| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margaret J Gill, Shannon M Ghee, Stiles M Harper, Ronald E Se. Inactivation of the lateral habenula reduces anxiogenic behavior and cocaine seeking under conditions of heightened stress. Pharmacology, biochemistry, and behavior. vol 111. 2014-06-13. PMID:23969093. |
here, we reversibly inactivated the lhb with gaba receptor agonists (baclofen/muscimol) in rats prior to testing in an open field, elevated plus maze, and defensive burying task in the presence or absence of yohimbine, a noradrenergic α2-receptor antagonist that acts as an anxiogenic stressor. |
2014-06-13 |
2023-08-12 |
rat |
| Andrew J Muzyk, Suzanne Kerns, Scott Brudney, Jane P Gagliard. Dexmedetomidine for the treatment of alcohol withdrawal syndrome: rationale and current status of research. CNS drugs. vol 27. issue 11. 2014-06-02. PMID:23975661. |
dexmedetomidine targets the noradrenergic system, an important but frequently overlooked secondary mechanism in the development of aws, and, in doing so, may reduce the need for excessive benzodiazepine use which can increase the risk of γ-aminobutyric acid (gaba)-mediated deliriogenesis and respiratory depression. |
2014-06-02 |
2023-08-12 |
Not clear |
| Michela Di Mauro, Guido Li Volsi, Flora Licat. Noradrenergic control of neuronal firing in cerebellar nuclei: modulation of GABA responses. Cerebellum (London, England). vol 12. issue 3. 2013-12-04. PMID:23096094. |
noradrenergic control of neuronal firing in cerebellar nuclei: modulation of gaba responses. |
2013-12-04 |
2023-08-12 |
rat |
| Michela Di Mauro, Guido Li Volsi, Flora Licat. Noradrenergic control of neuronal firing in cerebellar nuclei: modulation of GABA responses. Cerebellum (London, England). vol 12. issue 3. 2013-12-04. PMID:23096094. |
the alpha2 noradrenergic receptor agonist clonidine mimicked the depressive effect of na on gaba responses in mn and pin and its enhancing effects in ain and ln, while the alpha2 antagonist yohimbine partially blocked these effects. |
2013-12-04 |
2023-08-12 |
rat |
| Hiroshi Kawai, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumot. Behavioral and biochemical characterization of rats treated chronically with thioacetamide: proposal of an animal model for hepatic encephalopathy associated with cirrhosis. The Journal of toxicological sciences. vol 37. issue 6. 2013-06-21. PMID:23208432. |
in biochemical analyses, the taa rats exhibited elevated blood levels of ammonia, and increased metabolic activities of serotonergic and noradrenergic neurons in the brain, while the levels of glu and gaba were not affected. |
2013-06-21 |
2023-08-12 |
rat |
| E Del Cid-Pellitero, B E Jone. Immunohistochemical evidence for synaptic release of GABA from melanin-concentrating hormone containing varicosities in the locus coeruleus. Neuroscience. vol 223. 2013-05-01. PMID:22890079. |
our results suggest that although mch neurons can influence noradrenergic lc neurons through paracrine release and indirect effects of their peptide, they can also do so through synaptic release and direct postsynaptic effects of gaba and thus serve to inhibit the lc neurons during sleep, when they are silent, and the mch neurons discharge. |
2013-05-01 |
2023-08-12 |
Not clear |
| b' Noem\\xc3\\xad Rueda, Jes\\xc3\\xbas Fl\\xc3\\xb3rez, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural plasticity. vol 2012. 2013-04-03. PMID:22685678.' |
enhanced inhibition due to alterations in gaba(a)-mediated transmission and disturbances in the glutamatergic, noradrenergic and cholinergic systems, among others, has also been demonstrated. |
2013-04-03 |
2023-08-12 |
mouse |
