| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Patel, S M Parkin, M C Bibb. The effect of 5,6-dimethylxanthenone-4-acetic acid on tumour necrosis factor production by human immune cells. Anticancer research. vol 17. issue 1A. 1997-04-07. PMID:9066644. |
this study has demonstrated mrna for tnf alpha by rt-pcr in human and murine immune cells incubated with either 5,6-mexaa, faa or in culture medium alone. |
1997-04-07 |
2023-08-12 |
mouse |
| S A Hill, L E Sampson, D J Chapli. Anti-vascular approaches to solid tumour therapy: evaluation of vinblastine and flavone acetic acid. International journal of cancer. vol 63. issue 1. 1995-11-03. PMID:7558438. |
several agents have now been identified which exert their anti-tumour effects in large part via the tumour vasculature; these include tnf alpha and flavone acetic acid (faa). |
1995-11-03 |
2023-08-12 |
mouse |
| S A Hill, L E Sampson, D J Chapli. Anti-vascular approaches to solid tumour therapy: evaluation of vinblastine and flavone acetic acid. International journal of cancer. vol 63. issue 1. 1995-11-03. PMID:7558438. |
vinblastine, unlike, faa, causes no increase in plasma tnf alpha levels in mice bearing the cant tumour, suggesting 2 distinct mechanisms of anti-vascular activity for these structurally diverse agents. |
1995-11-03 |
2023-08-12 |
mouse |
| L A Eader, L Gusella, L Dorman, H A Youn. Induction of multiple cytokine gene expression and IRF-1 mRNA by flavone acetic acid in a murine macrophage cell line. Cellular immunology. vol 157. issue 1. 1994-08-24. PMID:8039245. |
using the mouse macrophage cell line, ana-1, we can demonstrate the direct induction of interferon beta (ifn beta), interleukin-6 (il-6), tumor necrosis factor-alpha (tnf alpha), and interferon response factor-1 (irf-1) mrna expression following treatment with faa. |
1994-08-24 |
2023-08-12 |
mouse |
| H Futami, L A Eader, K L Komschlies, R Bull, M E Gruys, J R Ortaldo, H A Young, R H Wiltrou. Flavone acetic acid directly induces expression of cytokine genes in mouse splenic leukocytes but not in human peripheral blood leukocytes. Cancer research. vol 51. issue 24. 1992-01-15. PMID:1742732. |
analysis of rna isolated from faa-treated mouse splenic leukocytes demonstrated that treatment with greater than or equal to 100 micrograms/ml of faa induced expression of tumor necrosis factor alpha (tnf-alpha) mrna by 1 h and induced maximal expression of tnf-alpha, alpha-interferon, and gamma-interferon mrna within 3 h. the expression of all cytokine genes was diminished by 6 h. interferon biological activity was detected in the supernatants of mouse splenic or peripheral blood leukocytes after treatment with faa. |
1992-01-15 |
2023-08-11 |
mouse |
| J C Murray, K A Smith, D M Ster. Flavone acetic acid potentiates the induction of endothelial procoagulant activity by tumour necrosis factor. European journal of cancer (Oxford, England : 1990). vol 27. issue 6. 1991-08-20. PMID:1829921. |
this increase was due to enhanced tissue factor expression on the endothelial cell surface, as evidenced by the blocking of the enhanced clotting with antibody to tissue factor, by substitution of normal with factor vii deficient plasma, or by simultaneous treatment of the endothelial cells with cycloheximide or actinomycin d. faa was not toxic to endothelial cell at concentrations up to 1.6 mg/ml over 4 h. combined treatment with faa and tumour necrosis factor alpha (tnf-alpha) (100 pg/ml) produced a 675-fold (range 160-1980) increase in tissue factor activity, compared to 5-fold and 50-fold increases for the individual agents respectively. |
1991-08-20 |
2023-08-11 |
human |
| G Pratesi, M Rodolfo, G Rovetta, G Parmian. Role of T cells and tumour necrosis factor in antitumour activity and toxicity of flavone acetic acid. European journal of cancer (Oxford, England : 1990). vol 26. issue 10. 1991-03-06. PMID:2148884. |
antitumour efficacy of faa was also reduced when the treatment was followed by injection of antitumour necrosis factor alpha (tnf alpha) antibodies. |
1991-03-06 |
2023-08-11 |
mouse |
| G Pratesi, M Rodolfo, G Rovetta, G Parmian. Role of T cells and tumour necrosis factor in antitumour activity and toxicity of flavone acetic acid. European journal of cancer (Oxford, England : 1990). vol 26. issue 10. 1991-03-06. PMID:2148884. |
