| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luke C Bartelt, Pawel M Switonski, Grażyna Adamek, Juliana Carvalho, Lisa A Duvick, Sabrina I Jarrah, Hayley S McLoughlin, Daniel R Scoles, Stefan M Pulst, Harry T Orr, Court Hull, Craig B Lowe, Albert R La Spad. Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214832. |
purkinje-enriched snrna-seq in sca7 cerebellum reveals zebrin identity loss as a central feature of polyglutamine ataxias. |
2023-05-23 |
2023-08-14 |
mouse |
| Alberto Benussi, Giorgi Batsikadze, Carina França, Rubens G Cury, Roderick P P W M Maa. The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias. Cells. vol 12. issue 8. 2023-05-16. PMID:37190102. |
the therapeutic potential of non-invasive and invasive cerebellar stimulation techniques in hereditary ataxias. |
2023-05-16 |
2023-08-14 |
Not clear |
| Alberto Benussi, Giorgi Batsikadze, Carina França, Rubens G Cury, Roderick P P W M Maa. The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias. Cells. vol 12. issue 8. 2023-05-16. PMID:37190102. |
the degenerative ataxias comprise a heterogeneous group of inherited and acquired disorders that are characterized by a progressive cerebellar syndrome, frequently in combination with one or more extracerebellar signs. |
2023-05-16 |
2023-08-14 |
Not clear |
| Alberto Benussi, Giorgi Batsikadze, Carina França, Rubens G Cury, Roderick P P W M Maa. The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias. Cells. vol 12. issue 8. 2023-05-16. PMID:37190102. |
in addition, a few smaller studies have explored deep brain stimulation (dbs) of the dentate nucleus as an invasive means to directly modulate cerebellar output, thereby aiming to alleviate ataxia severity. |
2023-05-16 |
2023-08-14 |
Not clear |
| Silvia Maria Marchese, Roberto Esposti, Veronica Farinelli, Claudia Ciaccio, Arianna De Laurentiis, Stefano D'Arrigo, Paolo Cavallar. Pediatric Slow-Progressive, but Not Non-Progressive Cerebellar Ataxia Delays Intra-Limb Anticipatory Postural Adjustments in the Upper Arm. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190585. |
we recently investigated the role of the cerebellum during development, reporting that children with genetic slow-progressive ataxia (slowp) show worse postural control during quiet stance and gait initiation compared to healthy children (h). |
2023-05-16 |
2023-08-14 |
Not clear |
| Xia Liu, Wei Lin, Lin Zhang, Wan-Li Zhang, Xiao-Ping Cheng, Yan-Hua Lian, Meng-Cheng Li, Shi-Zhong Wang, Xin-Yuan Chen, Shi-Rui Ga. Effects of cerebellar transcranial alternating current stimulation in cerebellar ataxia: study protocol for a randomised controlled trial. Frontiers in neuroscience. vol 17. 2023-05-14. PMID:37179566. |
therefore, the aim of this study is to 1) examine whether cerebellar tacs improves ataxia severity and various non-motor symptoms in a homogeneous cohort of ca patients consisting of msa-c and sca3, 2) explore the time course of these effects, and 3) assess the safety and tolerance of cerebellar tacs in all participants. |
2023-05-14 |
2023-08-14 |
human |
| Marjolaine Tremblay, Bernard Brais, Véronique Asselin, Martin Buffet, André Girard, Denis Girard, Djamal Berbiche, Cynthia Gagno. The Development of a New Patient-Reported Outcome Measure in Recessive Ataxias: The Person-Reported Ataxia Impact Scale. Cerebellum (London, England). 2023-05-10. PMID:37165279. |
autosomal recessive cerebellar ataxias (arcas) are inherited neurological disorders that can affect both the central and peripheral nervous systems. |
2023-05-10 |
2023-08-14 |
Not clear |
| Athanasia Alexoudi, Eustathios Vlachakis, Spyros N Deftereos, Stefanos Korfias, Stylianos Gatzoni. Implantable Subcutaneous Peripheral Nerve Stimulation Improves Degenerative Ataxia. Cureus. vol 15. issue 4. 2023-05-04. PMID:37139025. |
degenerative cerebellar ataxias have no pharmacological or rehabilitation evidence-based treatment so far. |
2023-05-04 |
2023-08-14 |
Not clear |
| Shiqian Han, Qijun Wang, Yongfeng Song, Mao Pang, Chunguang Ren, Jing Wang, Dongwei Guan, Wei Xu, Fangyong Li, Fengchao Wang, Xinyuan Zhou, Carlos Fernández-Hernando, Huiwen Zhang, Dianqing Wu, Zhijia Y. Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation. iScience. vol 26. issue 5. 2023-05-02. PMID:37128603. |
