| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lloyd Prosser, Amy MacDougall, Carole H Sudre, Emily N Manning, Ian B Malone, Phoebe Walsh, Olivia Goodkin, Hugh Pemberton, Frederik Barkhof, Geert Jan Biessels, David M Cash, Josephine Barne. Predicting Cognitive Decline in Nondemented Elders Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration. Neurology. 2022-11-10. PMID:36357185. |
here we compared the ability of baseline, single time-point biomarkers (csf amyloid 1-42, csf ptau-181, white matter hyperintensities (wmh), cerebral microbleeds (cmb), whole-brain volume, and hippocampal volume) to predict decline in cognitively normal individuals who later converted to mild cognitive impairment (mci) (cntomci), and those with mci who later converted to an alzheimer's disease (ad) diagnosis (mcitoad). |
2022-11-10 |
2023-08-14 |
Not clear |
| Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukaw. Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice. Scientific reports. vol 12. issue 1. 2022-11-10. PMID:36357544. |
cholinergic activation can enhance glutamatergic activity in the hippocampus under pathologic conditions, such as alzheimer's disease. |
2022-11-10 |
2023-08-14 |
mouse |
| David C Zhu, Chih-Ying Gwo, An-Wen Deng, Norman Scheel, Mari A Dowling, Rong Zhan. Hippocampus shape characterization with 3D Zernike transformation in clinical Alzheimer's disease progression. Human brain mapping. 2022-11-08. PMID:36346203. |
hippocampus shape characterization with 3d zernike transformation in clinical alzheimer's disease progression. |
2022-11-08 |
2023-08-14 |
human |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, we measured plasma amyloid beta (aβ)40, aβ42, total tau, and neurofilament light chain (nfl; n = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (wmh) volumes, and alzheimer's disease (ad)-signature cortical thickness (n = 917). |
2022-11-07 |
2023-08-14 |
human |
| Selene Tomassini, Agnese Sbrollini, Giacomo Covella, Paolo Sernani, Nicola Falcionelli, Henning Müller, Micaela Morettini, Laura Burattini, Aldo Franco Dragon. Brain-on-Cloud for automatic diagnosis of Alzheimer's disease from 3D structural magnetic resonance whole-brain scans. Computer methods and programs in biomedicine. vol 227. 2022-11-06. PMID:36335750. |
cortical and hippocampal atrophy caused by alzheimer's disease can be appreciated easily from a t1-weighted structural magnetic resonance scan. |
2022-11-06 |
2023-08-14 |
human |
| Kausalia Vijayaragavan, Bryan J Cannon, Dmitry Tebaykin, Marc Bossé, Alex Baranski, J P Oliveria, Syed A Bukhari, Dunja Mrdjen, M Ryan Corces, Erin F McCaffrey, Noah F Greenwald, Yari Sigal, Diana Marquez, Zumana Khair, Trevor Bruce, Mako Goldston, Anusha Bharadwaj, Kathleen S Montine, R Michael Angelo, Thomas J Montine, Sean C Bendal. Single-cell spatial proteomic imaging for human neuropathology. Acta neuropathologica communications. vol 10. issue 1. 2022-11-05. PMID:36333818. |
customized analysis strategies identified cell types and proteopathies in the hippocampus across stages of alzheimer's disease (ad) neuropathologic change. |
2022-11-05 |
2023-08-14 |
human |
| Balaji Kannappan, Jan Te Nijenhuis, Yu Yong Choi, Jang Jae Lee, Kyu Yeong Choi, Irena Balzekas, Ho Yub Jung, Youngshik Choe, Min Kyung Song, Ji Yeon Chung, Jung-Min Ha, Seong-Min Choi, Hoowon Kim, Byeong C Kim, Hang Joon Jo, Kun Ho Le. Can hippocampal subfield measures supply information that could be used to improve the diagnosis of Alzheimer's disease? PloS one. vol 17. issue 11. 2022-11-03. PMID:36327265. |
