| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sherri Cofield Kroll, Carole Frances Bennett, Tarah Winter Klinefelte. Update on Neurodegenerative Diseases and Glutamate: A PMHNP Single Case Study Report of a Diagnostically Complex Adult Patient, Interventions, and Unexpected Outcomes. Journal of the American Psychiatric Nurses Association. 2021-07-09. PMID:34238041. |
while dysfunction of serotonin and dopamine neurotransmitters has been studied in depth, in regard to the etiology of mental illness, the neurotransmitter glutamate and its dysfunction is now being explored as contributing to neurodegenerative psychiatric diseases, schizophrenia, autism, depression, and alzheimer's disease. |
2021-07-09 |
2023-08-13 |
Not clear |
| Jarid Goodma. Place vs. Response Learning: History, Controversy, and Neurobiology. Frontiers in behavioral neuroscience. vol 14. 2021-07-04. PMID:33643005. |
an exhaustive review of the neurotransmitter systems underlying place and response learning is subsequently provided, indicating important roles for glutamate, dopamine, acetylcholine, cannabinoids, and estrogen. |
2021-07-04 |
2023-08-13 |
human |
| Nabeel Ali, Amna Syeda, Tenzin Topgyal, Naseem Gaur, Asimul Isla. Parkinson's disease: A current perspectives on Parkinson's disease and key bioactive natural compounds as future potential drug candidates. Current drug targets. 2021-06-24. PMID:34165406. |
the hallmark of pd includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. |
2021-06-24 |
2023-08-13 |
Not clear |
| Jochen Michely, Shivakumar Viswanathan, Tobias U Hauser, Laura Delker, Raymond J Dolan, Christian Grefke. The role of dopamine in dynamic effort-reward integration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32268344. |
when deciding to act, the neurotransmitter dopamine is implicated in a valuation of prospective effort and reward. |
2021-06-23 |
2023-08-13 |
human |
| Yifeng Cheng, Xueyi Xie, Jiayi Lu, Himanshu Gangal, Wei Wang, Sebastian Melo, Xuehua Wang, Jared Jerger, Kayla Woodson, Eric Garr, Yufei Huang, Patricia Janak, Jun Wan. Optogenetic induction of orbitostriatal long-term potentiation in the dorsomedial striatum elicits a persistent reduction of alcohol-seeking behavior in rats. Neuropharmacology. vol 191. 2021-06-23. PMID:33894220. |
striatal synaptic plasticity is modulated by several critical neurotransmitter receptors, including dopamine d1 receptors (d1rs) and adenosine a2a receptors (a2ars). |
2021-06-23 |
2023-08-13 |
rat |
| Rupinder Kaur Sodhi, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Ranjana Bhandari, Baldeep Kumar, Anurag Kuha. IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson's disease. Neurotoxicology. vol 84. 2021-06-22. PMID:33774066. |
also, restoration of neurotransmitter levels (dopamine and homovanillic acid) in the striatum and increased striatal bdnf levels were observed. |
2021-06-22 |
2023-08-13 |
Not clear |
| Yuanhui Zhu, Fei Huan, Junfeng Wang, Xuexue Xie, Guoqin Yu, Xi Wang, Lei Jiang, Rong Gao, Hang Xiao, Haixia Ding, Jun Wan. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson's Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis. ACS chemical neuroscience. vol 11. issue 20. 2021-06-18. PMID:32926778. |
meanwhile, the tryptophan (trp) and tyrosine (tyr) neurotransmitter metabolites involving kynurenine (kyn), serotonin (5-ht), and dopamine (da) pathways were significantly changed in serum. |
2021-06-18 |
2023-08-13 |
mouse |
| Kristy R Howell, Amanda J La. Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental programming during development. Schizophrenia research. vol 217. 2021-06-17. PMID:31522868. |
schizophrenia (scz) is considered a highly polygenic, neurodevelopmental disorder associated with impaired neural circuit development, neurocognitive function and variations in neurotransmitter signaling systems, including dopamine. |
2021-06-17 |
2023-08-13 |
Not clear |
| Mohammad Shimia, Arad Iranmehr, Amir Valizadeh, Farhad Mirzaei, Mohamad Namvar, Ebrahim Rafiei, Ahsan Rahimi, Aida Khadivi, Kamkar Aeinfa. A placebo-controlled randomized clinical trial of amantadine hydrochloride for evaluating the functional improvement of patients following severe acute traumatic brain injury. Journal of neurosurgical sciences. 2021-06-11. PMID:34114429. |
considering the known derangements in the dopaminergic neurotransmitter systems following traumatic brain injury (tbi), dopamine agonists are used as a pharmacologic option. |
2021-06-11 |
2023-08-13 |
Not clear |
| Jens Häggman Henrikson, Ana Rita Pombo Antunes, Tadeusz Wieloch, Karsten Rusche. Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice. Brain research bulletin. vol 155. 2021-06-03. PMID:31805305. |
this study investigates if dopamine might affect plasticity by having a direct effect on synaptic plasticity through alterations in neurotransmitter release and re-uptake. |
2021-06-03 |
2023-08-13 |
mouse |
