| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Gu. MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization. Small (Weinheim an der Bergstrasse, Germany). 2023-03-05. PMID:36871144. |
age-related macular degeneration (amd), especially wet amd with choroidal neovascularization (cnv), commonly causes blindness in older patients and disruption of the choroid followed by second-wave injuries, including chronic inflammation, oxidative stress, and excessive matrix metalloproteinase 9 (mmp9) expression. |
2023-03-05 |
2023-08-14 |
mouse |
| Shuyan Zhu, Huimin Shan, Jianqiao Li, Lijie Pan, Shudan Wang, Jing Zhu, Hui Guo, Fenghua Mi, Xinyi Wu, Kunpeng Pan. Therapeutic potential of topical administration of acriflavine against hypoxia-inducible factors for corneal fibrosis. Frontiers in pharmacology. vol 13. 2022-11-07. PMID:36339559. |
transdifferentiation of keratocytes into fibroblasts or further into myofibroblasts, which produced denser and more disorganized extracellular matrix, is the major cause of corneal fibrosis and scarring, leading to corneal blindness. |
2022-11-07 |
2023-08-14 |
mouse |
| Liang Wang, Ying Tian, Yan Cao, Qiang Ma, Shuai Zha. MiR-137 promotes cell growth and inhibits extracellular matrix protein expression in H Neuroscience letters. vol 755. 2021-06-08. PMID:33865939. |
mir-137 promotes cell growth and inhibits extracellular matrix protein expression in h glaucoma is a progressive optic neuropathy in more than 25 % of cases in patients with permanent blindness. |
2021-06-08 |
2023-08-13 |
Not clear |
| April Nettesheim, Myoung Sup Shim, Angela Dixon, Urmimala Raychaudhuri, Haiyan Gong, Paloma B Lito. Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma. Journal of clinical medicine. vol 10. issue 1. 2021-02-19. PMID:33379277. |
extracellular matrix (ecm) deposition in the trabecular meshwork (tm) is one of the hallmarks of glaucoma, a group of human diseases and leading cause of permanent blindness. |
2021-02-19 |
2023-08-13 |
human |
| Chelsi Lopez, Shiwha Park, Seth Edwards, Selina Vong, Shujie Hou, Minyoung Lee, Hunter Sauerland, Jung-Jae Lee, Kyung Jae Jeon. Matrix Metalloproteinase-Deactivating Contact Lens for Corneal Melting. ACS biomaterials science & engineering. vol 5. issue 3. 2020-09-28. PMID:31692998. |
this potential cause of corneal blindness is caused by excessive expression of zinc-dependent matrix metalloproteinases (mmps) and has no satisfying cure as of now. |
2020-09-28 |
2023-08-13 |
Not clear |
| Szu-Yu Chen, Bo Han, Ying-Ting Zhu, Megha Mahabole, Jie Huang, David C Beebe, Scheffer C G Tsen. HC-HA/PTX3 Purified From Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence of Limbal Epithelial Progenitor/Stem Cells. Stem cells (Dayton, Ohio). vol 33. issue 11. 2016-08-01. PMID:26148958. |
hence, hc-ha/ptx3 uniquely upregulates bmp signaling in lncs which leads to bmp signaling in lepcs to achieve quiescence, helping explain how am transplantation is clinically useful to be used as a matrix for ex vivo expansion of lepcs and to treat corneal blindness caused by limbal stem cells deficiency. |
2016-08-01 |
2023-08-13 |
mouse |
| Panayiota Founti, Anna-Bettina Haidich, Anthoula Chatzikyriakidou, Angeliki Salonikiou, Eleftherios Anastasopoulos, Theofanis Pappas, Alexandros Lambropoulos, Ananth C Viswanathan, Fotis Topouzi. Ethnicity-Based Differences in the Association of LOXL1 Polymorphisms with Pseudoexfoliation/Pseudoexfoliative Glaucoma: A Meta-Analysis. Annals of human genetics. vol 79. issue 6. 2016-01-27. PMID:26404116. |
pseudoexfoliation (pex) is an age-related disorder of the extracellular matrix; it is strongly associated with glaucoma, the leading cause of irreversible blindness worldwide. |
2016-01-27 |
2023-08-13 |
Not clear |