can hippocampal subfield measures supply information that could be used to improve the diagnosis of alzheimer's disease? |
2022-11-03 |
2023-08-14 |
human |
| Balaji Kannappan, Jan Te Nijenhuis, Yu Yong Choi, Jang Jae Lee, Kyu Yeong Choi, Irena Balzekas, Ho Yub Jung, Youngshik Choe, Min Kyung Song, Ji Yeon Chung, Jung-Min Ha, Seong-Min Choi, Hoowon Kim, Byeong C Kim, Hang Joon Jo, Kun Ho Le. Can hippocampal subfield measures supply information that could be used to improve the diagnosis of Alzheimer's disease? PloS one. vol 17. issue 11. 2022-11-03. PMID:36327265. |
we conclude that the hippocampal subfield volumetric differences from structural imaging show promise for improving the diagnosis of alzheimer's disease. |
2022-11-03 |
2023-08-14 |
human |
| Mubeen A Ansari, Muddanna S Rao, Aishah Al-Jarallah, Fawzi M Babike. Early Time Course of Oxidative Stress in Hippocampal Synaptosomes and Cognitive Loss Following Impaired Insulin Signaling in Rats: Development of Sporadic Alzheimer's Disease. Brain research. 2022-11-03. PMID:36328067. |
early time course of oxidative stress in hippocampal synaptosomes and cognitive loss following impaired insulin signaling in rats: development of sporadic alzheimer's disease. |
2022-11-03 |
2023-08-14 |
rat |
| Hong-Yan Cai, Jing Qiao, Si-Ru Chen, Wei-Ping Fa. [Mitochondrial calcium uniporter knockdown in hippocampal neurons improved the learning and memory dysfunction of Alzheimer's disease mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 5. 2022-11-01. PMID:36319095. |
[mitochondrial calcium uniporter knockdown in hippocampal neurons improved the learning and memory dysfunction of alzheimer's disease mice]. |
2022-11-01 |
2023-08-14 |
mouse |
| Jenna N Adams, Soyun Kim, Batool Rizvi, Mithra Sathishkumar, Lisa Taylor, Alyssa L Harris, Abanoub Mikhail, David B Keator, Liv McMillan, Michael A Yass. Entorhinal-Hippocampal Circuit Integrity is Related to Mnemonic Discrimination and Amyloid-β Pathology in Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-10-27. PMID:36302636. |
mnemonic discrimination, a cognitive process that relies on hippocampal pattern separation, is one of the first memory domains to decline in aging and preclinical alzheimer's disease. |
2022-10-27 |
2023-08-14 |
human |
| Gohar Karapetyan, Katarine Fereshetyan, Hayk Harutyunyan, Konstantin Yenkoya. The synergy of β amyloid 1-42 and oxidative stress in the development of Alzheimer's disease-like neurodegeneration of hippocampal cells. Scientific reports. vol 12. issue 1. 2022-10-26. PMID:36284177. |
the synergy of β amyloid 1-42 and oxidative stress in the development of alzheimer's disease-like neurodegeneration of hippocampal cells. |
2022-10-26 |
2023-08-14 |
rat |
| Julia J Segura-Uribe, Paola Garcia-de la Torre, Tzayaka Castillo-Mendieta, Iván Bribiesca-Cruz, Sandra Orozco-Suárez, Marvin Soriano-Ursúa, Rodolfo Pinto-Almazán, Claudia Fuentes-Venado, Christian Guerra-Araiz. Tibolone Improves Memory and Decreases the Content of Amyloid-β Peptides and Tau Protein in the Hippocampus of a Mice Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-10-24. PMID:36278346. |
tibolone improves memory and decreases the content of amyloid-β peptides and tau protein in the hippocampus of a mice model of alzheimer's disease. |
2022-10-24 |
2023-08-14 |
mouse |
| Ankur Kumar, Bhupender Nehra, Dilpreet Singh, Dileep Kuma, Pooja A Chawl. Recent advances in the development of nitrogen-containing heterocyclic Anti-Alzheimer's agents. Current topics in medicinal chemistry. 2022-10-24. PMID:36278462. |
