| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dengrong Jiang, Peiying Liu, Zixuan Lin, Kaisha Hazel, George Pottanat, Emma Lucke, Abhay Moghekar, Jay J Pillai, Hanzhang L. MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe. NeuroImage. 2022-12-24. PMID:36565971. |
the medial temporal lobe (mtl) is a key area implicated in many brain diseases, such as alzheimer's disease. |
2022-12-24 |
2023-08-14 |
Not clear |
| Efthymia Maria Kapasouri, Diomidis C Ioannidis, Donnie Cameron, Vassilios S Vassiliou, Michael Hornberge. The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum: A Systematic Review and Meta-Analysis. Diagnostics (Basel, Switzerland). vol 12. issue 12. 2022-12-23. PMID:36552974. |
we sought to systematically review and meta-analy the role of cerebral blood flow (cbf) in the medial temporal lobe (mtl) using arterial spin labeling magnetic resonance imaging (asl-mri) and compare this in patients with alzheimer's disease (ad), individuals with mild cognitive impairment (mci), and cognitively normal adults (cn). |
2022-12-23 |
2023-08-14 |
human |
| Wei Liang, Kai Zhang, Peng Cao, Xiaoli Liu, Jinzhu Yang, Osmar R Zaian. Exploiting task relationships for Alzheimer's disease cognitive score prediction via multi-task learning. Computers in biology and medicine. vol 152. 2022-12-14. PMID:36516575. |
motivated by breakthroughs of multi-task learning (mtl), efforts have been made to extend mtl to improve the alzheimer's disease cognitive score prediction by exploiting structure correlation. |
2022-12-14 |
2023-08-14 |
Not clear |
| Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdo. APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia. PLoS biology. vol 20. issue 12. 2022-12-13. PMID:36512526. |
alzheimer's disease is marked by intracellular tau aggregates in the medial temporal lobe (mtl) and extracellular amyloid aggregates in the default network (dn). |
2022-12-13 |
2023-08-14 |
human |
| Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdo. APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia. PLoS biology. vol 20. issue 12. 2022-12-13. PMID:36512526. |
here, we examined codependent structural variations between the mtl's most vulnerable structure, the hippocampus (hc), and the dn at subregion resolution in individuals with alzheimer's disease and related dementia (adrd). |
2022-12-13 |
2023-08-14 |
human |
| Maria Stefania De Simone, Maria Giovanna Lombardi, Massimo De Tollis, Roberta Perri, Lucia Fadda, Carlo Caltagirone, Giovanni Augusto Carlesim. Forgetting rate for the familiarity and recollection components of recognition in amnestic mild cognitive impairment: A longitudinal study. Applied neuropsychology. Adult. 2022-10-20. PMID:36264763. |
here we aimed to investigate the rate of forgetting of the familiarity and recollection components of recognition in patients at the onset of medial temporal lobe (mtl) pathology and destined to convert to alzheimer's disease (ad). |
2022-10-20 |
2023-08-14 |
human |
| Raffaella Migliaccio, Federica Cacciaman. The temporal lobe in typical and atypical Alzheimer disease. Handbook of clinical neurology. vol 187. 2022-08-14. PMID:35964987. |
in typical amnestic late-onset alzheimer's disease (>65 years old; load), tau pathology gradually spreads to the brain from the medial temporal lobe (mtl). |
2022-08-14 |
2023-08-14 |
Not clear |
| Andrea Castegnaro, David Howett, Adrienne Li, Elizabeth Harding, Dennis Chan, Neil Burgess, John Kin. Assessing mild cognitive impairment using object-location memory in immersive virtual environments. Hippocampus. 2022-08-02. PMID:35916343. |
pathological changes in the medial temporal lobe (mtl) are found in the early stages of alzheimer's disease (ad) and aging. |
2022-08-02 |
2023-08-14 |
human |
| Steven J Granger, Luis Colon-Perez, Myra Saraí Larson, Michael Phelan, David B Keator, John T Janecek, Mithra T Sathishkumar, Anna P Smith, Liv McMillan, Dana Greenia, Maria M Corrada, Claudia H Kawas, Michael A Yass. Hippocampal dentate gyrus integrity revealed with ultrahigh resolution diffusion imaging predicts memory performance in older adults. Hippocampus. 2022-07-15. PMID:35838075. |
medial temporal lobe (mtl) atrophy is a core feature of age-related cognitive decline and alzheimer's disease (ad). |
2022-07-15 |
2023-08-14 |
Not clear |
| Robin de Flores, Sandhitsu R Das, Long Xie, Laura E M Wisse, Xueying Lyu, Preya Shah, Paul A Yushkevich, David A Wol. Medial temporal lobe networks in Alzheimer's disease: structural and molecular vulnerabilities. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-28. PMID:35086906. |
given the crucial role of the mtl and networks in the physiopathology of alzheimer's disease (ad), the present study aimed at i) investigate whether mtl atrophy propagates specifically within the at and pm networks, and ii) evaluate the vulnerability of these networks to ad proteinopathies.to do that, we used neuroimaging data acquired in human male and female in three distinct cohorts: i) resting-state functional mri from the aging brain cohort to define the at and pm networks (n=68), ii) longitudinal structural mri from adnigo/2 to highlight structural covariance patterns (n=349), and iii) pet data from adni3 to evaluate the networks' vulnerability to amyloid and tau (n=186).our results suggest that the atrophy of distinct mtl subregions propagates within the at and pm networks in a dissociable manner. |
