| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W C Benzing, J R Wujek, E K Ward, D Shaffer, K H Ashe, S G Younkin, K R Brunde. Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice. Neurobiology of aging. vol 20. issue 6. 2000-11-17. PMID:10674423. |
chronic expression of inflammatory cytokines, including interleukin-1beta, tumor necrosis factor alpha, and interleukin-6, by glia may underlie the neurodegenerative events that occur within the brains of patients with alzheimer's disease (ad). |
2000-11-17 |
2023-08-12 |
mouse |
| P Schubert, T Morino, H Miyazaki, T Ogata, Y Nakamura, C Marchini, S Ferron. Cascading glia reactions: a common pathomechanism and its differentiated control by cyclic nucleotide signaling. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818485. |
a pathological glia activation, stimulated by inflammatory proteins, beta-amyloid, or brain ischemia, is discussed as a common pathogenic factor for progressive nerve cell damage in vascular and alzheimer dementia. |
2000-06-02 |
2023-08-12 |
rat |
| L H Ho, R N Ratnaike, P D Zalewsk. Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells. Biochemical and biophysical research communications. vol 268. issue 1. 2000-03-01. PMID:10652229. |
age-related tissue zn deficiency may contribute to neuronal and glial cell death by apoptosis in alzheimer's dementia. |
2000-03-01 |
2023-08-12 |
human |
| J Hu, L J Van Eldi. Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation. Brain research. vol 842. issue 1. 1999-11-19. PMID:10526094. |
a prominent feature of alzheimer's disease (ad) pathology is an abundance of activated glia (astrocytes and microglia) in close proximity to the amyloid plaques. |
1999-11-19 |
2023-08-12 |
rat |
| V Soontornniyomkij, G Wang, C A Pittman, R L Hamilton, C A Wiley, C L Achi. Absence of brain-derived neurotrophic factor and trkB receptor immunoreactivity in glia of Alzheimer's disease. Acta neuropathologica. vol 98. issue 4. 1999-11-05. PMID:10502038. |
absence of brain-derived neurotrophic factor and trkb receptor immunoreactivity in glia of alzheimer's disease. |
1999-11-05 |
2023-08-12 |
human |
| S Engelborghs, M De Brabander, J De Crée, R D'Hooge, H Geerts, H Verhaegen, P P De Dey. Unchanged levels of interleukins, neopterin, interferon-gamma and tumor necrosis factor-alpha in cerebrospinal fluid of patients with dementia of the Alzheimer type. Neurochemistry international. vol 34. issue 6. 1999-08-31. PMID:10402228. |
several histopathological studies suggest that amyloidogenesis in dementia of the alzheimer type is accompanied by activated glia and glia-derived cytokines, leading to chronic, self-propagating, cytokine-mediated molecular and cellular reactions. |
1999-08-31 |
2023-08-12 |
Not clear |
| C F Lippa, K C Flanders, E S Kim, S Crou. TGF-beta receptors-I and -II immunoexpression in Alzheimer's disease: a comparison with aging and progressive supranuclear palsy. Neurobiology of aging. vol 19. issue 6. 1999-05-11. PMID:10192211. |
the transforming growth factor-betas (tgf-betas) influence cell survival, and tgf-beta2 shows increased immunoexpression in neurofibrillary tangle-bearing neurons and reactive glia in alzheimer's disease (ad) and progressive supranuclear palsy (psp). |
1999-05-11 |
2023-08-12 |
Not clear |
| P Schubert, T Ogata, H Miyazaki, C Marchini, S Ferroni, K Rudolph. Pathological immuno-reactions of glial cells in Alzheimer's disease and possible sites of interference. Journal of neural transmission. Supplementum. vol 54. 1999-03-11. PMID:9850925. |
a significant role of a pathological glial cell activation in the pathogenesis of alzheimer's disease is supported by the growing evidence that inflammatory proteins, which are produced by reactive astrocytes, promote the transformation of diffuse beta-amyloid deposits into the filamentous, neurotoxic form. |
1999-03-11 |
2023-08-12 |
Not clear |
| J G Schulz, D Megow, R Reszka, A Villringer, K M Einhäupl, U Dirnag. Evidence that glypican is a receptor mediating beta-amyloid neurotoxicity in PC12 cells. The European journal of neuroscience. vol 10. issue 6. 1998-11-09. PMID:9753095. |
docking of beta-amyloid fibrils to neuronal or glial cell membranes may be an early, necessary and intervenable step during the progression of alzheimer's disease. |
1998-11-09 |
2023-08-12 |
rat |
| M Rother, T Erkinjuntti, M Roessner, B Kittner, J Marcusson, I Karlsso. Propentofylline in the treatment of Alzheimer's disease and vascular dementia: a review of phase III trials. Dementia and geriatric cognitive disorders. vol 9 Suppl 1. 1998-11-06. PMID:9716243. |
propentofylline, a neuroprotective glial cell modulator, has been shown in preclinical studies to address some of the common pathological processes of alzheimer's disease (ad) and vascular dementia (vad), including glial cell activation and increased production of cytokines, free radicals, and glutamate. |
