| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Luine, D Bowling, M Hearn. Spatial memory deficits in aged rats: contributions of monoaminergic systems. Brain research. vol 537. issue 1-2. 1991-05-23. PMID:2085779. |
spatial memory performance was tested on an 8-arm radial maze, and levels of norepinephrine (ne), dopamine (da) and metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid, serotonin (5-ht) and metabolite 5-hydroxyindoleacetic acid were measured in brain areas which contribute to memory function--basal forebrain cholinergic nuclei, subfields of the hippocampus, frontal and entorhinal cortex--and in monoaminergic cell body areas. |
1991-05-23 |
2023-08-11 |
human |
| M J Meaney, D H Aitken, S Bhatnagar, R M Sapolsk. Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats. Neurobiology of aging. vol 12. issue 1. 1991-04-16. PMID:2002881. |
in both males and females, however, handling appears to prevent (or minimize) increased adrenal secretion in later life and to attenuate hippocampal cell loss and spatial memory impairments. |
1991-04-16 |
2023-08-11 |
rat |
| S M Onifer, W C Lo. Spatial memory deficit resulting from ischemia-induced damage to the hippocampus is ameliorated by intra-hippocampal transplants of fetal hippocampal neurons. Progress in brain research. vol 82. 1991-04-04. PMID:2290949. |
spatial memory deficit resulting from ischemia-induced damage to the hippocampus is ameliorated by intra-hippocampal transplants of fetal hippocampal neurons. |
1991-04-04 |
2023-08-11 |
Not clear |
| B G Lyeth, L W Jenkins, R J Hamm, C E Dixon, L L Phillips, G L Clifton, H F Young, R L Haye. Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain research. vol 526. issue 2. 1991-01-31. PMID:2257484. |
for example, following cerebral ischemia even partial hippocampal ca1 neuronal loss has been proposed to be sufficient to result in deficits in hippocampal dependent spatial memory. |
1991-01-31 |
2023-08-11 |
rat |
| B G Lyeth, L W Jenkins, R J Hamm, C E Dixon, L L Phillips, G L Clifton, H F Young, R L Haye. Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain research. vol 526. issue 2. 1991-01-31. PMID:2257484. |
these data strongly suggest that mild to moderate tbi is capable of producing prolonged spatial memory deficits in the rat without evidence of either neuronal cell death in the intrinsic hippocampus or overt axonal injury in hippocampal pathways. |
1991-01-31 |
2023-08-11 |
rat |
| H A Tilson, B Veronesi, R L McLamb, H B Matthew. Acute exposure to tris(2-chloroethyl)phosphate produces hippocampal neuronal loss and impairs learning in rats. Toxicology and applied pharmacology. vol 106. issue 2. 1991-01-23. PMID:2256115. |
these data underscore the potential health risk associated with exposure to trcp and support the conclusion that the hippocampus is intimately involved in spatial memory in rats. |
1991-01-23 |
2023-08-11 |
rat |
| S Tan, R C Kirk, W C Abraham, N McNaughto. Chlordiazepoxide reduces discriminability but not rate of forgetting in delayed conditional discrimination. Psychopharmacology. vol 101. issue 4. 1990-09-27. PMID:2388977. |
they also share a number of common behavioural effects and, in particular, both classes of drug interfere with spatial memory in the morris water maze--a test which is very sensitive to hippocampal dysfunction. |
1990-09-27 |
2023-08-11 |
Not clear |
| L F Jacobs, S J Gaulin, D F Sherry, G E Hoffma. Evolution of spatial cognition: sex-specific patterns of spatial behavior predict hippocampal size. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 16. 1990-09-20. PMID:2201026. |
hippocampal size is known to correlate positively with maze performance in laboratory mouse strains and with selective pressure for spatial memory among passerine bird species. |
1990-09-20 |
2023-08-11 |
mouse |
| D Corbett, S Evans, C Thomas, D Wang, R A Jona. MK-801 reduced cerebral ischemic injury by inducing hypothermia. Brain research. vol 514. issue 2. 1990-08-01. PMID:2162711. |
in gerbils made ischemic, but maintained at normal body temperature, a dose of 3.0 mg/kg of mk-801 provided no protection against hippocampal cell loss or spatial memory impairment. |
1990-08-01 |
2023-08-11 |
Not clear |
| R Tamura, T Ono, M Fukuda, K Nakamur. Recognition of egocentric and allocentric visual and auditory space by neurons in the hippocampus of monkeys. Neuroscience letters. vol 109. issue 3. 1990-05-31. PMID:2330131. |
