| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manal Tabbaa, Ashley Moses, Elizabeth A D Hammoc. Oxytocin receptor disruption in Avil-expressing cells results in blunted sociability and increased inter-male aggression. PloS one. vol 16. issue 11. 2021-12-03. PMID:34847180. |
oxytocin (oxt) is a neuroactive hormone that regulates social behaviors through its receptor (oxtr), with all previously identified social behavior effects attributed to the central nervous system, which has developmental origins in the neural tube. |
2021-12-03 |
2023-08-13 |
mouse |
| Elena V Kozlova, Matthew C Valdez, Maximillian E Denys, Anthony E Bishay, Julia M Krum, Kayhon M Rabbani, Valeria Carrillo, Gwendolyn M Gonzalez, Gregory Lampel, Jasmin D Tran, Brigitte M Vazquez, Laura M Anchondo, Syed A Uddin, Nicole M Huffman, Eduardo Monarrez, Duraan S Olomi, Bhuvaneswari D Chinthirla, Richard E Hartman, Prasada Rao S Kodavanti, Gladys Chompre, Allison L Phillips, Heather M Stapleton, Bernhard Henkelmann, Karl-Werner Schramm, Margarita C Curras-Collaz. Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71. Archives of toxicology. 2021-11-26. PMID:34687351. |
moreover, f1 l-de-71 displayed downregulated mrna transcripts for oxytocin (oxt) in the bed nucleus of the stria terminalis (bnst) and supraoptic nucleus, and vasopressin (avp) in the bnst and upregulated avp1ar in bnst, and oxtr in the paraventricular nucleus. |
2021-11-26 |
2023-08-13 |
mouse |
| Iris C Reiner, Gerald Gimpl, Manfred E Beutel, Marian J Bakermans-Kranenburg, Helge Frielin. OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study. Journal of molecular neuroscience : MN. 2021-11-25. PMID:34822109. |
we investigated stability and change of plasma and urinary oxytocin as well as oxtr dna methylation patterns through psychotherapy. |
2021-11-25 |
2023-08-13 |
human |
| Iris C Reiner, Gerald Gimpl, Manfred E Beutel, Marian J Bakermans-Kranenburg, Helge Frielin. OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study. Journal of molecular neuroscience : MN. 2021-11-25. PMID:34822109. |
serum and urine oxytocin was measured using standard elisa, and dna methylation of the oxtr gene was assessed using bisulfite sequencing at the time of admission (baseline) and at discharge and from controls at matched time points. |
2021-11-25 |
2023-08-13 |
human |
| Iris C Reiner, Gerald Gimpl, Manfred E Beutel, Marian J Bakermans-Kranenburg, Helge Frielin. OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study. Journal of molecular neuroscience : MN. 2021-11-25. PMID:34822109. |
plasma oxytocin, urinary oxytocin, and oxtr dna methylation patterns were intrapersonally relatively stable. |
2021-11-25 |
2023-08-13 |
human |
| Iris C Reiner, Gerald Gimpl, Manfred E Beutel, Marian J Bakermans-Kranenburg, Helge Frielin. OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study. Journal of molecular neuroscience : MN. 2021-11-25. PMID:34822109. |
oxtr-related factors were seemingly unaffected by inpatient psychotherapeutic treatment, but we found significant differences between remitting and non-remitting patients in urinary oxytocin and oxtr dna methylation. |
2021-11-25 |
2023-08-13 |
human |
| Kengo Horie, Katsuhiko Nishimor. CRISPR/Cas9-Mediated Genetic Engineering to Generate a Disease Model Prairie Vole, Based on Species-Optimized Assisted Reproductive Technology. Methods in molecular biology (Clifton, N.J.). vol 2384. 2021-11-19. PMID:34550573. |
recent studies of prairie voles have highlighted the importance of oxytocin (oxt) and oxytocin receptor (oxtr)-mediated mechanisms in the regulation of these behaviors.recently, we established assisted reproductive technologies for prairie voles, and successfully and efficiently generated an oxtr gene knockout (ko) prairie vole using clustered regularly interspaced short palindromic repeats (crispr)/crispr-associated protein 9 (cas9 ), a powerful genome editing tool with artificially developed single-strand guide rnas (sgrna) and cas9 endonucleases.herein, we describe the method for crispr /cas9-mediated generation of oxtr ko prairie vole. |
