| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Angioni, Cristina Cocco, Gian-Luca Ferri, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. Involvement of nigral oxytocin in locomotor activity: A behavioral, immunohistochemical and lesion study in male rats. Hormones and behavior. vol 83. 2017-09-07. PMID:27189764. |
since oxytocin-saporin injected into the substantia nigra caused a marked reduction of neurons immunoreactive for tyrosine hydroxylase (e.g., nigrostriatal dopaminergic neurons) and for vesicular glutamate transporters vglut1, vglut2 and vglut3 (e.g., glutamatergic neurons), but not for glutamic acid decarboxylase (e.g., gabaergic neurons), together these findings suggest that oxytocin influences locomotor activity by acting on receptors localized presynaptically in nigral glutamatergic nerve terminals (which control the activity of nigral gabaergic efferent neurons projecting to brain stem nuclei controlling locomotor activity), rather than on receptors localized in the cell bodies/dendrites of nigrostriatal dopaminergic neurons. |
2017-09-07 |
2023-08-13 |
rat |
| Jérôme Mairesse, Eleonora Gatta, Marie-Line Reynaert, Jordan Marrocco, Sara Morley-Fletcher, Marion Soichot, Lucie Deruyter, Gilles Van Camp, Hammou Bouwalerh, Francesca Fagioli, Anna Pittaluga, Delphine Allorge, Ferdinando Nicoletti, Stefania Maccar. Activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats. Psychoneuroendocrinology. vol 62. 2016-08-24. PMID:26231445. |
activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats. |
2016-08-24 |
2023-08-13 |
rat |
| Jérôme Mairesse, Eleonora Gatta, Marie-Line Reynaert, Jordan Marrocco, Sara Morley-Fletcher, Marion Soichot, Lucie Deruyter, Gilles Van Camp, Hammou Bouwalerh, Francesca Fagioli, Anna Pittaluga, Delphine Allorge, Ferdinando Nicoletti, Stefania Maccar. Activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats. Psychoneuroendocrinology. vol 62. 2016-08-24. PMID:26231445. |
here, we have found that activation of presynaptic oxytocin receptor with the potent agonist, carbetocin, enhanced depolarization-evoked glutamate release in the ventral hippocampus with no effect on gaba release. |
2016-08-24 |
2023-08-13 |
rat |
| Polymnia Georgiou, Panos Zanos, Mazdak Ehteramyan, Susanna Hourani, Ian Kitchen, Rafael Maldonado, Alexis Baile. Differential regulation of mGlu5 R and ΜOPr by priming- and cue-induced reinstatement of cocaine-seeking behaviour in mice. Addiction biology. vol 20. issue 5. 2016-06-01. PMID:25522112. |
given the evidence implicating the metabotropic glutamate receptor 5 (mglu5 r), μ-opioid receptor (mopr), κ-opioid receptor (Κopr) and oxytocin receptor (otr) systems in cocaine addiction and relapse, our aim was to assess the modulation of these receptors using a mouse model of cue- and priming-induced reinstatement of cocaine seeking. |
2016-06-01 |
2023-08-13 |
mouse |
| Kirsteen N Browning, Tanja Babic, Luca Toti, Gregory M Holmes, F Holly Coleman, R Alberto Travagl. Plasticity in the brainstem vagal circuits controlling gastric motor function triggered by corticotropin releasing factor. The Journal of physiology. vol 592. issue 20. 2016-05-16. PMID:25128570. |
we have shown recently that the ability of the anti-stress neuropeptide oxytocin (oxt) to modulate vagal brainstem circuits undergoes short-term plasticity via alterations in camp levels subsequent to vagal afferent fibre-dependent activation of metabotropic glutamate receptors. |
2016-05-16 |
2023-08-13 |
rat |
| Ivana Mesic, Yomayra F Guzman, Anita L Guedea, Vladimir Jovasevic, Kevin A Corcoran, Katherine Leaderbrand, Katsuhiko Nishimori, Anis Contractor, Jelena Radulovi. Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 10. 2016-05-09. PMID:25824423. |
