| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José M Oliva, Jorge Manzanare. Gene transcription alterations associated with decrease of ethanol intake induced by naltrexone in the brain of Wistar rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 6. 2007-07-27. PMID:17063152. |
voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (cpu), nucleus accumbens core (acb c) and shell (acb s), the expression of tyrosine hydroxylase (th) in the ventral tegmental area and substantia nigra, proenkephalin (penk) in the piriform cortex, olfactory tubercle, cpu, acb c and acb s, ventromedial nucleus (vmn) and paraventricular nucleus (pvn) of the hypothalamus, corticotropin releasing factor (crf) in pvn, cannabinoid cb(1) receptor (cb1-r) in the cpu, hippocampus and vmn, and serotonin transporter (5-htt) in the dorsal and median raphe nuclei. |
2007-07-27 |
2023-08-12 |
rat |
| Ilka Freiman, Alexandra Anton, Hannah Monyer, Michal J Urbanski, Bela Szab. Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice. The Journal of physiology. vol 575. issue Pt 3. 2007-06-29. PMID:16825300. |
analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice. |
2007-06-29 |
2023-08-12 |
mouse |
| Ilka Freiman, Alexandra Anton, Hannah Monyer, Michal J Urbanski, Bela Szab. Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice. The Journal of physiology. vol 575. issue Pt 3. 2007-06-29. PMID:16825300. |
cb(1) cannabinoid receptors are expressed in many neurons in the caudate-putamen. |
2007-06-29 |
2023-08-12 |
mouse |
| Ilka Freiman, Alexandra Anton, Hannah Monyer, Michal J Urbanski, Bela Szab. Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice. The Journal of physiology. vol 575. issue Pt 3. 2007-06-29. PMID:16825300. |
the aim was to establish a method for studying identified synaptic connections in the caudate-putamen, and to determine the effects of cannabinoids on these connections. |
2007-06-29 |
2023-08-12 |
mouse |
| David A Price, William A Owens, Georgianna G Gould, Alan Frazer, James L Roberts, Lynette C Daws, Andrea Giuffrid. CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum. Journal of neurochemistry. vol 101. issue 2. 2007-06-01. PMID:17250681. |
cb1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum. |
2007-06-01 |
2023-08-12 |
mouse |
| Birgit Engler, Ilka Freiman, Michal Urbanski, Bela Szab. Effects of exogenous and endogenous cannabinoids on GABAergic neurotransmission between the caudate-putamen and the globus pallidus in the mouse. The Journal of pharmacology and experimental therapeutics. vol 316. issue 2. 2006-04-04. PMID:16214880. |
effects of exogenous and endogenous cannabinoids on gabaergic neurotransmission between the caudate-putamen and the globus pallidus in the mouse. |
2006-04-04 |
2023-08-12 |
mouse |
| Leyre Urigüen, Fernando Berrendero, Catherine Ledent, Rafael Maldonado, Jorge Manzanare. Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice. The European journal of neuroscience. vol 22. issue 8. 2005-12-15. PMID:16262648. |
kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid cb1 receptor knockout mice. |
2005-12-15 |
2023-08-12 |
mouse |
| Leyre Urigüen, Fernando Berrendero, Catherine Ledent, Rafael Maldonado, Jorge Manzanare. Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice. The European journal of neuroscience. vol 22. issue 8. 2005-12-15. PMID:16262648. |
taken together, our results revealed that deletion of cb1 cannabinoid receptors produced a pronounced increase in the activity of kappa- and delta-opioid receptors in the caudate putamen. |
2005-12-15 |
2023-08-12 |
mouse |
| Andrea Cippitelli, Ainhoa Bilbao, Anita C Hansson, Ignacio del Arco, Wolfgang Sommer, Markus Heilig, Mauricio Massi, Francisco Javier Bermúdez-Silva, Miguel Navarro, Roberto Ciccocioppo, Fernando Rodríguez de Fonsec. Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats. The European journal of neuroscience. vol 21. issue 8. 2005-07-05. PMID:15869521. |
in situ hybridization studies revealed that, compared with wistar rats, msp animals have consistently greater cannabinoid cb1 receptor mrna expression in a number of brain areas, including the frontoparietal cortex, caudate-putamen and hippocampus (ca1 and dentate gyrus areas). |
2005-07-05 |
2023-08-12 |
rat |
| José M Oliva, Sergio Ortiz, Tomás Palomo, Jorge Manzanare. Spontaneous cannabinoid withdrawal produces a differential time-related responsiveness in cannabinoid CB1 receptor gene expression in the mouse brain. Journal of psychopharmacology (Oxford, England). vol 18. issue 1. 2004-08-30. PMID:15107186. |
interestingly, this spontaneous cannabinoid withdrawal resulted in cb1 gene expression upregulation (20-30%) in caudate-putamen, ventromedial hypothalamic nucleus, central amygdaloid nucleus and ca1, whereas in the ca3 field of hippocampus, a significant decrease (15-20%) was detected. |
2004-08-30 |
2023-08-12 |
mouse |
| Fernando Berrendero, Victoria Mendizábal, Patricia Murtra, Brigitte L Kieffer, Rafael Maldonad. Cannabinoid receptor and WIN 55 212-2-stimulated [35S]-GTPgammaS binding in the brain of mu-, delta- and kappa-opioid receptor knockout mice. The European journal of neuroscience. vol 18. issue 8. 2003-12-23. PMID:14622180. |