2021-11-19 |
2023-08-13 |
mouse |
| Kengo Horie, Katsuhiko Nishimor. CRISPR/Cas9-Mediated Genetic Engineering to Generate a Disease Model Prairie Vole, Based on Species-Optimized Assisted Reproductive Technology. Methods in molecular biology (Clifton, N.J.). vol 2384. 2021-11-19. PMID:34550573. |
this oxtr ko prairie vole can be a valuable tool to understand their unique social and prosocial behaviors and elucidate how the oxytocin system influences or modulates these behaviors in the brain. |
2021-11-19 |
2023-08-13 |
mouse |
| Ewa Szczepanska-Sadowska, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, Tymoteusz Żer. Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34768894. |
vasopressin interacts with three subtypes of receptors: v1ar, v1br, and v2r whereas oxytocin activates its own oxtr and v1ar receptors. |
2021-11-18 |
2023-08-13 |
Not clear |
| Forrest D Rogers, Sara M Freeman, Marina Anderson, Michelle C Palumbo, Karen L Bale. Compositional variation in early-life parenting structures alters oxytocin and vasopressin 1a receptor development in prairie voles (Microtus ochrogaster). Journal of neuroendocrinology. vol 33. issue 8. 2021-11-16. PMID:34189787. |
here, we present evidence that paternal absence (with and without alloparental substitution) may alter the ontogeny of neural oxytocin receptor (oxtr) and/or vasopressin 1a receptor (avpr1a) distribution in male and female prairie voles. |
2021-11-16 |
2023-08-13 |
Not clear |
| Magda Rybicka, Maria Kaźmierczak, Paulina Pawlicka, Ariadna Beata Łada-Maśko, Paulina Anikiej-Wiczenbach, Krzysztof Piotr Bielawsk. (Re-)activity in the caregiving situation: Genetic diversity within Oxytocin-Vasopressin Pathway is associated with salivary oxytocin and vasopressin concentrations in response to contact with a crying infant-simulator. Psychoneuroendocrinology. vol 131. 2021-11-12. PMID:34102428. |
oxytocin (ot) and vasopressin (avp) hormones as well as their receptors (oxtr and avpr1a) have been deemed crucial for caregiving and sensitive responsiveness to infant cues. |
2021-11-12 |
2023-08-13 |
Not clear |
| Luoyang Ding, Shane K Maloney, Mengzhi Wang, Jennifer Rodger, Lianmin Chen, Dominique Blach. Association between temperament related traits and single nucleotide polymorphisms in the serotonin and oxytocin systems in Merino sheep. Genes, brain, and behavior. vol 20. issue 3. 2021-11-09. PMID:33161622. |
variations like single nucleotide polymorphisms (snps) in the genes for tryptophan 5-hydroxylase (tph2), the serotonin transporter (slc6a4), the serotonin receptor (htr2a), and the oxytocin receptor (oxtr) are associated with behavioral phenotype in humans. |
2021-11-09 |
2023-08-13 |
Not clear |
| Irene Kalpokas, María Noel Martínez, Daniel Cavestany, Fernando Perdigón, Rodrigo Costa Mattos, Ana Meikl. Equine early pregnancy endocrine profiles and ipsilateral endometrial immune cell, gene expression and protein localisation response. Reproduction, fertility, and development. vol 33. issue 6. 2021-11-05. PMID:33752795. |
ipsilateral endometrial expression was assessed on days 7 and 13 after ovulation for the following transcripts: oestrogen receptor erα (esr1), progesterone receptor (pgr), progestin and adipoq receptor family member 5 (paqr5), oxytocin receptor (oxtr), prostaglandin-endoperoxide synthase 2 (ptgs2), raf-1 proto-oncogene serine/threonine kinase (raf1), p21-activated kinase 6 (pak6), fibroblast growth factor family member 9 (fgf9), igf1 and its receptor (igf1r), mucin 1 (muc1), osteopontin (opn), leptin receptor (lepr) and adiponectin receptors 1 and 2 (adipor1 and adipor2). |