here, we show that lithium treatment improves ataxia and feeding phenotypes, attenuates cerebellar inflammation and degeneration, and extends survival in |
2023-05-02 |
2023-08-14 |
Not clear |
| Takeru Honda, Ken Matsumura, Yuji Hashimoto, Takanori Yokota, Hidehiro Mizusawa, Soichi Nagao, Kinya Ishikaw. Temporal Relationship between Impairment of Cerebellar Motor Learning and Deterioration of Ataxia in Patients with Cerebellar Degeneration. Cerebellum (London, England). 2023-04-28. PMID:37115382. |
temporal relationship between impairment of cerebellar motor learning and deterioration of ataxia in patients with cerebellar degeneration. |
2023-04-28 |
2023-08-14 |
Not clear |
| Takeru Honda, Ken Matsumura, Yuji Hashimoto, Takanori Yokota, Hidehiro Mizusawa, Soichi Nagao, Kinya Ishikaw. Temporal Relationship between Impairment of Cerebellar Motor Learning and Deterioration of Ataxia in Patients with Cerebellar Degeneration. Cerebellum (London, England). 2023-04-28. PMID:37115382. |
ataxia and impaired motor learning are both fundamental features in diseases affecting the cerebellum. |
2023-04-28 |
2023-08-14 |
Not clear |
| Kyriakos Vattis, Anna C Luddy, Jessey S Ouillon, Nicole M Eklund, Christopher D Stephen, Jeremy D Schmahmann, Adonay S Nunes, Anoopum S Gupt. Sensitive quantification of cerebellar speech abnormalities using deep learning models. medRxiv : the preprint server for health sciences. 2023-04-17. PMID:37066308. |
speech changes are one of the earliest and most evident manifestations of cerebellar ataxias. |
2023-04-17 |
2023-08-14 |
Not clear |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
proinflammatory activation of microglia in the cerebellum hyperexcites purkinje cells to trigger ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
however, direct evidence that cerebellar microglial activation in vivo is sufficient to induce ataxia is still lacking. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
here, by employing chemogenetic approaches to manipulate cerebellar microglia selectively and directly, we found that specific chemogenetic activation of microglia in the cerebellar vermis directly leads to ataxia symptoms in wild-type mice and aggravated ataxic motor deficits in 3-acetylpyridine (3-ap) mice, a classic mouse model of cerebellar ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
mechanistically, cerebellar microglial proinflammatory activation induced by either chemogenetic m3d(gq) stimulation or 3-ap modeling hyperexcites purkinje cells (pcs), which consequently triggers ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
our findings thus reveal a causal relationship between proinflammatory activation of cerebellar microglia and ataxic motor symptoms, which may offer novel evidence for therapeutic intervention for cerebellar ataxias by targeting microglia and microglia-derived inflammatory mediators. |
2023-04-17 |
2023-08-14 |
mouse |
| Carolina Santos, Sofia Malheiro, Manuel Correia, Joana Damási. Gene Suppression Therapies in Hereditary Cerebellar Ataxias: A Systematic Review of Animal Studies. Cells. vol 12. issue 7. 2023-04-13. PMID:37048110. |
gene suppression therapies in hereditary cerebellar ataxias: a systematic review of animal studies. |
2023-04-13 |
2023-08-14 |
Not clear |
| Carolina Santos, Sofia Malheiro, Manuel Correia, Joana Damási. Gene Suppression Therapies in Hereditary Cerebellar Ataxias: A Systematic Review of Animal Studies. Cells. vol 12. issue 7. 2023-04-13. PMID:37048110. |
hereditary cerebellar ataxias (hcas) are a heterogenous group of neurodegenerative disorders associated with severe disability. |
2023-04-13 |
2023-08-14 |
Not clear |
| Nicolaas J M Arts, Maud E G van Dorst, Sandra H Vos, Roy P C Kessel. Coordination and Cognition in Pure Nutritional Wernicke's Encephalopathy with Cerebellar Degeneration after COVID-19 Infection: A Unique Case Report. Journal of clinical medicine. vol 12. issue 7. 2023-04-13. PMID:37048595. |
alcoholic cerebellar degeneration is a restricted form of cerebellar degeneration, clinically leading to an ataxia of stance and gait and occurring in the context of alcohol misuse in combination with malnutrition and thiamine depletion. |
2023-04-13 |
2023-08-14 |
Not clear |