| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ram Prasad Bora, Rajeev Prabhaka. Translational, rotational and internal dynamics of amyloid beta-peptides (Abeta40 and Abeta42) from molecular dynamics simulations. The Journal of chemical physics. vol 131. issue 15. 2010-09-29. PMID:20568886. |
in this study, diffusion constants [translational (d(t)) and rotational (d(r))], correlation times [rotational (tau(rot)) and internal (tau(int))], and the intramolecular order parameters (s(2)) of the alzheimer amyloid-beta peptides abeta40 and abeta42 have been calculated from 150 ns molecular dynamics simulations in aqueous solution. |
2010-09-29 |
2023-08-12 |
Not clear |
| Or A Shemesh, Micha E Spir. Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons. Acta neuropathologica. vol 120. issue 2. 2010-09-28. PMID:20422200. |
hallmark cellular pathology of alzheimer's disease induced by mutant human tau expression in cultured aplysia neurons. |
2010-09-28 |
2023-08-12 |
human |
| Or A Shemesh, Micha E Spir. Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons. Acta neuropathologica. vol 120. issue 2. 2010-09-28. PMID:20422200. |
using live confocal imaging to follow cytoskeletal elements, autophagosomes, lysosomes, anterogradely and retrogradely transported organelles, complemented with electron microscopy, we demonstrate that the expression of mutant human tau in cultured aplysia neurons leads to the development of hallmark alzheimer disease (ad) pathologies. |
2010-09-28 |
2023-08-12 |
human |
| Kwok-Fai Lau, Michael S Perkinton, Lilia Rodriguez, Declan M McLoughlin, Christopher C J Mille. An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. Neuroreport. vol 21. issue 11. 2010-09-28. PMID:20531236. |
glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in alzheimer's disease. |
2010-09-28 |
2023-08-12 |
Not clear |
| Sirui Zhou, Huriletemuer, Jing Wang, Binbin Wang, Shigang Zhao, De Sheng Wang, Chunyu Zhang, Xu M. Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients. Neuroscience letters. vol 480. issue 1. 2010-09-24. PMID:20188796. |
grb-associated binding protein 2 (gab2) may function as a risk factor of alzheimer disease (ad) by affecting hyperphosphorylation of tau, causing neurofibrillary tangles. |
2010-09-24 |
2023-08-12 |
Not clear |
| Zhiming Cui, Tao Tao, Chun Cheng, Junling Yang, Qin Shen, Yuhong Ji, Xiaohong Li, Haiou Liu, Aiguo Shen, Xiang L. SSeCKS promote beta-amyloid-induced PC12 cells neurotoxicity by up-regulating tau phosphorylation in Alzheimer's disease. Molecular and cellular biochemistry. vol 340. issue 1-2. 2010-09-21. PMID:20232114. |
ssecks promote beta-amyloid-induced pc12 cells neurotoxicity by up-regulating tau phosphorylation in alzheimer's disease. |
2010-09-21 |
2023-08-12 |
Not clear |
| Zhiming Cui, Tao Tao, Chun Cheng, Junling Yang, Qin Shen, Yuhong Ji, Xiaohong Li, Haiou Liu, Aiguo Shen, Xiang L. SSeCKS promote beta-amyloid-induced PC12 cells neurotoxicity by up-regulating tau phosphorylation in Alzheimer's disease. Molecular and cellular biochemistry. vol 340. issue 1-2. 2010-09-21. PMID:20232114. |
in alzheimer's disease, beta-amyloid peptide (abeta) could induce tau hyperphosphorylation which is the major cause of neuron apoptosis. |
2010-09-21 |
2023-08-12 |
Not clear |
| Cheng-Xin Gong, Inge Grundke-Iqbal, Khalid Iqba. Targeting tau protein in Alzheimer's disease. Drugs & aging. vol 27. issue 5. 2010-09-17. PMID:20450234. |
targeting tau protein in alzheimer's disease. |
2010-09-17 |
2023-08-12 |
Not clear |
| Susanne Wegmann, Yu Jin Jung, Subashchandrabose Chinnathambi, Eva-Maria Mandelkow, Eckhard Mandelkow, Daniel J Mulle. Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20566652. |
fibrous aggregates of tau protein are characteristic features of alzheimer disease. |
2010-09-17 |
2023-08-12 |
human |
| Melita Salkovic-Petrisic, Jelena Osmanovic, Edna Grünblatt, Peter Riederer, Siegfried Hoye. Modeling sporadic Alzheimer's disease: the insulin resistant brain state generates multiple long-term morphobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta. Journal of Alzheimer's disease : JAD. vol 18. issue 4. 2010-09-16. PMID:19661616. |
modeling sporadic alzheimer's disease: the insulin resistant brain state generates multiple long-term morphobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta. |
2010-09-16 |
2023-08-12 |
human |
