| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sahar F Mahmoud, Yaser H Elewa, Ahmed G Nomir, Ahmed M Rashwan, Ahmed E Noreldi. Calbindin Has a Potential Spatiotemporal Correlation with Proliferation and Apoptosis in the Postnatal Rat Kidney. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 2023-08-16. PMID:37584523. |
in the neonatal stage (1-day and 1-week-old rats), calbindin showed a positive reaction in the distal convoluted tubule (dct), a short nephron segment between the macula densa, collecting ducts, and tubules. |
2023-08-16 |
2023-09-07 |
rat |
| Valentina Carotti, Wouter H van Megen, Juan P Rigalli, Eric R Barros, Vera Sommers, Luco Rutten, Nico Sommerdijk, Dorien J M Peters, Jenny van Asbeck-van der Wijst, Joost G J Hoendero. Extracellular vesicles contribute to early cyst development in autosomal dominant polycystic kidney disease by cell-to-cell communication. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 7. 2023-05-30. PMID:37249915. |
given that evs are an important communicator between different nephron segments, we hypothesize that evs released from pkd1 knockout distal convoluted tubule (dct) cells can stimulate cyst growth in the downstream collecting duct (cd). |
2023-05-30 |
2023-08-14 |
Not clear |
| E A Gallafassi, M B Bezerra, N A Rebouça. Control of sodium and potassium homeostasis by renal distal convoluted tubules. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 56. 2023-02-15. PMID:36790288. |
wnk4, highly expressed in dct, activates the spak/osr1 kinases, which phosphorylate ncc and other regulatory proteins and transporters in the distal nephron. |
2023-02-15 |
2023-08-14 |
mouse |
| Jessica Paola Bahena-Lopez, Lorena Rojas-Vega, María Chávez-Canales, Silvana Bazua-Valenti, Rocío Bautista-Pérez, Ju-Hye Lee, Magdalena Madero, Natalia Vazquez-Manjarrez, Ivan Alquisiras-Burgos, Arturo Hernandez-Cruz, María Castañeda-Bueno, David H Ellison, Gerardo Gamb. Glucose/Fructose Delivery to the Distal Nephron Activates the Sodium-Chloride Cotransporter Journal of the American Society of Nephrology : JASN. 2022-10-26. PMID:36288902. |
glucose/fructose delivery to the distal nephron activates the sodium-chloride cotransporter the calcium-sensing receptor (casr) in the distal convoluted tubule (dct) activates the nacl cotransporter (ncc). |
2022-10-26 |
2023-08-14 |
Not clear |
| Nourah ALSaleh, Raghad ALJurushi, Rakan Alotaibi, Mohammed Alzahran. Gitelman syndrome: A first published clinical association with chronic pancreatitis, a case report and review of literature. International journal of surgery case reports. vol 91. 2022-01-29. PMID:35091353. |
gitelman syndrome (gs) is an autosomal recessive, salt-losing tubulopathy, also referred to as familial hypokalemia-hypomagnesemia, caused by mutation of genes encoding the sodium chloride cotransporter (ncct) and magnesium transporters in the thiazide sensitive segments of the distal convoluted tubule (dct) of the nephron. |
2022-01-29 |
2023-08-13 |
Not clear |
| Ava M Zapf, Paul R Grimm, Lama Al-Qusairi, Eric Delpire, Paul A Wellin. Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice. Frontiers in physiology. vol 12. 2022-01-24. PMID:35069250. |
studies in fhht mice engineered to constitutively activate spak specifically in the dct (ca-spak mice) revealed maladaptive remodeling of the aldosterone sensitive distal nephron (asdn), characterized by decrease in the potassium excretory channel, renal outer medullary potassium (romk), and epithelial sodium channel (enac), that contributes to the hyperkalemia. |
2022-01-24 |
2023-08-13 |
mouse |
| María Castañeda-Bueno, David H Ellison, Gerardo Gamb. Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule. EMBO molecular medicine. 2021-12-20. PMID:34927382. |
this phenomenon is explained, at least in part, by the interaction between salt reabsorption in the distal convoluted tubule (dct) and potassium secretion in the connecting tubule/collecting duct of the mammalian nephron: in order to achieve adequate k |
2021-12-20 |
2023-08-13 |
Not clear |
| Beatrix Sarkany, Gyula Kovac. Connecting tubules develop from the tip of the ureteric bud in the human kidney. Histochemistry and cell biology. 2021-09-23. PMID:34554322. |
the connecting tubule (cnt) is a unique segment of the nephron connecting the metanephric mesenchyme (mm)-derived distal convoluted tubule (dct) and ureteric bud (ub)-derived collecting duct (cd). |
2021-09-23 |
2023-08-13 |
mouse |
| Xiao-Tong Su, Chao-Ling Yang, David H Elliso. Kidney Is Essential for Blood Pressure Modulation by Dietary Potassium. Current cardiology reports. vol 22. issue 10. 2021-04-23. PMID:32789612. |
recent findings: although the distal convoluted tubule (dct) is a short part of the nephron that reabsorbs salt, via the sodium-chloride cotransporter (ncc), it is highly sensitive to changes in plasma potassium concentration. |
2021-04-23 |
2023-08-13 |
