| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Gao, Yudong Guo, Xiaofeng Liu, Deya Shang, Yongjian D. KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. Biochemical and biophysical research communications. vol 487. issue 1. 2017-06-12. PMID:28336438. |
klf15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of akt/mtor signaling. |
2017-06-12 |
2023-08-13 |
mouse |
| Li Gao, Yudong Guo, Xiaofeng Liu, Deya Shang, Yongjian D. KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. Biochemical and biophysical research communications. vol 487. issue 1. 2017-06-12. PMID:28336438. |
in the present study, we established a mouse model of cardiac hypertrophy and found that klf15 expression was down-regulated in hypertrophic hearts. |
2017-06-12 |
2023-08-13 |
mouse |
| Li Gao, Yudong Guo, Xiaofeng Liu, Deya Shang, Yongjian D. KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. Biochemical and biophysical research communications. vol 487. issue 1. 2017-06-12. PMID:28336438. |
the results indicated that klf15 overexpression protects mice from iso-induced cardiac hypertrophy, with reduced ratios of heart weight (hw)/body weight (bw) and cross-sectional area. |
2017-06-12 |
2023-08-13 |
mouse |
| Li Gao, Yudong Guo, Xiaofeng Liu, Deya Shang, Yongjian D. KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. Biochemical and biophysical research communications. vol 487. issue 1. 2017-06-12. PMID:28336438. |
to evaluate the roles of klf15 in cardiac hypertrophy, we generated transgenic mice overexpressing klf15 of klf15 knockdown mice and subsequently induced cardiac hypertrophy. |
2017-06-12 |
2023-08-13 |
mouse |
| Li Gao, Yudong Guo, Xiaofeng Liu, Deya Shang, Yongjian D. KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. Biochemical and biophysical research communications. vol 487. issue 1. 2017-06-12. PMID:28336438. |
increasing evidence indicate that the krüppel-like factor klf15, a member of cys2/his2 zinc-finger dna-binding proteins, attenuates cardiac hypertrophy. |
2017-06-12 |
2023-08-13 |
mouse |
| Domenick A Prosdocimo, Priti Anand, Xudong Liao, Han Zhu, Shamanthika Shelkay, Pedro Artero-Calderon, Lilei Zhang, Jacob Kirsh, D'Vesharronne Moore, Mariana G Rosca, Edwin Vazquez, Janos Kerner, Kemal M Akat, Zev Williams, Jihe Zhao, Hisashi Fujioka, Thomas Tuschl, Xiaodong Bai, P Christian Schulze, Charles L Hoppel, Mukesh K Jain, Saptarsi M Halda. Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism. The Journal of biological chemistry. vol 289. issue 9. 2014-04-25. PMID:24407292. |
although previous studies have defined kruppel-like factor 15 (klf15) as a transcriptional repressor of pathologic cardiac hypertrophy, a direct role for the klf family in cardiac metabolism has not been previously established. |
2014-04-25 |
2023-08-12 |
human |
| Claudia Noack, Maria-Patapia Zafiriou, Hans-Joerg Schaeffer, Anke Renger, Elena Pavlova, Rainer Dietz, Wolfram H Zimmermann, Martin W Bergmann, Laura C Zelarayá. Krueppel-like factor 15 regulates Wnt/β-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart. EMBO molecular medicine. vol 4. issue 9. 2013-01-18. PMID:22767436. |
in line with this, functional klf15 knock-out mice exhibited cardiac β-catenin transcriptional activation along with functional cardiac deterioration in normal homeostasis and upon hypertrophy. |
2013-01-18 |
2023-08-12 |
mouse |
| Joost J Leenders, Wino J Wijnen, Ingeborg van der Made, Monika Hiller, Melissa Swinnen, Thierry Vandendriessche, Marinee Chuah, Yigal M Pinto, Esther E Creemer. Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications. PloS one. vol 7. issue 5. 2012-09-26. PMID:22586493. |
using recombinant adeno-associated viruses (raav) we have overexpressed klf15 specifically in the mouse heart and provide the first evidence that elevation of cardiac klf15 levels prevents the development of cardiac hypertrophy in a model of angiotensin ii induced hypertrophy. |
2012-09-26 |
2023-08-12 |
mouse |
| Joost J Leenders, Wino J Wijnen, Ingeborg van der Made, Monika Hiller, Melissa Swinnen, Thierry Vandendriessche, Marinee Chuah, Yigal M Pinto, Esther E Creemer. Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications. PloS one. vol 7. issue 5. 2012-09-26. PMID:22586493. |
