| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Kakumu, H Tahara, A Fuji, K Yoshiok. Interleukin 1 alpha production by peripheral blood monocytes from patients with chronic liver disease and effect of sera on interleukin 1 alpha production. Journal of clinical & laboratory immunology. vol 26. issue 3. 1989-04-20. PMID:3148031. |
when monocytes were cultured for two days with bacterial lipopolysaccharide (lps), il 1 alpha production in asymptomatic hepatitis b virus carrier (asc) and patients with chronic active hepatitis (cah) was equivalent to that of controls (168 +/- 31 u/ml, mena +/- sd), while il 1 alpha levels generated by monocytes from liver cirrhosis (lc) (117 +/- 45 u/ml, p less than 0.01) were significantly lower than controls. |
1989-04-20 |
2023-08-11 |
Not clear |
| Y Iino, H Ishikawa, M Izuo, H Takikaw. Sequential hormone therapy with medroxyprogesterone acetate for 7, 12-dimethylbenz [alpha] anthracene-induced rat mammary tumors. Japanese journal of clinical oncology. vol 19. issue 1. 1989-04-19. PMID:2522157. |
two types of sequential hormone therapy with medroxyprogesterone acetate (mpa) were examined in female 93 sprague--dawley (sd) rats with 7,12-dimethylbenz [alpha] anthracene (dmba)-induced mammary tumors. |
1989-04-19 |
2023-08-11 |
rat |
| C Munck Petersen, B S Christiansen, L Heickendorff, J Ingersle. Synthesis and secretion of alpha 2-macroglobulin by human hepatocytes in culture. European journal of clinical investigation. vol 18. issue 5. 1989-04-18. PMID:2465899. |
in 24 h 10(6) hepatocytes secreted 160.5 +/- 82.2 ng of alpha 2-m (mean +/- sd, n = 5). |
1989-04-18 |
2023-08-11 |
human |
| E Raude, M Oellerich, P Weinel, M Freund, M Schrappe, H Riehm, H Poliwod. High-dose methotrexate: pharmacokinetics in children and young adults. International journal of clinical pharmacology, therapy, and toxicology. vol 26. issue 7. 1989-02-21. PMID:3209285. |
leucovorin up to 5 days was biphasic with mean half-lives (+/- sd) of 2.42 +/- 0.45 h for t1/2 alpha and 19.9 +/- 7.6 h for t1/2 beta. |
1989-02-21 |
2023-08-11 |
Not clear |
| P Höglund, L G Nilsso. Physiological disposition of intravenously administered 14C-labeled diltiazem in healthy volunteers. Therapeutic drug monitoring. vol 10. issue 4. 1989-01-25. PMID:3201524. |
this disposition of the drug could be described using a two-compartment model with half-lives of 0.40 +/- 0.48 h (mean +/- sd) in the alpha phase and 2.77 +/- 0.82 h in the beta phase. |
1989-01-25 |
2023-08-11 |
human |
| N A Lassen, A R Andersen, L Friberg, O B Paulso. The retention of [99mTc]-d,l-HM-PAO in the human brain after intracarotid bolus injection: a kinetic analysis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 8. issue 6. 1989-01-06. PMID:3192638. |
from the kinetic model and the measured values of r', k, and f, the following parameter values could be calculated: the average retained fraction of all tracer supplied to the brain, r = 0.38 +/- 0.05 (mean +/- sd), the conversion rate constant (lipophilic to hydrophilic tracer) in the brain k3 = 0.80 +/- 0.12 min-1, the efflux rate constant (brain to blood) k2 = 0.69 +/- 0.11 min-1, the conversion/clearance ratio alpha = k3/k2 = 1.18 +/- 0.25, the influx (blood clearance) constant k1 = 0.45 +/- 0.11 ml/g/min, and the brain/blood partition ratio lambda = k1/k2 = 0.67 +/- 0.23 ml/g. |
1989-01-06 |
2023-08-11 |
human |
| C P Verdon, J B Blumber. Influence of dietary vitamin E on the intermembrane transfer of alpha-tocopherol as mediated by an alpha-tocopherol binding protein. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 189. issue 1. 1988-12-05. PMID:3186764. |
among young rats, those fed vitamin e-deficient diets had the highest alpha tta, 5.02 +/- 3.10 pmole alpha[3h]t/min (mean +/- sd), which was different (p less than 0.05) from the spontaneous transfer rate of 2.10 pmole/min. |