1998-11-06 |
2023-08-12 |
Not clear |
| S A Frautschy, D L Horn, J J Sigel, M E Harris-White, J J Mendoza, F Yang, T C Saido, G M Col. Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 20. 1998-10-23. PMID:9763475. |
collectively, these data suggest that an age or alzheimer's-related defect in lysosomal/endosomal function could promote abeta deposition and dna fragmentation in neurons and glia similar to that found in alzheimer's disease. |
1998-10-23 |
2023-08-12 |
rat |
| J Hu, M J LaDu, L J Van Eldi. Apolipoprotein E attenuates beta-amyloid-induced astrocyte activation. Journal of neurochemistry. vol 71. issue 4. 1998-10-14. PMID:9751196. |
a common feature of alzheimer's disease pathology is an abundance of activated glia, indicative of an inflammatory reaction in the brain. |
1998-10-14 |
2023-08-12 |
human |
| S D Styren, M I Kamboh, S T DeKosk. Expression of differential immune factors in temporal cortex and cerebellum: the role of alpha-1-antichymotrypsin, apolipoprotein E, and reactive glia in the progression of Alzheimer's disease. The Journal of comparative neurology. vol 396. issue 4. 1998-09-08. PMID:9651008. |
expression of differential immune factors in temporal cortex and cerebellum: the role of alpha-1-antichymotrypsin, apolipoprotein e, and reactive glia in the progression of alzheimer's disease. |
1998-09-08 |
2023-08-12 |
human |
| R E Mrak, S T Griffin, D I Graha. Aging-associated changes in human brain. Journal of neuropathology and experimental neurology. vol 56. issue 12. 1998-01-23. PMID:9413275. |
aging is accompanied by increases in glial cell activation, in oxidative damage to proteins and lipids, in irreversible protein glycation, and in damage to dna, and such changes may underlie in part the age-associated increasing incidence of "degenerative" conditions such as alzheimer disease and parkinson disease. |
1998-01-23 |
2023-08-12 |
human |
| S Shoham, R P Ebstei. The distribution of beta-amyloid precursor protein in rat cortex after systemic kainate-induced seizures. Experimental neurology. vol 147. issue 2. 1997-11-21. PMID:9344561. |
the present study, which extensively characterized early changes in c-fos expression and betaapp-li in glia following kainate-induced seizures, is a potentially useful animal model for the in vivo study of numerous facets of betaapp synthesis and the possible role of such processes in alzheimer's disease. |
1997-11-21 |
2023-08-12 |
rat |
| D M Araujo, D C Hilt, P J Miller, D Wen, S Jiao, P A Lapcha. ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. Neuroscience. vol 80. issue 1. 1997-10-23. PMID:9252216. |
these findings suggest that glial cell line-derived neurotrophic factor may be a protective/restorative agent for a diverse population of neurons and imply that it may be a useful therapeutic tool for a variety of neurodegenerative diseases including parkinson's, huntington's and alzheimer's diseases. |
1997-10-23 |
2023-08-12 |
mouse |
| E Master, S L Chan, Z Ali-Kha. Ubiquitin (Ub) interacts non-covalently with Alzheimer amyloid precursor protein (betaPP): isolation of Ub-betaPP conjugates from brain extracts. Neuroreport. vol 8. issue 12. 1997-10-23. PMID:9295117. |
ubiquitin (ub)-immunocytochemistry on alzheimer's disease (ad) brain sections shows diverse ub-associated deposits in the neuropil and senile plaques, elevated levels of ub reactivity in hippocampal neurons and glia, and co-localization of ub and beta-amyloid precursor protein (betapp) epitope reactivity in dystrophic axons. |
1997-10-23 |
2023-08-12 |
Not clear |
| A Wu, M N Pangalos, S Efthimiopoulos, J Shioi, N K Robaki. Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 13. 1997-07-17. PMID:9185536. |
appicans are secreted or cell-associated brain chondroitin sulfate proteoglycans produced by glia cells and containing alzheimer amyloid precursor protein (app) as a core protein. |
1997-07-17 |
2023-08-12 |
rat |
| A J Patel, C Wickenden, A Jen, H A de Silv. Glial cell derived neurotrophic factors and Alzheimer's disease. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117568. |
glial cell derived neurotrophic factors and alzheimer's disease. |
1997-04-24 |
2023-08-12 |
Not clear |
| D Soffer, Y Sherman, R Tur-Kaspa, A Ei. Acquired hepatocerebral degeneration in a liver transplant recipient. Acta neuropathologica. vol 90. issue 1. 1995-11-22. PMID:7572073. |
autopsy revealed typical features of acquired hepatocerebral degeneration with diffuse but patchy pseudolaminar cortical necrosis, variable amount of neuronal loss in the cerebral cortex, basal ganglia and other areas, and proliferation of alzheimer type ii glia. |
1995-11-22 |
2023-08-12 |
Not clear |