| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Damien Dufour, Typhanie Dumontet, Isabelle Sahut-Barnola, Aude Carusi, Méline Onzon, Eric Pussard, James Jr Wilmouth, Julie Olabe, Cécily Lucas, Adrien Levasseur, Christelle Damon-Soubeyrand, Jean-Christophe Pointud, Florence Roucher-Boulez, Igor Tauveron, Guillaume Bossis, Edward T Yeh, David T Breault, Pierre Val, Anne-Marie Lefrançois-Martinez, Antoine Martine. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nature communications. vol 13. issue 1. 2022-12-21. PMID:36543805. |
in the adrenal cortex, an emblematic endocrine organ that mediates adaptation to physiological demands, the sumoylation gradient is inversely correlated with the gradient of cellular differentiation raising important questions about its role in functional zonation and the response to stress. |
2022-12-21 |
2023-08-14 |
mouse |
| Cécily Lucas, Kay-Sara Sauter, Michael Steigert, Delphine Mallet, James Wilmouth, Julie Olabe, Ingrid Plotton, Yves Morel, Daniel Aeberli, Franca Wagner, Hans Clevers, Amit V Pandey, Pierre Val, Florence Roucher-Boulez, Christa E Fluc. Loss of LGR4/GPR48 causes severe neonatal salt-wasting due to disrupted WNT signaling altering adrenal zonation. The Journal of clinical investigation. 2022-12-20. PMID:36538378. |
the impact of lgr4 inactivation was analyzed by adrenal cortex specific ablation of lgr4, using lgr4flox/flox mated with sf1:cre mice. |
2022-12-20 |
2023-08-14 |
mouse |
| Cécily Lucas, Kay-Sara Sauter, Michael Steigert, Delphine Mallet, James Wilmouth, Julie Olabe, Ingrid Plotton, Yves Morel, Daniel Aeberli, Franca Wagner, Hans Clevers, Amit V Pandey, Pierre Val, Florence Roucher-Boulez, Christa E Fluc. Loss of LGR4/GPR48 causes severe neonatal salt-wasting due to disrupted WNT signaling altering adrenal zonation. The Journal of clinical investigation. 2022-12-20. PMID:36538378. |
inactivation of lgr4 within the adrenal cortex in the mouse model caused decreased wnt signaling, aberrant zonation with deficient zg and reduced aldosterone production. |
2022-12-20 |
2023-08-14 |
mouse |
| Alaa B Abdellatif, Fabio L Fernandes-Rosa, Sheerazed Boulkroun, Maria-Christina Zennar. Vascular and hormonal interactions in the adrenal gland. Frontiers in endocrinology. vol 13. 2022-12-12. PMID:36506065. |
one hypothesis is that changes in vascular supply to the adrenal cortex, due to phenomena of atherosclerosis or high blood pressure, may influence the morphology of the adrenal cortex, resulting in a compensatory growth and nodule formation in response to local hypoxia. |
2022-12-12 |
2023-08-14 |
Not clear |
| Alaa B Abdellatif, Fabio L Fernandes-Rosa, Sheerazed Boulkroun, Maria-Christina Zennar. Vascular and hormonal interactions in the adrenal gland. Frontiers in endocrinology. vol 13. 2022-12-12. PMID:36506065. |
in this review, we will summarize our knowledge on the mechanisms regulating adrenal cortex development and function, describe adrenal vascularization in normal and pathological conditions and address the mechanisms allowing the cross-talk between the hormonal and vascular components to allow the extreme tissue plasticity of the adrenal cortex in response to endogenous and exogenous stimuli. |
2022-12-12 |
2023-08-14 |
Not clear |
| Xingen Wang, Chi-Sing Ng, Weihua Yin, Li Lian. Application of TFE3 Immunophenotypic and TFE3 mRNA Expressions in Diagnosis and Prognostication of Adrenal Cortical Neoplasms and Distinction From Kidney Tumors. Applied immunohistochemistry & molecular morphology : AIMM. vol 31. issue 1. 2022-12-08. PMID:36476598. |