| Kasthuri Bai Magalingam, Ammu Kutty Radhakrishnan, Sushela Devi Somanath, Shadab Md, Nagaraja Haleagrahar. Influence of serum concentration in retinoic acid and phorbol ester induced differentiation of SH-SY5Y human neuroblastoma cell line. Molecular biology reports. vol 47. issue 11. 2021-06-02. PMID:33098048. |
cells differentiated with ra/tpa or ra differentiated showed increased production of the α-synuclein (snca) neuroprotein and dopamine neurotransmitter compared to undifferentiated cells, regardless serum concentrations used. |
2021-06-02 |
2023-08-13 |
human |
| T V Davydova, M A Gruden, V S Kudrin, V B Narkevich, L A Vetrile, I A Zakharova, R D E Sewel. Antibodies to Glutamate Facilitate Spatial Memory Formation in the Morris Water Maze in Aging C57BL/6 mice. Bulletin of experimental biology and medicine. vol 169. issue 1. 2021-06-01. PMID:32474668. |
in animals treated with glutamate antibodies, the content of serotonin and dopamine metabolites 3-mt and hva in the hippocampus decreased, but no changes in the metabolism of neurotransmitter acids were revealed. |
2021-06-01 |
2023-08-13 |
mouse |
| Ariadna Jiménez-González, Claudia Gómez-Acevedo, Abraham Ochoa-Aguilar, Anahí Chavarrí. The Role of Glia in Addiction: Dopamine as a Modulator of Glial Responses in Addiction. Cellular and molecular neurobiology. 2021-05-31. PMID:34057683. |
dopamine is the pivotal neurotransmitter involved in neuronal drug reward mechanisms and its neuronal mechanisms have been intensely investigated in recent years. |
2021-05-31 |
2023-08-13 |
Not clear |
| Zhao-Yan Cheng, Qing-Peng Xia, Yu-Hui Hu, Chen Wang, Ling H. Dopamine D1 receptor agonist A-68930 ameliorates Aβ International immunopharmacology. vol 88. 2021-05-27. PMID:33182028. |
dopamine is an important catecholaminergic neurotransmitter that controls movement, reward, motivation, and cognition. |
2021-05-27 |
2023-08-13 |
Not clear |
| Zhifeng Zhong, Simin Zhou, Bin Xiang, Yu Wu, Jiaxin Xie, Peng L. Association of Peripheral Plasma Neurotransmitters with Cognitive Performance in Chronic High-altitude Exposure. Neuroscience. vol 463. 2021-05-19. PMID:33540052. |
consistent with this result, peripheral plasma dopa, dopamine, serotonin, 5-hiaa and glutamate were associated with brain neurotransmitter levels after chronic hh exposure in rats. |
2021-05-19 |
2023-08-13 |
rat |
| Zuoli Sun, Qijing Bo, Zhen Mao, Feng Li, Fan He, Christine Pao, Wenbiao Li, Yi He, Xin Ma, Chuanyue Wan. Reduced Plasma Dopamine-β-Hydroxylase Activity Is Associated With the Severity of Bipolar Disorder: A Pilot Study. Frontiers in psychiatry. vol 12. 2021-05-18. PMID:33995135. |
dopamine-β-hydroxylase (dβh) is an enzyme converting dopamine to norepinephrine, a key neurotransmitter in mood disorders, such as major depressive disorder (mdd) and bipolar disorder (bd). |
2021-05-18 |
2023-08-13 |
Not clear |
| Muhammed Khairujjaman Mazumder, Anupom Borah, Shuvasish Choudhur. Inhibitory potential of plant secondary metabolites on anti-Parkinsonian drug targets: Relevance to pathophysiology, and motor and non-motor behavioural abnormalities. Medical hypotheses. vol 137. 2021-05-14. PMID:31954292. |
parkinson's disease (pd), a progressive neurodegenerative motor disorder, is caused due to the loss of dopaminergic neurons in the substantia nigra pars compacta region of mid-brain and the resultant depletion of the levels of the neurotransmitter dopamine. |
2021-05-14 |
2023-08-13 |
Not clear |
| Pitchaimani Veerakumar, Shaktivel Manavalan, Shen-Ming Chen, Alagarsamy Pandikumar, King-Chuen Li. Ultrafine Bi-Sn nanoparticles decorated on carbon aerogels for electrochemical simultaneous determination of dopamine (neurotransmitter) and clozapine (antipsychotic drug). Nanoscale. vol 12. issue 43. 2021-05-14. PMID:33141140. |
ultrafine bi-sn nanoparticles decorated on carbon aerogels for electrochemical simultaneous determination of dopamine (neurotransmitter) and clozapine (antipsychotic drug). |
2021-05-14 |
2023-08-13 |
rat |
| Andrea Fabbrini, Andrea Guerr. Pathophysiological Mechanisms and Experimental Pharmacotherapy for L-Dopa-Induced Dyskinesia. Journal of experimental pharmacology. vol 13. 2021-05-08. PMID:33953618. |
recent advances in the understanding of the pathophysiological mechanisms underlying lid suggest that abnormalities in multiple neurotransmitter systems, in addition to dopaminergic nigrostriatal denervation and altered dopamine release and reuptake dynamics at the synaptic level, are involved in lid development. |
2021-05-08 |
2023-08-13 |
Not clear |
| Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U Mahajani, Kalyan S Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, Sebastian Kügle. Dopamine promotes the neurodegenerative potential of β-synuclein. Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:32730640. |
we show that in cultured rodent and human neurons a dopaminergic neurotransmitter phenotype substantially enhanced β-syn-induced neurodegeneration, irrespective if dopamine is synthesized within neurons or up-taken from extracellular space. |
2021-05-04 |
2023-08-13 |
human |