2021-11-05 |
2023-08-13 |
Not clear |
| Steven M Kogan, Dayoung Bae, Junhan Cho, Alicia K Smith, Shota Nishitan. Pathways linking adverse environments to emerging adults' substance abuse and depressive symptoms: A prospective analysis of rural African American men. Development and psychopathology. vol 33. issue 4. 2021-11-04. PMID:32693849. |
we also advance exploratory hypotheses regarding dna methylation in the oxytocin receptor gene (oxtr) as a moderator of the effects of stress on relational schemas. |
2021-11-04 |
2023-08-13 |
Not clear |
| Amy L Byrd, Irene Tung, Stephen D Manuck, Vera Vine, Michelle Horner, Alison E Hipwell, Stephanie D Step. An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social-emotional mediators. Development and psychopathology. vol 33. issue 4. 2021-11-04. PMID:32693857. |
early threat exposure is a transdiagnostic risk factor for psychopathology, and evidence suggests that genetic variation in the oxytocin receptor (oxtr) moderates this association. |
2021-11-04 |
2023-08-13 |
Not clear |
| Dan Li, Mingjun San, Jing Zhang, Anlan Yang, Wanhua Xie, Yang Chen, Xiaodan Lu, Yuntao Zhang, Mingyue Zhao, Xuechao Feng, Yaowu Zhen. Oxytocin receptor induces mammary tumorigenesis through prolactin/p-STAT5 pathway. Cell death & disease. vol 12. issue 6. 2021-11-04. PMID:34099636. |
oxytocin receptor (oxtr) is involved in social behaviors, thermoregulation, and milk ejection, yet little is known about its role in breast cancer. |
2021-11-04 |
2023-08-13 |
mouse |
| Christine M Bubac, Catherine I Cullingham, Janay A Fox, W Don Bowen, Cornelia E den Heyer, David W Coltma. Genetic association with boldness and maternal performance in a free-ranging population of grey seals (Halichoerus grypus). Heredity. vol 127. issue 1. 2021-11-01. PMID:33927365. |
we isolated and re-sequenced five genes: dopamine receptor d4 (drd4), serotonin transporter (sert), oxytocin receptor (oxtr), and melanocortin receptors 1 (mc1r) and 5 (mc5r). |
2021-11-01 |
2023-08-13 |
Not clear |
| Miriam A Schiele, Christiane Thiel, Leonie Kollert, Lena Fürst, Lisa Putschin, Rebekka Kehle, Walter Hauke, Marina Mahr, Elena Reinhold, Michael G Gottschalk, Markus Heinrichs, Michael Zaudig, Götz Berberich, Katharina Domschk. Oxytocin Receptor Gene DNA Methylation: A Biomarker of Treatment Response in Obsessive-Compulsive Disorder? Psychotherapy and psychosomatics. vol 90. issue 1. 2021-10-28. PMID:32920561. |
although epigenetic mechanisms such as dna methylation of the oxytocin receptor (oxtr) gene have previously been linked to ocd pathogenesis, epigenetic markers as predictors of treatment success have not yet been investigated in ocd. |
2021-10-28 |
2023-08-13 |
Not clear |
| Chao-Lan Huang, Fei Liu, Yan-Yan Zhang, Jiu Lin, Min Fu, Yue-Ling Li, Cheng Zhou, Chun-Jie Li, Jie-Fei She. Activation of oxytocin receptor in the trigeminal ganglion attenuates orofacial ectopic pain attributed to inferior alveolar nerve injury. Journal of neurophysiology. vol 125. issue 1. 2021-10-28. PMID:33326336. |
this study explores the effects of oxytocin receptor (oxtr) in the trigeminal ganglion (tg) on orofacial neuropathic pain. |
2021-10-28 |
2023-08-13 |
rat |
| Chao-Lan Huang, Fei Liu, Yan-Yan Zhang, Jiu Lin, Min Fu, Yue-Ling Li, Cheng Zhou, Chun-Jie Li, Jie-Fei She. Activation of oxytocin receptor in the trigeminal ganglion attenuates orofacial ectopic pain attributed to inferior alveolar nerve injury. Journal of neurophysiology. vol 125. issue 1. 2021-10-28. PMID:33326336. |
oxtr, a g protein-coupled receptor, has been demonstrated to play a significant role in analgesia after activation by its canonical agonist oxytocin (oxt) in the dorsal root ganglion. |
2021-10-28 |
2023-08-13 |
rat |