| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Pina Serra, Marina Quartu, Francesca Mascia, Annalisa Manca, Marianna Boi, M Giuseppina Pisu, Maria Letizia Lai, Marina Del Fiacc. Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human hippocampus and fascia dentata. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 23. issue 5. 2005-09-26. PMID:16002253. |
the immunohistochemical occurrence and localization of the receptor components of the glial cell line-derived neurotrophic factor (gdnf) family ligands, the ret receptor tyrosine kinase and gdnf family receptor (gfr) alpha-1 to -3, is described in the human post-mortem hippocampal formation at pre- and full-term newborn, and adult age. |
2005-09-26 |
2023-08-12 |
human |
| Paul Carmillo, Lone Dagø, Eric S Day, Dane S Worley, Anthony Rossomando, Lee Walus, Olivia Orozco, Carolyn Buckley, Stephan Miller, Albert Tse, Richard L Cate, Carl Rosenblad, Dinah W Y Sah, Mette Grønborg, Adrian Whitt. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry. vol 44. issue 7. 2005-04-25. PMID:15709767. |
glial cell line-derived neurotrophic factor (gdnf) receptor alpha-1 (gfr alpha 1) is highly selective for gdnf versus artemin. |
2005-04-25 |
2023-08-12 |
rat |
| Paul Carmillo, Lone Dagø, Eric S Day, Dane S Worley, Anthony Rossomando, Lee Walus, Olivia Orozco, Carolyn Buckley, Stephan Miller, Albert Tse, Richard L Cate, Carl Rosenblad, Dinah W Y Sah, Mette Grønborg, Adrian Whitt. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry. vol 44. issue 7. 2005-04-25. PMID:15709767. |
to clarify whether glial cell line-derived neurotrophic factor (gdnf) receptor alpha-1 (gfralpha1), the glycosylphosphatidylinositol (gpi)-linked coreceptor for gdnf, is also a functional coreceptor for artemin (art), we have studied receptor binding, signaling, and neuronal survival. |
2005-04-25 |
2023-08-12 |
rat |
| Marie-Claude Hofmann, Laura Braydich-Stolle, Martin Dy. Isolation of male germ-line stem cells; influence of GDNF. Developmental biology. vol 279. issue 1. 2005-04-18. PMID:15708562. |
we show in the present study that gfr alpha-1, the receptor for gdnf (glial cell line-derived neurotrophic factor), is strongly expressed by a subset of type a spermatogonia in the basal part of the seminiferous epithelium. |
2005-04-18 |
2023-08-12 |
mouse |
| Armin Blesch, Mark H Tuszynsk. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. The Journal of comparative neurology. vol 467. issue 3. 2004-01-23. PMID:14608602. |
glial cell line-derived neurotrophic factor (gdnf) is the prototypical member of a growth factor family that signals via the cognate receptors ret and gdnf-receptor alpha-1. |
2004-01-23 |
2023-08-12 |
Not clear |
| A Sarabi, B J Hoffer, L Olson, M Morale. Glial cell line neurotrophic factor-family receptor alpha-1 is present in central neurons with distinct phenotypes. Neuroscience. vol 116. issue 1. 2003-06-24. PMID:12535958. |
glial cell line neurotrophic factor-family receptor alpha-1 is present in central neurons with distinct phenotypes. |
2003-06-24 |
2023-08-12 |
Not clear |
| S Rémy, P Naveilhan, P Brachet, I Neve. Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells. Journal of neuroscience research. vol 64. issue 3. 2001-07-19. PMID:11319768. |
glial cell line-derived neurotrophic factor (gdnf) and neurturin (ntn) bind to gfr alpha-1 and gfr alpha-2 receptors, respectively, and their neurotrophic activity is mediated by the tyrosine kinase receptor, ret. |
2001-07-19 |
2023-08-12 |
rat |
| A Capes-Davis, S D Andrew, V J Hyland, S Twigg, D L Learoyd, T Dwight, D J Marsh, B G Robinso. Glucocorticoids differentially inhibit expression of the RET proto-oncogene. Gene expression. vol 8. issue 5-6. 2000-08-30. PMID:10947080. |
the ret proto-oncogene encodes a receptor tyrosine kinase activated by the binding of factors from the glial cell line-derived neurotrophic factor (gdnf) family to receptor-alpha components such as gdnf family receptor alpha-1 (gfr alpha-1). |
2000-08-30 |
2023-08-12 |
Not clear |
| A Hase, H Suzuki, K Arahata, C Akazaw. Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves. Neuroscience letters. vol 269. issue 1. 2000-06-21. PMID:10821644. |
as one of the target-derived trophic factors, glial cell line-derived neurotrophic factor (gdnf) has been shown to exert its effects on motor neurons via a receptor complex including gdnf receptor alpha 1 (gfr alpha-1). |
2000-06-21 |
2023-08-12 |
human |
| A Matsuo, S Nakamura, I Akiguch. Immunohistochemical localization of glial cell line-derived neurotrophic factor family receptor alpha-1 in the rat brain: confirmation of expression in various neuronal systems. Brain research. vol 859. issue 1. 2000-05-09. PMID:10720615. |
immunohistochemical localization of glial cell line-derived neurotrophic factor family receptor alpha-1 in the rat brain: confirmation of expression in various neuronal systems. |
2000-05-09 |
2023-08-12 |
rat |
| A Matsuo, S Nakamura, I Akiguch. Immunohistochemical localization of glial cell line-derived neurotrophic factor family receptor alpha-1 in the rat brain: confirmation of expression in various neuronal systems. Brain research. vol 859. issue 1. 2000-05-09. PMID:10720615. |
