| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margaret S Landis, Tracey Boyden, Simon Peg. Nasal-to-CNS drug delivery: where are we now and where are we heading? An industrial perspective. Therapeutic delivery. vol 3. issue 2. 2012-08-13. PMID:22834197. |
further discoveries in nasal nanotechnology, targeted delivery devices and diagnostic olfactory imaging will serve to fuel the advancements in this area of drug delivery. |
2012-08-13 |
2023-08-12 |
human |
| F K Che Harun, J A Covington, J W Gardne. Mimicking the biological olfactory system: a Portable electronic Mucosa. IET nanobiotechnology. vol 6. issue 2. 2012-08-09. PMID:22559706. |
the nasal chromatographic effect provides temporal information in the human olfactory system, and is mimicked here using two-coated retentive channels. |
2012-08-09 |
2023-08-12 |
human |
| Bhart-Anjan S Bhullar, Jesús Marugán-Lobón, Fernando Racimo, Gabe S Bever, Timothy B Rowe, Mark A Norell, Arhat Abzhano. Birds have paedomorphic dinosaur skulls. Nature. vol 487. issue 7406. 2012-08-09. PMID:22722850. |
paedomorphic enlargement of the eyes and associated brain regions parallels the enlargement of the nasal cavity and olfactory brain in mammals. |
2012-08-09 |
2023-08-12 |
Not clear |
| Xin Zhou, Jaime D'Agostino, Lei Li, Chad D Moore, Garold S Yost, Xinxin Din. Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. Drug metabolism and disposition: the biological fate of chemicals. vol 40. issue 4. 2012-08-03. PMID:22228748. |
the aim of this study was to determine whether mouse cyp2a5 and cyp2f2 play critical roles in the bioactivation of 3-methylindole (3mi), a tissue-selective toxicant, in the target tissues, the nasal olfactory mucosa (om) and lung. |
2012-08-03 |
2023-08-12 |
mouse |
| b' D Manestar, R Ti\\xc4\\x87ac, S Mari\\xc4\\x8di\\xc4\\x87, G Malvi\\xc4\\x87, D \\xc4\\x8corak, M Marjanovi\\xc4\\x87 Kavanagh, D Prgomet, R Star\\xc4\\x8devi\\xc4\\x8. Amount of airflow required for olfactory perception in laryngectomees: a prospective interventional study. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. vol 37. issue 1. 2012-07-31. PMID:22257443.' |
to determine minimum airflow rate required for olfactory stimulation in successfully rehabilitated laryngectomised patients after learning the polite yawning technique (pyt) and to confirm the hypothesis that sense of smell is rehabilitated once the nasal airflow is re-established. |
2012-07-31 |
2023-08-12 |
Not clear |
| Norio Kondo, Hideaki Takahashi, Yoko Nii, Junichi Naga. Olfactory neuroblastoma: 15 years of experience. Anticancer research. vol 32. issue 5. 2012-07-30. PMID:22593448. |
olfactory neuroblastoma is a rare malignant neoplasm of the nasal cavity and of the paranasal sinus. |
2012-07-30 |
2023-08-12 |
Not clear |
| Guy S Padzys, Christiane Tankosic, Marie Trabalon, Jean-Marc Martrett. Craniofacial development and physiological state after early oral breathing in rats. European journal of oral sciences. vol 120. issue 1. 2012-07-20. PMID:22288917. |
reversible nasal obstruction was further associated with reduced dimensions of the olfactory bulbs lasting into adulthood and an initial decrease in lung weight. |
2012-07-20 |
2023-08-12 |
rat |
| Clémence Lorentz, Béatrice Marie, Jean Michel Vignaud, Roger Jankowsk. Respiratory epithelial adenomatoid hamartomas of the olfactory clefts. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 269. issue 3. 2012-07-10. PMID:21877250. |
reah can be observed either as bilateral pseudotumours confined to the olfactory clefts (n = 12 between 2003 and 2008) or associated to nasal polyposis of the ethmoid labyrinths. |
2012-07-10 |
2023-08-12 |
Not clear |
| Duc Trung Nguyen, Phi-Linh Nguyen-Thi, Roger Jankowsk. How does measured olfactory function correlate with self-ratings of the sense of smell in patients with nasal polyposis? The Laryngoscope. vol 122. issue 5. 2012-07-10. PMID:22374618. |
how does measured olfactory function correlate with self-ratings of the sense of smell in patients with nasal polyposis? |
2012-07-10 |
2023-08-12 |
Not clear |
| Duc Trung Nguyen, Phi-Linh Nguyen-Thi, Roger Jankowsk. How does measured olfactory function correlate with self-ratings of the sense of smell in patients with nasal polyposis? The Laryngoscope. vol 122. issue 5. 2012-07-10. PMID:22374618. |
the objectives of this study were to investigate correlations, before and after surgery, between olfactory function self-ratings and measurements, and self-ratings of nasal obstruction and smell; and to establish cutoff points of self-rating scores for smell reduction in patients with nasal polyposis (np). |
