| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José R Maldonad. Neuropathogenesis of delirium: review of current etiologic theories and common pathways. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 21. issue 12. 2014-07-18. PMID:24206937. |
in general, the most commonly described neurotransmitter changes associated with delirium include deficiencies in acetylcholine and/or melatonin availability; excess in dopamine, norepinephrine, and/or glutamate release; and variable alterations (e.g., either a decreased or increased activity, depending on delirium presentation and cause) in serotonin, histamine, and/or γ-aminobutyric acid. |
2014-07-18 |
2023-08-12 |
Not clear |
| Gregory B Crawford, Meera Agar M, Stephen J Quinn, Jane Phillips, Caroline Litster, Natasha Michael, Matthew Doogue, Debra Rowett, David C Curro. Pharmacovigilance in hospice/palliative care: net effect of haloperidol for delirium. Journal of palliative medicine. vol 16. issue 11. 2014-07-09. PMID:24138282. |
haloperidol, a butyrophenone derivative and dopamine antagonist, is commonly prescribed for nausea, vomiting, and delirium in hospice/palliative care. |
2014-07-09 |
2023-08-12 |
human |
| Irene J Zaal, Arjen J C Sloote. Delirium in critically ill patients: epidemiology, pathophysiology, diagnosis and management. Drugs. vol 72. issue 11. 2012-12-05. PMID:22804788. |
however, alterations to neurotransmitters, especially acetylcholine and dopamine, inflammatory pathways and an aberrant stress response are proposed mechanisms leading to intensive care unit (icu) delirium. |
2012-12-05 |
2023-08-12 |
Not clear |
| Luzius A Steine. Postoperative delirium. Part 1: pathophysiology and risk factors. European journal of anaesthesiology. vol 28. issue 9. 2011-12-14. PMID:21785356. |
on a neurotransmitter level, impaired cholinergic transmission and disturbances of the intricate interactions between dopamine, serotonin and acetylcholine seem to play an important role in the development of delirium. |
2011-12-14 |
2023-08-12 |
Not clear |
| Fulvio Lauretani, Gian Paolo Ceda, Marcello Maggio, Anna Nardelli, Marsilio Saccavini, Luigi Ferrucc. Capturing side-effect of medication to identify persons at risk of delirium. Aging clinical and experimental research. vol 22. issue 5-6. 2011-05-19. PMID:21422797. |
in particular, an imbalance between levels of acetylcholine and monoamine (such as dopamine) may cause delirium. |
2011-05-19 |
2023-08-12 |
Not clear |
| Deborah D Moye. Review article: terminal delirium in geriatric patients with cancer at end of life. The American journal of hospice & palliative care. vol 28. issue 1. 2011-05-04. PMID:21057140. |
this article explores the hyperactive and hypoactive delirium subtypes as well as the pathophysiology of terminal delirium and the theory of acetylcholine deficiency and dopamine excess. |
2011-05-04 |
2023-08-12 |
Not clear |
| Barbara C van Munster, Sophia E J A de Rooij, Mojgan Yazdanpanah, Pentti J Tienari, Kaisu H Pitkälä, Robert J Osse, Dimitrios Adamis, Orla Smit, Marijke S van der Steen, Miriam van Houten, Terhi Rahkonen, Raimo Sulkava, Jouko V Laurila, Timo E Strandberg, Joke H M Tulen, Louwerens Zwang, Alastair J D MacDonald, Adrian Treloar, Eric J G Sijbrands, Aeilko H Zwinderman, Johanna C Korevaa. The association of the dopamine transporter gene and the dopamine receptor 2 gene with delirium, a meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 2. 2010-12-20. PMID:19739106. |
previously, associations between delirium and the dopamine transporter gene (solute carrier family 6, member 3 (slc6a3)) and dopamine receptor 2 gene (drd2) were found. |
2010-12-20 |
2023-08-12 |
human |
| Anja Heymann, Claudia Spie. [Postoperative delirium and cognitive deficit. Prevention and therapy]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. vol 45. issue 2. 2010-05-04. PMID:20155641. |
for delirium prevention there are drugs available acting on different receptor systems (acetylcholine, dopamine, opioid, glutamate). |
2010-05-04 |
2023-08-12 |
Not clear |
| Katrin Singler, Martina Hafner, Cornel Siebe. [Delirium is a very common and life-threatening condition]. Therapeutische Umschau. Revue therapeutique. vol 67. issue 2. 2010-03-29. PMID:20131213. |
today, the leading hypothesized mechanism for the pathogenesis of delirium focuses on a central cholinergic deficiency and dopamine excess. |
2010-03-29 |
2023-08-12 |
Not clear |
| Katrin Singler, Martina Hafner, Cornel Siebe. [Delirium is a very common and life-threatening condition]. Therapeutische Umschau. Revue therapeutique. vol 67. issue 2. 2010-03-29. PMID:20131213. |
besides, other neurotransmitters, such as dopamine, serotonin, norepinephrine, glutamate and gamma-aminobutyric acid (gaba) may also contribute to delirium. |
2010-03-29 |
2023-08-12 |
Not clear |