alzheimer's disease is usually triggered by numerous associated factors, including depleted amount of acetylcholine (ach), excessive aggregation of β-amyloid peptide (aβ), tau hyperphosphorylation with neurofibrillary tangle formation as well as deposition of feeble plaques in a specific portion of the brain (hippocampus and cortex). |
2022-10-24 |
2023-08-14 |
Not clear |
| Marie-Ève Martineau-Dussault, Claire André, Véronique Daneault, Andrée-Ann Baril, Katia Gagnon, Hélène Blais, Dominique Petit, Jacques Y Montplaisir, Dominique Lorrain, Célyne Bastien, Carol Hudon, Maxime Descoteaux, Arnaud Boré, Guillaume Theaud, Cynthia Thompson, Julie Legault, Guillermo E Martinez Villar, Alexandre Lafrenière, Chantal Lafond, Danielle Gilbert, Julie Carrier, Nadia Gosseli. Medial temporal lobe and obstructive sleep apnea: Effect of sex, age, cognitive status and free-water. NeuroImage. Clinical. vol 36. 2022-10-22. PMID:36272339. |
medial temporal structures, namely the hippocampus, the entorhinal cortex and the parahippocampal gyrus, are particularly vulnerable to alzheimer's disease and hypoxemia. |
2022-10-22 |
2023-08-14 |
human |
| Jennyfer Tena, Izumi Maezawa, Mariana Barboza, Maurice Wong, Chenghao Zhu, Michael Russelle Alverez, Lee-Way Jin, Angela M Zivkovic, Carlito B Lebrill. Regio-Specific N-Glycome and N-Glycoproteome Map of the Elderly Human Brain with and without Alzheimer's Disease. Molecular & cellular proteomics : MCP. 2022-10-17. PMID:36252735. |
to obtain the broader representation of glycan compositions, four subjects with two in their seventies and two in their nineties representing two alzheimer disease subjects, one hippocampal sclerosis subject, and one subject with no cognitive impairment were analyzed. |
2022-10-17 |
2023-08-14 |
human |
| Hongyan Cai, Jing Qiao, Siru Chen, Junting Yang, Christian Hölscher, Zhaojun Wang, Jinshun Qi, Meina W. MCU knockdown in hippocampal neurons improves memory performance in an APP/PS1/tau transgenic mouse Alzheimer's disease model. Acta biochimica et biophysica Sinica. 2022-10-14. PMID:36239352. |
mcu knockdown in hippocampal neurons improves memory performance in an app/ps1/tau transgenic mouse alzheimer's disease model. |
2022-10-14 |
2023-08-14 |
mouse |
| Cintya Nirvana Dutta, Leonardo Christov-Moore, Hernando Ombao, Pamela K Dougla. Neuroprotection in late life attention-deficit/hyperactivity disorder: A review of pharmacotherapy and phenotype across the lifespan. Frontiers in human neuroscience. vol 16. 2022-10-13. PMID:36226261. |
crucially, these neuroprotective effects were significant in brain regions (e.g., hippocampus, amygdala) where severe volume loss is linked to cognitive impairment and alzheimer's disease. |
2022-10-13 |
2023-08-14 |
Not clear |
| Saeid Bagheri-Mohammadi, Sahar Askari, Behrang Alani, Maryam Moosavi, Rasoul Ghasem. Cinnamaldehyde Regulates Insulin and Caspase-3 Signaling Pathways in the Sporadic Alzheimer's Disease Model: Involvement of Hippocampal Function via IRS-1, Akt, and GSK-3β Phosphorylation. Journal of molecular neuroscience : MN. 2022-10-09. PMID:36210429. |
cinnamaldehyde regulates insulin and caspase-3 signaling pathways in the sporadic alzheimer's disease model: involvement of hippocampal function via irs-1, akt, and gsk-3β phosphorylation. |
2022-10-09 |
2023-08-14 |
rat |
| Philip S Crooke, John T Tossberg, Rachel M Heinrich, Krislyn P Porter, Thomas M Aun. Reduced RNA adenosine-to-inosine editing in hippocampus vasculature associated with Alzheimer's disease. Brain communications. vol 4. issue 5. 2022-10-05. PMID:36196083. |
reduced rna adenosine-to-inosine editing in hippocampus vasculature associated with alzheimer's disease. |
2022-10-05 |
2023-08-14 |
Not clear |