| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Oczkowska, Wojciech Kozubski, Margarita Lianeri, Jolanta Dorszewsk. Mutations in PRKN and SNCA Genes Important for the Progress of Parkinson's Disease. Current genomics. vol 14. issue 8. 2014-02-17. PMID:24532983. |
despite numerous debates and controversies in the literature about the role of mutations in the snca and prkn genes in the pathogenesis of pd, it is evident that these genes play a key role in maintaining dopamine (da) neuronal homeostasis and that the dysfunction of this homeostasis is relevant to both familial (fpd) and sporadic (spd) pd with different onset. |
2014-02-17 |
2023-08-12 |
Not clear |
| Claire E Wilcox, Eric D Claus, Sara K Blaine, Marilee Morgan, Kent E Hutchiso. Genetic variation in the alpha synuclein gene (SNCA) is associated with BOLD response to alcohol cues. Journal of studies on alcohol and drugs. vol 74. issue 2. 2013-07-22. PMID:23384371. |
preclinical studies implicate the gene encoding the alpha synuclein protein (snca) in the pathophysiology of alcohol dependence and dopamine neuron function. |
2013-07-22 |
2023-08-12 |
Not clear |
| Alessandro Tozzi, Cinzia Costa, Sabrina Siliquini, Michela Tantucci, Barbara Picconi, Alexander Kurz, Suzana Gispert, Georg Auburger, Paolo Calabres. Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice. Neurobiology of aging. vol 33. issue 8. 2012-10-24. PMID:21684039. |
the interactions between certain α-synuclein (snca) conformations and dopamine (da) metabolism cause selective da neuron degeneration in parkinson's disease (pd). |
2012-10-24 |
2023-08-12 |
mouse |
| Christina E Khodr, Jyothi Pedapati, Ye Han, Martha C Boh. Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra. Developmental neurobiology. vol 72. issue 6. 2012-09-28. PMID:22021082. |
inclusion of a portion of the native snca 3'utr reduces toxicity of human s129a snca on striatal-projecting dopamine neurons in rat substantia nigra. |
2012-09-28 |
2023-08-12 |
human |
| Ye Han, Christina E Khodr, Mohan K Sapru, Jyothi Pedapati, Martha C Boh. A microRNA embedded AAV α-synuclein gene silencing vector for dopaminergic neurons. Brain research. vol 1386. 2012-03-12. PMID:21338582. |
in da pc12 cells, neither vector decreased expression of rat snca, tyrosine hydroxylase (th), dopamine transporter (dat) or the vesicular monoamine transporter (vmat). |
2012-03-12 |
2023-08-12 |
human |
| Yong-Qiang Yang, Fan L. [Inheritance mechnisam of gene SNCA for alcohol dependence]. Yi chuan = Hereditas. vol 32. issue 11. 2011-05-20. PMID:21513161. |
here, the relationship between snca gene and dopamine, the variation and expression of snca gene in alcohol-dependent patients were reviewed. |
2011-05-20 |
2023-08-12 |
Not clear |
| Yong-Qiang Yang, Fan L. [Inheritance mechnisam of gene SNCA for alcohol dependence]. Yi chuan = Hereditas. vol 32. issue 11. 2011-05-20. PMID:21513161. |
alpha-synuclein coded by snca gene can regulate the function of dopamine in multiple levels, and dopamine is an important neurotransmitter in alcohol preference. |
2011-05-20 |
2023-08-12 |
Not clear |
| Joanne Clark, Elizabeth L Clore, Kangni Zheng, Anthony Adame, Eliezer Masliah, David K Simo. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808797. |
despite the transient nature of the impact of nac on brain glutathione, the loss of dopaminergic terminals at 1 year associated with snca overexpression was significantly attenuated by nac supplementation, as measured by immunoreactivity for tyrosine hydroxylase in the striatum (p = 0.007; unpaired, two-tailed t-test), with a similar but nonsignificant trend for dopamine transporter (dat) immunoreactivity. |
2010-11-04 |
2023-08-12 |
mouse |
| M Plaas, A Karis, J Innos, E Rebane, V Baekelandt, A Vaarmann, H Luuk, E Vasar, S Kok. Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59. issue 2. 2008-11-25. PMID:18622040. |
moreover, snca a30p mice expressed the altered sensitivity to vmat2 inhibitor reserpine, possibly reflecting a functional deficiency of dopamine. |
2008-11-25 |
2023-08-12 |
mouse |
| Tiebing Liang, Lucinda G Car. Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring rats. Journal of neurochemistry. vol 99. issue 2. 2007-01-08. PMID:17029600. |
snca modulates dopamine transmission and the dopamineregic system, which play a role in mediating the rewarding properties of alcohol consumption. |
2007-01-08 |
2023-08-12 |
rat |