| Małgorzata Nita, Barbara Strzałka-Mrozik, Andrzej Grzybowski, Urszula Mazurek, Wanda Romaniu. Age-related macular degeneration and changes in the extracellular matrix. Medical science monitor : international medical journal of experimental and clinical research. vol 20. 2014-12-18. PMID:24938626. |
age-related macular degeneration (amd) is the leading cause of permanent, irreversible, central blindness (scotoma in the central visual field that makes reading and writing impossible, stereoscopic vision, recognition of colors and details) in patients over the age of 50 years in european and north america countries, and an important role is attributed to disorders in the regulation of the extracellular matrix (ecm). |
2014-12-18 |
2023-08-13 |
Not clear |
| Valeria Occelli, Jonathan B Lin, Simon Lacey, K Sathia. Loss of form vision impairs spatial imagery. Frontiers in human neuroscience. vol 8. 2014-03-28. PMID:24678294. |
participants with blindness resulting in the loss of form vision at or after age 6, and age- and gender-matched sighted participants, performed a spatial imagery task requiring memorization of a 4 × 4 lettered matrix and subsequent mental construction of shapes within the matrix from four-letter auditory cues. |
2014-03-28 |
2023-08-12 |
human |
| Sridevi Mony, Seung Joon Lee, Jeffrey F Harper, Sonali P Barwe, Sigrid A Langhan. Regulation of Na,K-ATPase β1-subunit in TGF-β2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells. Experimental eye research. vol 115. 2013-12-13. PMID:23810808. |
proliferative vitreo retinopathy (pvr) is associated with extracellular matrix membrane (ecm) formation on the neural retina and disruption of the multilayered retinal architecture leading to distorted vision and blindness. |
2013-12-13 |
2023-08-12 |
human |
| A J Augustin, U Schmidt-Erfurt. Verteporfin therapy and triamcinolone acetonide: convergent modes of action for treatment of neovascular age-related macular degeneration. European journal of ophthalmology. vol 16. issue 6. 2007-03-06. PMID:17191188. |
choroidal neovascularization associated with age-related macular degeneration is the primary cause of blindness in the elderly in developed countries, due to a number of pathogenic effects, including angiogenesis, cell-mediated inflammation, leukocyte adhesion and extravasation, and matrix remodeling. |
2007-03-06 |
2023-08-12 |
Not clear |
| Angels Natividad, Graham Cooke, Martin J Holland, Matthew J Burton, Hassan M Joof, Kirk Rockett, Dominic P Kwiatkowski, David C W Mabey, Robin L Baile. A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection. BMC medical genetics. vol 7. 2006-08-01. PMID:16643654. |
a dysregulated extracellular matrix (ecm) proteolysis during the processes of tissue repair following infection and inflammation are thought to play a key role in the development of fibrotic sequelae of infection, which ultimately leads to blindness. |
2006-08-01 |
2023-08-12 |
human |
| Sergiu T Leu, Suchitra Batni, Monte J Radeke, Lincoln V Johnson, Don H Anderson, Dennis O Cleg. Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration. Experimental eye research. vol 74. issue 1. 2002-05-13. PMID:11878827. |
drusen are abnormal extracellular matrix deposits characteristic of age-related macular degeneration (amd), a leading cause of blindness in the aging human population. |
2002-05-13 |
2023-08-12 |
human |
| J K Park, J J O'Donnell, V E Shih, J F Gusella, V Rames. A 15-bp deletion in exon 5 of the ornithine aminotransferase (OAT) locus associated with gyrate atrophy. Human mutation. vol 1. issue 4. 1993-06-10. PMID:1301936. |
gyrate atrophy of the choroid and retina (ga) is an autosomal recessive disorder in which a deficiency of the mitochondrial matrix enzyme ornithine aminotransferase (oat) leads to progressive blindness. |
1993-06-10 |
2023-08-11 |
Not clear |