| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Davolio, J T Greenamyr. Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid. Neuroscience letters. vol 192. issue 1. 1995-10-19. PMID:7675303. |
the ca1 region of hippocampus is selectively vulnerable to a variety of insults, including hypoxia-ischemia and alzheimer's disease, but the basis of this regional susceptibility is poorly understood. |
1995-10-19 |
2023-08-12 |
Not clear |
| K Wakabayashi, W G Honer, E Maslia. Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease. Brain research. vol 667. issue 1. 1995-04-24. PMID:7895080. |
we quantified by microdensitometry the immunoreactivity (ir) to monoclonal antibodies (sp6, sp12, sp15 and sp18) against various synaptic proteins in the molecular layers of the dentate gyrus, ca4, ca3, ca1, subiculum and entorhinal cortex in alzheimer's disease (ad), lewy body variant of ad (lbv) and diffuse lewy body disease (dlbd). |
1995-04-24 |
2023-08-12 |
Not clear |
| J C Vickers, B M Riederer, R A Marugg, V Buée-Scherrer, L Buée, A Delacourte, J H Morriso. Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease. Neuroscience. vol 62. issue 1. 1995-02-09. PMID:7816192. |
in the alzheimer's disease cases, most of the surviving ca1 neurons showed intense labeling for the neurofilament triplet proteins, with many of these neurons giving off abnormal "sprouting" processes. |
1995-02-09 |
2023-08-12 |
human |
| J C Vickers, B M Riederer, R A Marugg, V Buée-Scherrer, L Buée, A Delacourte, J H Morriso. Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease. Neuroscience. vol 62. issue 1. 1995-02-09. PMID:7816192. |
these results indicate that there are changes in the cytoskeleton of ca1 neurons associated with age which are likely to involve an increase in the level of neurofilament proteins and may be a predisposing factor contributing towards their high degree of vulnerability in degenerative conditions such as alzheimer's disease. |
1995-02-09 |
2023-08-12 |
human |
| D E Pellegrini-Giampietro, M V Bennett, R S Zuki. AMPA/kainate receptor gene expression in normal and Alzheimer's disease hippocampus. Neuroscience. vol 61. issue 1. 1994-11-28. PMID:7969894. |
in sections from alzheimer's disease brain, a high degree of intersubject variability was observed: some samples showed markedly reduced glur1 mrna levels in dentate gyrus, ca1 and ca3 relative to controls; others showed no changes. |
1994-11-28 |
2023-08-12 |
human |
| M J West, P D Coleman, D G Flood, J C Troncos. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet (London, England). vol 344. issue 8925. 1994-10-13. PMID:7916070. |
the most distinctive alzheimer's disease related neuron loss was seen in the ca1 region of the hippocampus. |
1994-10-13 |
2023-08-12 |
human |
| M J West, P D Coleman, D G Flood, J C Troncos. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet (London, England). vol 344. issue 8925. 1994-10-13. PMID:7916070. |
in the normal ageing group there was almost no neuron loss in this region (final neuron count in the ca1 region: 4.40 x 10(6) neurons for the alzheimer's disease group vs 14.08 x 10(6) neurons in the normal ageing group). |
1994-10-13 |
2023-08-12 |
human |
| P Giannakopoulos, P R Hof, S Mottier, J P Michel, C Boura. Neuropathological changes in the cerebral cortex of 1258 cases from a geriatric hospital: retrospective clinicopathological evaluation of a 10-year autopsy population. Acta neuropathologica. vol 87. issue 5. 1994-09-15. PMID:8059598. |
neurofibrillary tangles were often observed in the ca1 field and the inferior temporal cortex of non-demented individuals and were present in most cases with alzheimer's disease. |
1994-09-15 |
2023-08-12 |
Not clear |
| A Hiran. Hirano bodies and related neuronal inclusions. Neuropathology and applied neurobiology. vol 20. issue 1. 1994-07-13. PMID:8208338. |
they occur preferentially in the neuronal processes of the ca1 area in ammon's horn in a wide variety of conditions, especially amyotrophic lateral sclerosis and parkinsonism-dementia complex on guam, alzheimer's disease, pick's disease and 'normal' elderly individuals. |
1994-07-13 |
2023-08-12 |
Not clear |
| M F Casanova, N W Carosella, J M Gold, J E Kleinman, D R Weinberger, R E Power. A topographical study of senile plaques and neurofibrillary tangles in the hippocampi of patients with Alzheimer's disease and cognitively impaired patients with schizophrenia. Psychiatry research. vol 49. issue 1. 1994-04-25. PMID:8140181. |
in alzheimer's disease, degenerative changes invariably predominated in the ca1 subfield, subiculum, and proisocortex. |
1994-04-25 |