repression of cardiac hypertrophy by klf15: underlying mechanisms and therapeutic implications. |
2012-09-26 |
2023-08-12 |
mouse |
| Joost J Leenders, Wino J Wijnen, Ingeborg van der Made, Monika Hiller, Melissa Swinnen, Thierry Vandendriessche, Marinee Chuah, Yigal M Pinto, Esther E Creemer. Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications. PloS one. vol 7. issue 5. 2012-09-26. PMID:22586493. |
previous studies have shown that klf15 inhibits cardiac hypertrophy by repressing the activity of pivotal cardiac transcription factors such as gata4, mef2 and myocardin. |
2012-09-26 |
2023-08-12 |
mouse |
| Anita Woods, Claudine G James, Guoyan Wang, Holly Dupuis, Frank Beie. Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Ror-alpha signalling in endochondral bone growth. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:20196782. |
expression of ror-alpha target genes, (lpl, fatty acid binding protein 4 [fabp4], cd36 and kruppel-like factor 5 [klf15]) were induced during chondrocyte hypertrophy and by cytochalasin d and are cholesterol dependent. |
2011-12-23 |
2023-08-12 |
mouse |
| Joost J Leenders, Yigal M Pinto, Esther E Creemer. Tapping the brake on cardiac growth-endogenous repressors of hypertrophic signaling. Journal of molecular and cellular cardiology. vol 51. issue 2. 2011-10-25. PMID:21586293. |
in addition, we will focus on factors such as kruppel-like factors (klf4, klf15 and klf10) and histone deacetylases (hdacs), which constitute a relevant group of nuclear proteins that repress transcription of the hypertrophic gene program in cardiomyocytes. |
2011-10-25 |
2023-08-12 |
mouse |
| Joost J Leenders, Wino J Wijnen, Monika Hiller, Ingeborg van der Made, Viola Lentink, Rick E W van Leeuwen, Veronica Herias, Saraswati Pokharel, Stephane Heymans, Leon J de Windt, Morten A Høydal, Yigal M Pinto, Esther E Creemer. Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20566642. |
here, we report that the constitutive presence of krüppel-like factor 15 (klf15) is lost in pathological hypertrophy and that this loss precedes progression toward heart failure. |
2010-09-17 |
2023-08-12 |
Not clear |
| Takahiro Horie, Koh Ono, Hitoo Nishi, Yoshitaka Iwanaga, Kazuya Nagao, Minako Kinoshita, Yasuhide Kuwabara, Rieko Takanabe, Koji Hasegawa, Toru Kita, Takeshi Kimur. MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. Biochemical and biophysical research communications. vol 389. issue 2. 2009-10-14. PMID:19720047. |
the expression levels of klf15 and glut4 were decreased at the left ventricular hypertrophy and congestive heart failure stage in a rat model. |
2009-10-14 |
2023-08-12 |
human |
| Sudeshna Fisch, Susan Gray, Stephane Heymans, Saptarsi M Haldar, Baiqiu Wang, Otmar Pfister, Lei Cui, Ajay Kumar, Zhiyong Lin, Sucharita Sen-Banerjee, Hiranmoy Das, Christine A Petersen, Ulrike Mende, Barbara A Burleigh, Yan Zhu, Yigal M Pinto, Yigal Pinto, Ronglih Liao, Mukesh K Jai. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 17. 2007-06-06. PMID:17438289. |
myocardial expression of klf15 is reduced in rodent models of hypertrophy and in biopsy samples from patients with pressure-overload induced by chronic valvular aortic stenosis. |
2007-06-06 |
2023-08-12 |
mouse |
| Sudeshna Fisch, Susan Gray, Stephane Heymans, Saptarsi M Haldar, Baiqiu Wang, Otmar Pfister, Lei Cui, Ajay Kumar, Zhiyong Lin, Sucharita Sen-Banerjee, Hiranmoy Das, Christine A Petersen, Ulrike Mende, Barbara A Burleigh, Yan Zhu, Yigal M Pinto, Yigal Pinto, Ronglih Liao, Mukesh K Jai. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 17. 2007-06-06. PMID:17438289. |
herein, we identify the kruppel-like factor 15 (klf15) as an inhibitor of cardiac hypertrophy. |
2007-06-06 |
2023-08-12 |
mouse |
| Sudeshna Fisch, Susan Gray, Stephane Heymans, Saptarsi M Haldar, Baiqiu Wang, Otmar Pfister, Lei Cui, Ajay Kumar, Zhiyong Lin, Sucharita Sen-Banerjee, Hiranmoy Das, Christine A Petersen, Ulrike Mende, Barbara A Burleigh, Yan Zhu, Yigal M Pinto, Yigal Pinto, Ronglih Liao, Mukesh K Jai. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 17. 2007-06-06. PMID:17438289. |
overexpression of klf15 in neonatal rat ventricular cardiomyocytes inhibits cell size, protein synthesis and hypertrophic gene expression. |
2007-06-06 |
2023-08-12 |
mouse |