| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Ransmayr, P Cervera, E C Hirsch, W Berger, W Fischer, Y Agi. Alzheimer's disease: is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology? Neuroscience. vol 47. issue 4. 1992-06-05. PMID:1374541. |
in contrast, a significant loss of pyramidal neurons was found only in ca1, and the density of neurofibrillary tangles was markedly increased only in ca1 and the subiculum in alzheimer's disease. |
1992-06-05 |
2023-08-11 |
human |
| D Dewar, D T Chalmers, D I Graham, J McCulloc. Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus. Brain research. vol 553. issue 1. 1991-12-24. PMID:1933277. |
glutamate metabotropic binding and ampa binding were reduced significantly in ca1 in subjects with alzheimer's disease whereas kainate binding was minimally altered in this region. |
1991-12-24 |
2023-08-11 |
human |
| H J Gertz, H Krüger, S Patt, J Cervos-Navarr. Tangle-bearing neurons show more extensive dendritic trees than tangle-free neurons in area CA1 of the hippocampus in Alzheimer's disease. Brain research. vol 548. issue 1-2. 1991-09-19. PMID:1714332. |
tangle-bearing neurons show more extensive dendritic trees than tangle-free neurons in area ca1 of the hippocampus in alzheimer's disease. |
1991-09-19 |
2023-08-11 |
Not clear |
| H J Gertz, H Krüger, S Patt, J Cervos-Navarr. Tangle-bearing neurons show more extensive dendritic trees than tangle-free neurons in area CA1 of the hippocampus in Alzheimer's disease. Brain research. vol 548. issue 1-2. 1991-09-19. PMID:1714332. |
to elucidate the pathogenetic significance of neurofibrillary tangles in alzheimer's disease, the dendritic tree of tangle-bearing and unaffected pyramidal cells of area ca1 of the hippocampus was morphometrically examined. |
1991-09-19 |
2023-08-11 |
Not clear |
| J Bauer, S Strauss, U Schreiter-Gasser, U Ganter, P Schlegel, I Witt, B Yolk, M Berge. Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS letters. vol 285. issue 1. 1991-08-14. PMID:1712317. |
strong perinuclear alpha 2m immunoreactivity in hippocampal ca1 neurons of alzheimer's disease brains indicates that neuronal cells are the site of alpha 2m synthesis in ad brains. |
1991-08-14 |
2023-08-11 |
human |
| S Katayama, S Kito, Y Yamamura, E Tahara, I Kanazaw. Alteration of muscarinic receptor subtypes in CA1 field of hippocampus in senile dementia of Alzheimer type: an autoradiographic study. Hiroshima journal of medical sciences. vol 39. issue 4. 1991-05-23. PMID:2086562. |
alteration of muscarinic receptor subtypes in ca1 field of hippocampus in senile dementia of alzheimer type: an autoradiographic study. |
1991-05-23 |
2023-08-11 |
Not clear |
| M J Somerville, M E Percy, C Bergeron, L K Yoong, E A Grima, D R McLachla. Localization and quantitation of 68 kDa neurofilament and superoxide dismutase-1 mRNA in Alzheimer brains. Brain research. Molecular brain research. vol 9. issue 1-2. 1991-05-21. PMID:1850065. |
the cerebellar cortex and hippocampal ca1 and ca2 regions were compared in these two groups of subjects, since in ad the ca2 region of the hippocampus and the cerebellum have been found to be relatively unaffected by the alzheimer process in comparison to the hippocampal ca1 region. |
1991-05-21 |
2023-08-11 |
human |
| P Cras, M Kawai, S Siedlak, P Mulvihill, P Gambetti, D Lowery, P Gonzalez-DeWhitt, B Greenberg, G Perr. Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. The American journal of pathology. vol 137. issue 2. 1990-09-17. PMID:2117395. |
the greatest concurrence of app immunoreactivity and reactive microglia was seen in the subiculum and area ca1, regions with a high density of congophilic plaques and subject to intense alzheimer's pathology. |
1990-09-17 |
2023-08-11 |
human |
| J B Penney, W F Maragos, J T Greenamyre, D L Debowey, Z Hollingsworth, A B Youn. Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias. Journal of neurology, neurosurgery, and psychiatry. vol 53. issue 4. 1990-06-25. PMID:2160518. |
binding was decreased significantly for all ligands except quisqualate in stratum pyramidale of ca1 of the alzheimer's disease brains. |
1990-06-25 |
2023-08-11 |
human |
| A C McKee, K S Kosik, M B Kennedy, N W Kowal. Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase. Journal of neuropathology and experimental neurology. vol 49. issue 1. 1990-02-26. PMID:2153760. |
in alzheimer's disease (ad) staining intensity of ca1 and subicular neurons is strikingly increased despite nft formation and neuronal depletion. |
1990-02-26 |
2023-08-11 |
human |
| M P Mattson, P B Guthrie, S B Kate. Intrinsic factors in the selective vulnerability of hippocampal pyramidal neurons. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2690106. |
selective degeneration of pyramidal neurons in regions ca1 and ca3 of the hippocampus is a common structural correlate of several neurodegenerative conditions including alzheimer's disease, epilepsy and stroke. |
1990-01-31 |
2023-08-11 |
rat |
| B J Crain, P C Burge. The laminar distribution of neuritic plaques in the fascia dentata of patients with Alzheimer's disease. Acta neuropathologica. vol 76. issue 1. 1988-08-25. PMID:3394497. |
examination of 19 brains from patients with alzheimer's disease showed approximately the same number of plaques in the stratum moleculare of the fascia dentata and in ca1 (sommer's sector) of the hippocampus, even though the area of the latter is much greater. |
1988-08-25 |
2023-08-11 |
Not clear |
| S Bahmanyar, G A Higgins, D Goldgaber, D A Lewis, J H Morrison, M C Wilson, S K Shankar, D C Gajduse. Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease. Science (New York, N.Y.). vol 237. issue 4810. 1987-07-29. PMID:3299701. |
this messenger rna was also present in the neurons of all the hippocampal fields from monkeys, normal humans and, although to a lesser extent in cornu ammonis 1, patients with alzheimer's disease. |
1987-07-29 |
2023-08-11 |
monkey |
| D T Monaghan, J W Geddes, D Yao, C Chung, C W Cotma. [3H]TCP binding sites in Alzheimer's disease. Neuroscience letters. vol 73. issue 2. 1987-04-15. PMID:3029638. |
some alzheimer's cases showed no changes in binding site density while other cases showed substantial declines in the ca1 region. |
1987-04-15 |
2023-08-11 |
human |
| D T Monaghan, J W Geddes, D Yao, C Chung, C W Cotma. [3H]TCP binding sites in Alzheimer's disease. Neuroscience letters. vol 73. issue 2. 1987-04-15. PMID:3029638. |
[3h]tcp binding in the ca1 region from alzheimer's patients was reduced an average of 40% while the other hippocampal regions were unaffected. |
1987-04-15 |
2023-08-11 |
human |
| D T Monaghan, J W Geddes, D Yao, C Chung, C W Cotma. [3H]TCP binding sites in Alzheimer's disease. Neuroscience letters. vol 73. issue 2. 1987-04-15. PMID:3029638. |
it is proposed that the loss of [3h]tcp sites in the hippocampal ca1 region of certain alzheimer's cases is associated with the greater cell loss observed in cases of severe alzheimer's disease. |
1987-04-15 |
2023-08-11 |
human |