| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Romano, F Borrelli, I Fasolino, R Capasso, F Piscitelli, Mg Cascio, Rg Pertwee, D Coppola, L Vassallo, P Orlando, V Di Marzo, Aa Izz. The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis. British journal of pharmacology. vol 169. issue 1. 2014-09-05. PMID:23373571. |
the cannabinoid trpa1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis. |
2014-09-05 |
2023-08-12 |
Not clear |
| Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhan. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins & other lipid mediators. vol 100-101. 2014-01-24. PMID:23219970. |
cannabinoids have been consistently shown to suppress microglia activation and the release of cytotoxic factors including nitric oxide, superoxide and proinflammatory cytokines. |
2014-01-24 |
2023-08-12 |
Not clear |
| Pál Pacher, Ken Macki. Interplay of cannabinoid 2 (CB2) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegeneration. Journal of molecular medicine (Berlin, Germany). vol 90. issue 4. 2012-08-17. PMID:22371074. |
interplay of cannabinoid 2 (cb2) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegeneration. |
2012-08-17 |
2023-08-12 |
Not clear |
| Jianren Song, Alexandros Kyriakatos, Abdeljabbar El Manir. Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 15. 2012-06-15. PMID:22496555. |
we then show that the polarity of the endocannabinoid modulation is gated by nitric oxide to enable simultaneously potentiation of excitation and depression of inhibition within the spinal locomotor networks. |
2012-06-15 |
2023-08-12 |
Not clear |
| Jianren Song, Alexandros Kyriakatos, Abdeljabbar El Manir. Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 15. 2012-06-15. PMID:22496555. |
our results suggest that endocannabinoid and nitric oxide systems interact to mediate inversion of the polarity of synaptic plasticity within the locomotor networks. |
2012-06-15 |
2023-08-12 |
Not clear |
| Shuxian Hu, Wen S Sheng, Robert Bryan Roc. Immunomodulatory properties of kappa opioids and synthetic cannabinoids in HIV-1 neuropathogenesis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 6. issue 4. 2012-02-29. PMID:21850403. |
based upon findings that synthetic cannabinoids inhibit hiv-1 expression in human microglia and suppress production of inflammatory mediators such as nitric oxide (no) in human astrocytes, as well as a substantial literature demonstrating neuroprotective properties of cannabinoids in other systems, synthetic cannabinoids have also emerged as potential therapeutic agents in hiv neuropathogenesis. |
2012-02-29 |
2023-08-12 |
human |
| Thomas J Younts, Pablo E Castill. The battle over inhibitory synaptic plasticity in satiety brain circuits. Neuron. vol 71. issue 3. 2011-10-18. PMID:21835336. |
new research shows that an animal's satiety state dictates the polarity of long-term inhibitory synaptic plasticity in the hypothalamus, which is mediated by an activity-dependent competition between endocannabinoid and nitric oxide signaling. |
2011-10-18 |
2023-08-12 |
Not clear |
| Alaleh Asghari-Roodsari, Ali Lesani, Mehrak Javadi-Paydar, Leila Tabatabaeefar, Seyed Mohammad Tavangar, Abbas Norouzi, Ahmad Reza Dehpou. Tocolytic effect of delta9-tetrahydrocannabinol in mice model of lipopolysaccharide--induced preterm delivery: role of nitric oxide. Reproductive sciences (Thousand Oaks, Calif.). vol 17. issue 4. 2010-06-24. PMID:20228383. |
in this study, we explained that exogenous cannabinoid, delta(9)-tetrahydrocannabinol (thc), has a preventive effect in a murine model of lipopolysaccharide (lps)-induced preterm delivery and the contribution of nitric oxide (no) pathway as a mechanism involved in this process. |
2010-06-24 |
2023-08-12 |
mouse |
| Andrea De Laurentiis, Javier Fernandez-Solari, Claudia Mohn, Berenice Burdet, María A Zorrilla Zubilete, Valeria Rettor. The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide. Journal of neuroimmunology. vol 221. issue 1-2. 2010-04-23. PMID:20207018. |
anandamide, through its receptors, also increased hypothalamic nitric oxide (no) which inhibited oxt release, ending the stimulatory effect of the endocannabinoid. |
2010-04-23 |
2023-08-12 |
Not clear |
| Shi Di, Marc M Maxson, Alier Franco, Jeffrey G Taske. Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 2. 2009-04-08. PMID:19144839. |
the simultaneous rapid stimulation of nitric oxide and endocannabinoid synthesis by glucocorticoids has important implications for the impact of stress on the brain as well as on neural-immune interactions in the hypothalamus. |
2009-04-08 |
2023-08-12 |
Not clear |
| G La Rana, R Russo, G D'Agostino, O Sasso, G Mattace Raso, A Iacono, R Meli, D Piomelli, A Calignan. AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors. Neuropharmacology. vol 54. issue 3. 2008-06-12. PMID:18093621. |
using specific antagonists or enzyme inhibitors, we demonstrate that cannabinoids act at several levels: data on the 3rd day suggest a strong involvement of substance p (sp) and calcitonin gene-related peptide (cgrp) in the control of vascular tone, whereas at the 7th and 14th days the major role seems to be played by prostaglandins (pgs) and nitric oxide (no). |