the localization of glial cell line-derived neurotrophic factor (gdnf) family receptor alpha-1 (gfralpha-1) was investigated in rat brain by immunohistochemistry using a polyclonal antibody against a specific sequence of the rat protein. |
2000-05-09 |
2023-08-12 |
rat |
| N V Botchkareva, V A Botchkarev, P Welker, M Airaksinen, W Roth, P Suvanto, S Müller-Röver, I M Hadshiew, C Peters, R Pau. New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. The American journal of pathology. vol 156. issue 3. 2000-03-23. PMID:10702420. |
glial cell line-derived neurotrophic factor (gdnf), neurturin (ntn), and their receptors, gdnf family receptor alpha-1 (gfralpha-1) and gdnf family receptor alpha-2 (gfralpha-2), are critically important for kidney and nervous system development. |
2000-03-23 |
2023-08-12 |
mouse |
| T C Burazin, A L Gundlac. Localization of GDNF/neurturin receptor (c-ret, GFRalpha-1 and alpha-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581409. |
recent studies have identified a multi-component receptor system for the neurotrophic factor, glial cell line-derived neurotrophic factor (gdnf) and its homolog, neurturin (ntn), comprising the signaling tyrosine kinase, ret and multiple gpi-linked binding proteins, gdnf family receptor alpha-1 and alpha-2 (gfralpha-1 and gfralpha-2). |
2000-02-14 |
2023-08-12 |
rat |
| S Homma, R W Oppenheim, H Yaginuma, S Kimur. Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Developmental biology. vol 217. issue 1. 2000-02-04. PMID:10625540. |
we have cloned a partial cdna of chicken glial cell line-derived neurotrophic factor (gdnf) and systematically examined its expression pattern as well as that of gdnf-binding components (gdnf family receptor alpha-1 and 2: gfralpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: ret) during very early developmental stages. |
2000-02-04 |
2023-08-12 |
chicken |
| H Tsujino, K Mansur, S Kiryu-Seo, K Namikawa, T Kitahara, K Tanabe, T Ochi, H Kiyam. Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats. Brain research. Molecular brain research. vol 70. issue 2. 1999-09-08. PMID:10407179. |
discordant expression of c-ret and glial cell line-derived neurotrophic factor receptor alpha-1 mrnas in response to motor nerve injury in neonate rats. |
1999-09-08 |
2023-08-12 |
rat |
| H Tsujino, K Mansur, S Kiryu-Seo, K Namikawa, T Kitahara, K Tanabe, T Ochi, H Kiyam. Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats. Brain research. Molecular brain research. vol 70. issue 2. 1999-09-08. PMID:10407179. |
following hypoglossal nerve axotomy in neonate rat, glial cell line-derived neurotrophic factor (gdnf) receptor alpha-1 (gfralpha-1) mrna expression was dramatically suppressed in the injured motoneurons, while a slight increase of c-ret mrna expression was observed. |
1999-09-08 |
2023-08-12 |
rat |
| R M Melillo, M V Barone, G Lupoli, A M Cirafici, F Carlomagno, R Visconti, B Matoskova, P P Di Fiore, G Vecchio, A Fusco, M Santor. Ret-mediated mitogenesis requires Src kinase activity. Cancer research. vol 59. issue 5. 1999-03-22. PMID:10070972. |
to test the involvement of c-src in ret-mediated signaling, we measured the levels of c-src activity in nih3t3 cells coexpressing ret and the accessory gfr alpha-1 receptor or an epidermal growth factor receptor/ret chimeric receptor when the cells were stimulated by glial cell line-derived neurotrophic factor or epidermal growth factor, respectively. |
1999-03-22 |
2023-08-12 |
human |
| M Trupp, C Raynoschek, N Belluardo, C F Ibáñe. Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Molecular and cellular neurosciences. vol 11. issue 1-2. 1998-08-07. PMID:9608533. |
glial cell line-derived neurotrophic factor (gdnf) mediates neuronal survival through a receptor complex composed of the c-retproto-oncogene and gfr alpha-1, a member of a family of gpi-anchored receptors. |
1998-08-07 |
2023-08-12 |
rat |
| T Hishiki, Y Nimura, E Isogai, K Kondo, S Ichimiya, Y Nakamura, T Ozaki, S Sakiyama, M Hirose, N Seki, H Takahashi, N Ohnuma, M Tanabe, A Nakagawar. Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2. Cancer research. vol 58. issue 10. 1998-06-10. PMID:9605760. |
glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-ret, gfr alpha-1, and gfr alpha-2. |
1998-06-10 |
2023-08-12 |
human |
| T Hishiki, Y Nimura, E Isogai, K Kondo, S Ichimiya, Y Nakamura, T Ozaki, S Sakiyama, M Hirose, N Seki, H Takahashi, N Ohnuma, M Tanabe, A Nakagawar. Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2. Cancer research. vol 58. issue 10. 1998-06-10. PMID:9605760. |
recently, glial cell line-derived neurotrophic factor (gdnf) and a second family member, neurturin (ntn), have been found to mediate their signals by binding to a heterotetrameric complex of c-ret tyrosine kinase receptors and glycosylphosphatidylinositol-linked proteins, gfr alpha-1 (gdnfr-alpha) or gfr alpha-2 (trnr2/gdnfr-beta/ntnr-alpha/retl2). |
1998-06-10 |
2023-08-12 |
human |