| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Shen Lin, Liang-Yu Chen, Steven S S Wang, Yung Chang, Wen-Yih Che. Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide. Colloids and surfaces. B, Biointerfaces. vol 65. issue 2. 2008-09-30. PMID:18514493. |
the deposition of beta-amyloid (abeta) on cell membranes is considered as one of the primary factors in having alzheimer's disease (ad). |
2008-09-30 |
2023-08-12 |
Not clear |
| Esperanza Arias, Sonia Gallego-Sandín, Mercedes Villarroya, Antonio G García, Manuela G Lópe. Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 315. issue 3. 2006-01-23. PMID:16144975. |
we have studied the neuroprotective effects of these drugs, in comparison with nicotine, on cell death caused by beta-amyloid (abeta) and okadaic acid, two models that are relevant to alzheimer's pathology, in the human neuroblastoma cell line sh-sy5y. |
2006-01-23 |
2023-08-12 |
human |
| D Aguado-Llera, E Arilla-Ferreiro, A Campos-Barros, L Puebla-Jiménez, V Barrio. Protective effects of insulin-like growth factor-I on the somatostatinergic system in the temporal cortex of beta-amyloid-treated rats. Journal of neurochemistry. vol 92. issue 3. 2005-06-24. PMID:15659230. |
because alterations of the somatostatinergic system have been described in alzheimer's disease, we investigated the effects of the abeta peptide and the possible protective role of igf-i on the somatostatinergic system of the rat temporal cortex and on cell death and phosphorylated (p)-akt levels in this area. |
2005-06-24 |
2023-08-12 |
rat |
| W G Wood, U Igbavbo. Cholesterol trafficking and amyloid beta peptides. Pharmacopsychiatry. vol 36 Suppl 2. 2003-12-10. PMID:14574629. |
alterations of cholesterol homeostasis can have pronounced consequences on cell structure and function and may be both a cause and casualty of alzheimer's disease. |
2003-12-10 |
2023-08-12 |
Not clear |
| G Münch, J Gasic-Milenkovic, T Arend. Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease. Journal of neural transmission. Supplementum. issue 65. 2003-10-20. PMID:12946049. |
effect of advanced glycation endproducts on cell cycle and their relevance for alzheimer's disease. |
2003-10-20 |
2023-08-12 |
Not clear |
| I F Smith, L D Plant, J P Boyle, R A Skinner, H A Pearson, C Peer. Chronic hypoxia potentiates capacitative Ca2+ entry in type-I cortical astrocytes. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753070. |
prolonged hypoxia exerts profound effects on cell function, and has been associated with increased production of amyloid beta peptides (a beta ps) of alzheimer's disease. |
2003-07-24 |
2023-08-12 |
rat |
| Onno Kranenburg, Loes M J Kroon-Batenburg, Arie Reijerkerk, Ya-Ping Wu, Emile E Voest, Martijn F B G Gebbin. Recombinant endostatin forms amyloid fibrils that bind and are cytotoxic to murine neuroblastoma cells in vitro. FEBS letters. vol 539. issue 1-3. 2003-04-24. PMID:12650943. |
like beta-amyloid, found in the brains of patients with alzheimer's disease, amyloid endostatin binds to and is toxic to neuronal cells, whereas soluble endostatin has no effect on cell viability. |
2003-04-24 |
2023-08-12 |
Not clear |
| H S Chae, J H Bach, M W Lee, H S Kim, Y S Kim, K Y Kim, K Y Choo, S H Choi, C H Park, S H Lee, Y H Suh, S S Kim, W B Le. Estrogen attenuates cell death induced by carboxy-terminal fragment of amyloid precursor protein in PC12 through a receptor-dependent pathway. Journal of neuroscience research. vol 65. issue 5. 2001-10-25. PMID:11536323. |
in the present study, we investigated effects of estrogen on cell death induced by carboxy-terminal fragment of amyloid precursor protein (ct), a candidate causative substance in the pathogenesis of alzheimer's disease. |
2001-10-25 |
2023-08-12 |
Not clear |
| J Hoffmann, C U Pietrzik, M P Kummer, C Twiesselmann, C Bauer, V Herzo. Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 47. issue 3. 1999-03-11. PMID:10026239. |
binding and selective detection of the secretory n-terminal domain of the alzheimer amyloid precursor protein on cell surfaces. |
1999-03-11 |
2023-08-12 |
Not clear |
| J T Gallaghe. Structure-activity relationship of heparan sulphate. Biochemical Society transactions. vol 25. issue 4. 1998-04-13. PMID:9449976. |
in addition to the issues already discussed, it has a profound effect on cell adhesion and migration through its interaction with many extracellular matrix proteins, most notably fibronectin and thrombospondin; it is closely linked to lipid metabolism through its capacity to bind low-density lipoprotein and lipoprotein lipase; and aberrations in hs structure and degradation are linked to human malignancy and alzheimer's disease [26,27]. |
1998-04-13 |
2023-08-12 |
human |