here we investigated how gq-protein-coupled metabotropic glutamate receptor 5 (mglur5) and oxytocin receptor (oxtr) affect social affiliation and social memory. |
2016-05-09 |
2023-08-13 |
Not clear |
| A Rubio-Casillas, C M Rodríguez-Quintero, G Rodríguez-Manzo, A Fernández-Guast. Unraveling the modulatory actions of serotonin on male rat sexual responses. Neuroscience and biobehavioral reviews. vol 55. 2016-03-31. PMID:25979142. |
experimental evidence suggests that low 5-ht concentrations produce stimulatory actions on male ejaculatory aspects that might be mediated by the blockade of the gabaergic neurotransmission in the mpoa and spinal cord, which in turn releases a tonic inhibition that allows other neurotransmitters such as glutamate, noradrenaline, oxytocin and dopamine to initiate a sequence of molecular events resulting in the expression of ejaculation. |
2016-03-31 |
2023-08-13 |
rat |
| Ramón A Piñol, Heather Jameson, Anastas Popratiloff, Norman H Lee, David Mendelowit. Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons. PloS one. vol 9. issue 11. 2015-12-15. PMID:25379676. |
we also demonstrate that while a single photoactivation of pvn terminals only activates glutamatergic receptors in brainstem cardiac vagal neurons (cvns), neurons that dominate the neural control of heart rate, both the paired pulse facilitation, and sustained enhancement of glutamate release in this pathway is mediated by activation of oxytocin receptors. |
2015-12-15 |
2023-08-13 |
rat |
| N Singewald, C Schmuckermair, N Whittle, A Holmes, K J Ressle. Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders. Pharmacology & therapeutics. vol 149. 2015-12-15. PMID:25550231. |
the purpose of this review is to outline the literature showing how pharmacological interventions targeting neurotransmitter systems including serotonin, dopamine, noradrenaline, histamine, glutamate, gaba, cannabinoids, neuropeptides (oxytocin, neuropeptides y and s, opioids) and other targets (neurotrophins bdnf and fgf2, glucocorticoids, l-type-calcium channels, epigenetic modifications) as well as their downstream signaling pathways, can augment fear extinction and strengthen extinction memory persistently in preclinical models. |
2015-12-15 |
2023-08-13 |
Not clear |
| Luyi Zhou, Wei-Lun Sun, Amy B Young, Kunhee Lee, Jacqueline F McGinty, Ronald E Se. Oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function. The international journal of neuropsychopharmacology. vol 18. issue 1. 2015-09-30. PMID:25539504. |
oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function. |
2015-09-30 |
2023-08-13 |
Not clear |
| T Mannari, S Miyat. Activity-dependent Notch signalling in the hypothalamic-neurohypophysial system of adult mouse brains. Journal of neuroendocrinology. vol 26. issue 8. 2015-04-17. PMID:24943269. |
double-labelling immunohistochemistry using vesicular gaba transporter and glutamate transporter revealed that dll4 was localised at a subpopulation of excitatory and inhibitory axonal boutons against somatodendrites of arginine vasopressin (avp)- and oxytocin (oxt)-containing magnocellular neurones. |
2015-04-17 |
2023-08-13 |
mouse |
| C M Dwye. Maternal behaviour and lamb survival: from neuroendocrinology to practical application. Animal : an international journal of animal bioscience. vol 8. issue 1. 2014-08-11. PMID:24103485. |
oxytocin release causes an increase in the neurotransmitters noradrenaline, acetylcholine, glutamate and γ-aminobutyric acid (gaba) in the olfactory bulb, and other brain regions important for maternal behaviour. |
2014-08-11 |
2023-08-12 |
Not clear |
| Anjana Bali, Amteshwar Singh Jagg. Multifunctional aspects of allopregnanolone in stress and related disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 48. 2014-08-01. PMID:24044974. |
