| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philip Gerard Gasquoin. Contributions of the insula to cognition and emotion. Neuropsychology review. vol 24. issue 2. 2014-09-12. PMID:24442602. |
neuroimaged abnormal grey matter volumes or activity levels in the insula have been associated with schizophrenia, eating disorders, anxiety and mood disorders, conduct disorder, autism, addiction, and chronic pain. |
2014-09-12 |
2023-08-12 |
Not clear |
| Heide Klumpp, David Post, Mike Angstadt, Daniel A Fitzgerald, K Luan Pha. Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder. Biology of mood & anxiety disorders. vol 3. 2014-05-20. PMID:23547713. |
anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder. |
2014-05-20 |
2023-08-12 |
human |
| Heide Klumpp, David Post, Mike Angstadt, Daniel A Fitzgerald, K Luan Pha. Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder. Biology of mood & anxiety disorders. vol 3. 2014-05-20. PMID:23547713. |
generalized social anxiety disorder (gsad) is associated with a heightened neural sensitivity to signals that convey threat, as evidenced by exaggerated amygdala and/or insula activation when processing face stimuli that express negative emotions. |
2014-05-20 |
2023-08-12 |
human |
| Andrea N Goldstein, Stephanie M Greer, Jared M Saletin, Allison G Harvey, Jack B Nitschke, Matthew P Walke. Tired and apprehensive: anxiety amplifies the impact of sleep loss on aversive brain anticipation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 26. 2013-09-05. PMID:23804084. |
however, excessive anticipatory responding and associated hyper-reactivity in the amygdala and insula are integral to anxiety disorders. |
2013-09-05 |
2023-08-12 |
Not clear |
| Sean N Hatton, Jim Lagopoulos, Daniel F Hermens, Sharon L Naismith, Maxwell R Bennett, Ian B Hicki. Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study. BMC psychiatry. vol 12. 2013-04-02. PMID:22607202. |
magnetic resonance imaging (mri) studies have shown changes in anterior insula gray matter volume (gmv) in psychosis, bipolar, depression and anxiety disorders in older patients, but few studies have investigated insula gmv changes in young people. |
2013-04-02 |
2023-08-12 |
Not clear |
| Dean T Acheson, Murray B Stein, Martin P Paulus, Lakshmi Ravindran, Alan N Simmons, James B Lohr, Victoria B Risbroug. Effects of anxiolytic treatment on potentiated startle during aversive image anticipation. Human psychopharmacology. vol 27. issue 4. 2013-01-04. PMID:22782542. |
in functional magnetic resonance imaging studies, anticipation of fearful/threatening images has been shown to robustly activate the insular cortex and amygdala in healthy subjects, in subjects with high trait anxiety, and in some with anxiety disorders. |
2013-01-04 |
2023-08-12 |
human |
| Heide Klumpp, Mike Angstadt, K Luan Pha. Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biological psychology. vol 89. issue 1. 2012-04-26. PMID:22027088. |
aberrant subcortical-prefrontal connectivity may contribute to insula hyper-reactivity to threat in generalized social anxiety disorder (gsad). |
2012-04-26 |
2023-08-12 |
human |
| Heide Klumpp, Mike Angstadt, K Luan Pha. Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biological psychology. vol 89. issue 1. 2012-04-26. PMID:22027088. |
insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. |
2012-04-26 |
2023-08-12 |
human |
| L R Demenescu, R Renken, R Kortekaas, M-J van Tol, J B C Marsman, M A van Buchem, N J A van der Wee, D J Veltman, J A den Boer, A Alema. Neural correlates of perception of emotional facial expressions in out-patients with mild-to-moderate depression and anxiety. A multicenter fMRI study. Psychological medicine. vol 41. issue 11. 2012-02-01. PMID:21557888. |
anxiety disorders have also been associated with increased activation of emotional structures such as the amygdala and insula. |
2012-02-01 |
2023-08-12 |
Not clear |
| Frederico G Graeff, Hélio Zangross. The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders. Central nervous system agents in medicinal chemistry. vol 10. issue 3. 2011-01-07. PMID:20528764. |
this action would result in less activation of the amygdala, medial pfc and insula by warning signals, as shown by the reviewed results obtained with functional neuroimaging in healthy volunteers and patients with anxiety disorders. |
2011-01-07 |
2023-08-12 |
human |
| Mark S George, Herbert E Ward, Philip T Ninan, Mark Pollack, Ziad Nahas, Berry Anderson, Samet Kose, Robert H Howland, Wayne K Goodman, James C Ballenge. A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders. Brain stimulation. vol 1. issue 2. 2010-10-19. PMID:20633378. |
because the vagus nerve sends information to brain regions important in anxiety regulation (locus coeruleus, orbitofrontal cortex, insula, hippocampus and amygdala), this pathway might be involved in perceiving or manifesting various somatic and cognitive symptoms that characterize anxiety disorders. |
2010-10-19 |
2023-08-12 |
Not clear |
| Lisa M Shin, Israel Liberzo. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 1. 2010-02-24. PMID:19625997. |
activation in the insular cortex appears to be heightened in many of the anxiety disorders. |
2010-02-24 |
2023-08-12 |
Not clear |
| Sabin G Shah, Heide Klumpp, Mike Angstadt, Pradeep J Nathan, K Luan Pha. Amygdala and insula response to emotional images in patients with generalized social anxiety disorder. Journal of psychiatry & neuroscience : JPN. vol 34. issue 4. 2009-09-10. PMID:19568481. |
amygdala and insula response to emotional images in patients with generalized social anxiety disorder. |
2009-09-10 |
2023-08-12 |
human |
| Sabin G Shah, Heide Klumpp, Mike Angstadt, Pradeep J Nathan, K Luan Pha. Amygdala and insula response to emotional images in patients with generalized social anxiety disorder. Journal of psychiatry & neuroscience : JPN. vol 34. issue 4. 2009-09-10. PMID:19568481. |
functional brain imaging studies have demonstrated amygdala and insula hyper-reactivity to probes of social threat in participants with generalized social anxiety disorder (gsad). |
2009-09-10 |
2023-08-12 |
human |
| Sanjay J Mathew, Rebecca B Price, Dennis S Charne. Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics. American journal of medical genetics. Part C, Seminars in medical genetics. vol 148C. issue 2. 2008-05-22. PMID:18412102. |
neuroanatomical and neuroimaging research in anxiety disorders has centered on the role of the amygdala, reciprocal connections between the amygdala and the prefrontal cortex, and, most recently, alterations in interoceptive processing by the anterior insula. |
2008-05-22 |
2023-08-12 |
Not clear |
| Murray B Stein, Dan J Stei. Social anxiety disorder. Lancet (London, England). vol 371. issue 9618. 2008-05-06. PMID:18374843. |
functional neuroimaging studies point to increased activity in amygdala and insula in patients with social anxiety disorder, and genetic studies are increasingly focusing on this and other (eg, personality trait neuroticism) core phenotypes to identify risk loci. |
2008-05-06 |
2023-08-12 |
Not clear |
| Alan Simmons, Scott C Matthews, Martin P Paulus, Murray B Stei. Intolerance of uncertainty correlates with insula activation during affective ambiguity. Neuroscience letters. vol 430. issue 2. 2008-04-18. PMID:18079060. |
previously observed insula hyperactivity in anxiety disorder individuals may therefore be directly linked to altered processes of uncertainty. |
2008-04-18 |
2023-08-12 |
human |