1988-12-05 |
2023-08-11 |
human |
| N Milman, N Graudal, H C Anderse. Acute phase reactants in the elderly. Clinica chimica acta; international journal of clinical chemistry. vol 176. issue 1. 1988-11-21. PMID:2458869. |
the acute phase reactants displayed no sex differences, but were significantly higher in elderly than in younger persons (mean +/- sd): esr 13 +/- 10 mm/h vs 4 +/- 3 mm/h (p less than 0.001); fibrinogen 4.35 +/- 0.95 g/l vs 3.33 +/- 0.54 g/l (p less than 0.001); orosomucoid 0.68 +/- 0.20 g/l vs 0.60 +/- 0.16 g/l (p less than 0.01); alpha 1-antitrypsin 2.16 +/- 0.38 g/l vs 1.84 +/- 0.43 g/l (p less than 0.001); haptoglobin 1.30 +/- 0.50 g/l vs 1.00 +/- 0.30 g/l (p less than 0.001). |
1988-11-21 |
2023-08-11 |
human |
| R C Gaver, N Colombo, M D Green, A M George, G Deeb, A D Morris, R M Canetta, J L Speyer, R H Farmen, F M Muggi. The disposition of carboplatin in ovarian cancer patients. Cancer chemotherapy and pharmacology. vol 22. issue 3. 1988-10-12. PMID:3044634. |
in patients with a clcr of about 60 ml/min or greater, carboplatin decayed biexponentially with a mean t1/2 alpha of 1.6 h and a t1/2 beta of 3.0 h. the mean (+/- sd) residence time, total body clearance, and apparent volume of distribution were 3.5 +/- 0.4 h, 4.4 +/- 0.85 l/h, and 16 +/- 3 l, respectively. |
1988-10-12 |
2023-08-11 |
Not clear |
| Y Fukabor. [Determination of 5 alpha-androstane-3 alpha, 17 beta-diol in human serum by GC-SIM and influence of age-associated change]. Nihon Naibunpi Gakkai zasshi. vol 64. issue 5. 1988-10-11. PMID:3410142. |
when these healthy men were classified into three age groups of 20-39, 40-59 and 60-79 years, the values (mean +/- sd) for serum a3 alpha diol were 189.3 +/- 77.7 (n = 20), 127.9 +/- 59.5 (n = 28), and 94.9 +/- 52.9 (n = 73) pg/ml, respectively. |
1988-10-11 |
2023-08-11 |
human |
| W C Hubbard, M C Alley, T L McLemore, M R Boy. Profiles of prostaglandin biosynthesis in sixteen established cell lines derived from human lung, colon, prostate, and ovarian tumors. Cancer research. vol 48. issue 17. 1988-09-26. PMID:3409218. |
prostaglandin f2 alpha production (pmol/10(6) cells +/- sd) was: lovo (0.3 +/- 0.1); nci-h322 (0.6 +/- 0.2); nci-h358 (0.4 +/- 0.1); ekvx (1.8 +/- 0.4); and a427 (11.1 +/- 3.1). |
1988-09-26 |
2023-08-11 |
human |
| J Gruskay, A T Costarino, R A Polin, S Baumgar. Nonoliguric hyperkalemia in the premature infant weighing less than 1000 grams. The Journal of pediatrics. vol 113. issue 2. 1988-09-08. PMID:3397805. |
serum creatinine concentrations were the same in both groups (1.04 +/- 0.16 sd mg/dl in normokalemic vs 1.19 +/- 0.24 mg/dl in hyperkalemic infants, beta less than 0.2 at alpha = 0.05), and glomerular filtration rates did not differ significantly (6.29 +/- 1.78 ml/min/1.73 m2 in normokalemic vs 5.70 +/- 1.94 ml/min/1.73 m2 in hyperkalemic infants, beta less than 0.2 at alpha = 0.05). |
1988-09-08 |
2023-08-11 |
human |
| K Takeshita, I Fukazawa, N Futaki, K Kameo, K Tomisawa, S Otomo, H Aihar. Immunopharmacological studies of new 3-benzoyl-4-mercaptobutyric acids. Immunomodulating effects. Arzneimittel-Forschung. vol 38. issue 4. 1988-08-30. PMID:3041971. |
a number of d-penicillamine (pa) derivatives (3-benzoyl-4-mercaptobutyric acids) having acetylthio groups on an alpha or beta position of a carboxylic acid, were synthesized and examined for their immunological effects compared with pa. new pa derivatives suppressed adjuvant-induced arthritis (aa) in sd rats and enhanced aa in lewis rats like pa. suppressive effects of 2-acetylthiomethyl-3-(4-methyl-benzoyl)propionic acid (compound ii-3) on aa in sd rats was most potent among pa derivatives and pa. ii-3 enhanced type ii collagen-induced arthritis in rats more effectively than pa, and it slightly prolonged the survival time of nzbxnzw hybrid (bwf1) mice. |
1988-08-30 |
2023-08-11 |
mouse |
