| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqiang Liu, Jing Han, Lintao Jia, Jean-Christian Maillet, Guang Bai, Lin Xu, Zhengping Jia, Qiaohua Zheng, Wandong Zhang, Robert Monette, Zul Merali, Zhou Zhu, Wei Wang, Wei Ren, Xia Zhan. Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning. PloS one. vol 5. issue 12. 2011-07-05. PMID:21187978. |
these data not only provide the first evidence, to our knowledge, that nmda receptor-dependent synaptic depression at vta dopamine circuitry requires glur2 endocytosis, but also suggest an essential contribution of such synaptic depression to cannabinoid-associated addictive learning, in addition to pointing to novel pharmacological strategies for the treatment of cannabis addiction. |
2011-07-05 |
2023-08-12 |
rat |
| Eric Murillo-Rodríguez, Marcela Palomero-Rivero, Diana Millán-Aldaco, Raphael Mechoulam, René Drucker-Colí. Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats. Life sciences. vol 88. issue 11-12. 2011-05-06. PMID:21262236. |
effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats. |
2011-05-06 |
2023-08-12 |
rat |
| José María Pelayo-Terán, Rocío Pérez-Iglesias, Ignacio Mata, Eugenio Carrasco-Marín, José Luis Vázquez-Barquero, Benedicto Crespo-Facorr. Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications. Psychiatry research. vol 179. issue 3. 2010-11-23. PMID:20493536. |
the val158met polymorphism of the comt (catechol-o-methyltransferase) gene, involved in dopamine regulation and related to negative symptoms, has been previously thought to interact with cannabis use in the modulation of risk of psychosis. |
2010-11-23 |
2023-08-12 |
Not clear |
| Rebecca Kuepper, Paul D Morrison, Jim van Os, Robin M Murray, Gunter Kenis, Cécile Henque. Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines. Schizophrenia research. vol 121. issue 1-3. 2010-11-08. PMID:20580531. |
does dopamine mediate the psychosis-inducing effects of cannabis? |
2010-11-08 |
2023-08-12 |
Not clear |
| Rebecca Kuepper, Paul D Morrison, Jim van Os, Robin M Murray, Gunter Kenis, Cécile Henque. Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines. Schizophrenia research. vol 121. issue 1-3. 2010-11-08. PMID:20580531. |
animal research suggests that delta-9-tetrahydrocannabinol (thc, the main psychoactive component of cannabis) increases dopamine levels in several regions of the brain, including striatal and prefrontal areas. |
2010-11-08 |
2023-08-12 |
Not clear |
| Rebecca Kuepper, Paul D Morrison, Jim van Os, Robin M Murray, Gunter Kenis, Cécile Henque. Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines. Schizophrenia research. vol 121. issue 1-3. 2010-11-08. PMID:20580531. |
since dopamine is hypothesized to represent a crucial common final pathway between brain biology and actual experience of psychosis, a focus on dopamine may initially be productive in the examination of the psychotomimetic effects of cannabis. |
2010-11-08 |
2023-08-12 |
Not clear |
| Marcello Solinas, Gianluigi Tanda, Carrie E Wertheim, Steven R Goldber. Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D(2)-induced formation of anandamide. Psychopharmacology. vol 209. issue 2. 2010-05-28. PMID:20179908. |
although delta-9-tetreahydrocannabinol (thc)-induced elevations in accumbal dopamine levels are believed to play an important role in the abuse-related effects of cannabis, little direct evidence has been provided that the dopaminergic system is involved in the psychotropic effects of thc. |
2010-05-28 |
2023-08-12 |
Not clear |
| Didier Jutras-Aswad, Jennifer A DiNieri, Tibor Harkany, Yasmin L Hur. Neurobiological consequences of maternal cannabis on human fetal development and its neuropsychiatric outcome. European archives of psychiatry and clinical neuroscience. vol 259. issue 7. 2009-11-23. PMID:19568685. |
it posits that studying in utero cannabis exposure in association with genetic mutations of neural systems that have strong relationships to endocannabinoid function, such as the dopamine, opioid, glutamate, and gaba, might help to identify individuals at risk. |
2009-11-23 |
2023-08-12 |
human |
| Paul R A Stokes, Mitul A Mehta, H Valerie Curran, Gerome Breen, Paul M Grasb. Can recreational doses of THC produce significant dopamine release in the human striatum? NeuroImage. vol 48. issue 1. 2009-10-26. PMID:19539765. |
thus cannabis use may increase dopamine release in the human striatum leading to vulnerability to psychosis. |
2009-10-26 |
2023-08-12 |
human |
| Aysun Baransel Baransel Isir, Sibel Oguzkan, Muradiye Nacak, Senay Gorucu, Hikmet Ergin Dulger, Ahmet Arsla. The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence. The American journal of forensic medicine and pathology. vol 29. issue 4. 2009-04-23. PMID:19259017. |
cannabis stimulates dopamine release and activates dopaminergic reward neurons in central pathways that lead to enhanced dependence. |
2009-04-23 |
2023-08-12 |
Not clear |
