| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiashang Liu, Ruijia Yan, Bixue Wang, Shu Chen, Hua Hong, Changsheng Liu, Xi Che. Decellularized Extracellular Matrix enriched with GDNF Enhances Neurogenesis and Remyelination for Improved Motor Recovery after Spinal Cord Injury. Acta biomaterialia. 2024-04-14. PMID:38615813. |
decellularized extracellular matrix enriched with gdnf enhances neurogenesis and remyelination for improved motor recovery after spinal cord injury. |
2024-04-14 |
2024-04-17 |
Not clear |
| Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S Harris, Byung Il Lee, Mengke Yang, Robert A Ellingford, Raja S Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M Smeeth, Mirjam L Adams, Teresa Niccoli, Rosa Rademakers, Marka van Blitterswijk, Anny Devoy, Soyon Hong, Linda Partridge, Alyssa N Coyne, Pietro Fratta, Dario R Alessi, Ben Davies, Marc Aurel Busche, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaac. PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature neuroscience. 2024-02-29. PMID:38424324. |
quantitative proteomics revealed an increase in extracellular matrix (ecm) proteins in (gr)400 and (pr)400 spinal cord, with the collagen col6a1 the most increased protein. |
2024-02-29 |
2024-03-03 |
mouse |
| Mario Díaz, Noemí Fabelo, M Virginia Martín, Guido Santos, Isidre Ferre. Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis. Journal of molecular medicine (Berlin, Germany). 2024-01-29. PMID:38285093. |
key messages: the lipid matrix of multimolecular membrane complexes named lipid rafts are altered in human spinal cord in sporadic amyotrophic lateral sclerosis (als). |
2024-01-29 |
2024-01-31 |
human |
| Xiaochen Su, Menghao Teng, Yingang Zhang, Wenchen J. Decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through Wnt/ Biomedical materials (Bristol, England). vol 19. issue 1. 2023-12-04. PMID:38044745. |
decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through wnt/ spinal cord injury (sci) causes tissue destruction and neuronal apoptosis, which impede neural function recovery. |
2023-12-04 |
2023-12-10 |
Not clear |
| Lena Mungenast, Ronya Nieminen, Carine Gaiser, Ana Bela Faia-Torres, Jürgen Rühe, Laura Suter-Dic. Electrospun decellularized extracellular matrix scaffolds promote the regeneration of injured neurons. Biomaterials and biosystems. vol 11. 2023-07-10. PMID:37427248. |
traumatic injury to the spinal cord (sci) causes the transection of neurons, formation of a lesion cavity, and remodeling of the microenvironment by excessive extracellular matrix (ecm) deposition and scar formation leading to a regeneration-prohibiting environment. |
2023-07-10 |
2023-08-14 |
human |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
the effects of ast were examined on the motor function, spinal cord edema, integrity of blood-spinal cord barrier (bscb), and expression of high mobility group box 1 (hmgb1), toll-like receptor 4 (tlr4), nuclear factor-kappa b (nf-κb), glial fibrillary acidic protein (gfap), and aquaporin-4 (aqp4), and matrix metallopeptidase- 9 (mmp-9) post-sci. |
2023-05-05 |
2023-08-14 |
rat |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
after spinal cord injury, hmgb1 is rapidly expressed by neurons, microglia and ependymal cells, and it is either actively or passively released into the extracellular matrix and blood circulation; furthermore, it also participates in the pathophysiological process of spinal cord injury. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yang Xu, Xiuying He, Yangyang Wang, Jiao Jian, Xia Peng, Lie Zhou, Yi Kang, Tinghua Wan. 5-Fluorouracil reduces the fibrotic scar via inhibiting matrix metalloproteinase 9 and stabilizing microtubules after spinal cord injury. CNS neuroscience & therapeutics. 2022-08-03. PMID:35918897. |