| Julius Popp, Piotr Lewczuk, Michael Linnebank, Gabriela Cvetanovska, Yvo Smulders, Heike Kölsch, Ingo Frommann, Johannes Kornhuber, Wolfgang Maier, Frank Jesse. Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 18. issue 4. 2010-09-16. PMID:19661622. |
disturbed homocysteine metabolism is a risk factor for alzheimer's disease (ad) and may contribute to the disease pathophysiology by increasing both amyloid-beta (abeta) production and phosphorylated tau (p-tau) accumulation. |
2010-09-16 |
2023-08-12 |
human |
| Yuh-Te Lin, Jiin-Tsuey Cheng, Yun-Chin Yao, Juo, Yuk-Keung Lo, Ching-Hwung Lin, Luo-Ping Ger, Pei-Jung L. Increased total TAU but not amyloid-beta(42) in cerebrospinal fluid correlates with short-term memory impairment in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 18. issue 4. 2010-09-16. PMID:19749420. |
increased total tau but not amyloid-beta(42) in cerebrospinal fluid correlates with short-term memory impairment in alzheimer's disease. |
2010-09-16 |
2023-08-12 |
Not clear |
| Victoria Campos-Peña, José Tapia-Ramírez, Carmen Sánchez-Torres, Marco Antonio Meraz-Rio. Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane. Journal of Alzheimer's disease : JAD. vol 18. issue 4. 2010-09-16. PMID:19749435. |
the hallmark of alzheimer's disease is the pathological aggregation of tau proteins into paired helical filaments and neurofibrillary tangles. |
2010-09-16 |
2023-08-12 |
Not clear |
| M L Spatara, A S Robinso. Transgenic mouse and cell culture models demonstrate a lack of mechanistic connection between endoplasmic reticulum stress and tau dysfunction. Journal of neuroscience research. vol 88. issue 9. 2010-09-16. PMID:20143409. |
in vivo aggregation of tau protein is a hallmark of many neurodegenerative disorders, including alzheimer's disease (ad). |
2010-09-16 |
2023-08-12 |
mouse |
| Jing Huang, Yu-juan Chen, Wei-hong Bian, Jing Yu, Yu-wu Zhao, Xue-yuan Li. Unilateral amyloid-beta25-35 injection into the rat amygdala increases the expressions of aberrant tau phosphorylation kinases. Chinese medical journal. vol 123. issue 10. 2010-09-16. PMID:20529587. |
the purpose of this study was to investigate whether it would prompt the progress of alzheimer disease via enhancement of aberrant phosphorylated tau that results from its increased kinase gene expression. |
2010-09-16 |
2023-08-12 |
rat |
| Steven Lehre. Glioblastoma and dementia may share a common cause. Medical hypotheses. vol 75. issue 1. 2010-09-13. PMID:20181435. |
alzheimer's disease has been identified as a protein misfolding disorder (proteopathy), caused by accumulation of abnormally folded a-beta and tau proteins in the brain. |
2010-09-13 |
2023-08-12 |
Not clear |
| Kisha J Young, James P Bennet. The mitochondrial secret(ase) of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 20 Suppl 2. 2010-09-13. PMID:20442493. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized clinically by progressive decline in memory and cognition and pathologically by extracellular amyloid-beta (abeta) deposits and intraneuronal aggregates of hyperphosphorylated tau. |
2010-09-13 |
2023-08-12 |
Not clear |
| Gary E Gibson, Qingli Sh. A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. Journal of Alzheimer's disease : JAD. vol 20 Suppl 2. 2010-09-13. PMID:20463407. |
alzheimer's disease (ad) is defined by senile plaques made of amyloid-beta peptide (abeta), neurofibrillary tangles made of hyperphosphorylated tau proteins, and memory deficits. |
2010-09-13 |
2023-08-12 |
Not clear |
| Johanne Bertrand, Patrick Sénéchal, Mathieu Zummo-Soucy, Vanessa Plouffe, Nicole Lecler. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20550628. |
in tauopathies including alzheimer's disease, the axonal microtubule-associated protein tau becomes hyperphosphorylated at pathological epitopes and accumulates in the somato-dendritic compartment. |
2010-09-13 |
2023-08-12 |
human |
| Scott D Ryan, Shawn N Whitehead, Leigh Anne Swayne, Tia C Moffat, Weimin Hou, Martin Ethier, André J G Bourgeois, Juliet Rashidian, Alexandre P Blanchard, Paul E Fraser, David S Park, Daniel Figeys, Steffany A L Bennet. Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 49. 2010-09-08. PMID:19926863. |
acute intraneuronal accumulation of c16:0 paf but not c16:0 lyso-paf initiated cyclin-dependent kinase 5-mediated hyperphosphorylation of tau on alzheimer disease-specific epitopes. |
2010-09-08 |
2023-08-12 |
mouse |