the results are consistent with a role of the hippocampus in spatial memory. |
1990-05-31 |
2023-08-11 |
monkey |
| D J Clarke, A Björklun. Restoration of cholinergic circuitry in the hippocampus by foetal grafts. EXS. vol 57. 1990-03-15. PMID:2533098. |
in aged rats, judged as being behaviourally impaired with respect to their spatial memory, there appears to be an intrinsic denervation of the septohippocampal pathway such that the hippocampus is depleted of cholinergic markers. |
1990-03-15 |
2023-08-11 |
rat |
| M C Buhot, P Rage, L Seg. Changes in exploratory behaviour of hamsters following treatment with 8-hydroxy-2-(di-n-propylamino)tetralin. Behavioural brain research. vol 35. issue 2. 1989-12-22. PMID:2530993. |
8-oh-dpat is assumed to act on 5-ht somatodendritic autoreceptors, lowering 5-ht utilization in the hippocampus, which is the main structure implicated in spatial memory. |
1989-12-22 |
2023-08-11 |
human |
| E Reyes, J Wolfe, D D Savag. The effects of prenatal alcohol exposure on radial arm maze performance in adult rats. Physiology & behavior. vol 46. issue 1. 1989-12-21. PMID:2813555. |
these results suggest that in utero administration of ethanol affects spatial memory capacity in rat, an observation consistent with other deficits seen in hippocampus of rats prenatally exposed to ethanol. |
1989-12-21 |
2023-08-11 |
rat |
| B J Knowlton, M L Shapiro, D S Olto. Hippocampal seizures disrupt working memory performance but not reference memory acquisition. Behavioral neuroscience. vol 103. issue 5. 1989-12-19. PMID:2803557. |
the effect of hippocampal seizures in rats was assessed in two spatial memory tasks: the reference memory task was a simultaneous two-choice discrimination in a t-maze. |
1989-12-19 |
2023-08-11 |
rat |
| S D Iversen, S B Dunnet. Functional compensation afforded by grafts of foetal neurones. Progress in neuro-psychopharmacology & biological psychiatry. vol 13. issue 3-4. 1989-08-21. PMID:2664895. |
cholinergic depletion of these forebrain structures impair performance on spatial memory tasks, which are reversed by grafts of foetal basal forebrain neurones to cortex or hippocampus. |
1989-08-21 |
2023-08-11 |
rat |
| A Horita, M A Carino, J Zabawska, H La. TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesioned rats. Peptides. vol 10. issue 1. 1989-08-14. PMID:2501767. |
microinjection of ibotenic acid into medial septum of rats decreased choline acetyltransferase (cat) and high-affinity choline uptake (hacu) activities in hippocampus and retarded the learning of a spatial memory task in the radial-arm maze. |
1989-08-14 |
2023-08-11 |
rat |
| M A Howard, A Gross, M S Grady, R S Langer, E Mathiowitz, H R Winn, M R Mayber. Intracerebral drug delivery in rats with lesion-induced memory deficits. Journal of neurosurgery. vol 71. issue 1. 1989-07-28. PMID:2567778. |
twenty rats received bilateral fimbria-fornix lesions, producing cholinergic denervation of the hippocampus and marked impairment in spatial memory. |
1989-07-28 |
2023-08-11 |
rat |
| P Tandon, R L McLamb, D Novicki, D L Shuey, H A Tilso. Fetal hippocampal cell suspensions ameliorate behavioral effects of intradentate colchicine in the rat. Brain research. vol 473. issue 2. 1989-05-10. PMID:3233493. |
histological observations showed the presence of surviving hippocampal explants in both the lesioned and the control rat brains, suggesting that the presence of viable implants facilitates the recovery of behavioral function in rats with spatial memory deficits. |
1989-05-10 |
2023-08-11 |
rat |
| G Richter-Levin, M Sega. Raphe cells grafted into the hippocampus can ameliorate spatial memory deficits in rats with combined serotonergic/cholinergic deficiencies. Brain research. vol 478. issue 1. 1989-04-27. PMID:2924115. |
raphe cells grafted into the hippocampus can ameliorate spatial memory deficits in rats with combined serotonergic/cholinergic deficiencies. |
1989-04-27 |
2023-08-11 |
rat |
| J R Krebs, D F Sherry, S D Healy, V H Perry, A L Vaccarin. Hippocampal specialization of food-storing birds. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 4. 1989-03-27. PMID:2919184. |
retrieval of stored food relies on an accurate and long-lasting spatial memory, and hippocampal damage disrupts memory for storage sites. |
1989-03-27 |
2023-08-11 |
Not clear |