| Barbara C van Munster, Mojgan Yazdanpanah, Michael W T Tanck, Sophia E J A de Rooij, Elsmarieke van de Giessen, Eric J G Sijbrands, Aeilko H Zwinderman, Johanna C Korevaa. Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 1. 2010-03-23. PMID:19309018. |
dopamine excess appears to be critical in the final common pathway of delirium. |
2010-03-23 |
2023-08-12 |
Not clear |
| Barbara C van Munster, Mojgan Yazdanpanah, Michael W T Tanck, Sophia E J A de Rooij, Elsmarieke van de Giessen, Eric J G Sijbrands, Aeilko H Zwinderman, Johanna C Korevaa. Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 1. 2010-03-23. PMID:19309018. |
the aim of this study was to investigate whether genetic polymorphisms in three dopamine-related genes (the dopamine receptor 2 (drd2), dopamine receptor 3 (drd3), and the dopamine transporter (slc6a3) gene) were associated with delirium. |
2010-03-23 |
2023-08-12 |
Not clear |
| Barbara C van Munster, Mojgan Yazdanpanah, Michael W T Tanck, Sophia E J A de Rooij, Elsmarieke van de Giessen, Eric J G Sijbrands, Aeilko H Zwinderman, Johanna C Korevaa. Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 1. 2010-03-23. PMID:19309018. |
although validation of these results is needed our results support a role for the dopamine transporter and dopamine receptor 2 in the pathogenesis of delirium. |
2010-03-23 |
2023-08-12 |
Not clear |
| Deborah C Mash, Linda Duque, John Pablo, Yujing Qin, Nikhil Adi, W Lee Hearn, Bruce A Hyma, Steven B Karch, Henrik Druid, Charles V Wetl. Brain biomarkers for identifying excited delirium as a cause of sudden death. Forensic science international. vol 190. issue 1-3. 2009-10-29. PMID:19541436. |
while the contribution of restraint, struggle and the use of conductive energy devices (ced) to the cause and manner of death raise controversy, a cns dysfunction of dopamine signaling may underlie the delirium and fatal autonomic dysfunction. |
2009-10-29 |
2023-08-12 |
human |
| Deborah C Mash, Linda Duque, John Pablo, Yujing Qin, Nikhil Adi, W Lee Hearn, Bruce A Hyma, Steven B Karch, Henrik Druid, Charles V Wetl. Brain biomarkers for identifying excited delirium as a cause of sudden death. Forensic science international. vol 190. issue 1-3. 2009-10-29. PMID:19541436. |
dopamine transporter levels were below the range of values measured in age-matched controls, providing pathologic evidence for increased risk of chaotic dopamine signaling in excited delirium. |
2009-10-29 |
2023-08-12 |
human |
| Milagros I Figueroa-Ramos, Carmen Mabel Arroyo-Novoa, Kathryn A Lee, Geraldine Padilla, Kathleen A Puntill. Sleep and delirium in ICU patients: a review of mechanisms and manifestations. Intensive care medicine. vol 35. issue 5. 2009-09-21. PMID:19165463. |
delirium is related to an imbalance in the synthesis, release, and inactivation of some neurotransmitters, particularly acetylcholine and dopamine. |
2009-09-21 |
2023-08-12 |
Not clear |
| Michael D Köhnke, Anil Batra, Werner Kolb, Annette M Köhnke, Ulrich Lutz, Sandra Schick, Ines Gaertne. Association of the dopamine transporter gene with alcoholism. Alcohol and alcoholism (Oxford, Oxfordshire). vol 40. issue 5. 2006-01-11. PMID:15996968. |
it was investigated whether the allele a9 of the dopamine transporter gene (dat1; slc6a3) is associated with alcoholism, delirium tremens (dt), alcohol withdrawal seizures (aws), or the daily alcohol intake. |
2006-01-11 |
2023-08-12 |
Not clear |
| Jee-Yeon Kim, In-Kwa Jung, Changsu Han, Sook-Haeng Cho, Leen Kim, Seung-Hyun Kim, Bun-Hee Lee, Heon-Jeong Lee, Yong-Ku Ki. Antipsychotics and dopamine transporter gene polymorphisms in delirium patients. Psychiatry and clinical neurosciences. vol 59. issue 2. 2005-05-16. PMID:15823165. |
antipsychotics and dopamine transporter gene polymorphisms in delirium patients. |
2005-05-16 |
2023-08-12 |
human |
| Jee-Yeon Kim, In-Kwa Jung, Changsu Han, Sook-Haeng Cho, Leen Kim, Seung-Hyun Kim, Bun-Hee Lee, Heon-Jeong Lee, Yong-Ku Ki. Antipsychotics and dopamine transporter gene polymorphisms in delirium patients. Psychiatry and clinical neurosciences. vol 59. issue 2. 2005-05-16. PMID:15823165. |
the main objective of the present study was to determine the relationship between treatment responses of delirium and genetic polymorphisms in the dopamine transporter. |
2005-05-16 |
2023-08-12 |
human |
| Jee-Yeon Kim, In-Kwa Jung, Changsu Han, Sook-Haeng Cho, Leen Kim, Seung-Hyun Kim, Bun-Hee Lee, Heon-Jeong Lee, Yong-Ku Ki. Antipsychotics and dopamine transporter gene polymorphisms in delirium patients. Psychiatry and clinical neurosciences. vol 59. issue 2. 2005-05-16. PMID:15823165. |
relatively low doses of risperidone and haloperidol exhibited similar efficacies, and dopamine transporter polymorphisms do not appear to play a major role in the action of antipsychotics on delirium. |
2005-05-16 |
2023-08-12 |
human |