5-fluorouracil reduces the fibrotic scar via inhibiting matrix metalloproteinase 9 and stabilizing microtubules after spinal cord injury. |
2022-08-03 |
2023-08-14 |
Not clear |
| L Luo, J-X Yang, T Luo, D Liu, G-H Wu, J-M H. A study on the mechanism of PP2A in the recovery of SCI in rats through downregulation of MMP-9 via MAPK signaling pathway. European review for medical and pharmacological sciences. vol 25. issue 23. 2021-12-17. PMID:34919217. |
the aim of this study was to investigate the mechanism of action of protein phosphatase 2a (pp2a) in the recovery of spinal cord injury (sci) in rats by downregulating matrix metalloproteinase 9 (mmp-9) via the mitogen-activated protein kinase (mapk) signaling pathway. |
2021-12-17 |
2023-08-13 |
rat |
| Yuan-Huan Ma, Hui-Juan Shi, Qing-Shuai Wei, Qing-Wen Deng, Jia-Hui Sun, Zhou Liu, Bi-Qin Lai, Ge Li, Ying Ding, Wan-Ting Niu, Yuan-Shan Zeng, Xiang Zen. Developing a mechanically matched decellularized spinal cord scaffold for the in situ matrix-based neural repair of spinal cord injury. Biomaterials. vol 279. 2021-12-02. PMID:34700225. |
however, a bioscaffold with mechanical properties that match those of the pathological spinal cord tissue and a pro-regenerative matrix that allows robust neurogenesis for overcoming post-sci scar formation has yet to be developed. |
2021-12-02 |
2023-08-13 |
Not clear |
| Shui-Sheng Yu, Zi-Yu Li, Xin-Zhong Xu, Fei Yao, Yang Luo, Yan-Chang Liu, Li Cheng, Mei-Ge Zheng, Jue-Hua Jin. M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558535. |
after spinal cord injury (sci), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon regeneration. |
2021-11-10 |
2023-08-13 |
Not clear |
| Hossein Zeinali, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Diosgenin ameliorates cellular and molecular changes in multiple sclerosis in C57BL/6 mice. Multiple sclerosis and related disorders. vol 55. 2021-10-19. PMID:34425463. |
serum and spinal cord tissue level of tumor necrosis factor alpha (tnfα) and tissue levels of matrix metalloproteinase 9 (mmp-9) and interleukin 17 (il-17) as inflammatory markers, microtubule-associated proteins 1a/1b light chain 3a (map1lc3a), and activity dependent neuroprotector homeobox (adnp) as neuroprotective markers were assayed using enzyme linked immunosorbent assay (elisa) method. |
2021-10-19 |
2023-08-13 |
mouse |
| b' Vito Antonio Baldassarro, Marco Sanna, Andrea Bighinati, Michele Sannia, Marco Gusciglio, Luciana Giardino, Luca Lorenzini, Laura Calz\\xc3\\xa. A Time-Course Study of the Expression Level of Synaptic Plasticity-Associated Genes in Un-Lesioned Spinal Cord and Brain Areas in a Rat Model of Spinal Cord Injury: A Bioinformatic Approach. International journal of molecular sciences. vol 22. issue 16. 2021-09-08. PMID:34445312.' |
the main results are: (i) a different gene expression regulation is observed in the spinal cord (sc) segments rostral and caudal to the lesion; (ii) long lasting changes in the sc includes the extracellular matrix (ecm) enzymes |
2021-09-08 |
2023-08-13 |
rat |
| Eric J Marrotte, Khari Johnson, Ryan M Schweller, Rachel Chapla, Brian E Mace, Daniel T Laskowitz, Jennifer L Wes. Induction of Neurogenesis and Angiogenesis in a Rat Hemisection Spinal Cord Injury Model With Combined Neural Stem Cell, Endothelial Progenitor Cell, and Biomimetic Hydrogel Matrix Therapy. Critical care explorations. vol 3. issue 6. 2021-06-26. PMID:34151277. |
induction of neurogenesis and angiogenesis in a rat hemisection spinal cord injury model with combined neural stem cell, endothelial progenitor cell, and biomimetic hydrogel matrix therapy. |
2021-06-26 |
2023-08-13 |
rat |
