| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumangali Kailainathan, Thomas M Piers, Jee Hyun Yi, Seongmin Choi, Mark S Fahey, Eva Borger, Frank J Gunn-Moore, Laurie O'Neill, Michael Lever, Daniel J Whitcomb, Kwangwook Cho, Shelley J Alle. Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF). Pharmacological research. vol 104. 2016-12-13. PMID:26687096. |
healthy young carriers of the met66 form (present in ∼30% caucasians) have reduced hippocampal volume and impaired hippocampal-dependent memory function, yet the same polymorphic population shows enhanced cognitive recovery after traumatic brain injury, delayed cognitive dysfunction during aging, and lower risk of late-onset alzheimer's disease (ad) compared to those with the more common val66 polymorphism. |
2016-12-13 |
2023-08-13 |
human |
| Elizabeth Monserrat Hernández-Hernández, Carolina Serrano-García, Rubén Antonio Vázquez-Roque, Alfonso Díaz, Elibeth Monroy, Antonio Rodríguez-Moreno, Benjamin Florán, Gonzalo Flore. Chronic administration of resveratrol prevents morphological changes in prefrontal cortex and hippocampus of aged rats. Synapse (New York, N.Y.). vol 70. issue 5. 2016-12-13. PMID:26789275. |
morphological changes in dendrites of the pyramidal neurons of the prefrontal cortex (pfc) and hippocampus have been reported in the brain of aging humans, or in humans with neurodegenerative diseases such as alzheimer's disease. |
2016-12-13 |
2023-08-13 |
rat |
| Keith A Josephs, Melissa E Murray, Jennifer L Whitwell, Nirubol Tosakulwong, Stephen D Weigand, Leonard Petrucelli, Amanda M Liesinger, Ronald C Petersen, Joseph E Parisi, Dennis W Dickso. Updated TDP-43 in Alzheimer's disease staging scheme. Acta neuropathologica. vol 131. issue 4. 2016-12-13. PMID:26810071. |
we show that in addition to the eight original regions we previously reported [amygdala, entorhinal cortex, subiculum, dentate gyrus of the hippocampus, occipitotemporal cortex, inferior temporal cortex, middle frontal cortex and basal ganglia (putamen/globus pallidum)] that tdp-43 is also deposited in the insular cortex, ventral striatum, basal forebrain, substantia nigra, midbrain tectum, and the inferior olive of the medulla oblongata, in alzheimer's disease. |
2016-12-13 |
2023-08-13 |
Not clear |
| Zhi-Qiang Xu, Huang Huang, Ya-Li Chen, Yun-Ying Gao, Jun Xu, Charles Marshall, Zhi-You Cai, Ming Xia. Different Expression Patterns of Amyloid-β Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-β Pathogenesis. Journal of Alzheimer's disease : JAD. vol 51. issue 1. 2016-12-13. PMID:26836155. |
extensive loss of hippocampal neurons serves a pathological basis for irreversible cognitive impairment in patients with alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
mouse |
| Jean-Pascal Morin, Giovanni Cerón-Solano, Giovanna Velázquez-Campos, Gustavo Pacheco-López, Federico Bermúdez-Rattoni, Sofía Díaz-Cintr. Spatial Memory Impairment is Associated with Intraneural Amyloid-β Immunoreactivity and Dysfunctional Arc Expression in the Hippocampal-CA3 Region of a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 51. issue 1. 2016-12-13. PMID:26836189. |
dysfunction of synaptic communication in cortical and hippocampal networks has been suggested as one of the neuropathological hallmarks of the early stages of alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
mouse |
| Kanchan Bisht, Kaushik P Sharma, Cynthia Lecours, Maria Gabriela Sánchez, Hassan El Hajj, Giampaolo Milior, Adrián Olmos-Alonso, Diego Gómez-Nicola, Giamal Luheshi, Luc Vallières, Igor Branchi, Laura Maggi, Cristina Limatola, Oleg Butovsky, Marie-Ève Trembla. Dark microglia: A new phenotype predominantly associated with pathological states. Glia. vol 64. issue 5. 2016-12-13. PMID:26847266. |