| Humberto Salgado, Francisco Garcia-Oscos, Laura Martinolich, Shawn Hall, Robert Restom, Kuei Y Tseng, Marco Atzor. Pre- and postsynaptic effects of norepinephrine on γ-aminobutyric acid-mediated synaptic transmission in layer 2/3 of the rat auditory cortex. Synapse (New York, N.Y.). vol 66. issue 1. 2012-03-07. PMID:21905124. |
noradrenergic terminals from the locus coeruleus release norepinephrine (ne) throughout most brain areas, including the auditory cortex, where they affect neural processing by modulating numerous cellular properties including the inhibitory γ-aminobutyric acid (gaba)ergic transmission. |
2012-03-07 |
2023-08-12 |
rat |
| Nicole L Corteen, Tomilola M Cole, Ayshia Sarna, Werner Sieghart, Jerome D Swinn. Localization of GABA-A receptor alpha subunits on neurochemically distinct cell types in the rat locus coeruleus. The European journal of neuroscience. vol 34. issue 2. 2012-01-05. PMID:21692880. |
here, we show that the gaba(a)r alpha1 subunit is expressed exclusively in neurochemically and morphologically diverse non-noradrenergic cell types within the lc, which may innervate the principal noradrenergic cells. |
2012-01-05 |
2023-08-12 |
rat |
| Nicole L Corteen, Tomilola M Cole, Ayshia Sarna, Werner Sieghart, Jerome D Swinn. Localization of GABA-A receptor alpha subunits on neurochemically distinct cell types in the rat locus coeruleus. The European journal of neuroscience. vol 34. issue 2. 2012-01-05. PMID:21692880. |
in contrast, non-overlapping gaba(a)r alpha2 and alpha3 subunit-immunoreactive puncta were enriched on noradrenergic dendrites and, to a lesser extent, on somata. |
2012-01-05 |
2023-08-12 |
rat |
| Christina Herold, Nicola Palomero-Gallagher, Burkhard Hellmann, Sven Kröner, Carsten Theiss, Onur Güntürkün, Karl Zille. The receptor architecture of the pigeons' nidopallium caudolaterale: an avian analogue to the mammalian prefrontal cortex. Brain structure & function. vol 216. issue 3. 2011-12-12. PMID:21293877. |
here we analyzed binding-site densities of glutamatergic ampa, nmda and kainate receptors, gabaergic gaba(a), muscarinic m(1), m(2) and nicotinic (nach) receptors, noradrenergic α(1) and α(2), serotonergic 5-ht(1a) and dopaminergic d(1)-like receptors using quantitative in vitro receptor autoradiography. |
2011-12-12 |
2023-08-12 |
human |
| S P S Ghuman, R Morris, D G Spiller, R F Smith, H Dobso. Integration between different hypothalamic nuclei involved in stress and GnRH secretion in the ewe. Reproduction in domestic animals = Zuchthygiene. vol 45. issue 6. 2011-06-02. PMID:19602180. |
in conclusion, neuroanatomical evidence is provided for the ewe supporting the hypothesis that brainstem noradrenergic and hypothalamic gaba neurones are important in modulating the activity of crh and avp neurones in the paraventricular nucleus, as well as β-endorphin neurones in the arcuate nucleus. |
2011-06-02 |
2023-08-12 |
Not clear |
| X F Li, A M I Knox, K T O'Byrn. Corticotrophin-releasing factor and stress-induced inhibition of the gonadotrophin-releasing hormone pulse generator in the female. Brain research. vol 1364. 2011-03-21. PMID:20727865. |
although the precise sites and mechanisms of action remain to be elucidated, noradrenergic and gamma-amino-butyric acid (gaba) neurones are implicated in the system's regulation, and opioids and kisspeptin in the medial preoptic area (mpoa) and hypothalamic arcuate nucleus (arc) may operate downstream of the crf neuronal system. |
2011-03-21 |
2023-08-12 |
rat |
| Andres M Kanne. Depression and epilepsy: A bidirectional relation? Epilepsia. vol 52 Suppl 1. 2011-01-31. PMID:21214536. |
these mechanisms include a hyperactive hypothalamic-pituitary-adrenal (hpa) axis and its neuroanatomic and neuropathologic complications, as well as disturbances in serotonergic, noradrenergic, γ-aminobutyric acid (gaba)ergic and glutamatergic neurotransmitter systems, all of which may be interrelated. |
2011-01-31 |
2023-08-12 |
Not clear |
