| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel Goedert, Maria Grazia Spillantin. Ordered Assembly of Tau Protein and Neurodegeneration. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096024. |
the tau filament folds of alzheimer's and pick's diseases appear to be conserved between different cases of disease. |
2020-04-08 |
2023-08-13 |
mouse |
| Michel Goedert, Maria Grazia Spillantin. Ordered Assembly of Tau Protein and Neurodegeneration. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096024. |
these findings show that filamentous tau adopts one fold in alzheimer's disease and a different fold in pick's disease, establishing the existence of distinct conformers. |
2020-04-08 |
2023-08-13 |
mouse |
| Tara Tracy, Kathryn C Claiborn, Li Ga. Regulation of Tau Homeostasis and Toxicity by Acetylation. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096027. |
multiple neurodegenerative conditions including alzheimer's disease and frontotemporal dementia are characterized by the accumulation of tau in the brain, associated with synapse loss and cognitive decline. |
2020-04-08 |
2023-08-13 |
Not clear |
| Maoping Tang, Jarreau Harrison, Carol A Deaton, Gail V W Johnso. Tau Clearance Mechanisms. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096028. |
maintaining appropriate levels of tau is key for neuronal health; hence perturbations in tau clearance mechanisms are likely significant contributors to neurodegenerative diseases such as alzheimer's disease and frontotemporal lobar degeneration. |
2020-04-08 |
2023-08-13 |
Not clear |
| Hans Zempel, Eckhard Mandelko. Mechanisms of Axonal Sorting of Tau and Influence of the Axon Initial Segment on Tau Cell Polarity. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096029. |
tau is a microtubule-associated protein (map) that is mainly sorted into the axons in physiological conditions, but missorted in alzheimer disease and related tauopathies. |
2020-04-08 |
2023-08-13 |
Not clear |
| Diane P Hanger, Despoina Goniotaki, Wendy Nobl. Synaptic Localisation of Tau. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096032. |
in alzheimer's disease, frontotemporal dementia and related tauopathies, highly phosphorylated tau accumulates as intraneuronal protein aggregates that are likely responsible for the demise of neurons and the subsequent progressive cognitive decline. |
2020-04-08 |
2023-08-13 |
Not clear |
| Benjamin Combs, Rebecca L Mueller, Gerardo Morfini, Scott T Brady, Nicholas M Kanaa. Tau and Axonal Transport Misregulation in Tauopathies. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096030. |
signs of fast axonal transport disruption are pervasive in alzheimer's disease and other tauopathies and various mechanisms have been proposed for regulation of fast axonal transport by tau. |
2020-04-08 |
2023-08-13 |
Not clear |
| Zhi Ruan, Tsuneya Ikez. Tau Secretion. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096034. |
the pathological propagation of tau protein is a hallmark of multiple neurodegenerative disorders, collectively referred to tauopathies with alzheimer's disease (ad) being most prevalent, but including a range of frontotemporal dementias (ftds). |
2020-04-08 |
2023-08-13 |
Not clear |
| Elena Rodriguez-Vieitez, Henrietta M Nielse. Associations Between APOE Variants, Tau and α-Synuclein. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096038. |
while tau is a hallmark of alzheimer's disease (ad) and other non-ad tauopathies, and α-synuclein is the pathological feature of the spectrum of synucleinopathies including parkinson's disease (pd), parkinson's disease with dementia (pdd) and dementia with lewy bodies (dlb), the presence of co-pathologies is very frequent in all these diseases. |
2020-04-08 |
2023-08-13 |
human |
| Gilbert Gallardo, David M Holtzma. Amyloid-β and Tau at the Crossroads of Alzheimer's Disease. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096039. |
amyloid-β and tau at the crossroads of alzheimer's disease. |
2020-04-08 |
2023-08-13 |
mouse |
| Makoto Higuch. Tau PET Imaging. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096041. |
the deposition of fibrillar tau aggregates has been implicated in alzheimer's disease (ad) and allied neurodegenerative disorders collectively referred to as tauopathies. |
2020-04-08 |
2023-08-13 |
human |
| Hirohisa Watanabe, Epifanio Bagarinao, Takamasa Yokoi, Hiroshi Yamaguchi, Shinsuke Ishigaki, Michihito Mausuda, Masahisa Katsuno, Gen Sobu. Tau Accumulation and Network Breakdown in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096042. |
tau accumulation and network breakdown in alzheimer's disease. |
2020-04-08 |
2023-08-13 |
Not clear |
| Hirohisa Watanabe, Epifanio Bagarinao, Takamasa Yokoi, Hiroshi Yamaguchi, Shinsuke Ishigaki, Michihito Mausuda, Masahisa Katsuno, Gen Sobu. Tau Accumulation and Network Breakdown in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096042. |
misfolded and aggregated tau and amyloid β (aβ) proteins are the pathological hallmarks of alzheimer's disease (ad). |
2020-04-08 |
2023-08-13 |
Not clear |
| Maud Gratuze, Aurélie Joly-Amado, Luc Buee, Didier Vieau, David Blu. Tau, Diabetes and Insulin. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096044. |
tau protein which was discovered in 1975 [310] became of great interest when it was identified as the main component of neurofibrillary tangles (nft), a pathological feature in the brain of patients with alzheimer's disease (ad) [39, 110, 232]. |
2020-04-08 |
2023-08-13 |
Not clear |
| Heiko Braak, Kelly Del Tredic. Top-Down Projections Direct the Gradual Progression of Alzheimer-Related Tau Pathology Throughout the Neocortex. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096045. |
in sporadic alzheimer's disease (sad), tau pathology gradually but relentlessly progresses from the transentorhinal region of the temporal lobe into both the allocortex and temporal high order association areas of the neocortex. |
2020-04-08 |
2023-08-13 |
Not clear |
| Simon Dujardin, Bradley T Hyma. Tau Prion-Like Propagation: State of the Art and Current Challenges. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096046. |
it has been almost a decade since the hypothesis of active tau protein propagation in alzheimer's disease and associated tauopathies was formally raised. |
2020-04-08 |
2023-08-13 |
Not clear |
| Kenneth S Kosik, Songi Ha. Tau Condensates. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096047. |
among this subset is the tau protein, a critically important inclusion in a class of conditions known as the tauopathies, which include alzheimer's disease. |
2020-04-08 |
2023-08-13 |
Not clear |
| Sumihiro Maeda, Akihiko Takashim. Tau Oligomers. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096050. |
the accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including alzheimer's disease. |
2020-04-08 |
2023-08-13 |
Not clear |
| Julika J Götz, Jürgen Göt. Experimental Models of Tauopathy - From Mechanisms to Therapies. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096051. |
another aspect is the emerging role of tau in the translational machinery and the finding that the somatodendritic accumulation of tau in alzheimer's disease may in part be due to the induction of the de novo synthesis of tau by amyloid-β via the fyn/erk/s6 pathway. |
2020-04-08 |
2023-08-13 |
mouse |
| Mikio Shoj. Cerebrospinal Fluid and Plasma Tau as a Biomarker for Brain Tauopathy. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096052. |
cerebrospinal fluid (csf) tau and phosphorylated tau (ptau) are definite biomarkers of alzheimer's disease (ad). |
2020-04-08 |
2023-08-13 |
Not clear |