our work uncovered the existence of a new microglial phenotype that is rarely present under steady state conditions, in hippocampus, cerebral cortex, amygdala, and hypothalamus, but becomes abundant during chronic stress, aging, fractalkine signaling deficiency (cx3 cr1 knockout mice), and alzheimer's disease pathology (app-ps1 mice). |
2016-12-13 |
2023-08-13 |
mouse |
| Orly Lazarov, Carolyn Holland. Hippocampal neurogenesis: Learning to remember. Progress in neurobiology. vol 138-140. 2016-12-13. PMID:26855369. |
it has become increasingly clear that while neuronal cell loss in the entorhinal cortex and hippocampus occurs in alzheimer's disease, it is preceded by a long period of deficits in the connectivity of the hippocampal formation that contributes to the vulnerability of these circuits. |
2016-12-13 |
2023-08-13 |
Not clear |
| Orly Lazarov, Carolyn Holland. Hippocampal neurogenesis: Learning to remember. Progress in neurobiology. vol 138-140. 2016-12-13. PMID:26855369. |
this review will examine the evidence suggesting that hippocampal neurogenesis plays a role in cognitive function that is affected in alzheimer's disease, will discuss the cognitive assessments used for the detection of alzheimer's disease in humans and rodent models of familial alzheimer's disease, and their value for unraveling the mechanism underlying the development of cognitive impairments and dementia. |
2016-12-13 |
2023-08-13 |
Not clear |
| V Frazzini, S Guarnieri, M Bomba, R Navarra, C Morabito, M A Mariggiò, S L Sens. Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer's disease mouse model. Cell death & disease. vol 7. 2016-12-13. PMID:26890139. |
altered kv2.1 functioning promotes increased excitability in hippocampal neurons of an alzheimer's disease mouse model. |
2016-12-13 |
2023-08-13 |
mouse |
| V Frazzini, S Guarnieri, M Bomba, R Navarra, C Morabito, M A Mariggiò, S L Sens. Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer's disease mouse model. Cell death & disease. vol 7. 2016-12-13. PMID:26890139. |
we investigated kv2.1 currents and its relation to the intrinsic synaptic activity of hippocampal neurons from 3xtg-ad (triple transgenic mouse model of alzheimer's disease) mice, a widely employed preclinical ad model. |
2016-12-13 |
2023-08-13 |
mouse |
| Wasco Wruck, Friederike Schröter, James Adjay. Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks. Journal of Alzheimer's disease : JAD. vol 50. issue 4. 2016-12-13. PMID:26890743. |
meta-analysis of transcriptome data related to hippocampus biopsies and ipsc-derived neuronal cells from alzheimer's disease patients reveals an association with foxa1 and foxa2 gene regulatory networks. |
2016-12-13 |
2023-08-13 |
Not clear |
| Printha Wijesinghe, S K Shankar, Yasha T Chickabasaviah, Catherine Gorrie, Dhammika Amaratunga, Sanjayah Hulathduwa, K Sunil Kumara, Kamani Samarasinghe, Yoo Hun Suh, H W Steinbusch, K Ranil D De Silv. Cytoskeletal Pathologies of Age-Related Diseases between Elderly Sri Lankan (Colombo) and Indian (Bangalore) Brain Samples. Current Alzheimer research. vol 13. issue 3. 2016-12-13. PMID:26906356. |
alzheimer related pathologies were not different among elders, however, in colombo males, neurofibrillary tangle grade was significantly higher in the region of hippocampus (odds ratio = 1.46, 95% confidence interval = 0.07-0.7) and at risk in midbrain substantia nigra (p = 0.075). |
2016-12-13 |
2023-08-13 |
Not clear |
| Yan-Qiu Cui, Qi Wang, Dong-Mei Zhang, Jun-Ya Wang, Bing Xiao, Yan Zheng, Xiao-Min Wan. Triptolide Rescues Spatial Memory Deficits and Amyloid-β Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice. Current Alzheimer research. vol 13. issue 3. 2016-12-13. PMID:26906357. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease characterized by aggregation of amyloid-β (aβ) peptide in the hippocampus and cortex of brain. |