in contrast, the efficacy of cb1 receptor activation by the cannabinoid agonist win 55 212-2 was dramatically reduced in the caudate-putamen of mor knockout animals. |
2003-12-23 |
2023-08-12 |
mouse |
| Belen Ferrer, Nick Asbrock, Satish Kathuria, Daniele Piomelli, Andrea Giuffrid. Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511339. |
to address this question, we used an isotope dilution assay to measure endocannabinoid levels in the caudate-putamen, globus pallidus and substantia nigra of intact and unilaterally 6-ohda-lesioned rats undergoing acute or chronic treatment with levodopa (50 mg/kg). |
2003-12-05 |
2023-08-12 |
rat |
| Belen Ferrer, Nick Asbrock, Satish Kathuria, Daniele Piomelli, Andrea Giuffrid. Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511339. |
in 6-ohda-lesioned rats, anandamide levels were significantly reduced in the caudate-putamen ipsilateral to the lesion; however, neither acute nor chronic levodopa treatment affected endocannabinoid levels in these animals. |
2003-12-05 |
2023-08-12 |
rat |
| José M Oliva, Sergio Ortiz, Tomás Palomo, Jorge Manzanare. Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice. Journal of neurochemistry. vol 85. issue 1. 2003-04-23. PMID:12641731. |
spontaneous cannabinoid withdrawal produced time-related significant alterations in gene transcription: (i) decreased (20%) tyrosine hydroxylase (th) mrna levels in the ventral tegmental area and increased (50%) in substantia nigra; (ii) increased proenkephalin (penk) gene expression more than 100% in caudate-putamen, nucleus accumbens, olfactory tubercle and piriform cortex; (iii) increased (20-40%) pro-opiomelanocortin (pomc) gene expression in the arcuate nucleus of the hypothalamus. |
2003-04-23 |
2023-08-12 |
mouse |
| J J Rodriguez, K Mackie, V M Picke. Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 3. 2001-06-07. PMID:11157068. |
cannabinoids and opioids are widely consumed drugs of abuse that produce motor depression, in part via respective activation of the cannabinoid subtype 1 receptor (cb1r) and the mu-opioid receptor (muor), in the striatal circuitry originating in the caudate putamen nucleus (cpn). |
2001-06-07 |
2023-08-12 |
rat |
| G Gerdeman, D M Lovinge. CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum. Journal of neurophysiology. vol 85. issue 1. 2001-02-15. PMID:11152748. |
cb1 cannabinoid receptors in the neostriatum mediate profound motor deficits induced when cannabinoid drugs are administered to rodents. |
2001-02-15 |
2023-08-12 |
rat |
| K J Page, L Besret, M Jain, E M Monaghan, S B Dunnett, B J Everit. Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and mu-opioid receptor binding in the basal ganglia. Experimental brain research. vol 130. issue 2. 2000-02-25. PMID:10672467. |
effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and mu-opioid receptor binding in the basal ganglia. |
2000-02-25 |
2023-08-12 |
human |
| J Corchero, J Romero, F Berrendero, J Fernandez-Ruiz, J A Ramos, J A Fuentes, J Manzanare. Time-dependent differences of repeated administration with Delta9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by mu-opioid and CB1-cannabinoid receptors in the caudate-putamen. Brain research. Molecular brain research. vol 67. issue 1. 1999-05-21. PMID:10101241. |
the purpose of the present study was to examine the time-related effects of repeated administration of delta9-tetrahydrocannabinol during 1, 3, 7 and 14 days on cannabinoid and mu-opioid receptor agonist-stimulated [35s]gtpgammas binding, and cb1 cannabinoid receptor and proenkephalin gene expression in the caudate-putamen. |
1999-05-21 |
2023-08-12 |
Not clear |
| J Corchero, J Romero, F Berrendero, J Fernandez-Ruiz, J A Ramos, J A Fuentes, J Manzanare. Time-dependent differences of repeated administration with Delta9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by mu-opioid and CB1-cannabinoid receptors in the caudate-putamen. Brain research. Molecular brain research. vol 67. issue 1. 1999-05-21. PMID:10101241. |
these results also suggest a possible interaction between the cannabinoid and opioid systems in the caudate-putamen which may be potentially relevant in the understanding of the alterations of motor behavior that occur after prolonged exposure to cannabinoids. |
1999-05-21 |
2023-08-12 |
Not clear |
| J Romero, F Berrendero, L García-Gil, J A Ramos, J J Fernández-Rui. Cannabinoid receptor and WIN-55,212-2-stimulated [35S]GTP gamma S binding and cannabinoid receptor mRNA levels in the basal ganglia and the cerebellum of adult male rats chronically exposed to delta 9-tetrahydrocannabinol. Journal of molecular neuroscience : MN. vol 11. issue 2. 1999-05-20. PMID:10096037. |
in summary, the chronic exposure to delta 9-thc resulted in a decrease in cannabinoid receptor binding and mrna levels in the caudate-putamen, where cell bodies of cannabinoid receptor-containing neurons in the basal ganglia are located. |
1999-05-20 |
2023-08-12 |
rat |