Rinn. Striatal 6-[18F]fluorodopa accumulation after combined inhibition of peripheral catechol-O-methyltransferase and monoamine oxidase type B: differing response in relation to presynaptic dopaminergic dysfunction. Synapse (New York, N.Y.). vol 27. issue 4. 1998-01-14. PMID:9372556. |
the aim was to investigate the effects of inhibition of monoamine oxidase type b (mao-b) with selegiline alone and the combined inhibition of peripheral catechol-o-methyltransferase (comt) with entacapone and mao-b with selegiline on striatal 6-[18f]fluorodopa (fdopa) accumulation, and whether the effect of entacapone + selegiline on fdopa uptake differed depending on the severity of the presynaptic dopaminergic dysfunction. |
1998-01-14 |
2023-08-12 |
human |
| J T Guimarães, M A Vieira-Coelho, M P Serrão, P Soares-da-Silv. Opossum kidney (OK) cells in culture synthesize and degrade the natriuretic hormone dopamine: a comparison with rat renal tubular cells. The international journal of biochemistry & cell biology. vol 29. issue 4. 1997-12-09. PMID:9363646. |
to explore further the usefulness of opossum kidney (ok) cells in the study of renal dopaminergic physiology, we have undertaken the study of aromatic l-amino acid decarboxylase (aaad), catechol-o-methyltransferase (comt) and type a and b monoamine oxidase (mao-a and mao-b), the main enzymes involved in the synthesis and degradation of dopamine. |
1997-12-09 |
2023-08-12 |
rat |
| J T Guimarães, M A Vieira-Coelho, M P Serrão, P Soares-da-Silv. Opossum kidney (OK) cells in culture synthesize and degrade the natriuretic hormone dopamine: a comparison with rat renal tubular cells. The international journal of biochemistry & cell biology. vol 29. issue 4. 1997-12-09. PMID:9363646. |
the amounts of the enzymes aaad, comt and mao-a found in this cell line are likely to be sufficient to reproduce, under in vitro conditions, the environment in which the renal dopaminergic system normally operates. |
1997-12-09 |
2023-08-12 |
rat |
| D J Vandenbergh, L A Rodriguez, I T Miller, G R Uhl, H M Lachma. High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. American journal of medical genetics. vol 74. issue 4. 1997-11-06. PMID:9259381. |
comt plays a prominent role in dopaminergic circuits important for drug reward, and comt alleles encode enzymes whose activities vary from three- to four-fold. |
1997-11-06 |
2023-08-12 |
human |
| R D Strous, N Bark, S S Parsia, J Volavka, H M Lachma. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry research. vol 69. issue 2-3. 1997-07-03. PMID:9109174. |
considering the role of comt in dopamine metabolism and the involvement of dopaminergic pathways in the pathogenesis of schizophrenia and violence, we screened 37 patients with schizophrenia to determine whether or not a behavioral association with the comt polymorphism exists. |
1997-07-03 |
2023-08-12 |
Not clear |
| M Karayiorgou, M Altemus, B L Galke, D Goldman, D L Murphy, J Ott, J A Gogo. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 9. 1997-05-27. PMID:9114031. |
in the present study, we address the role of the gene for catechol-o-methyltransferase (comt), a key modulator of dopaminergic and noradrenergic neurotransmission, in the genetic predisposition to obsessive-compulsive disorder (ocd). |
1997-05-27 |
2023-08-12 |
Not clear |
| T Klockgether, P A Löschmann, U Wüllne. New medical and surgical treatments for Parkinson's disease. Current opinion in neurology. vol 7. issue 4. 1994-12-20. PMID:7952244. |
catechol-o-methyl-transferase (comt) inhibitors supplement the variety of antiparkinsonian drugs interacting with the dopaminergic system. |
1994-12-20 |
2023-08-12 |
Not clear |
| R S Miletich, G Comi, K Bankiewicz, R Plunkett, R Adams, G Di Chiro, I J Kopi. 6-[18F]fluoro-L-dihydroxyphenylalanine metabolism and positron emission tomography after catechol-O-methyltransferase inhibition in normal and hemiparkinsonian monkeys. Brain research. vol 626. issue 1-2. 1994-02-14. PMID:8281420. |
because of decreased omfd formation, however, comt inhibition improves the specificity of 6fd-pet and facilitates in-vivo detection of a wide range of dopaminergic innervation densities in cerebral structures. |
1994-02-14 |
2023-08-12 |
monkey |
| J G Cannon, P Qiji. Isomeric monomethyl ether derivatives of (RS)-9,10-dihydroxyaporphine ("isoapomorphine") as possible products of metabolism by catechol-O-methyltransferase. Journal of medicinal chemistry. vol 34. issue 3. 1991-04-17. PMID:2002449. |
the in vivo dopaminergic inactivity of isoapomorphine (as compared with that of apomorphine) seems to be due to factors other than metabolic inactivation by comt. |
1991-04-17 |
2023-08-11 |
Not clear |
| H Rollema, D Mastebroek, H Wikström, K Svensson, A Carlsson, S Sundel. Enantiomers of 3-(3,4-dihydroxyphenyl)- and 3-(3-hydroxyphenyl)-N-n-propylpiperidine: central pre- and postsynaptic dopaminergic effects and pharmacokinetics. Journal of medicinal chemistry. vol 29. issue 10. 1986-11-19. PMID:3761308. |
however, the very interesting observation was made that, when inhibiting comt by means of tropolone and subsequently treating the rats with high doses of (s)-(-)-3-ppp (ip), postsynaptic dopaminergic activity was elicited. |
1986-11-19 |
2023-08-11 |
rat |
| F Lhermitte, A Rosa, E Como. [Abnormal movements of patients with Parkinsonism treated with L-dopa and anomalies of dopamine metabolism]. Revue neurologique. vol 133. issue 1. 1977-05-20. PMID:847319. |
the authors express the view that abnormal movements while under l-dopa treatment are dependent on two factors: one, the hypersensitivity of dopaminergic reception, the other, the greater or lesser preponderance of the comt isozyme giving rise to 4-o-methylates; |
1977-05-20 |
2023-08-11 |
Not clear |