| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pnina Scherzer, Anca Gal-Moscovici, David Sheikh-Hamad, Mordecai M Popovtze. Sodium-pump gene-expression, protein abundance and enzyme activity in isolated nephron segments of the aging rat kidney. Physiological reports. vol 3. issue 6. 2015-06-09. PMID:26056060. |
na-k-atpase activity (assayed microfluorometrically), mrna (rt-pcr), and protein abundance (immunoblotting) were quantitated in the following isolated nephron segments: pct, pst, mtal, dct, and ccd from 2, 8, 15, and 24 month-old-rats. |
2015-06-09 |
2023-08-13 |
rat |
| Hannsjörg W Seyberth, Karl P Schlingman. Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects. Pediatric nephrology (Berlin, Germany). vol 26. issue 10. 2011-12-21. PMID:21503667. |
two segments along the distal nephron are primarily involved in the pathogenesis of slts: the thick ascending limb of henle's loop, and the distal convoluted tubule (dct). |
2011-12-21 |
2023-08-12 |
Not clear |
| Mayuko Ohno, Keiko Uchida, Teiko Ohashi, Kosaku Nitta, Akihito Ohta, Motoko Chiga, Sei Sasaki, Shinichi Uchid. Immunolocalization of WNK4 in mouse kidney. Histochemistry and cell biology. vol 136. issue 1. 2011-11-08. PMID:21660484. |
by performing double immunofluorescence of wnk4 with several nephron-segment-specific markers, we have found that wnk4 is present in podocytes in glomeruli, the cortical thick ascending limb of henle's loop including macula densa, and the medullary collecting ducts (mcd), in addition to the previously identified nephron segments, i.e., dct and ccd. |
2011-11-08 |
2023-08-12 |
mouse |
| Mayuko Ohno, Keiko Uchida, Teiko Ohashi, Kosaku Nitta, Akihito Ohta, Motoko Chiga, Sei Sasaki, Shinichi Uchid. Immunolocalization of WNK4 in mouse kidney. Histochemistry and cell biology. vol 136. issue 1. 2011-11-08. PMID:21660484. |
these results are consistent with the finding that wnk4 constitutes a kinase cascade with osr1/spak and ncc in the dct, and highlights a novel role for wnk4 in nephron segments newly identified as being wnk4-positive in this study. |
2011-11-08 |
2023-08-12 |
mouse |
| Aparna Renigunta, Vijay Renigunta, Turgay Saritas, Niels Decher, Kerim Mutig, Siegfried Waldegge. Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function. The Journal of biological chemistry. vol 286. issue 3. 2011-02-24. PMID:21081491. |
tamm-horsfall glycoprotein (thgp) or uromodulin is a membrane protein exclusively expressed along the thick ascending limb (tal) and early distal convoluted tubule (dct) of the nephron. |
2011-02-24 |
2023-08-12 |
mouse |
| Sylvain Pradervand, Annie Zuber Mercier, Gabriel Centeno, Olivier Bonny, Dmitri Firso. A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule. Pflugers Archiv : European journal of physiology. vol 460. issue 6. 2011-02-03. PMID:20686783. |
in this review, we present an in-depth analysis of microarray-based gene expression profiles available for microdissected mouse distal nephron segments, i.e., the distal convoluted tubule (dct) and the connecting tubule (cnt), and for the cortical portion of the collecting duct (ccd; zuber et al., proc natl acad sci usa 106:16523-16528, 2009). |
2011-02-03 |
2023-08-12 |
mouse |
| Bob Glaudemans, Nine V A M Knoers, Joost G J Hoenderop, René J M Bindel. New molecular players facilitating Mg(2+) reabsorption in the distal convoluted tubule. Kidney international. vol 77. issue 1. 2010-04-01. PMID:19812536. |
the dct is the final determinant of plasma mg(2+) levels, as the more distal nephron segments are largely impermeable to mg(2+). |
2010-04-01 |
2023-08-12 |
Not clear |
| Annie Mercier Zuber, Gabriel Centeno, Sylvain Pradervand, Svetlana Nikolaeva, Lionel Maquelin, Léonard Cardinaux, Olivier Bonny, Dmitri Firso. Molecular clock is involved in predictive circadian adjustment of renal function. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 38. 2009-11-06. PMID:19805330. |
here, we studied the molecular mechanisms underlying circadian rhythms in the distal nephron segments, i.e., distal convoluted tubule (dct) and connecting tubule (cnt) and the cortical collecting duct (ccd). |
2009-11-06 |
2023-08-12 |
mouse |
| Qi Xi, Joost G J Hoenderop, René J M Bindel. Regulation of magnesium reabsorption in DCT. Pflugers Archiv : European journal of physiology. vol 458. issue 1. 2009-07-24. PMID:18949482. |
the distal convoluted tubule (dct) is the shortest segment of the nephron and consists of an early (dct1) and late part (dct2). |
2009-07-24 |
2023-08-12 |
Not clear |
| Yo-ichi Nabeshim. [Discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis]. Clinical calcium. vol 18. issue 7. 2008-09-26. PMID:18591743. |
unveiled molecular functions of alpha-kl and fgf23 provided answers for several important questions regarding the mechanisms of calcium and phosphate homeostasis that remained to be solved, such as : (i) what is the non-hormonal regulatory system that directly responds to the fluctuation of extracellular ca(2+), (ii) how is na(+), k(+)-atpase activity enhanced in response to low calcium stimuli in the parathyroid glands, (iii) what is the exact role of fgf23 in calcium and phosphorus metabolism, (iv) how is ca(2+) influx through trpv5 controlled in the dct nephron, and finally (v) how is calcium homeostasis regulated in cerebrospinal fluid. |
