| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Phillips, B Crag. Does consumption of alcohol in the presence of disulfiram cause brain damage? Toxicology and applied pharmacology. vol 69. issue 1. 1983-07-29. PMID:6857682. |
after blocking aldehyde dehydrogenase activity with disulfiram in rats, a single injection of ethanol or a single day of inhaling ethanol vapor resulted in neuronal degeneration in the cerebral cortex and elsewhere that was detected by a specific silver stain and by electron microscopy. |
1983-07-29 |
2023-08-12 |
rat |
| S Saraswathi, N S Vasa. Alterations in the rat renal glycosaminoglycans in streptozotocin-induced diabetes. Biochimica et biophysica acta. vol 755. issue 2. 1983-05-05. PMID:6600934. |
glycosaminoglycans were isolated and purified from the kidney cortex of control and diabetic rats by means of digestion with collagenase, pronase and ethanol precipitation. |
1983-05-05 |
2023-08-12 |
rat |
| S C Phillips, B G Crag. A change in susceptibility of rat cerebellar Purkinje cells to damage by alcohol during fetal, neonatal and adult life. Neuropathology and applied neurobiology. vol 8. issue 6. 1983-04-15. PMID:7162557. |
the dura overlying the cerebellum of separate adult male rats was superfused with 100% ethanol for 1 h and no abnormalities were detected with electron microscopy in the exposed cortex 6 days later. |
1983-04-15 |
2023-08-12 |
rat |
| T Berger, E D French, G R Siggins, W T Shier, F E Bloo. Ethanol and some tetrahydroisoquinolines alter the discharge of cortical and hippocampal neurons: relationship to endogenous opioids. Pharmacology, biochemistry, and behavior. vol 17. issue 4. 1983-02-25. PMID:7178189. |
the activity of single neurons in rat cortex or hippocampus (hpc) was recorded to test two hypotheses: (1) neuronal effects of ethanol are mediated by an endogenous opiate-like mechanism (for example, by release of an endogenous opioid peptide), and; (2) ethanol-induced formation of aldehyde-catecholamine condensation products (tetrahydroisoquinolines; tiqs) might contribute to some acute actions of ethanol. |
1983-02-25 |
2023-08-12 |
rat |
| M Burgal, J Lizondo, S Grisoli. Marked inhibitory effect of ethanol on aspartate binding to a fraction of hydrophobic proteins from rat cerebral cortex. Physiological chemistry and physics. vol 14. issue 1. 1983-02-14. PMID:7178243. |
marked inhibitory effect of ethanol on aspartate binding to a fraction of hydrophobic proteins from rat cerebral cortex. |
1983-02-14 |
2023-08-12 |
rat |
| R L Novack, J C LaManna, M Rosentha. Ethanol and acetaldehyde alter brain mitochondrial redox responses to direct cortical stimulation in vivo. Neuropharmacology. vol 21. issue 10. 1983-01-19. PMID:6292768. |
to determine whether and how ethanol and acetaldehyde alter brain oxidative metabolic activity, reduction/oxidation shifts of components of the mitochondrial respiratory chain were optically measured, in situ, from cat cerebral cortex. |
1983-01-19 |
2023-08-12 |
cat |
| L Volicer, T M Biagion. Effect of ethanol administration and withdrawal on GABA receptor binding in rat cerebral cortex. Substance and alcohol actions/misuse. vol 3. issue 1-2. 1982-12-16. PMID:6291180. |
effect of ethanol administration and withdrawal on gaba receptor binding in rat cerebral cortex. |
1982-12-16 |
2023-08-12 |
rat |
| L Volicer, T M Biagion. Effect of ethanol administration and withdrawal on GABA receptor binding in rat cerebral cortex. Substance and alcohol actions/misuse. vol 3. issue 1-2. 1982-12-16. PMID:6291180. |
sodium independent gaba receptor binding was measured in synaptosomes prepared from cerebral cortex of rats made ethanol dependent by three daily ethanol administrations. |
1982-12-16 |
2023-08-12 |
rat |
| T C Howerton, M J Marks, A C Collin. Norepinephrine, gamma-aminobutyric acid, and choline reuptake kinetics and the effects of ethanol in long-sleep and short-sleep mice. Substance and alcohol actions/misuse. vol 3. issue 1-2. 1982-12-16. PMID:7135160. |
in vitro ethanol dose-response curves (0-1.7 m) for these neurotransmitters showed highly significant inhibition of reuptake except for reuptake of choline in cortex. |
1982-12-16 |
2023-08-12 |
mouse |
| T C Howerton, M J Marks, A C Collin. Norepinephrine, gamma-aminobutyric acid, and choline reuptake kinetics and the effects of ethanol in long-sleep and short-sleep mice. Substance and alcohol actions/misuse. vol 3. issue 1-2. 1982-12-16. PMID:7135160. |
on the other hand, choline reuptake was very sensitive to ethanol in striatum, but was unaffected in cortex. |
1982-12-16 |
2023-08-12 |
mouse |