2008-06-12 |
2023-08-12 |
rat |
| O A Sergeeva, N Doreulee, A N Chepkova, T Kazmierczak, H L Haa. Long-term depression of cortico-striatal synaptic transmission by DHPG depends on endocannabinoid release and nitric oxide synthesis. The European journal of neuroscience. vol 26. issue 7. 2008-01-29. PMID:17868368. |
long-term depression of cortico-striatal synaptic transmission by dhpg depends on endocannabinoid release and nitric oxide synthesis. |
2008-01-29 |
2023-08-12 |
mouse |
| Mehdi Ghasemi, Hamed Sadeghipour, Ahmad R Dehpou. Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. BJU international. vol 100. issue 6. 2008-01-03. PMID:17850365. |
to investigate the ability of acute administration of the endogenous cannabinoid, anandamide, in vitro to alter the nonadrenegic noncholinergic (nanc)-mediated relaxation of corpus cavernosum (cc) in diabetic rats and the possible role of nitric oxide (no), as it is well known that erectile dysfunction (ed) affects 35-75% of men with diabetes mellitus and several studies have been conducted to find appropriate strategies for treating diabetes-induced ed. |
2008-01-03 |
2023-08-12 |
rat |
| Ali Roohbakhsh, Akbar Hajizadeh Moghaddam, Roohollah Massoudi, Mohammad-Reza Zarrindas. Role of dorsal hippocampal cannabinoid receptors and nitric oxide in anxiety like behaviours in rats using the elevated plus-maze test. Clinical and experimental pharmacology & physiology. vol 34. issue 3. 2007-03-14. PMID:17250643. |
role of dorsal hippocampal cannabinoid receptors and nitric oxide in anxiety like behaviours in rats using the elevated plus-maze test. |
2007-03-14 |
2023-08-12 |
rat |
| Estery C Mbvundula, Rowena A D Bunning, K D Rainsfor. Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro. The Journal of pharmacy and pharmacology. vol 58. issue 3. 2006-07-07. PMID:16536902. |
it is concluded that biologically stable synthetic cannabinoids protect cartilage matrix from degradation induced by cytokines and this effect is possibly cb-receptor mediated and involves effects on prostaglandin and nitric oxide metabolism. |
2006-07-07 |
2023-08-12 |
cattle |
| Silvia Ortega-Gutiérrez, Eduardo Molina-Holgado, Angel Arévalo-Martín, Fernando Correa, Alma Viso, María L López-Rodríguez, Vincenzo Di Marzo, Carmen Guaz. Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 10. 2006-03-06. PMID:15941768. |
additionally, in microglial cells, ucm707 decreases the production of the proinflammatory cytokines tumor necrosis factor (tnf)-alpha, interleukin (il)-1beta, and il-6; reduces nitric oxide levels and inducible nitric oxide synthase expression; and is able to potentiate the action of a subeffective dose of the endocannabinoid anandamide. |
2006-03-06 |
2023-08-12 |
mouse |
| M R Namaz. Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition. Journal of the European Academy of Dermatology and Venereology : JEADV. vol 19. issue 3. 2005-09-02. PMID:15857457. |
based on the immunopathogenesis of psoriasis, this paper introduces three novel, potential treatments for this clinical conundrum: (i) cannabinoids, which exert inhibitory effects on antigen processing and macrophage/t-cell interaction and also on the release of il-2, tnf-alpha and nitric oxide from immune cells; (ii) loratadine, which is an antihistamine capable of increasing [corrected] the camp/cgmp ratio and the production of leukotriene b4; and (iii) allopurinol, which scavenges free radicals, inhibits the production of tnf-alpha, and downregulates the expression of intercellular adhesion molecule-1 and p2x7 receptors on monocytes/macrophages, which are involved in antigen presentation and production of the inflammatory response, respectively. |
2005-09-02 |
2023-08-12 |
Not clear |
| Estery C Mbvundula, Rowena A D Bunning, K D Rainsfor. Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage. Biochemical pharmacology. vol 69. issue 4. 2005-03-07. PMID:15670582. |
synthetic cannabinoids, r-(+)-win-55,212 (win-2) and s-(-)-win-55,212 (win-3) and the endocannabinoid, anandamide, were investigated on unstimulated or il-1-stimulated nitric oxide (no) production in bovine articular chondrocytes as well as on cartilage proteoglycan breakdown in bovine nasal cartilage explants. |
2005-03-07 |
2023-08-12 |
cattle |
| Francisco Molina-Holgado, Eduardo Molina-Holgado, Carmen Guaza, Nancy J Rothwel. Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. Journal of neuroscience research. vol 67. issue 6. 2002-04-09. PMID:11891798. |
role of cb1 and cb2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. |
2002-04-09 |
2023-08-12 |
mouse |
| T V Bilfinger, M Salzet, C Fimiani, D G Deutsch, G Tramu, G B Stefan. Pharmacological evidence for anandamide amidase in human cardiac and vascular tissues. International journal of cardiology. vol 64 Suppl 1. 1998-10-06. PMID:9687088. |
the endogenous cannabinoid, anandamide, in a dose-dependent manner stimulated the release of nitric oxide (no) from saphenous vein, internal thoracic artery and right atrium tissue segments in vitro. |
1998-10-06 |
2023-08-12 |
human |