| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Kumsta, Markus Heinrich. Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Current opinion in neurobiology. vol 23. issue 1. 2013-07-24. PMID:23040540. |
we discuss molecular genetic studies which identified variations in specific genes contributing to individual differences in social behavior and cognition, with a focus on the gene coding for the oxytocin receptor (oxtr) emerging as a particularly promising candidate. |
2013-07-24 |
2023-08-12 |
human |
| Robert Kumsta, Markus Heinrich. Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Current opinion in neurobiology. vol 23. issue 1. 2013-07-24. PMID:23040540. |
with regard to the variability in individual responses to oxytocin administration, we advocate the need for pharmacogenetic approaches in order to test how the efficacy of oxytocin administration is modulated by genetic variation of oxtr or other genes involved in oxytocin signaling. |
2013-07-24 |
2023-08-12 |
human |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
mice heterozygous for the oxytocin receptor gene (oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. |
2013-07-12 |
2023-08-12 |
mouse |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
we characterised the behavioural phenotype of mice heterozygous (oxtr(+/-)) for the oxytocin receptor gene (oxtr) and compared it with that of oxtr null mice (oxtr(-/-)), which display autistic-like behaviours, including impaired sociability and preference for social novelty, impaired cognitive flexibility, and increased aggression. |
2013-07-12 |
2023-08-12 |
mouse |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
by autoradiography, oxtr(+/-) mice were found to have approximately 50% fewer oxytocin receptors (oxtrs) in all of the examined brain regions. |
2013-07-12 |
2023-08-12 |
mouse |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
we then investigated the rescue of the oxtr(+/-) social deficits by oxytocin (ot) and thr(4)gly(7)ot (tgot) administered i.c.v. |
2013-07-12 |
2023-08-12 |
mouse |
| M Sala, D Braida, A Donzelli, R Martucci, M Busnelli, E Bulgheroni, T Rubino, D Parolaro, K Nishimori, B Chin. Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22967062. |
in line with this, a low dose of the selective oxytocin antagonist desglydtyrovt blocks the rescue effect of tgot only in the oxtr(+/-) genotype, whereas the less selective antagonist sr49059 blocks rescue in both genotypes. |
2013-07-12 |
2023-08-12 |
mouse |
| Christiane Montag, Eva-Maria Brockmann, Anja Lehmann, Daniel J Müller, Dan Rujescu, Jürgen Gallina. Association between oxytocin receptor gene polymorphisms and self-rated 'empathic concern' in schizophrenia. PloS one. vol 7. issue 12. 2013-06-25. PMID:23284802. |
the nonapeptide oxytocin (oxt) and its receptor (oxtr) have been implicated in social cognition, empathy, emotion and stress regulation in humans. |
2013-06-25 |
2023-08-12 |
Not clear |
| Robert Kumsta, Elisabeth Hummel, Frances S Chen, Markus Heinrich. Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience. Frontiers in neuroscience. vol 7. 2013-06-05. PMID:23734094. |
we provide an overview of the functional importance of oxytocin receptor gene (oxtr) promoter methylation and summarize studies that have investigated the role of oxtr methylation in behavioral phenotypes. |
2013-06-05 |
2023-08-12 |
human |
| Yuichiro Watanabe, Naoshi Kaneko, Ayako Nunokawa, Masako Shibuya, Jun Egawa, Toshiyuki Somey. Oxytocin receptor (OXTR) gene and risk of schizophrenia: case-control and family-based analyses and meta-analysis in a Japanese population. Psychiatry and clinical neurosciences. vol 66. issue 7. 2013-05-29. PMID:23252931. |
oxytocin receptor (oxtr) gene and risk of schizophrenia: case-control and family-based analyses and meta-analysis in a japanese population. |
2013-05-29 |
2023-08-12 |
Not clear |
| Roger L H Pobbe, Brandon L Pearson, D Caroline Blanchard, Robert J Blanchar. Oxytocin receptor and Mecp2 308/Y knockout mice exhibit altered expression of autism-related social behaviors. Physiology & behavior. vol 107. issue 5. 2013-05-17. PMID:22406388. |
