| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J O Rinne, T Myllykylä, P Lönnberg, P Marjamäk. A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease. Brain research. vol 547. issue 1. 1991-09-05. PMID:1860068. |
brain nicotinic receptors were studied in the frontal cortex, temporal cortex, hippocampus and caudate nucleus in patients with parkinson's disease (pd), alzheimer's disease (ad) and control. |
1991-09-05 |
2023-08-11 |
Not clear |
| J K Blusztajn, I Lopez Gonzalez-Coviella, M Logue, J H Growdon, R J Wurtma. Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer's disease but not of Down's syndrome patients. Brain research. vol 536. issue 1-2. 1991-05-21. PMID:2150771. |
concentrations of glycerophosphocholine and of glycerophosphoethanolamine, the metabolites of two major membrane phospholipid classes, phosphatidylcholine and phosphatidylethanolamine respectively, were determined post-mortem in cortical areas 20 and 40 and in cerebellum and caudate nucleus of brains obtained at autopsy from patients with alzheimer's disease, down's syndrome and age-matched control subjects. |
1991-05-21 |
2023-08-11 |
human |
| H B Niznik, E F Fogel, F F Fassos, P Seema. The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus. Journal of neurochemistry. vol 56. issue 1. 1991-02-15. PMID:1987318. |
upon photolysis, [125i]fapp specifically incorporated into a polypeptide of apparent mr = 62,000 in membranes from both the putamen and the caudate nucleus of control, alzheimer's, schizophrenia, and huntington's diseased brain, and following complete deglycosylation, migrated as an mr approximately 48,000 polypeptide. |
1991-02-15 |
2023-08-11 |
Not clear |
| P J Tyrrell, G V Sawle, V Ibanez, P M Bloomfield, K L Leenders, R S Frackowiak, M N Rosso. Clinical and positron emission tomographic studies in the 'extrapyramidal syndrome' of dementia of the Alzheimer type. Archives of neurology. vol 47. issue 12. 1991-01-11. PMID:2252449. |
fifteen of 20 patients underwent fluoro-18-dopa scans, which showed no significant difference in fluoro-18-dopa uptake into the caudate and putamen between normal subjects and the rigid and nonrigid patients with alzheimer's disease, in contrast to the marked reduction in fluoro-18-dopa uptake into the putamen that is observed in parkinson's disease. |
1991-01-11 |
2023-08-11 |
human |
| S Lehéricy, E C Hirsch, P Cervera, L B Hersh, J J Hauw, M Ruberg, Y Agi. Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 21. 1989-12-08. PMID:2682652. |
cholinergic neurons were studied by immunohistochemistry with an antiserum against human choline acetyltransferase in the caudate nucleus, putamen, and ventral striatum (including the nucleus accumbens) of three patients with alzheimer disease and three control subjects. |
1989-12-08 |
2023-08-11 |
human |
| S Lehéricy, E C Hirsch, P Cervera, L B Hersh, J J Hauw, M Ruberg, Y Agi. Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 21. 1989-12-08. PMID:2682652. |
in the ventral striatum of patients with alzheimer disease, a 60% decrease in the number of cholinergic neurons was observed, whereas in the caudate nucleus and putamen values for control subjects and patients were similar. |
1989-12-08 |
2023-08-11 |
human |
| S Flament, A Delacourte, B Hémon, A Défosse. Characterization of two pathological tau protein, variants in Alzheimer brain cortices. Journal of the neurological sciences. vol 92. issue 2-3. 1989-12-01. PMID:2509637. |
tau 64 and 69 were not found in regions of alzheimer brains where the alzheimer pathology was absent (caudate nucleus or cerebellum for example). |
1989-12-01 |
2023-08-11 |
Not clear |
| C B Nemeroff, J S Kizer, G P Reynolds, G Bissett. Neuropeptides in Alzheimer's disease: a postmortem study. Regulatory peptides. vol 25. issue 1. 1989-06-22. PMID:2566190. |
in addition, in alzheimer's disease, srif was also reduced in concentration in the hypothalamus, whereas crf concentrations were reduced in the caudate nucleus. |
1989-06-22 |
2023-08-11 |
Not clear |
| I M Mazurkiewicz-Kwilecki, S Nsonwa. Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients. Canadian journal of physiology and pharmacology. vol 67. issue 1. 1989-06-16. PMID:2713757. |
in postmortem brains of alzheimer patients, statistically significant decreases in histamine levels were observed in the frontal (45%), temporal (20%), and occipital cortices (38%) and in the caudate nucleus (25%). |
1989-06-16 |
2023-08-11 |
Not clear |
| A Delacourte, L Bué. [Alzheimer's disease: the glial reaction is general and severe in all areas of the central nervous system]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 308. issue 13. 1989-06-15. PMID:2496895. |
moreover, there was a 11 fold gfap increase (p less than 0.001) in the other regions of the alzheimer brains that do not present the alzheimer pathology, such as caudate nucleus, cerebellum or brain stem. |
1989-06-15 |
2023-08-11 |
Not clear |
| M D Simpson, M C Royston, J F Deakin, A J Cross, D M Mann, P Slate. Regional changes in [3H]D-aspartate and [3H]TCP binding sites in Alzheimer's disease brains. Brain research. vol 462. issue 1. 1988-12-21. PMID:2846124. |