tfe3 immunostaining was performed on a large cohort of samples including 40 adrenal cortex tissues, 95 adrenocortical adenoma (aca), 11 adrenocortical carcinoma (acc), 53 ccrcc, and 18 pheochromocytomas. |
2022-12-08 |
2023-08-14 |
Not clear |
| Nour Abou Nader, Gustavo Zamberlam, Alexandre Boye. Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430866. |
transgenic mouse models to study the development and maintenance of the adrenal cortex. |
2022-11-26 |
2023-08-14 |
mouse |
| Nour Abou Nader, Gustavo Zamberlam, Alexandre Boye. Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430866. |
mechanisms leading to the development, zonation and maintenance of the adrenal cortex are complex and have been studied since the 1800s. |
2022-11-26 |
2023-08-14 |
mouse |
| Nour Abou Nader, Gustavo Zamberlam, Alexandre Boye. Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430866. |
this review lists and details the distinct cre recombinase mouse strains available to study the adrenal cortex, and the remarkable progress total and conditional knockout mouse models have enabled us to make in our understanding of the molecular mechanisms regulating the development and maintenance of the adrenal cortex. |
2022-11-26 |
2023-08-14 |
mouse |
| Asad Ullah, Farah Ayman Elsaid Mohamed, Jaffar Khan, Katharine Tracy, Muhabat Khan, Samiha Mohsen, Abdul Qahar Khan Yasinzai, Kaleemullah Badini, Philip T Sobash, Saleh Heneidi, Nagla Abdel Kari. Current Understanding of "Mixed Corticomedullary Adrenal Tumor" and an Insight into Genomic Profiling. Clinics and practice. vol 12. issue 6. 2022-11-22. PMID:36412675. |
the pathophysiology of malignant mcmts is not well understood; the most prevailing theories are that it is a composite tumor of embryologically derived mesodermal (adrenal cortex) and neural crest (medulla) origin, perpetuating as two distinct cell lines forming a singular mass. |
2022-11-22 |
2023-08-14 |
Not clear |
| Asad Ullah, Farah Ayman Elsaid Mohamed, Jaffar Khan, Katharine Tracy, Muhabat Khan, Samiha Mohsen, Abdul Qahar Khan Yasinzai, Kaleemullah Badini, Philip T Sobash, Saleh Heneidi, Nagla Abdel Kari. Current Understanding of "Mixed Corticomedullary Adrenal Tumor" and an Insight into Genomic Profiling. Clinics and practice. vol 12. issue 6. 2022-11-22. PMID:36412675. |
clinical features and laboratory diagnosis are associated with hypersecretions of the adrenal cortex and medulla. |
2022-11-22 |
2023-08-14 |
Not clear |
| Yuka Sakata, Keren Cheng, Michinori Mayama, Yasunari Seita, Andrea J Detlefsen, Clementina A Mesaros, Trevor M Penning, Kyosuke Shishikura, Wenli Yang, Richard J Auchus, Jerome F Strauss, Kotaro Sasak. Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells. Developmental cell. vol 57. issue 22. 2022-11-22. PMID:36413950. |
the mechanisms leading to adrenal cortex development and steroid synthesis in humans remain poorly understood due to the paucity of model systems. |
2022-11-22 |
2023-08-14 |
human |
| Yuka Sakata, Keren Cheng, Michinori Mayama, Yasunari Seita, Andrea J Detlefsen, Clementina A Mesaros, Trevor M Penning, Kyosuke Shishikura, Wenli Yang, Richard J Auchus, Jerome F Strauss, Kotaro Sasak. Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells. Developmental cell. vol 57. issue 22. 2022-11-22. PMID:36413950. |
herein, we recapitulate human fetal adrenal cortex specification processes through stepwise induction of human-induced pluripotent stem cells through posterior intermediate mesoderm-like and adrenocortical progenitor-like states to ultimately generate fetal zone adrenal-cortex-like cells (fzlcs), as evidenced by histomorphological, ultrastructural, and transcriptome features and adrenocorticotropic hormone (acth)-independent Δ5 steroid biosynthesis. |
