| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adnan H Khan, Itay Chowers, Andrew J Loter. Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment. Cells. vol 12. issue 13. 2023-07-14. PMID:37443742. |
the chronic inflammatory state in amd is complex, with contributions from cells of the innate and adaptive branches of the immune system, sometimes with overlapping features, and the interaction of their secretory products with retinal cells such as microglia and retinal pigment epithelium (rpe), extracellular matrix and choroidal vascular endothelial cells. |
2023-07-14 |
2023-08-14 |
Not clear |
| Akari Hashimoto, Nanami Kawamura, Etsuko Tarusawa, Ikuko Takeda, Yuki Aoyama, Nobuhiko Ohno, Mio Inoue, Mai Kagamiuchi, Daisuke Kato, Mami Matsumoto, Yoshihiro Hasegawa, Junichi Nabekura, Anne Schaefer, Andrew J Moorhouse, Takeshi Yagi, Hiroaki Wak. Microglia enable cross-modal plasticity by removing inhibitory synapses. Cell reports. 2023-04-22. PMID:37086724. |
the enhanced cross-modal response is mediated by selective removal of inhibitory synapse terminals on pyramidal neurons by the microglia in the v2l via matrix metalloproteinase 9 signaling. |
2023-04-22 |
2023-08-14 |
Not clear |
| Tanner Clifford, Zachary Finkel, Brianna Rodriguez, Adelina Joseph, Li Ca. Current Advancements in Spinal Cord Injury Research-Glial Scar Formation and Neural Regeneration. Cells. vol 12. issue 6. 2023-03-29. PMID:36980193. |
the scar border is a physicochemical barrier composed of elongated astrocytes, fibroblasts, and microglia secreting chondroitin sulfate proteoglycans, collogen, and the dense extra-cellular matrix. |
2023-03-29 |
2023-08-14 |
Not clear |
| Fong Kuan Wong, Emilia Favuzz. The brain's polymath: Emerging roles of microglia throughout brain development. Current opinion in neurobiology. vol 79. 2023-02-27. PMID:36848726. |
we summarize recent findings showing that microglia regulate neuronal numbers and influence neuronal connectivity through a bidirectional communication between microglia and neurons, processes regulated by neuronal activity and the remodeling of the extracellular matrix. |
2023-02-27 |
2023-08-14 |
Not clear |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
after spinal cord injury, hmgb1 is rapidly expressed by neurons, microglia and ependymal cells, and it is either actively or passively released into the extracellular matrix and blood circulation; furthermore, it also participates in the pathophysiological process of spinal cord injury. |
2023-01-30 |
2023-08-14 |
Not clear |
| Julianne B Carroll, Shaida Hamidi, Mark L Gabriel. Microglial heterogeneity and complement component 3 elimination within emerging multisensory midbrain compartments during an early critical period. Frontiers in neuroscience. vol 16. 2023-01-23. PMID:36685243. |
cd11b-expressing microglia while homogeneously distributed at birth, are biased to modular fields at p8 and then the surrounding matrix by p12. |
2023-01-23 |
2023-08-14 |
mouse |
| Mari Gotoh, Yasunori Miyamoto, Hiroko Ikeshima-Kataok. Astrocytic Neuroimmunological Roles Interacting with Microglial Cells in Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36675113. |
in this review paper, we mostly focus on the functional role of astrocytes in the extracellular matrix and on interactions between reactive astrocytes and reactive microglia in normal states and in neurodegenerative diseases, because the authors feel it is necessary to elucidate the mechanisms among activated glial cells in the pathology of neurological diseases in order to pave the way for drug discovery. |
2023-01-21 |
2023-08-14 |
human |
| Sheikh Azimullah, Richard L Jayaraj, Mohamed Fizur Nagoor Meeran, Fakhreya Y Jalal, Abdu Adem, Shreesh Ojha, Rami Beira. Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677744. |
administration of rot caused a considerable loss of dopaminergic neurons, subsequent to a significant reduction in the antioxidant defense systems, increased lipid peroxidation, and activation of microglia and astrocytes, along with the production of pro-inflammatory cytokines (il-6, tnf-α, il-1β) and matrix metalloproteinase-9. |
2023-01-21 |
2023-08-14 |
Not clear |
| Fan-Li Lin, Yu-Wen Cheng, Li-Huei Chen, Jau-Der Ho, Jing-Lun Yen, Mong-Heng Wang, Tzong-Huei Lee, George Hsia. Retinal protection by fungal product theissenolactone B in a sodium iodate-induced AMD model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-19. PMID:36535199. |
retinal protection by fungal product theissenolactone b in a sodium iodate-induced amd model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity. |
2022-12-19 |
2023-08-14 |
Not clear |
| Hiroshi Ued. Prothymosin α-derived hexapeptide prevents the brain damage and sequelae due to ischemia-hemorrhage. Peptides. 2022-12-10. PMID:36496010. |
mechanisms underlying their beneficial actions may be related to the fact that protα inhibits the production of matrix metalloproteases (mmps) in microglia and vascular endothelial cells. |