2023-08-12 |
Not clear |
| K L Jansen, R L Faull, P Storey, R A Lesli. Loss of sigma binding sites in the CA1 area of the anterior hippocampus in Alzheimer's disease correlates with CA1 pyramidal cell loss. Brain research. vol 623. issue 2. 1993-12-13. PMID:8221112. |
loss of sigma binding sites in the ca1 area of the anterior hippocampus in alzheimer's disease correlates with ca1 pyramidal cell loss. |
1993-12-13 |
2023-08-12 |
Not clear |
| J R Seckl, K L French, D O'Donnell, M J Meaney, N P Nair, C M Yates, G Fin. Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. Brain research. Molecular brain research. vol 18. issue 3. 1993-06-24. PMID:8497185. |
the distribution and intensity of mr and gr mrna expression in the hippocampus of alzheimer's disease were similar to that in control tissue, with high expression in dentate gyrus and ca2-4, but significantly lower expression in ca1. |
1993-06-24 |
2023-08-12 |
human |
| M K Sutherland, L Wong, M J Somerville, L K Yoong, C Bergeron, M Parmentier, D R McLachla. Reduction of calbindin-28k mRNA levels in Alzheimer as compared to Huntington hippocampus. Brain research. Molecular brain research. vol 18. issue 1-2. 1993-05-21. PMID:8479289. |
mrna levels for calbindin-28k were reduced by 35% in ca1 and ca2 regions of alzheimer hippocampus, as compared to huntington control. |
1993-05-21 |
2023-08-12 |
Not clear |
| J Ułas, L C Brunner, L Nguyen, C W Cotma. Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. Neuroscience. vol 52. issue 4. 1993-04-15. PMID:8450977. |
reduced density of a1 receptors in the molecular layer of the dentate gyrus most probably reflects damage of the perforant path input in alzheimer's disease, while altered binding in the ca1 and ca3 regions is probably due to loss of intrinsic neurons. |
1993-04-15 |
2023-08-12 |
human |
| P W Landfield, O Thibault, M L Mazzanti, N M Porter, D S Ker. Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis. Journal of neurobiology. vol 23. issue 9. 1993-01-28. PMID:1469387. |
this paper reviews evidence that brain aging and alzheimer's disease (ad) are somehow closely related and that the hippocampus (ca1) is highly vulnerable to cell loss under both conditions. |
1993-01-28 |
2023-08-11 |
Not clear |
| M K Sutherland, L Wong, M J Somerville, P Handley, L Yoong, C Bergeron, D R McLachla. Reduction of thyroid hormone receptor c-ERB A alpha mRNA levels in the hippocampus of Alzheimer as compared to Huntington brain. Neurobiology of aging. vol 13. issue 2. 1992-10-13. PMID:1387923. |
message levels for a thyroid hormone receptor highly expressed in brain (c-erb a alpha) was reduced by 52% in ca1 and 43% in ca2 in alzheimer hippocampus as compared to huntington controls. |
1992-10-13 |
2023-08-11 |
Not clear |
| M Ikeda, D Dewar, J McCulloc. Selective reduction of [125I]apamin binding sites in Alzheimer hippocampus: a quantitative autoradiographic study. Brain research. vol 567. issue 1. 1992-07-01. PMID:1667746. |
in alzheimer's disease there was a marked and discrete loss of [125i]apamin binding sites in the subiculum (control = 1.10 +/- 0.10 pmol/g; alzheimer = 0.71 +/- 0.09 pmol/g) and ca1 (control = 1.41 +/- 0.09 pmol/g; alzheimer = 0.85 +/- 0.11 pmol/g; values are mean +/- s.e.m.). |
1992-07-01 |
2023-08-11 |
human |
| M K Sutherland, M J Somerville, L K Yoong, C Bergeron, M R Haussler, D R McLachla. Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels. Brain research. Molecular brain research. vol 13. issue 3. 1992-06-29. PMID:1317496. |
we have shown that mrna pool size for calbindin-28k was reduced, on average, by 35% in alzheimer hippocampal ca1 cells, as compared to huntington control (manuscript in preparation). |
1992-06-29 |
2023-08-11 |
Not clear |
| M K Sutherland, M J Somerville, L K Yoong, C Bergeron, M R Haussler, D R McLachla. Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels. Brain research. Molecular brain research. vol 13. issue 3. 1992-06-29. PMID:1317496. |
message levels for vdr were reduced, on average, by 34% and 31%, respectively, in alzheimer hippocampal ca1 and ca2 pyramidal cells, as compared to huntington control. |
1992-06-29 |
2023-08-11 |
Not clear |
| M K Sutherland, M J Somerville, L K Yoong, C Bergeron, M R Haussler, D R McLachla. Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels. Brain research. Molecular brain research. vol 13. issue 3. 1992-06-29. PMID:1317496. |
these results show that in alzheimer hippocampal ca1 cells, vdr mrna pool size is downregulated and that this downregulation may play a role in the reduction of calbindin-28k expression. |
1992-06-29 |
2023-08-11 |
Not clear |