| J A Stokes, R A Harri. Alcohols and synaptosomal calcium transport. Molecular pharmacology. vol 22. issue 1. 1982-12-02. PMID:7121453. |
these results suggest that the calcium channels in cerebellum are more sensitive to ethanol than the calcium channels in cortex, whereas sodium channels in cortex are more sensitive than those in cerebellum. |
1982-12-02 |
2023-08-12 |
mouse |
| L Volicer, T M Biagion. Effect of ethanol administration and withdrawal on benzodiazepine receptor binding in the rat brain. Neuropharmacology. vol 21. issue 3. 1982-06-14. PMID:6280096. |
administration of single doses of ethanol or presence of ethanol in the incubation medium does not change 3h-flunitrazepam binding in rat cerebral cortex, hippocampus and cerebellum. |
1982-06-14 |
2023-08-12 |
rat |
| L Volicer, T M Biagion. Effect of ethanol administration and withdrawal on benzodiazepine receptor binding in the rat brain. Neuropharmacology. vol 21. issue 3. 1982-06-14. PMID:6280096. |
in rats made dependent on ethanol by three daily ethanol administrations for six days and sacrifices 1 hr after the last ethanol dose 3h-flunitrazepam binding is decreased in the cerebral cortex and cerebellum. |
1982-06-14 |
2023-08-12 |
rat |
| A W Chan, P H Heubusc. Relationship of brain cyclic nucleotide levels and the interaction of ethanol with chlordiazepoxide. Biochemical pharmacology. vol 31. issue 1. 1982-04-12. PMID:6277337. |
ethanol alone or cdp by itself did not cause any change in brain c-amp levels, except for a transient decrease in the cerebral cortex and midbrain at 0.5 hr after ethanol injection, as well as a transient increase in the cerebellum at 0.5 hr after cdp injection. |
1982-04-12 |
2023-08-12 |
mouse |
| J E Peters, W J Steel. Changes in in vivo rates of protein synthesis on free and membrane-bound polysomes in rat brain during the development of physical dependence on ethanol and after the withdrawal of ethanol. Brain research. vol 231. issue 2. 1982-04-12. PMID:7198928. |
during early withdrawal, 12 h after the last dose of ethanol, there was an increase in the rate of free polysomes in the pons-medulla and striatum-septum and on membrane-bound polysomes in the hippocampus-amygdala, and a decrease in the rate on free polysomes in the cortex and thalamus-hypothalamus and on membrane-bound polysomes in the cortex. |
1982-04-12 |
2023-08-12 |
rat |
| J O Owasoyo, C A Iramai. Effect of acute ethanol intoxication on the enzymes of the cholinergic system in mouse brain. Toxicology letters. vol 9. issue 3. 1982-02-22. PMID:7198309. |
the activities of acetylcholinesterase (ache) and choline acetyltransferase (chat) in the cerebral cortex, cerebellum, hypothalamus, hippocampus, midbrain and pons of adult, male mice injected with 2 g/kg ethanol and of control mice injected with physiological saline, were determined by spectrophotometric methods. |
1982-02-22 |
2023-08-12 |
mouse |
| J O Owasoyo, C A Iramai. Effect of acute ethanol intoxication on the enzymes of the cholinergic system in mouse brain. Toxicology letters. vol 9. issue 3. 1982-02-22. PMID:7198309. |
all animals were killed 30 min after injection between 11.00 h and 12.00 h. results show that the acute dose of ethanol significantly decreased ache activity only in the cerebral cortex whereas chat activity was reduced in the cerebral cortex, hypothalamus and hippocampus. |
1982-02-22 |
2023-08-12 |
mouse |
| A T Tan, R Dular, I R Inne. Alcohol feeding alters (3H)dopamine uptake into rat cortical and brain stem synaptosomes. Progress in biochemical pharmacology. vol 18. 1982-02-12. PMID:7312868. |
the uptake of (3h)dopamine into nerve endings (synaptosomes) isolated from cortex and brain stem of rats under various stages of ethanol intoxication were studied. |
1982-02-12 |
2023-08-12 |
rat |
| A T Tan, R Dular, I R Inne. Alcohol feeding alters (3H)dopamine uptake into rat cortical and brain stem synaptosomes. Progress in biochemical pharmacology. vol 18. 1982-02-12. PMID:7312868. |
in cortex, 16 h after acute treatment, the uptake was slightly (about 10%) elevated from that of control in contrast to chronic rats, which were 43 and 41% more than that of the control after withdrawal from ethanol for 48 and 120 h, respectively. |
1982-02-12 |
2023-08-12 |
rat |
| M E Hillbom, T M Terv. Ethanol and acetaldehyde do not increase the blood-brain and blood-retinal barrier permeability to sodium fluorescein. Experientia. vol 37. issue 9. 1982-01-20. PMID:7197634. |
no extravasation of sodium fluorescein from capillaries of the cerebral cortex and retina could be demonstrated in rats during severe nonlethal ethanol and/or acetaldehyde poisoning. |
1982-01-20 |
2023-08-12 |
rat |