2008-09-26 |
2023-08-12 |
mouse |
| P Richard Grimm, Ruth M Foutz, Robert Brenner, Steven C Sanso. Identification and localization of BK-beta subunits in the distal nephron of the mouse kidney. American journal of physiology. Renal physiology. vol 293. issue 1. 2007-08-17. PMID:17459953. |
both antibodies (anti-bk-beta4 and anti-gfp) localized bk-beta4 to the thick ascending limb (tal), distal convoluted tubule (dct), and ics of the distal nephron. |
2007-08-17 |
2023-08-12 |
mouse |
| Qiang Leng, Kristopher T Kahle, Jesse Rinehart, Gordon G MacGregor, Frederick H Wilson, Cecilia M Canessa, Richard P Lifton, Steven C Heber. WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). The Journal of physiology. vol 571. issue Pt 2. 2006-07-11. PMID:16357011. |
it is known that wnk3 is expressed in the nephron's distal convoluted tubule (dct) and stimulates ncc activity. |
2006-07-11 |
2023-08-12 |
xenopus_laevis |
| Wei Tian, Michele Salanova, Hongshi Xu, Jessie N Lindsley, Terry T Oyama, Sharon Anderson, Sebastian Bachmann, David M Cohe. Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments. American journal of physiology. Renal physiology. vol 287. issue 1. 2004-07-08. PMID:15026302. |
therefore, trpv4 is expressed in only those nephron segments that are constitutively (i.e., atl, tal, and dct) or conditionally (i.e., collecting duct) water impermeant and where generation of a substantial transcellular osmotic gradient could be expected. |
2004-07-08 |
2023-08-12 |
mouse |
| Nine V A M Knoers, Joke C de Jong, Iwan C Meij, Lambert P W J Van Den Heuvel, Rene J M Bindel. Genetic renal disorders with hypomagnesemia and hypocalciuria. Journal of nephrology. vol 16. issue 2. 2003-08-20. PMID:12768080. |
the defective proteins involved in both diseases are located within the distal convoluted tubule (dct), a segment of the nephron known to play an important role in active magnesium reabsorption in the nephron. |
2003-08-20 |
2023-08-12 |
Not clear |
| Osamu Saito, Youfei Guan, Zhonghua Qi, Linda S Davis, Martin Kömhoff, Yukihiko Sugimoto, Shuh Narumiya, Richard M Breyer, Matthew D Breye. Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract. American journal of physiology. Renal physiology. vol 284. issue 6. 2003-06-20. PMID:12631554. |
intrarenal expression of the fp receptor in the dct and ccd suggests an important role for the fp receptor regulating water and solute transport in these segments of the nephron. |
2003-06-20 |
2023-08-12 |
mouse |
| H Velázquez, T Silva, E Andújar, G V Desir, D H Ellison, R Grege. The distal convoluted tubule of rabbit kidney does not express a functional sodium channel. American journal of physiology. Renal physiology. vol 280. issue 3. 2001-03-22. PMID:11181416. |
we sought to assess whether the distal convoluted tubule (dct) segment of the rabbit nephron expresses a functional epithelial sodium channel. |
2001-03-22 |
2023-08-12 |
rabbit |
| D Andreasen, B L Jensen, P B Hansen, T H Kwon, S Nielsen, O Skøt. The alpha(1G)-subunit of a voltage-dependent Ca(2+) channel is localized in rat distal nephron and collecting duct. American journal of physiology. Renal physiology. vol 279. issue 6. 2001-01-03. PMID:11097617. |
rt-pcr analysis of microdissected rat nephron segments revealed alpha(1g) expression in the distal convoluted tubule (dct), in the connecting tubule and cortical collecting duct (ct+ccd), and inner medullary collecting duct (imcd). |
2001-01-03 |
2023-08-12 |
rat |
| W Yang, P A Friedman, R Kumar, J L Omdahl, B K May, M L Siu-Caldera, G S Reddy, S Christako. Expression of 25(OH)D3 24-hydroxylase in distal nephron: coordinate regulation by 1,25(OH)2D3 and cAMP or PTH. The American journal of physiology. vol 276. issue 4. 1999-05-18. PMID:10198318. |
we conclude that 1) although the pct is the major site of localization of 24ohase, 24ohase mrna and activity can also be localized in the distal nephron; 2) both pth and camp modulate the induction of 24ohase expression by 1,25(oh)2d3 in dct cells in a manner different from that reported in the pct; and 3) in dct cells, upregulation of vdr levels by camp, and not an effect on cres in the 24ohase promoter, is one mechanism involved in the camp-mediated modulation of 24ohase transcription. |
1999-05-18 |
2023-08-12 |
mouse |
| D D Fanestil, D A Vaughn, P Blakel. Metabolic acid-base influences on renal thiazide receptor density. The American journal of physiology. vol 272. issue 6 Pt 2. 1997-08-18. PMID:9227621. |
the result is that delivery of na from dct is enhanced during acidosis and decreased during alkalosis, assisting in compensatory changes in distal nephron secretion of hydrogen ion. |
1997-08-18 |
2023-08-12 |
rat |
| D D Fanestil, D A Vaughn, L Ma, R H Hyde, M P Print. Thiazide diuretics normalize urinary calcium in spontaneously hypertensive male rats. Kidney international. vol 51. issue 4. 1997-06-20. PMID:9083265. |
we postulate that hypercalciuria in shr is a manifestation of incomplete uptake of calcium from the tubule lumen across the apical cell membrane in the dct of the shr nephron. |
1997-06-20 |
2023-08-12 |
rat |