alzheimer's disease was associated with a reduction in [3h]d-aspartate binding density in temporal cortex and caudate nucleus. |
1988-12-21 |
2023-08-11 |
human |
| O Nordström, M Eliaz, T Bartfai, C G Gottfrie. Increased affinity of choline acetyltransferase for choline in Alzheimer's disease: a steady-state kinetic study. Brain research. vol 420. issue 2. 1987-12-22. PMID:3676768. |
the steady-state kinetics of choline acetyltransferase (cat) from autopsy samples of human caudate nucleus of aged controls and of patients with alzheimer's disease was studied. |
1987-12-22 |
2023-08-11 |
human |
| K Oyanagi, H Takahashi, K Wakabayashi, F Ikut. Selective involvement of large neurons in the neostriatum of Alzheimer's disease and senile dementia: a morphometric investigation. Brain research. vol 411. issue 2. 1987-08-28. PMID:3607428. |
in order to evaluate the quantitative changes in the neostriatum of alzheimer type (sdat), sections of the caudate head (cn) and putamen (pt) from 4 ad/sdat and 6 age-matched control cases were stained with klüver-barrera, and the cell body and nuclear areas of the neurons were measured by a digitizer. |
1987-08-28 |
2023-08-11 |
Not clear |
| A Nordberg, P Nyberg, R Adolfsson, B Winbla. Cholinergic topography in Alzheimer brains: a comparison with changes in the monoaminergic profile. Journal of neural transmission. vol 69. issue 1-2. 1987-07-16. PMID:3585318. |
the topographical distribution of the choline acetyltransferase (chat) activity and the number of muscarinic binding sites was studied in the anterio-posterior direction of the caudate nucleus, hippocampus, globus pallidus and putamen of four subjects with senile dementia of alzheimer type (ad/sdat) and in the same regions in six controls. |
1987-07-16 |
2023-08-11 |
human |
| J M Hiller, Y Itzhak, E J Simo. Selective changes in mu, delta and kappa opioid receptor binding in certain limbic regions of the brain in Alzheimer's disease patients. Brain research. vol 406. issue 1-2. 1987-06-05. PMID:3032356. |
the most consistent finding in alzheimer's disease brains was an increase in kappa binding in all 6 areas of the limbic system examined, with the putamen and caudate regions showing significant increases of 114% and 53%, respectively. |
1987-06-05 |
2023-08-11 |
Not clear |
| J M Hiller, Y Itzhak, E J Simo. Selective changes in mu, delta and kappa opioid receptor binding in certain limbic regions of the brain in Alzheimer's disease patients. Brain research. vol 406. issue 1-2. 1987-06-05. PMID:3032356. |
total binding and binding to mu and delta receptors in frontal cortex, caudate and hippocampus of alzheimer's disease brains was indistinguishable from levels seen in these brain areas from control individuals. |
1987-06-05 |
2023-08-11 |
Not clear |
| B Szelies, A Karenber. [Disorders of glucose metabolism in Pick's disease]. Fortschritte der Neurologie-Psychiatrie. vol 54. issue 12. 1987-03-30. PMID:3493192. |
pick's disease can be differentiated against presenile dementia represented by alzheimer's disease in that the pattern of reduced metabolism characteristic of alzheimer's disease is different from that of pick's disease where in accordance with the clinical syndrome the glucose metabolism in the frontal and temporobasal regions in reduced, involving also the structures of the hippocampus and an equally significant reduction of glucose metabolism in the caudate nucleus. |
1987-03-30 |
2023-08-11 |
Not clear |
| C G Gottfries, T Bartfai, A Carlsson, S Eckernäs, L Svennerhol. Multiple biochemical deficits in both gray and white matter of Alzheimer brains. Progress in neuro-psychopharmacology & biological psychiatry. vol 10. issue 3-5. 1987-02-06. PMID:3797685. |
in the brains from the alzheimer patients the examination of gray matter (caudate nucleus and hippocampus) showed a significant reduced activity of choline-acetyl transferase (cat) and a reduction of acetylcholinesterase (ache) that bordered significance in the hippocampus. |
1987-02-06 |
2023-08-11 |
cat |
| H Arai, T Moroji, K Kosaka, R Iizuk. Extrahypophyseal distribution of alpha-melanocyte stimulating hormone (alpha-MSH)-like immunoreactivity in postmortem brains from normal subjects and Alzheimer-type dementia patients. Brain research. vol 377. issue 2. 1986-09-17. PMID:3524751. |
in the alzheimer brains, although the temporal cortex and hippocampus had normal concentrations of alpha-msh-li, the cingulate cortex, caudate and substantia nigra showed significantly lower concentrations of alpha-msh-li than those of the control brains. |
1986-09-17 |
2023-08-11 |
human |
| C M Yates, J Simpson, A Gordo. Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease. Neuroscience letters. vol 65. issue 2. 1986-07-01. PMID:2940479. |
5-hydroxytryptamine (5-ht) and choline acetyltransferase (chat) were assayed in amygdala, cingulate cortex and caudate nucleus of post-mortem brains from 7 cases of down's syndrome (6 with the neuropathological features of alzheimer's disease and one with no such features), 9 cases of alzheimer's disease and 12 controls. |
1986-07-01 |
2023-08-11 |
Not clear |