| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
here we shown that isoflurane and hfd/stz dramatically and synergistically induced hippocampal ir and fear memory impairment. |
2021-09-14 |
2023-08-13 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
administration of 25% glucose to metformin-pretreated mice induced hyperglycemia, but surprisingly did not reverse the benefits of metformin on hippocampal insulin signaling and fear memory following isoflurane anesthesia. |
2021-09-14 |
2023-08-13 |
mouse |
| Lisa R Goldberg, Dana Zeid, Munir Gunes Kutlu, Robert D Cole, Valeria Lallai, Aswathy Sebastian, Istvan Albert, Christie D Fowler, Vinay Parikh, Thomas J Goul. Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring. Addiction biology. vol 26. issue 1. 2021-09-09. PMID:31782218. |
paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring. |
2021-09-09 |
2023-08-13 |
mouse |
| Min Soo Kang, Jin-Hee Ha. Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation. Molecular brain. vol 14. issue 1. 2021-09-01. PMID:33407673. |
formation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (mec) inputs to the hippocampus during learning events. |
2021-09-01 |
2023-08-13 |
mouse |
| Daniela Astudillo, Daniel Karmelic, Barbara S Casas, Nikolai Otmakhov, Veronica Palma, Magdalena Sanhuez. CaMKII inhibitor 1 (CaMK2N1) mRNA is upregulated following LTP induction in hippocampal slices. Synapse (New York, N.Y.). vol 74. issue 10. 2021-08-10. PMID:32320502. |
camk2n1/2 mrnas are rapidly and differentially upregulated in the hippocampus and amygdala after acquisition or retrieval of fear memory. |
2021-08-10 |
2023-08-13 |
rat |
| Chun Wang, Xu Cao, Jing Yin, Wen-Rui Gao, Wei-Ran Li, Jin-Shun Qi, Mei-Na W. [Chronic sleep deprivation exacerbates cognitive and pathological impairments in APP/PS1/tau triple transgenic Alzheimer's disease model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 3. 2021-07-08. PMID:34230948. |
the results showed that: (1) chronic sleep deprivation did not affect anxiety- (p = 0.539) and depression-like behaviors (p = 0.874) in 3xtg-ad mice; (2) chronic sleep deprivation exacerbated the impairments of object recognition memory (p < 0.001), working memory (p = 0.002) and the conditioned fear memory (p = 0.039) in 3xtg-ad mice; (3) chronic sleep deprivation increased amyloid β (aβ) deposition (p < 0.001) and microglial activation (p < 0.001) in the hippocampus of 3xtg-ad mice, without inducing abnormal tau phosphorylation and neurofibrillary tangles. |
2021-07-08 |
2023-08-13 |
mouse |
| Chun Wang, Xu Cao, Jing Yin, Wen-Rui Gao, Wei-Ran Li, Jin-Shun Qi, Mei-Na W. [Chronic sleep deprivation exacerbates cognitive and pathological impairments in APP/PS1/tau triple transgenic Alzheimer's disease model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 3. 2021-07-08. PMID:34230948. |
these results indicate that chronic sleep deprivation exacerbates the impairments of recognition memory, working memory and conditioned fear memory in 3xtg-ad mice by aggravating aβ deposition and the excessive activation of microglia in the hippocampus. |
2021-07-08 |
2023-08-13 |
mouse |
| Jung-Pyo Oh, Jin-Hee Ha. A critical role of hippocampus for formation of remote cued fear memory. Molecular brain. vol 13. issue 1. 2021-07-07. PMID:32799906. |
a critical role of hippocampus for formation of remote cued fear memory. |
2021-07-07 |
2023-08-13 |
mouse |
| Jung-Pyo Oh, Jin-Hee Ha. A critical role of hippocampus for formation of remote cued fear memory. Molecular brain. vol 13. issue 1. 2021-07-07. PMID:32799906. |
given a well-established role of hippocampus for memory reactivation, hippocampus is likely involved in consolidation process of fear memory. |
2021-07-07 |
2023-08-13 |
mouse |
| Jung-Pyo Oh, Jin-Hee Ha. A critical role of hippocampus for formation of remote cued fear memory. Molecular brain. vol 13. issue 1. 2021-07-07. PMID:32799906. |
muscimol infusion before remote test of auditory fear memory did not affect memory retrieval, indicating hippocampus is not a brain site for storage of remote cued fear memory. |
2021-07-07 |
2023-08-13 |
mouse |
| Jung-Pyo Oh, Jin-Hee Ha. A critical role of hippocampus for formation of remote cued fear memory. Molecular brain. vol 13. issue 1. 2021-07-07. PMID:32799906. |
moreover, memory reactivation enforced by re-exposure to the conditioned tone could compensate for hippocampal inactivation, as memory-reactivated mice showed normal remote auditory fear memory despite hippocampal inactivation. |
2021-07-07 |
2023-08-13 |
mouse |
| Yuanyuan Xu, Mike T Lin, Xiang-Ming Zh. GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior. Molecular brain. vol 13. issue 1. 2021-07-07. PMID:32993733. |