| Yoshiyuki Hattori, Naotetsu Kanamoto, Kumi Kawano, Hiroshi Iwakura, Masakatsu Sone, Masako Miura, Akihiro Yasoda, Naohisa Tamura, Hiroshi Arai, Takashi Akamizu, Kazuwa Nakao, Yoshie Maitan. Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma. International journal of oncology. vol 37. issue 3. 2010-11-30. PMID:20664939. |
to compare mouse adrenal tumors and human pheochromacytoma, we found that the expressions of noradrenergic neuron-related genes, including dopa decarboxylase, phenylethanolamine-n-methyltransferase and chromogranin b, were up-regulated in humans but not in mice; however, the expression of neuroblastoma-related genes, including mycn, paired-like homeobox 2b, gamma-aminobutyric acid a receptor beta3 subunit, islet 1 and kinesin family member 1a, was up-regulated in both species. |
2010-11-30 |
2023-08-12 |
mouse |
| Q Nai, H W Dong, C Linster, M Enni. Activation of alpha1 and alpha2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20466037. |
the differential affinities of alpha1 and alpha2 noradrenergic receptor subtypes may allow for differential modulation of gaba release and olfactory processing as a function of the level of ne release, which in turn, is regulated by behavioral state. |
2010-11-23 |
2023-08-12 |
rat |
| Hong Wei, Hanna Viisanen, Antti Pertovaar. Descending modulation of neuropathic hypersensitivity by dopamine D2 receptors in or adjacent to the hypothalamic A11 cell group. Pharmacological research. vol 59. issue 5. 2009-08-26. PMID:19416636. |
the results indicate that activation of the dopamine d2 receptor in a11 may selectively suppress neuropathic hypersensitivity, due to mechanisms that involve gaba(a) receptors in the hypothalamus and descending noradrenergic pathways acting on spinal alpha(2)-adrenoceptors, possibly together with a slight contribution of descending serotoninergic pathways acting on spinal 5-ht(1a) receptors. |
2009-08-26 |
2023-08-12 |
rat |
| Aleksandra Bortel, Lucyna Słomian, Dariusz Nitka, Michał Swierszcz, Mirella Jaksz, Beata Adamus-Sitkiewicz, Przemysław Nowak, Jadwiga Jośko, Richard M Kostrzewa, Ryszard Bru. Neonatal N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) treatment modifies the vulnerability to phenobarbital- and ethanol-evoked sedative-hypnotic effects in adult rats. Pharmacological reports : PR. vol 60. issue 3. 2009-01-15. PMID:18622057. |
to study the influence of the central noradrenergic system on sensitivity to sedative-hypnotic effects mediated by the aminobutyric acid (gaba) system, intact rats were contrasted with rats in which noradrenergic nerves were largely destroyed shortly after birth with the neurotoxin dsp-4 [n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine; 50 mg/kg sc x2, p1 and p3]. |
2009-01-15 |
2023-08-12 |
rat |
| Aleksandra Bortel, Lucyna Słomian, Dariusz Nitka, Michał Swierszcz, Mirella Jaksz, Beata Adamus-Sitkiewicz, Przemysław Nowak, Jadwiga Jośko, Richard M Kostrzewa, Ryszard Bru. Neonatal N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) treatment modifies the vulnerability to phenobarbital- and ethanol-evoked sedative-hypnotic effects in adult rats. Pharmacological reports : PR. vol 60. issue 3. 2009-01-15. PMID:18622057. |
these findings indicate that the noradrenergic system exerts a prominent influence on sedative-hypnotics acting via gabaergic systems in the brain without directly altering gaba levels in the brain. |
2009-01-15 |
2023-08-12 |
rat |
| Max Sizemore, David J Perke. Noradrenergic and GABA B receptor activation differentially modulate inputs to the premotor nucleus RA in zebra finches. Journal of neurophysiology. vol 100. issue 1. 2008-11-05. PMID:18463188. |
noradrenergic and gaba b receptor activation differentially modulate inputs to the premotor nucleus ra in zebra finches. |
2008-11-05 |
2023-08-12 |
Not clear |