| S P Ackland, K E Choi, M J Ratain, M J Egorin, S F Williams, J A Sinkule, J D Bitra. Human plasma pharmacokinetics of thiotepa following administration of high-dose thiotepa and cyclophosphamide. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 6. issue 7. 1988-08-19. PMID:3134519. |
biexponential plasma decay curves were seen in ten patients, with a t 1/2 alpha of 10.0 +/- 6.4 minutes, a t 1/2 beta of 174 +/- 61 minutes and a total body clearance of 379 +/- 153 ml/h/kg (mean +/- sd). |
1988-08-19 |
2023-08-11 |
human |
| F Nomura, H Matsuda, H Hirose, R Shirakura, M Ohtani, M Kaneko, Y Kawashim. Assessment of prostacyclin and thromboxane A2 release during reperfusion after global ischemia induced by crystalloid cardioplegia--comparison between warm and cold ischemia. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. vol 20. issue 2. 1988-08-19. PMID:3292253. |
6-keto-pgf1 alpha flux was significantly higher (p less than 0.025) in the warm group at 1, 5, and 10 min of rp (4,202 +/- 1,412, 2,475 +/- 1,875, and 1,255 +/- 633 pg/g.min, mean +/- sd) compared to those in the cold group (1,504 +/- 1,245, 434 +/- 641, and 370 +/- 329 pg/g.min). |
1988-08-19 |
2023-08-11 |
Not clear |
| C N Karson, R Coppola, D G Danie. Alpha frequency in schizophrenia: an association with enlarged cerebral ventricles. The American journal of psychiatry. vol 145. issue 7. 1988-07-26. PMID:3381933. |
furthermore, those patients with low alpha frequency had significantly larger lateral ventricles, as measured by ct scan, than did other schizophrenic patients (mean +/- sd ventricle-brain ratios = 9.8 +/- 1.9 versus 5.0 +/- 2.4; p less than 0.01). |
1988-07-26 |
2023-08-11 |
human |
| W D Spotnitz, M W Keller, D D Watson, S P Nolan, S Kau. Success of internal mammary bypass grafting can be assessed intraoperatively using myocardial contrast echocardiography. Journal of the American College of Cardiology. vol 12. issue 1. 1988-07-22. PMID:2897985. |
respective values for alpha and beta (mean + 1 sd) were similar for the patent left anterior descending coronary artery and after internal mammary artery bypass grafting distal to the occluded artery (0.11 +/- 0.10 versus 0.10 +/- 0.10, and 2.5 +/- 2.4 versus 1.1 +/- 0.56). |
1988-07-22 |
2023-08-11 |
dog |
| S J Emans, E Grace, E R Woods, J Mansfield, J F Crigle. Treatment with dexamethasone of androgen excess in adolescent patients. The Journal of pediatrics. vol 112. issue 5. 1988-06-07. PMID:3361397. |
fourteen hirsute girls, ages 12 to 22 years (mean +/- sd: 17.2 +/- 2.6 years), in whom 21-hydroxylase deficiency was excluded by a 1-hour intravenous alpha 1-24 corticotropin test, were evaluated by a 4-day dexamethasone test and then treated with a bedtime dose of dexamethasone (0.5 mg in 10 patients, 0.25 mg in four) for 0.6 to 3.4 years (1.3 +/- 0.8 years). |
1988-06-07 |
2023-08-11 |
Not clear |
| E Gepts, F Camu, I D Cockshott, E J Dougla. Disposition of propofol administered as constant rate intravenous infusions in humans. Anesthesia and analgesia. vol 66. issue 12. 1988-01-04. PMID:3500657. |
derived pharmacokinetic parameters expressed as mean values +/- sd indicated an initial fast distribution (t1/2 pi; 2.8 +/- 1.2 min), with an intermediate phase (t1/2 alpha; 31.4 +/- 14.7 min), and a long terminal phase (t1/2 beta; 355 +/- 227 min), a large volume of distribution at steady state (vss, 287 +/- 213 l), and a high blood clearance (clb, 1.7 +/- 0.3 l/min). |
1988-01-04 |
2023-08-11 |
Not clear |
| R K Naz, P H Naylor, A L Goldstei. Thymosin alpha 1 levels in human seminal plasma and follicular fluid: implication in germ cell function. International journal of fertility. vol 32. issue 5. 1987-12-15. PMID:2889684. |
in the seminal plasma of 19 males studies, t alpha 1 levels varied from 614 to 2,604 pg/ml (mean +/- sd, 1,682.4 +/- 453.9 pg/ml). |
1987-12-15 |
2023-08-11 |
human |