these findings showed that gpr68 contributes to hippocampal ltp and aversive fear memory. |
2021-07-07 |
2023-08-13 |
mouse |
| Laura Durieux, Victor Mathis, Karine Herbeaux, Marc-Antoine Muller, Alexandra Barbelivien, Chantal Mathis, Rémy Schlichter, Sylvain Hugel, Monique Majchrzak, Lucas Lecourtie. Involvement of the lateral habenula in fear memory. Brain structure & function. vol 225. issue 7. 2021-07-06. PMID:32642914. |
however, very few data have been gathered with respect to its role in fear memory formation, especially in learning paradigms in which brain areas involved in cognitive processes like the hippocampus (hpc) and the medial prefrontal cortex (mpfc) are required. |
2021-07-06 |
2023-08-13 |
rat |
| Chun-An Chen, Wei Wang, Steen E Pedersen, Ayush Raman, Michelle L Seymour, Fernanda R Ruiz, Anping Xia, Meike E van der Heijden, Li Wang, Jiani Yin, Joanna Lopez, Megan E Rech, Richard A Lewis, Samuel M Wu, Zhandong Liu, Fred A Pereira, Robia G Pautler, Huda Y Zoghbi, Christian P Schaa. Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity. Human molecular genetics. vol 29. issue 5. 2021-07-05. PMID:31600777. |
the mice showed altered fear memory, and further electrophysiological investigation in hippocampal slices revealed significantly reduced long-term potentiation and long-term depression. |
2021-07-05 |
2023-08-13 |
mouse |
| Cheng-Long Yu, Jin-Nan Li, Ping Gan, Li-Ping Wang, Yue-Xiong Yang, Da-Fu Yu, Rong-Rong Mao, Fu-Qiang Xu, Qi-Xin Zhou, Gal Richter-Levin, Lin Xu, Heng Zho. Developing of Focal Ischemia in the Hippocampus or the Amygdala Reveals a Regional Compensation Rule for Fear Memory Acquisition. eNeuro. vol 8. issue 2. 2021-07-02. PMID:33785521. |
developing of focal ischemia in the hippocampus or the amygdala reveals a regional compensation rule for fear memory acquisition. |
2021-07-02 |
2023-08-13 |
rat |
| Cheng-Long Yu, Jin-Nan Li, Ping Gan, Li-Ping Wang, Yue-Xiong Yang, Da-Fu Yu, Rong-Rong Mao, Fu-Qiang Xu, Qi-Xin Zhou, Gal Richter-Levin, Lin Xu, Heng Zho. Developing of Focal Ischemia in the Hippocampus or the Amygdala Reveals a Regional Compensation Rule for Fear Memory Acquisition. eNeuro. vol 8. issue 2. 2021-07-02. PMID:33785521. |
these results suggest that the circuit compensation between the hippocampus and the amygdala is critical for fear memory acquisition. |
2021-07-02 |
2023-08-13 |
rat |
| Xiao-Pei Zhao, Feng Zhong, Ru-Yi Luo, Yan-Ling Zhang, Cong Luo, Hui Li, Ru-Ping Da. Early-life sevoflurane exposure impairs fear memory by suppressing extracellular signal-regulated kinase signaling in the bed nucleus of stria terminalis GABAergic neurons. Neuropharmacology. vol 191. 2021-06-23. PMID:33933475. |
after the fear memory test, expression of phosphorylated extracellular signaling-regulated kinase (p-erk) and c-fos were elevated in the bed nucleus of the stria terminalis (bnst) and central amygdala, but not in the hippocampus or prefrontal cortex. |
2021-06-23 |
2023-08-13 |
mouse |
| Sylvie L Lesuis, Paul J Lucassen, Harm J Kruger. Early life stress amplifies fear responses and hippocampal synaptic potentiation in the APPswe/PS1dE9 Alzheimer mouse model. Neuroscience. vol 454. 2021-05-14. PMID:31302265. |
we conclude that in appswe/ps1de9 mice, els increases fear memory in the conditioning context as well as a novel context, which is accompanied by aberrant hippocampal synaptic potentiation. |
2021-05-14 |
2023-08-13 |
mouse |
| Manuela Simonetti, Eszter Paldy, Christian Njoo, Kiran Kumar Bali, Thomas Worzfeld, Claudia Pitzer, Thomas Kuner, Stefan Offermanns, Daniela Mauceri, Rohini Kune. The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology. Molecular psychiatry. vol 26. issue 4. 2021-05-14. PMID:31444474. |
we observed that plexin-b2 and sema4c are expressed in forebrain areas related to fear memory, such as the anterior cingulate cortex, amygdala and the hippocampus, and their expression is regulated by aversive stimuli that induce fear memory. |
2021-05-14 |
2023-08-13 |
mouse |
| Cheryl F Harding, Carolyn L Pytte, Kimberly G Page, Kelly J Ryberg, Edna Normand, Gregory J Remigio, Richard A DeStefano, David B Morris, Julia Voronina, Ariel Lopez, Lauren A Stalbow, Erin P Williams, Nohely Abre. Mold inhalation causes innate immune activation, neural, cognitive and emotional dysfunction. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:31751617. |
levels of hippocampal immune activation correlated with decreased neurogenesis, contextual memory deficits, and/or enhanced auditory-cued fear memory. |
2021-04-27 |
2023-08-13 |
mouse |