moreover, recent studies have also described the involvement of other multiple targets including brain-derived neurotrophic factor (bdnf), glutamate, dopamine, opioids, oxytocin, and calcium channels. |
2014-08-01 |
2023-08-12 |
Not clear |
| Michael C Andresen, Jessica A Fawley, Mackenzie E Hofman. Peptide and lipid modulation of glutamatergic afferent synaptic transmission in the solitary tract nucleus. Frontiers in neuroscience. vol 6. 2013-01-22. PMID:23335875. |
presynaptic receptors for angiotensin (at1), vasopressin (v1a), oxytocin, opioid (mor), ghrelin (ghsr1), and cholecystokinin differentially control glutamate release on particular subsets of neurons with most other st afferents unaffected. |
2013-01-22 |
2023-08-12 |
Not clear |
| Citlali Trueta, Francisco F De-Migue. Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system. Frontiers in physiology. vol 3. 2012-10-02. PMID:22969726. |
the catalog of these molecules includes low molecular weight transmitters such as monoamines, acetylcholine, glutamate, gama-aminobutiric acid (gaba), adenosine-5-triphosphate (atp), and a list of peptides including substance p, brain-derived neurotrophic factor (bdnf), and oxytocin. |
2012-10-02 |
2023-08-12 |
Not clear |
| Praful S Singru, Gábor Wittmann, Erzsébet Farkas, Györgyi Zséli, Csaba Fekete, Ronald M Lecha. Refeeding-activated glutamatergic neurons in the hypothalamic paraventricular nucleus (PVN) mediate effects of melanocortin signaling in the nucleus tractus solitarius (NTS). Endocrinology. vol 153. issue 8. 2012-10-01. PMID:22700769. |
all refeeding-activated neurons in the pvnv and pvnl expressed the mrna of the glutamatergic marker, type 2 vesicular glutamate transporter (vglut2), indicating their glutamatergic phenotype, but only rare neurons contained oxytocin. |
2012-10-01 |
2023-08-12 |
rat |
| Iain S McGregor, Michael T Bowe. Breaking the loop: oxytocin as a potential treatment for drug addiction. Hormones and behavior. vol 61. issue 3. 2012-06-25. PMID:22198308. |
very recent preclinical studies have illustrated a remarkable ability of exogenously delivered oxytocin to inhibit stimulant and alcohol self-administration, to alter associated drug-induced changes in dopamine, glutamate and fos expression in cortical and basal ganglia sites, and to prevent stress and priming-induced relapse to drug seeking. |
2012-06-25 |
2023-08-12 |
Not clear |
| Yang Yao, Li-Ying Fu, Xiaobing Zhang, Anthony N van den Po. Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons. American journal of physiology. Regulatory, integrative and comparative physiology. vol 302. issue 7. 2012-05-25. PMID:22262306. |
neither vasopressin nor oxytocin showed substantial excitatory actions on lateral hypothalamic inhibitory neurons identified in a glutamate decarboxylase 67 (gad67)-gfp mouse. |
2012-05-25 |
2023-08-12 |
mouse |
| Ipe Nina. Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex. Journal of neurochemistry. vol 119. issue 2. 2011-11-15. PMID:21848811. |
oxytocin produced a significant suppression of glutamatergic neurotransmission in the il-mpfc layer v pyramidal neurons which was mediated by a reduction in glutamate release. |
2011-11-15 |
2023-08-12 |
Not clear |
| G D Griffin, L M Flanagan-Cat. Ovarian hormone action in the hypothalamic ventromedial nucleus: remodelling to regulate reproduction. Journal of neuroendocrinology. vol 23. issue 6. 2011-09-12. PMID:21518031. |
the new working model synthesises the recent evidence for rewiring with insights from electrophysiological and behavioural pharmacological studies that pertain to the roles of oxytocin and glutamate in vmh neural activity and mating behaviour. |
2011-09-12 |
2023-08-12 |
rat |