2016-12-13 |
2023-08-13 |
mouse |
| Eduardo J Fernandez-Perez, Christian Peters, Luis G Aguay. Membrane Damage Induced by Amyloid Beta and a Potential Link with Neuroinflammation. Current pharmaceutical design. vol 22. issue 10. 2016-12-13. PMID:26972288. |
it is well accepted that cortical and hippocampal synaptic densities are reduced in alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Michelle K Lupton, Lachlan Strike, Narelle K Hansell, Wei Wen, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Katie L McMahon, Greig I de Zubicaray, Amelia A Assareh, Andrew Simmons, Petroula Proitsi, John F Powell, Grant W Montgomery, Derrek P Hibar, Eric Westman, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Velas, Simon Lovestone, Henry Brodaty, David Ames, Julian N Trollor, Nicholas G Martin, Paul M Thompson, Perminder S Sachdev, Margaret J Wrigh. The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973105. |
the effect of increased genetic risk for alzheimer's disease on hippocampal and amygdala volume. |
2016-12-13 |
2023-08-13 |
Not clear |
| Michelle K Lupton, Lachlan Strike, Narelle K Hansell, Wei Wen, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Katie L McMahon, Greig I de Zubicaray, Amelia A Assareh, Andrew Simmons, Petroula Proitsi, John F Powell, Grant W Montgomery, Derrek P Hibar, Eric Westman, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Velas, Simon Lovestone, Henry Brodaty, David Ames, Julian N Trollor, Nicholas G Martin, Paul M Thompson, Perminder S Sachdev, Margaret J Wrigh. The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973105. |
reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Stefano Delli Pizzi, Raffaella Franciotti, Giovanna Bubbico, Astrid Thomas, Marco Onofrj, Laura Bonann. Atrophy of hippocampal subfields and adjacent extrahippocampal structures in dementia with Lewy bodies and Alzheimer's disease. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973109. |
atrophy of hippocampal subfields and adjacent extrahippocampal structures in dementia with lewy bodies and alzheimer's disease. |
2016-12-13 |
2023-08-13 |
Not clear |
| Stefano Delli Pizzi, Raffaella Franciotti, Giovanna Bubbico, Astrid Thomas, Marco Onofrj, Laura Bonann. Atrophy of hippocampal subfields and adjacent extrahippocampal structures in dementia with Lewy bodies and Alzheimer's disease. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973109. |
specific alterations of the different hippocampal subfields and adjacent extrahippocampal structures could differently contribute to the pathophysiology of alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2016-12-13 |
2023-08-13 |
Not clear |
| Evan Fletcher, Sylvia Villeneuve, Pauline Maillard, Danielle Harvey, Bruce Reed, William Jagust, Charles DeCarl. β-amyloid, hippocampal atrophy and their relation to longitudinal brain change in cognitively normal individuals. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973117. |
use of hippocampal volume in prior studies was based on the notion that limbic circuit degeneration is an early manifestation of the alzheimer's disease (ad) pathophysiology. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jennifer L Au, Nina Weishaupt, Hayley J Nell, Shawn N Whitehead, David F Cechett. Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke. Journal of visualized experiments : JoVE. issue 109. 2016-12-13. PMID:27022854. |
motor and hippocampal dependent spatial learning and reference memory assessment in a transgenic rat model of alzheimer's disease with stroke. |
2016-12-13 |
2023-08-13 |
rat |