2012-07-10 |
2023-08-12 |
Not clear |
| Abby A Li, Jefferson Fowles, Marcy I Banton, Catherine Picut, Daniel T Kirkpatric. Acute inhalation study of allyl alcohol for derivation of acute exposure guideline levels. Inhalation toxicology. vol 24. issue 4. 2012-07-10. PMID:22429142. |
severe, irreversible nasal olfactory epithelial lesions were present in 50 ppm/8-hour males. |
2012-07-10 |
2023-08-12 |
rat |
| V S Sharova, M S Izvol'skaia, S N Voronova, L A Zakharov. [Effect of bacterial endotoxin on migration of gonadotropin-releasing, hormone producing neurons in rat embryogenesis]. Ontogenez. vol 42. issue 6. 2012-06-20. PMID:22288106. |
at the same time, the number of grh-neurons in the nasal area of the head of 17- and 19-day-old embryos increased by 40 and 50%, respectively, whereas it increased by 20% in olfactory bulbs of 17-day-old embryos and did not changed in olfactory bulbs of 19-day-old embryos. |
2012-06-20 |
2023-08-12 |
rat |
| Ofra Ziv-Polat, Hadas Skaat, Abraham Shahar, Shlomo Marge. Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering. International journal of nanomedicine. vol 7. 2012-06-19. PMID:22419873. |
adult nasal olfactory mucosa (nom) cells were seeded in the transparent fibrin scaffolds in the absence or presence of the free or conjugated bfgf-iron oxide nanoparticles. |
2012-06-19 |
2023-08-12 |
Not clear |
| Nathalie Boone, Aurélie Bergon, Béatrice Loriod, Arnaud Devèze, Catherine Nguyen, Felicia B Axelrod, El Chérif Ibrahi. Genome-wide analysis of familial dysautonomia and kinetin target genes with patient olfactory ecto-mesenchymal stem cells. Human mutation. vol 33. issue 3. 2012-06-08. PMID:22190446. |
to better understand the specificity of neuron loss in fd, we modeled the molecular mechanisms of ikbkap mrna splicing by studying human olfactory ecto-mesenchymal stem cells (hoe-mscs) derived from fd patient nasal biopsies. |
2012-06-08 |
2023-08-12 |
human |
| Shiv Bahadur, Kamla Patha. Physicochemical and physiological considerations for efficient nose-to-brain targeting. Expert opinion on drug delivery. vol 9. issue 1. 2012-05-29. PMID:22171740. |
nasal drug delivery that exploits the olfactory and trigeminal neuronal pathways to deliver drugs to the brain is being widely explored by pharmaceutical companies, for the delivery of challenging drugs. |
2012-05-29 |
2023-08-12 |
Not clear |
| Chih-Hung Shu, Po-Lei Lee, An-Suey Shiao, Kee-Tak Chen, Ming-Ying La. Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment. The Laryngoscope. vol 122. issue 4. 2012-05-29. PMID:22302665. |
topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment. |
2012-05-29 |
2023-08-12 |
Not clear |
| Chih-Hung Shu, Po-Lei Lee, An-Suey Shiao, Kee-Tak Chen, Ming-Ying La. Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment. The Laryngoscope. vol 122. issue 4. 2012-05-29. PMID:22302665. |
this study was designed to evaluate whether applying topical corticosteroids with a squirt system was more effective than using a nasal spray to maintain olfactory improvement following oral corticosteroids. |
2012-05-29 |
2023-08-12 |
Not clear |
| John Douglas Hoekman, Rodney J Y H. Effects of localized hydrophilic mannitol and hydrophobic nelfinavir administration targeted to olfactory epithelium on brain distribution. AAPS PharmSciTech. vol 12. issue 2. 2012-05-16. PMID:21519984. |
direct nose-to-brain access is believed to be achieved through nervous connections which travel from the cns across the cribriform plate into the olfactory region of the nasal cavity. |
2012-05-16 |
2023-08-12 |
rat |
| John Douglas Hoekman, Rodney J Y H. Effects of localized hydrophilic mannitol and hydrophobic nelfinavir administration targeted to olfactory epithelium on brain distribution. AAPS PharmSciTech. vol 12. issue 2. 2012-05-16. PMID:21519984. |
therefore, we have developed a pressurized olfactory delivery (pod) device which consistently and non-invasively deposited a majority of drug to the olfactory region of the nasal cavity in rats. |
2012-05-16 |
2023-08-12 |
rat |
| John Douglas Hoekman, Rodney J Y H. Effects of localized hydrophilic mannitol and hydrophobic nelfinavir administration targeted to olfactory epithelium on brain distribution. AAPS PharmSciTech. vol 12. issue 2. 2012-05-16. PMID:21519984. |
using both a hydrophobic drug, mannitol (log p = -3.1), and a hydrophobic drug, nelfinavir (log p = 6.0), and pod device, we compared brain and blood levels after nasal deposition primarily on the olfactory region with pod or nose drops which deposited primarily on the respiratory region in rats. |
2012-05-16 |
2023-08-12 |
rat |