when anti-tnf alpha antibodies were given after faa treatment, the toxicity was greatly reduced (3/14 mice died compared with 10/15). |
1991-03-06 |
2023-08-11 |
mouse |
| H Futami, R L Hornung, T T Back, R Bull, E Gruys, R H Wiltrou. Systemic alkalinization inhibits the ability of flavone acetic acid to augment natural killer activity, induce cytokine gene expression, and synergize with interleukin 2 for the treatment of murine renal cancer. Cancer research. vol 50. issue 24. 1991-01-23. PMID:2253233. |
by northern blot analysis, it was shown that the induction of mrna for ifn-alpha, ifn-gamma, and tumor necrosis factor alpha by faa in the spleen cells of mice was significantly reduced in alkalinized mice. |
1991-01-23 |
2023-08-11 |
mouse |
| L L Thomsen, L M Ching, B C Bagule. Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid. Cancer research. vol 50. issue 21. 1990-11-21. PMID:2170013. |
these results strongly imply that faa and active xaa derivatives function as low molecular weight stimulators of nitric oxide formation in macrophages, possibly acting on the same differentiation pathway as do endotoxin and tumor necrosis factor alpha. |
1990-11-21 |
2023-08-11 |
mouse |
| T J Sayers, T A Wiltrout, K McCormick, C Husted, R H Wiltrou. Antitumor effects of alpha-interferon and gamma-interferon on a murine renal cancer (Renca) in vitro and in vivo. Cancer research. vol 50. issue 17. 1990-09-27. PMID:2117482. |
additional experiments demonstrated that the in vivo administration of faa rapidly induced the expression of the genes, as well as the biologically active proteins, for alpha- and beta-interferons (ifns) as well as tumor necrosis factor alpha. |
1990-09-27 |
2023-08-11 |
mouse |
| K F Mace, R L Hornung, R H Wiltrout, H A Youn. Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict dose dependency and therapeutic efficacy against murine renal cancer. Cancer research. vol 50. issue 6. 1990-04-12. PMID:1689611. |
interferon alpha and interferon gamma mrna in the spleen was upregulated within 1.5 h after faa administration, with peak induction occurring by about 2 h. an upregulation of tumor necrosis factor alpha mrna was detected in the spleen by 0.5-1 h after treatment with peak induction occurring by 1-1.5 h. induction of tumor necrosis factor alpha mrna was also detected in hepatic nonparenchymal cells. |
1990-04-12 |
2023-08-11 |
mouse |
| K F Mace, R L Hornung, R H Wiltrout, H A Youn. Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict dose dependency and therapeutic efficacy against murine renal cancer. Cancer research. vol 50. issue 6. 1990-04-12. PMID:1689611. |
no up-regulation of splenic mrna for tumor necrosis factor beta, il-1 alpha or beta, or il-2 was detected after faa administration. |
1990-04-12 |
2023-08-11 |
mouse |
| J Cummings, J F Smyt. Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumours. Cancer chemotherapy and pharmacology. vol 24. issue 5. 1989-09-21. PMID:2667786. |
faa stimulates nk cell activity, induces interferon alpha and synergises with interleukin 2 in the treatment of murine renal cancer. |
1989-09-21 |
2023-08-11 |
Not clear |
| R L Hornung, H A Young, W J Urba, R H Wiltrou. Immunomodulation of natural killer cell activity by flavone acetic acid: occurrence via induction of interferon alpha/beta. Journal of the National Cancer Institute. vol 80. issue 15. 1988-10-25. PMID:3418728. |
antibody neutralization studies indicated that faa induced ifn of the alpha/beta type, while molecular hybridization studies demonstrated that faa rapidly stimulated the production of ifn alpha mrna in splenic leukocytes. |
1988-10-25 |
2023-08-11 |
mouse |
| A Petroni, A Borghi, M Blasevich, P Grossi, A Bertazzo, C Gall. Effects of hypoxia and recovery on brain eicosanoids and carbohydrate metabolites in rat brain cortex. Brain research. vol 415. issue 2. 1987-09-17. PMID:3607494. |
brain faa did not change during recovery, but levels of prostaglandin f2 alpha (pgf2 alpha), prostaglandin e2 (pgf2) and thromboxane b2 (txb2) were raised, at 5 min, and those of 6-keto-pgf1 alpha were reduced with respect to pre-hypoxia. |
1987-09-17 |
2023-08-11 |
rat |