this report reviews the behaviors of oxytocin receptor (oxtr) and mecp2(308/y) wild-type (wt) and knockout (ko) mice, in a number of tests specifically designed to provide information on behaviors that may show functional parallels to the core symptoms of asd. |
2013-05-17 |
2023-08-12 |
mouse |
| Abigail A Marsh, Henry H Yu, Daniel S Pine, Elena K Gorodetsky, David Goldman, R J R Blai. The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype. Psychopharmacology. vol 224. issue 4. 2013-05-10. PMID:22763666. |
the influence of oxytocin administration on responses to infant faces and potential moderation by oxtr genotype. |
2013-05-10 |
2023-08-12 |
Not clear |
| Abigail A Marsh, Henry H Yu, Daniel S Pine, Elena K Gorodetsky, David Goldman, R J R Blai. The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype. Psychopharmacology. vol 224. issue 4. 2013-05-10. PMID:22763666. |
in addition, given that preliminary evidence suggests that a single-nucleotide polymorphism of the oxytocin receptor (oxtr) gene, rs53576, may influence behaviors associated with parental sensitivity, we assessed whether such responses vary according to oxtr rs53576 genotype. |
2013-05-10 |
2023-08-12 |
Not clear |
| M C Cornelis, M M Glymour, S-C Chang, E J T Tchetgen, L Liang, K C Koenen, J H Kang, L R Pasquale, E B Rimm, I Kawachi, L D Kubzansk. Oxytocin receptor (OXTR) is not associated with optimism in the Nurses' Health Study. Molecular psychiatry. vol 17. issue 12. 2013-05-07. PMID:22212599. |
oxytocin receptor (oxtr) is not associated with optimism in the nurses' health study. |
2013-05-07 |
2023-08-12 |
Not clear |
| G L Poirier, M I Cordero, C Sand. Female vulnerability to the development of depression-like behavior in a rat model of intimate partner violence is related to anxious temperament, coping responses, and amygdala vasopressin receptor 1a expression. Frontiers in behavioral neuroscience. vol 7. 2013-05-06. PMID:23641204. |
expression was examined by analyses of targeted candidate genes, serotonin transporter (slc6a4), vasopressin receptor 1a, (avpr1a), and oxytocin receptor (oxtr). |
2013-05-06 |
2023-08-12 |
rat |
| Sau-Yeen Loke, Kazuhiro Tanaka, Wei-Yi On. Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. Journal of neurochemistry. vol 124. issue 6. 2013-04-29. PMID:23294445. |
western blots confirmed down-regulation of oxytocin receptor (oxtr) at 1 day post-7β-hc treatment. |
2013-04-29 |
2023-08-12 |
rat |
| E Unternaehrer, P Luers, J Mill, E Dempster, A H Meyer, S Staehli, R Lieb, D H Hellhammer, G Meinlschmid. Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress. Translational psychiatry. vol 2. 2013-03-14. PMID:22892716. |
we investigated quantitative dna methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (oxtr) and brain-derived neurotrophic factor (bdnf ). |
2013-03-14 |
2023-08-12 |
human |
| Ada Johansson, Lars Westberg, Kenneth Sandnabba, Patrick Jern, Benny Salo, Pekka Santtil. Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption. Psychoneuroendocrinology. vol 37. issue 9. 2013-01-14. PMID:22421562. |
associations between oxytocin receptor gene (oxtr) polymorphisms and self-reported aggressive behavior and anger: interactions with alcohol consumption. |
2013-01-14 |
2023-08-12 |
Not clear |
| Ada Johansson, Lars Westberg, Kenneth Sandnabba, Patrick Jern, Benny Salo, Pekka Santtil. Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption. Psychoneuroendocrinology. vol 37. issue 9. 2013-01-14. PMID:22421562. |
oxytocin has been implicated in the regulation of social as well as aggressive behaviors, and in a recent study we found that the effect of alcohol on aggressive behavior was moderated by the individual's genotype on an oxytocin receptor gene (oxtr) polymorphism (johansson et al., 2012). |
2013-01-14 |
2023-08-12 |
Not clear |
| Ruth Feldman, Orna Zagoory-Sharon, Omri Weisman, Inna Schneiderman, Ilanit Gordon, Rina Maoz, Idan Shalev, Richard P Ebstei. Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biological psychiatry. vol 72. issue 3. 2012-11-20. PMID:22336563. |
sensitive parenting is associated with plasma oxytocin and polymorphisms in the oxtr and cd38 genes. |
2012-11-20 |
2023-08-12 |
human |