| Hannah J Baumann, Gautam Mahajan, Trevor R Ham, Patricia Betonio, Chandrasekhar R Kothapalli, Leah P Shriver, Nic D Leipzi. Softening of the chronic hemi-section spinal cord injury scar parallels dysregulation of cellular and extracellular matrix content. Journal of the mechanical behavior of biomedical materials. vol 110. 2021-05-14. PMID:32957245. |
softening of the chronic hemi-section spinal cord injury scar parallels dysregulation of cellular and extracellular matrix content. |
2021-05-14 |
2023-08-13 |
Not clear |
| Claire Richard, Claude Bendavid, Juliette Hascoet, Quentin Alimi, Zine-Eddine Khene, Jacques Kerdraon, Caroline Voiry, Charlène Brochard, Guillaume Bouguen, Laurent Siproudhis, Andrea Manunta, Xavier Gamé, Benoit Peyronne. Urinary biomarkers profiles in patients with neurogenic detrusor overactivity according to their neurological condition. World journal of urology. vol 38. issue 9. 2021-05-06. PMID:31741027. |
the aim of this study was to investigate the disease-specific urinary levels variations of neurotrophins (ngf, bdnf), mediators of inflammation (tgfβ-1, pge-2) and markers of extracellular matrix alterations (timp-2) in patients with multiple sclerosis (ms) spinal cord injury (sci), or spina bifida (sb), and neurogenic detrusor overactivity (ndo). |
2021-05-06 |
2023-08-13 |
Not clear |
| Xing Cheng, Zhengran Yu, Jinghui Xu, Daping Quan, Houqing Lon. Pathophysiological Changes and the Role of Notch-1 Activation After Decompression in a Compressive Spinal Cord Injury Rat Model. Frontiers in neuroscience. vol 15. 2021-03-15. PMID:33584186. |
hematoxylin and eosin staining was performed to assess pathophysiological changes, while hypoxia-inducible factor 1 alpha, vascular endothelial growth factor (vegf), von willebrand factor (vwf), matrix metalloproteinase (mmp)-9, mmp-2, notch-1, and hes-1 expression in the spinal cord were examined by immunohistochemical analysis or quantitative pcr. |
2021-03-15 |
2023-08-13 |
rat |
| Gerburg Keilhoff, Benjamin Lucas, Katja Uhde, Hisham Fans. Selected gene profiles of stressed NSC-34 cells and rat spinal cord following peripheral nerve reconstruction and minocycline treatment. Experimental and therapeutic medicine. vol 11. issue 5. 2020-10-01. PMID:27168790. |
the mrna and protein expression levels of b cell lymphoma-2 (bcl-2), bcl-2-associated x protein (bax), caspase-3, major histocompatibility complex i (mhc i), tumor necrosis factor-α (tnf-α), activating transcription factor 3 (atf3), vascular endothelial growth factor (vegf), matrix metalloproteinase 9 (mmp9), and growth associated protein-43 (gap-43) were monitored in the rat lumbar spinal cord following microsurgical reconstruction of the sciatic nerves and minocycline treatment. |
2020-10-01 |
2023-08-13 |
rat |
| Sara Rezaei, Salar Bakhtiyari, Khairolah Assadollahi, Somayeh Heidarizadi, Ardashir Moayeri, Monireh Aziz. Evaluating Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Intervention Time in Rats. Basic and clinical neuroscience. vol 11. issue 1. 2020-09-28. PMID:32483473. |
the proteoglycans of the extracellular matrix increases in the glial scar during spinal cord injury and significantly affects the inhibition of axonal regeneration. |
2020-09-28 |
2023-08-13 |
rat |
| Ziyuan Yu, Hongru Li, Peng Xia, Weijian Kong, Yuxin Chang, Chuan Fu, Kai Wang, Xiaoyu Yang, Zhiping Q. Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury. Journal of biological engineering. vol 14. 2020-09-28. PMID:32774454. |
traffic accidents, falls, and many other events may cause traumatic spinal cord injuries (scis), resulting in nerve cells and extracellular matrix loss in the spinal cord, along with blood loss, inflammation, oxidative stress (os), and others. |
2020-09-28 |
2023-08-13 |
Not clear |