| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Xu, Wei Li, Mengmeng Shi, Xiaofan Xu, Dongmin Guo, Zhenghai Liu, Ling Chen, Xiaolin Zhong, Wenyu Ca. Systemic treatment with GnRH agonist produces antidepressant-like effects in LPS induced depression male mouse model. Neuropharmacology. 2023-04-24. PMID:37094770. |
in light of the research findings presented here, we propose that, at least in the hippocampus, gnrh appears to act on gnrhr to regulate higher order non-reproductive functions associated with the microglia mediated neuroinflammation. |
2023-04-24 |
2023-08-14 |
mouse |
| Courtney M Kloske, Mary D Gearon, Erica M Weekman, Colin Rogers, Ela Patel, Adam Bachstetter, Peter T Nelson, Donna M Wilcoc. Association between APOE genotype and microglial cell morphology. Journal of neuropathology and experimental neurology. 2023-04-22. PMID:37087107. |
for rod microglia, a reduction was seen in e4-control patients in the hippocampus whereas in the smtg an increase was seen in e4-dementia patients. |
2023-04-22 |
2023-08-14 |
human |
| Hyeji Jung, Dongsu Lee, Heejung You, Myungha Lee, Hyeonho Kim, Eunji Cheong, Ji Won U. LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment. Scientific reports. vol 13. issue 1. 2023-04-21. PMID:37085584. |
we demonstrated that, 3 days after lps injection, microglia in the hippocampus were significantly activated due to the lps-induced inflammation in association with alterations in cellular morphology, microglial density, and expression of phagocytic markers. |
2023-04-21 |
2023-08-14 |
mouse |
| Jian Lu, Xiaoyan Tao, Hongyu Dai, Sunan Gao, Hongmei Zho. Peripheral and cerebral inflammation induced by repeated anesthesia and surgery do not cause impairment of learning and memory in middle‑aged mice. Acta neurobiologiae experimentalis. vol 83. issue 1. 2023-04-20. PMID:37078813. |
up‑regulation of iba1 and gfap, respectively, indicated activation of microglia and astrocytes in the hippocampus. |
2023-04-20 |
2023-08-14 |
mouse |
| Jian Lu, Xiaoyan Tao, Hongyu Dai, Sunan Gao, Hongmei Zho. Peripheral and cerebral inflammation induced by repeated anesthesia and surgery do not cause impairment of learning and memory in middle‑aged mice. Acta neurobiologiae experimentalis. vol 83. issue 1. 2023-04-20. PMID:37078813. |
the present results revealed that serum il‑6, il‑1β, and s‑100β concentrations were enhanced after multiple instances of anesthesia and surgery, and microglia and astrocytes in the hippocampus were activated. |
2023-04-20 |
2023-08-14 |
mouse |
| Jianchen Fan, Xinyan Dong, Yejiao Tang, Xuehui Wang, Donghui Lin, Lifen Gong, Chen Chen, Jie Jiang, Weida Shen, Anyu Xu, Xiangnan Zhang, Yicheng Xie, Xin Huang, Linghui Zen. Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072932. |
preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy. |
2023-04-19 |
2023-08-14 |
Not clear |
| Kun Yu, Xue-Kang Zhang, Han-Chun Xiong, Si-Si Liang, Zi-Yun Lu, Yong-Qiang Wu, Yu Chen, Su-Jun Xia. Stellate ganglion block alleviates postoperative cognitive dysfunction via inhibiting TLR4/NF-κB signaling pathway. Neuroscience letters. 2023-04-19. PMID:37075883. |
we found that the development of pocd was associated with the activation of toll-like receptor 4/nuclear factor kapa-b (tlr4/nf-κb) signaling pathway in the microglia in dorsal hippocampus, which induced the production of pro-inflammatory mediators (tnf-α, il-1β, il-6) and promoted neuroinflammation. |
2023-04-19 |
2023-08-14 |
rat |
| Mi Li, Xian Wang, Lijie Yang, Yong Jiang, Yiqiang Xie, Kai L. Acupuncture improves learning and memory ability of posttraumatic stress disorder model rats through epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway. Technology and health care : official journal of the European Society for Engineering and Medicine. 2023-04-17. PMID:37066940. |
microglia express phosphatidylinositol 3-kinase (pi3k) has been implicated in the induction and maintenance of long-term potentiation (ltp) and in hippocampal synaptic plasticity. |
2023-04-17 |
2023-08-14 |
rat |
| Cheng-Long Zhu, Jian Xie, Qiang Liu, Yi Wang, Hui-Ru Li, Chang-Meng Yu, Peng Li, Xiao-Ming Deng, Jin-Jun Bian, Jia-Feng Wan. PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy. International journal of biological sciences. vol 19. issue 5. 2023-04-14. PMID:37056920. |
here, we firstly show that in murine sepsis model, neutrophils and nets promote blood-brain barrier (bbb) disruption, neuronal apoptosis and microglia activation in hippocampus and induce hippocampus-dependent memory impairment. |
2023-04-14 |
2023-08-14 |
human |
| Qirun Wang, Yi-Yan Wang, Wen-Jun Pu, Xiaohong Ma, Rong-Jun N. Dynamic changes in microglia in the mouse hippocampus during administration and withdrawal of the CSF1R inhibitor PLX3397. Journal of anatomy. 2023-04-11. PMID:37038887. |
dynamic changes in microglia in the mouse hippocampus during administration and withdrawal of the csf1r inhibitor plx3397. |
2023-04-11 |
2023-08-14 |
mouse |