| Matthijs G Bossong, Bart N M van Berckel, Ronald Boellaard, Lineke Zuurman, Robert C Schuit, Albert D Windhorst, Joop M A van Gerven, Nick F Ramsey, Adriaan A Lammertsma, René S Kah. Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 3. 2009-03-30. PMID:18754005. |
however, it is currently unknown if cannabis can stimulate striatal dopamine neurotransmission in humans. |
2009-03-30 |
2023-08-12 |
human |
| Matthijs G Bossong, Bart N M van Berckel, Ronald Boellaard, Lineke Zuurman, Robert C Schuit, Albert D Windhorst, Joop M A van Gerven, Nick F Ramsey, Adriaan A Lammertsma, René S Kah. Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 3. 2009-03-30. PMID:18754005. |
here we show that delta 9-tetrahydrocannabinol (thc), the main psychoactive component in cannabis, induces dopamine release in the human striatum. |
2009-03-30 |
2023-08-12 |
human |
| D Parolaro, T Rubin. The role of the endogenous cannabinoid system in drug addiction. Drug news & perspectives. vol 21. issue 3. 2008-11-03. PMID:18560613. |
for a long time, dopamine has been consistently associated with the reinforcing effects of most drugs of abuse but, recently, pharmacological evidence points to the possibility that pharmacological management of the endocannabinoid system might not only block the direct reinforcing effect of cannabis, opioids, nicotine and ethanol, but also prevent the relapse to various drugs of abuse including opioids, cocaine, nicotine, alcohol and amphetamine. |
2008-11-03 |
2023-08-12 |
Not clear |
| Lorenza S Colzato, Bernhard Homme. Cannabis, cocaine, and visuomotor integration: evidence for a role of dopamine D1 receptors in binding perception and action. Neuropsychologia. vol 46. issue 5. 2008-07-22. PMID:18242650. |
cannabis, cocaine, and visuomotor integration: evidence for a role of dopamine d1 receptors in binding perception and action. |
2008-07-22 |
2023-08-12 |
Not clear |
| Hans Bouwmeester, Mirjam A F M Gerrits, John G Roozemond, Jolanda Snapper, Eric Ronken, Chris G Kruse, Herman G M Westenberg, Jan M van Re. Neonatal basolateral amygdala lesions affect monoamine and cannabinoid brain systems in adult rats. The international journal of neuropsychopharmacology. vol 10. issue 6. 2008-01-02. PMID:17076936. |
dopamine plays a key role in the pathogenesis of schizophrenia, and cannabis use has been implicated in the risk for developing schizophrenia. |
2008-01-02 |
2023-08-12 |
rat |
| Malcolm B Bowers, Joshua T Kantrowit. Elevated plasma dopamine metabolites in cannabis psychosis. The American journal of psychiatry. vol 164. issue 10. 2007-11-01. PMID:17898360. |
elevated plasma dopamine metabolites in cannabis psychosis. |
2007-11-01 |
2023-08-12 |
Not clear |
| Marcello Solinas, Maria Scherma, Liana Fattore, Jessica Stroik, Carrie Wertheim, Gianluigi Tanda, Walter Fratta, Steven R Goldber. Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 21. 2007-06-22. PMID:17522306. |
in rats, systemic administration of the selective alpha7 nicotinic acetylcholine receptor antagonist methyllycaconitine (mla), but not the selective heteromeric non-alpha7 nicotinic acetylcholine receptor antagonist dihydrobetaerythroidine, (1) antagonized the discriminative effects of delta-9-tetrahydrocannabinol (thc), the main active ingredient in cannabis, (2) reduced intravenous self-administration of the synthetic cannabinoid cb1 receptor agonist win55,212-2 [(r)-(+)-[2,3-dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone, mesylate salt], and (3) decreased thc-induced dopamine elevations in the shell of the nucleus accumbens. |
2007-06-22 |
2023-08-12 |
rat |
| Virgina M Pickel, Jane Chan, Christopher S Kearn, Kenneth Macki. Targeting dopamine D2 and cannabinoid-1 (CB1) receptors in rat nucleus accumbens. The Journal of comparative neurology. vol 495. issue 3. 2006-04-28. PMID:16440297. |
these distributions have direct relevance to the rewarding and euphoric as well as motor effects produced by marijuana and by addictive drugs enhancing dopamine levels in the acb. |
2006-04-28 |
2023-08-12 |
rat |
| Xinyu Wang, Diana Dow-Edwards, Virginia Anderson, Howard Minkoff, Yasmin L Hur. In utero marijuana exposure associated with abnormal amygdala dopamine D2 gene expression in the human fetus. Biological psychiatry. vol 56. issue 12. 2005-03-14. PMID:15601599. |
in utero marijuana exposure associated with abnormal amygdala dopamine d2 gene expression in the human fetus. |
2005-03-14 |
2023-08-12 |
human |
| Christopher D Verrico, J David Jentsch, Robert H Rot. Persistent and anatomically selective reduction in prefrontal cortical dopamine metabolism after repeated, intermittent cannabinoid administration to rats. Synapse (New York, N.Y.). vol 49. issue 1. 2003-07-17. PMID:12710016. |
thus, the cognitive dysfunction produced by heavy, long-term cannabis use may be subserved, in part, by drug-induced alterations in frontal cortical dopamine turnover. |
2003-07-17 |
2023-08-12 |
rat |