| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Johnson, E Robert. Proline, glutamate and glutamine metabolism in mouse brain synaptosomes. Brain research. vol 323. issue 2. 1985-04-15. PMID:6151865. |
[3h]arg can be converted in mouse brain nerve terminals to orn, which in turn gives rise to glu, pro and gaba. |
1985-04-15 |
2023-08-12 |
mouse |
| Y Yoneda, E Robert. A new synaptosomal biosynthetic pathway of proline from ornithine and its negative feedback inhibition by proline. Brain research. vol 239. issue 2. 1982-09-10. PMID:6124304. |
incubation of [3h]orn with the sonicated mouse brain p2 fraction not only resulted in the extensive formation of [3h]pro, but also yielded [3h]glu and [3h]gaba. |
1982-09-10 |
2023-08-12 |
mouse |
| Y Yoneda, E Robert. A new synaptosomal biosynthetic pathway of proline from ornithine and its negative feedback inhibition by proline. Brain research. vol 239. issue 2. 1982-09-10. PMID:6124304. |
in vitro addition of pro (0.1-1 mm) inhibited the formation of [3h]pro from [3h]orn to the extent of 40-75%, while increasing the accumulations of [3h]glu and [3h]gaba without affecting the consumption of [3h]orn. |
1982-09-10 |
2023-08-12 |
mouse |
| Y Yoneda, E Roberts, G W Diet. A new synaptosomal biosynthetic pathway of glutamate and GABA from ornithine and its negative feedback inhibition by GABA. Journal of neurochemistry. vol 38. issue 6. 1982-07-22. PMID:6122722. |
formation of each of these three major amino acids from [3h]orn was strongly inhibited by the addition of gaba (1-5 mm). |
1982-07-22 |
2023-08-12 |
mouse |
| Y Yoneda, E Roberts, G W Diet. A new synaptosomal biosynthetic pathway of glutamate and GABA from ornithine and its negative feedback inhibition by GABA. Journal of neurochemistry. vol 38. issue 6. 1982-07-22. PMID:6122722. |
these results clearly show that one of the molecular mechanisms underlying the negative feedback inhibition of synaptosomal gaba biosynthesis from orn is a competitive inhibition by gaba of the brain oat activity that is responsible for the formation of l-glutamic-gamma-semialdehyde in equilibrium with l-delta 1-pyrroline-5-carboxylic acid from orn. |
1982-07-22 |
2023-08-12 |
mouse |
| Y Yoneda, E Roberts, G W Diet. A new synaptosomal biosynthetic pathway of glutamate and GABA from ornithine and its negative feedback inhibition by GABA. Journal of neurochemistry. vol 38. issue 6. 1982-07-22. PMID:6122722. |
in sonicates of mouse brain synaptosomes, we demonstrated that gamma-aminobutyric acid (gaba) can be formed when l-ornithine (orn) through l-glutamic acid (glu), but not through putrescine (put). |
1982-07-22 |
2023-08-12 |
mouse |
| Y Yoneda, E Roberts, G W Diet. A new synaptosomal biosynthetic pathway of glutamate and GABA from ornithine and its negative feedback inhibition by GABA. Journal of neurochemistry. vol 38. issue 6. 1982-07-22. PMID:6122722. |
incubation of these sonicates with [3h]orn yielded not only [3h]glu and [3h]l-proline (pro) but also produced [3h]gaba from the [3h]glu. |
1982-07-22 |
2023-08-12 |
mouse |
| Y Yoneda, E Roberts, G W Diet. A new synaptosomal biosynthetic pathway of glutamate and GABA from ornithine and its negative feedback inhibition by GABA. Journal of neurochemistry. vol 38. issue 6. 1982-07-22. PMID:6122722. |
thus, the results suggest that gaba may play an important role in restricting the metabolic flow from orn to glu and thence to gaba. |
1982-07-22 |
2023-08-12 |
mouse |
| Y Yoneda, E Roberts, G W Diet. A new synaptosomal biosynthetic pathway of glutamate and GABA from ornithine and its negative feedback inhibition by GABA. Journal of neurochemistry. vol 38. issue 6. 1982-07-22. PMID:6122722. |
the inhibition of gaba was competitive with orn. |
1982-07-22 |
2023-08-12 |
mouse |
| S Silbernag. Renal transport of amino acids. Klinische Wochenschrift. vol 57. issue 19. 1980-03-24. PMID:392175. |
specificity: separate transport mechanisms exist for a) the "acidic" aa (glu and asp); b) the "dibasic" aa (arg, lys, orn); c) cystine/cystine; d) the "imino" acids (pro, oh-pro and other n-substituted aa); e) the beta- and gamma-aa (beta-ala, gaba, taurine); f) all other "neutral" aa. |
1980-03-24 |
2023-08-11 |
Not clear |