| Qirun Wang, Yi-Yan Wang, Wen-Jun Pu, Xiaohong Ma, Rong-Jun N. Dynamic changes in microglia in the mouse hippocampus during administration and withdrawal of the CSF1R inhibitor PLX3397. Journal of anatomy. 2023-04-11. PMID:37038887. |
in this study, we examined the effects of plx3397 in the drinking water of mice on microglia in the hippocampus using ionized calcium-binding adapter molecule 1 (iba1, a microglial marker) immunocytochemistry. |
2023-04-11 |
2023-08-14 |
mouse |
| Diego A Ojeda, Oliver Hutton, Robert Hopkins, Felino Cagampang, Neil R Smyth, Tom P Fleming, Judith Eckert, Sandrine Willaime-Morawe. Preimplantation or gestation/lactation high-fat diet alters adult offspring metabolism and neurogenesis. Brain communications. vol 5. issue 2. 2023-04-10. PMID:37033334. |
a maternal high-fat diet also increased the density of astrocytes and microglia in the hippocampus of high-fat diet males and females. |
2023-04-10 |
2023-08-14 |
mouse |
| Su Jiang, Ying Xiong, Xinyan Wan. Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice. Neuropathology : official journal of the Japanese Society of Neuropathology. 2023-04-10. PMID:37037475. |
the treatment of engeletin dramatically suppressed the activation of microglia and apoptosis induced by sev in the hippocampus of neonatal mice. |
2023-04-10 |
2023-08-14 |
mouse |
| Naveen Nagarajan, Mario R Capecch. Optogenetic stimulation of mouse Hoxb8 microglia in specific regions of the brain induces anxiety, grooming, or both. Molecular psychiatry. 2023-04-10. PMID:37037872. |
optogenetic stimulation of hoxb8 microglia in the ventral ca1 region of the hippocampus (vca1) induces both behaviors as well as freezing. |
2023-04-10 |
2023-08-14 |
mouse |
| Marta Vicente-Rodríguez, Renzo Mancuso, Alba Peris-Yague, Camilla Simmons, Diego Gómez-Nicola, V Hugh Perry, Federico Turkheimer, Simon Lovestone, Christine A Parker, Diana Cas. Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease. Journal of neuroinflammation. vol 20. issue 1. 2023-04-09. PMID:37032328. |
importantly, we show that the selective csf1r inhibitor, jnj-40346527 (jnj527), attenuated the disease-dependent increase in tspo signal, particularly in the dentate gyrus of the hippocampus, where jnj527 attenuated the number of iba1+ microglia and neurons, but not gfap+ astrocytes or endothelial cells. |
2023-04-09 |
2023-08-14 |
mouse |
| Kazi Atikur Rahman, Marta Orlando, Ayub Boulos, Ewa Andrzejak, Dietmar Schmitz, Noam E Ziv, Harald Prüss, Craig C Garner, Aleksandra Ichkov. Microglia actively remove NR1 autoantibody-bound NMDA receptors and associated post-synaptic proteins in neuron microglia co-cultures. Glia. 2023-04-07. PMID:37026600. |
here, using a patient-derived monoclonal nr1 autoantibody (hnr1-mab) and a co-culture system of microglia and neurons, we could show that hnr1-mab bound to hippocampal neurons led to microglia-mediated removal of hnr1-mab bound nmdars. |
2023-04-07 |
2023-08-14 |
Not clear |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Dharmendra Kumar Khatri, Shashi Bala Sing. Sphingosine 1 phosphate lyase inhibition rescues cognition in diabetic mice by promoting anti-inflammatory microglia. Behavioural brain research. 2023-03-30. PMID:36997095. |
we further evaluated the effect of fingolimod on the activation of microglia in the pre-frontal cortex (pfc) and hippocampus of diabetic mice. |
2023-03-30 |
2023-08-14 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Dharmendra Kumar Khatri, Shashi Bala Sing. Sphingosine 1 phosphate lyase inhibition rescues cognition in diabetic mice by promoting anti-inflammatory microglia. Behavioural brain research. 2023-03-30. PMID:36997095. |
our study revealed that fingolimod inhibited s1pl and promoted anti-inflammatory microglia in both pfc and hippocampus of diabetic mice as it increased ym-1 and arginase-1. |
2023-03-30 |
2023-08-14 |
mouse |
| Yue Wang, Ziwen Cai, Gaofeng Zhan, Xing Li, Shan Li, Xuan Wang, Shiyong Li, Ailin Lu. Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978961. |
we revealed that cape pretreatment suppressed oxidative stress and promoted the switch of microglia from the m1 to the m2 type in the hippocampus, thereby ameliorating cognitive impairment caused by anesthesia and surgery. |
2023-03-29 |
2023-08-14 |
mouse |
| Barbara Fülöp, Ágnes Hunyady, Noémi Bencze, Viktória Kormos, Nikolett Szentes, Ádám Dénes, Nikolett Lénárt, Éva Borbély, Zsuzsanna Helye. IL-1 Mediates Chronic Stress-Induced Hyperalgesia Accompanied by Microglia and Astroglia Morphological Changes in Pain-Related Brain Regions in Mice. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982563. |
increased iba1+ integrated density in the central nucleus of amygdala, primary somatosensory cortex hind limb representation part, hippocampus cornu ammonis area 3 (ca3) and periaqueductal gray matter (pag) was present, accompanied by a cell number increase in iba1+ microglia in stressed female wts but not in il-1 kos. |
2023-03-29 |
2023-08-14 |
mouse |