2022-11-22 |
2023-08-14 |
human |
| Nour Abou Nader, Étienne Blais, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boye. Effect of Inactivation of Journal of the Endocrine Society. vol 7. issue 1. 2022-11-21. PMID:36405866. |
effect of inactivation of recent conditional knockout of core components of the hippo signaling pathway in the adrenal gland of mice has demonstrated that this pathway must be tightly regulated to ensure proper development and maintenance of the adrenal cortex. |
2022-11-21 |
2023-08-14 |
mouse |
| Nour Abou Nader, Étienne Blais, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boye. Effect of Inactivation of Journal of the Endocrine Society. vol 7. issue 1. 2022-11-21. PMID:36405866. |
we report herein that the most upstream kinases of the pathway, the mammalian ste20-like protein kinases 1 and 2 (mst1and mst2, respectively), are expressed in the mouse adrenal cortex with mst2 expression being restricted to the zona glomerulosa (zg). |
2022-11-21 |
2023-08-14 |
mouse |
| Sophie Howarth, Luca Giovanelli, Catherine Napier, Simon H Pearc. Heterogeneous natural history of Addison's disease: mineralocorticoid deficiency may predominate. Endocrine connections. 2022-11-18. PMID:36398876. |
autoimmune addison's disease (aad) is defined as primary adrenal insufficiency due to immune-mediated destruction of the adrenal cortex. |
2022-11-18 |
2023-08-14 |
Not clear |
| Sophie Howarth, Luca Giovanelli, Catherine Napier, Simon H Pearc. Heterogeneous natural history of Addison's disease: mineralocorticoid deficiency may predominate. Endocrine connections. 2022-11-18. PMID:36398876. |
all three patients show varying degrees of mineralocorticoid deficiency, suggesting that recovery of zona fasciculata function in the adrenal cortex may occur independently to that of the zona glomerulosa. |
2022-11-18 |
2023-08-14 |
Not clear |
| Jacqueline Yano Maher, Veronica Gomez-Lobo, Deborah P Merk. The management of congenital adrenal hyperplasia during preconception, pregnancy, and postpartum. Reviews in endocrine & metabolic disorders. 2022-11-18. PMID:36399318. |
congenital adrenal hyperplasia (cah) is a group of autosomal recessive disorders of steroidogenesis of the adrenal cortex, most commonly due to 21-hydroxylase deficiency caused by mutations in the cyp21a2 gene. |
2022-11-18 |
2023-08-14 |
Not clear |
| Zhi-Lian Sun, Jun-Ying He, Xiao-Ling Cheng, Xiao-Xia Tan, Wei-Hua W. Diagnosis, treatment and genetic analysis of a case of familial aldosteronism type II with WFS1 gene mutation. Yi chuan = Hereditas. vol 44. issue 11. 2022-11-17. PMID:36384999. |
primary aldosteronism (pa) is a disease characterized by hypertension and hypokalemia due to the excessive aldosterone secretion from the adrenal cortex, which leads to the retention of both water and sodium, and the inhibition of the renin-angiotensin system as well. |
2022-11-17 |
2023-08-14 |
Not clear |
| Shingo Hatoya, Ryoji Kanegi, Tomoyo Nabetani, Shoko Oji, Takeshi Izawa, Satoshi Hirai, Kikuya Sugiur. Atypical hypoadrenocorticism with intact zona glomerulosa of the adrenal cortex after long-term observation: a case report of a dog. The Journal of veterinary medical science. 2022-11-13. PMID:36372430. |
atypical hypoadrenocorticism with intact zona glomerulosa of the adrenal cortex after long-term observation: a case report of a dog. |
2022-11-13 |
2023-08-14 |
dog |