2022-12-10 |
2023-08-14 |
human |
| Kathryn E Sánchez, Kiran Bhaskar, Gary A Rosenber. Apoptosis-associated speck-like protein containing a CARD-mediated release of matrix metalloproteinase 10 stimulates a change in microglia phenotype. Frontiers in molecular neuroscience. vol 15. 2022-10-28. PMID:36305000. |
apoptosis-associated speck-like protein containing a card-mediated release of matrix metalloproteinase 10 stimulates a change in microglia phenotype. |
2022-10-28 |
2023-08-14 |
Not clear |
| Niek F H N van Bree, Margareta Wilhel. The Tumor Microenvironment of Medulloblastoma: An Intricate Multicellular Network with Therapeutic Potential. Cancers. vol 14. issue 20. 2022-10-27. PMID:36291792. |
the tme of mb consists of an intricate multicellular network of tumor cells, progenitor cells, astrocytes, neurons, supporting stromal cells, microglia, immune cells, extracellular matrix components, and vasculature systems. |
2022-10-27 |
2023-08-14 |
Not clear |
| Daniel T Gray, Salma Khattab, Jeri Meltzer, Kelsey McDermott, Rachel Schwyhart, Irina Sinakevitch, Wolfgang Härtig, Carol A Barne. Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques. Cerebral cortex (New York, N.Y. : 1991). 2022-09-28. PMID:36169578. |
microglia, the innate immune cells of the brain, play critical roles in maintaining synapse function, including through a recently identified role in regulating the brain extracellular matrix. |
2022-09-28 |
2023-08-14 |
monkey |
| Daniel T Gray, Salma Khattab, Jeri Meltzer, Kelsey McDermott, Rachel Schwyhart, Irina Sinakevitch, Wolfgang Härtig, Carol A Barne. Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques. Cerebral cortex (New York, N.Y. : 1991). 2022-09-28. PMID:36169578. |
this study sought to determine the relationship between age, microglia, and extracellular matrix structure densities in the macaque retrosplenial cortex. |
2022-09-28 |
2023-08-14 |
monkey |
| Daniel T Gray, Salma Khattab, Jeri Meltzer, Kelsey McDermott, Rachel Schwyhart, Irina Sinakevitch, Wolfgang Härtig, Carol A Barne. Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques. Cerebral cortex (New York, N.Y. : 1991). 2022-09-28. PMID:36169578. |
microglia, parvalbumin (pv)-expressing interneurons and extracellular matrix structures, known as perineuronal nets (pnns), were immuno- and histochemically labeled. |
2022-09-28 |
2023-08-14 |
monkey |
| Victoria Dahl, Hawley Helmbrecht, Ana Rios Sigler, Kate Hildahl, Holly Sullivan, Sanjana Janakiraman, Saahiti Jasti, Elizabeth Nanc. Characterization of a mGluR5 Knockout Rat Model with Hallmarks of Fragile X Syndrome. Life (Basel, Switzerland). vol 12. issue 9. 2022-09-23. PMID:36143345. |
in response to injury, reactive microglia release matrix metalloproteases, contribute to extracellular matrix (ecm) breakdown, and are responsible for eradicating cellular and molecular debris. |
2022-09-23 |
2023-08-14 |
rat |
| Yuri Chelyshe. More Attention on Segments Remote from the Primary Spinal Cord Lesion Site. Frontiers in bioscience (Landmark edition). vol 27. issue 8. 2022-08-30. PMID:36042182. |
activated macrophages secrete pro-inflammatory cytokines and matrix metalloproteinases, which, in turn, induce astrocytes and microglia towards a pro-inflammatory phenotype. |
2022-08-30 |
2023-08-14 |
Not clear |
| Hengyi Wang, Yuanliang Xia, Baoqin Li, Yuehong Li, Changfeng F. Reverse Adverse Immune Microenvironments by Biomaterials Enhance the Repair of Spinal Cord Injury. Frontiers in bioengineering and biotechnology. vol 10. 2022-06-01. PMID:35646849. |
among them, microglia, macrophages, neutrophils, lymphocytes, astrocytes, and the release of various cytokines, as well as the destruction of the extracellular matrix are mainly involved in the imbalance of the immune microenvironment. |
2022-06-01 |
2023-08-13 |
Not clear |
| Shannon Tansley, Ning Gu, Alba Ureña Guzmán, Weihua Cai, Calvin Wong, Kevin Lister, Einer Muñoz-Pino, Noosha Yousefpour, R Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G Gkogkas, James W Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S Mogil, Arkady Khoutorsk. Microglia-mediated degradation of perineuronal nets promotes pain. Science (New York, N.Y.). 2022-05-26. PMID:35617374. |
we discovered that following peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets (pnns), in lamina i of the spinal cord dorsal horn. |
2022-05-26 |
2023-08-13 |
Not clear |
| Xiaojie Zhao, Fan Zhang, Suresh R Kandel, Frédéric Brau, Johnny J H. HIV Tat and cocaine interactively alter genome-wide DNA methylation and gene expression and exacerbate learning and memory impairments. Cell reports. vol 39. issue 5. 2022-05-04. PMID:35508123. |
these genes are mostly enriched at the neuronal function-, cell morphology-, and synapse formation-related extracellular matrix (ecm) receptor-ligand interaction pathway and mostly impacted in microglia. |
2022-05-04 |
2023-08-13 |
mouse |