Not clear |
| Jacques Teulon, Wen-Hui Wan. Studying Na Methods in cell biology. vol 153. 2020-05-04. PMID:31395377. |
studying na aldosterone-sensitive distal nephron (asdn) including the distal convoluted tubule (dct), connecting tubule (cnt) and collecting duct (cd) plays an important role in the regulation of hormone-dependent na |
2020-05-04 |
2023-08-13 |
Not clear |
| Wararat Kittikulsuth, Peter A Friedman, Alfred van Hoek, Yang Gao, Donald E Koha. Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells. BMC nephrology. vol 18. issue 1. 2018-05-17. PMID:28882112. |
the distal convoluted tubule (dct) is an important nephron site for parathyroid hormone (pth) and calcitonin regulation of urinary divalent cation excretion. |
2018-05-17 |
2023-08-13 |
Not clear |
| Sebastian Bachmann, Kerim Muti. Regulation of renal Na-(K)-Cl cotransporters by vasopressin. Pflugers Archiv : European journal of physiology. vol 469. issue 7-8. 2018-04-23. PMID:28577072. |
nacl reabsorption in the distal nephron, which includes the thick ascending limb (tal) and distal convoluted tubule (dct), largely depends on the activity of two structurally related na-(k)-cl cotransporters, nkcc2 in tal and ncc in dct. |
2018-04-23 |
2023-08-13 |
Not clear |
| Wen-Hui Wan. Basolateral Kir4.1 activity in the distal convoluted tubule regulates K secretion by determining NaCl cotransporter activity. Current opinion in nephrology and hypertension. vol 25. issue 5. 2018-01-17. PMID:27306796. |
recently, genetic studies and animal models have indicated that inwardly rectifying k channel 4.1 (kir4.1 or kcnj10) in the distal convoluted tubule (dct) may play a role in the regulation of k secretion in the aldosterone-sensitive distal nephron by targeting the nacl cotransporter (ncc). |
2018-01-17 |
2023-08-13 |
Not clear |
| Jeroen H F de Baaij, Andreas Kompatscher, Daan H H M Viering, Caro Bos, René J M Bindels, Joost G J Hoendero. P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis. PloS one. vol 11. issue 6. 2017-07-19. PMID:27254077. |
the purinergic cation channel p2x6 has been previously localized to the distal convoluted tubule (dct), a nephron segment important for mg2+ and na+ reabsorption, but its role in ion transport remains unknown. |
2017-07-19 |
2023-08-13 |
mouse |
| Francesco Trepiccione, Christelle Soukaseum, Anna Iervolino, Federica Petrillo, Miriam Zacchia, Gunther Schutz, Dominique Eladari, Giovambattista Capasso, Juliette Hadchoue. A fate-mapping approach reveals the composite origin of the connecting tubule and alerts on "single-cell"-specific KO model of the distal nephron. American journal of physiology. Renal physiology. vol 311. issue 5. 2017-07-05. PMID:27582101. |
the distal nephron is a heterogeneous part of the nephron composed by six different cell types, forming the epithelium of the distal convoluted (dct), connecting, and collecting duct. |
2017-07-05 |
2023-08-13 |
Not clear |
| Jeroen H F de Baai. The art of magnesium transport. Magnesium research. vol 28. issue 3. 2016-08-18. PMID:26446763. |
within the kidney, the distal convoluted tubule (dct) segment determines the final mg(2+) excretion, since no reabsorption takes place beyond this segment of the nephron. |
2016-08-18 |
2023-08-13 |
mouse |
| Susan M Wal. The role of pendrin in blood pressure regulation. American journal of physiology. Renal physiology. vol 310. issue 3. 2016-06-06. PMID:26538443. |
pendrin is a na(+)-independent cl(-)/hco3(-) exchanger found in the apical regions of type b and non-a, non-b intercalated cells within the aldosterone-sensitive region of the nephron, i.e., the distal convoluted tubule (dct), the connecting tubule (cnt), and the cortical collecting duct (ccd). |
2016-06-06 |
2023-08-13 |
mouse |
| Sophia N Verouti, Emilie Boscardin, Edith Hummler, Simona Fratesch. Regulation of blood pressure and renal function by NCC and ENaC: lessons from genetically engineered mice. Current opinion in pharmacology. vol 21. 2015-12-14. PMID:25613995. |
ncc is responsible for na(+) reabsorption in the distal convoluted tubule (dct) of the nephron, while enac reabsorbs the filtered na(+) in the late dct and in the cortical collecting ducts (ccd) providing the final renal adjustment to na(+) balance. |
2015-12-14 |
2023-08-13 |
mouse |
| James A McCormick, David H Elliso. Distal convoluted tubule. Comprehensive Physiology. vol 5. issue 1. 2015-08-31. PMID:25589264. |
the distal convoluted tubule (dct) is a short nephron segment, interposed between the macula densa and collecting duct. |
2015-08-31 |
2023-08-13 |
human |
| James A McCormick, David H Elliso. Distal convoluted tubule. Comprehensive Physiology. vol 5. issue 1. 2015-08-31. PMID:25589264. |
dct cells are rich in mitochondria, and possess the highest density of na+/k+-atpase along the nephron, where it is expressed on the highly amplified basolateral membranes. |
2015-08-31 |
2023-08-13 |
human |