2022-01-28 |
2023-08-13 |
human |
| b' Ondrej Lerch, Martina Pa\\xc5\\x99\\xc3\\xadzkov\\xc3\\xa1, Martin Vyhn\\xc3\\xa1lek, Zuzana Nedelsk\\xc3\\xa1, Jakub Hort, Jan Lacz\\xc3\\xb. APOE\\xc9\\x9b4 Allele Moderates the Association Between Basal Forebrain Nuclei Volumes and Allocentric Navigation in Older Adults Without Dementia. Journal of Alzheimer\'s disease : JAD. 2022-01-17. PMID:35034896.' |
cholinergic deficit and medial temporal lobe (mtl) atrophy are hallmarks of alzheimer's disease (ad) leading to early allocentric spatial navigation (asn) impairment. |
2022-01-17 |
2023-08-13 |
Not clear |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
the mechanisms underlying accumulation of alzheimer's disease (ad)-related tau pathology outside of the medial temporal lobe (mtl) in older adults are unknown but crucial to understanding cognitive decline. |
2021-11-23 |
2023-08-13 |
human |
| Jenna N Adams, Anne Maass, David Berron, Theresa M Harrison, Suzanne L Baker, Wesley P Thomas, Morgan Stanfill, William J Jagus. Reduced Repetition Suppression in Aging is Driven by Tau-Related Hyperactivity in Medial Temporal Lobe. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 17. 2021-11-19. PMID:33731446. |
tau deposition begins in the medial temporal lobe (mtl) in aging and alzheimer's disease (ad), and mtl neural dysfunction is commonly observed in these groups. |
2021-11-19 |
2023-08-13 |
human |
| Sadhana Ravikumar, Laura E M Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L Bedard, Sandhitsu R Das, Edward B Lee, M Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A Detre, Gabor Mizsei, John Q Trojanowski, John L Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María Del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J Irwin, David A Wolk, Ricardo Insausti, Paul A Yushkevic. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34689831. |
tau neurofibrillary tangle (nft) pathology in the medial temporal lobe (mtl) is closely linked to neurodegeneration, and is the early pathological change associated with alzheimer's disease (ad). |
2021-11-05 |
2023-08-13 |
human |
| Léa Chauveau, Elizabeth Kuhn, Cassandre Palix, Francesca Felisatti, Valentin Ourry, Vincent de La Sayette, Gaël Chételat, Robin de Flore. Medial Temporal Lobe Subregional Atrophy in Aging and Alzheimer's Disease: A Longitudinal Study. Frontiers in aging neuroscience. vol 13. 2021-11-02. PMID:34720998. |
medial temporal lobe (mtl) atrophy is a key feature of alzheimer's disease (ad), however, it also occurs in typical aging. |
2021-11-02 |
2023-08-13 |
Not clear |
| Neha Sinha, Chelsie N Berg, Michael A Yassa, Mark A Gluc. Increased dynamic flexibility in the medial temporal lobe network following an exercise intervention mediates generalization of prior learning. Neurobiology of learning and memory. vol 177. 2021-10-21. PMID:33186745. |
the mtl is one of the earliest brain regions impacted by alzheimer's disease. |
2021-10-21 |
2023-08-13 |
Not clear |
| Amy N Murray, Hannah L Chandler, Thomas M Lancaste. Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease. Neurobiology of aging. vol 98. 2021-09-20. PMID:33227567. |
preclinical models of alzheimer's disease (ad) suggest that volumetric reductions in medial temporal lobe (mtl) structures manifest before clinical onset. |
2021-09-20 |
2023-08-13 |
human |
| Laura E M Wisse, Molly B Ungrady, Ranjit Ittyerah, Sydney A Lim, Paul A Yushkevich, David A Wolk, David J Irwin, Sandhitsu R Das, Murray Grossma. Cross-sectional and longitudinal medial temporal lobe subregional atrophy patterns in semantic variant primary progressive aphasia. Neurobiology of aging. vol 98. 2021-08-23. PMID:33341654. |
we aimed to investigate the mtl subregional atrophy pattern cross-sectionally and longitudinally in patients with svppa as compared with controls and patients with alzheimer's disease (ad). |
2021-08-23 |
2023-08-13 |
Not clear |
| Marie-Louise Montandon, Sven Haller, Max Scheffler, Panteleimon Giannakopoulos, François R Herrmann, Gabriel Gold, Enikö Kövar. Medial temporal lobe volume is associated with neuronal loss but not with hippocampal microinfarcts despite their high frequency in aging brains. Neurobiology of aging. vol 95. 2021-07-09. PMID:32739558. |
medial temporal lobe (mtl) atrophy is an important marker for the clinical diagnosis of alzheimer's disease at its prodromal stages. |
2021-07-09 |
2023-08-13 |
Not clear |
| Shan Cong, Xiaohui Yao, Zhi Huang, Shannon L Risacher, Kwangsik Nho, Andrew J Saykin, Li She. Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data. Neurobiology of aging. vol 95. 2021-07-09. PMID:32768867. |
this study aims to examine how genetics influences alzheimer's disease (ad) pathogenesis via mtl substructures by analyzing high-resolution magnetic resonance imaging (mri) data. |
2021-07-09 |
2023-08-13 |
Not clear |