| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alan J Thomas, Paul Donaghy, Gemma Roberts, Sean J Colloby, Nicky A Barnett, George Petrides, Jim Lloyd, Kirsty Olsen, John-Paul Taylor, Ian McKeith, John T O'Brie. Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies. Psychological medicine. vol 49. issue 3. 2020-03-23. PMID:29692275. |
diagnostic accuracy of dopaminergic imaging in prodromal dementia with lewy bodies. |
2020-03-23 |
2023-08-13 |
Not clear |
| Alan J Thomas, Paul Donaghy, Gemma Roberts, Sean J Colloby, Nicky A Barnett, George Petrides, Jim Lloyd, Kirsty Olsen, John-Paul Taylor, Ian McKeith, John T O'Brie. Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies. Psychological medicine. vol 49. issue 3. 2020-03-23. PMID:29692275. |
dopaminergic imaging has high diagnostic accuracy for dementia with lewy bodies (dlb) at the dementia stage. |
2020-03-23 |
2023-08-13 |
Not clear |
| Rory Durcan, Paul C Donaghy, Nicky A Barnett, Kirsty Olsen, Alison J Yarnall, John-Paul Taylor, Ian McKeith, John T O'Brien, Alan J Thoma. Prevalence and severity of symptoms suggestive of gastroparesis in prodromal dementia with Lewy bodies. International journal of geriatric psychiatry. vol 34. issue 7. 2020-02-17. PMID:30901488. |
therefore, a high prevalence of gastroparesis symptoms would be expected in prodromal dementia with lewy bodies (dlb) and be highest in those with a dopaminergic deficit on imaging. |
2020-02-17 |
2023-08-13 |
Not clear |
| Lina Patterson, Steven P Rushton, Johannes Attems, Alan J Thomas, Christopher M Morri. Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders. Brain pathology (Zurich, Switzerland). vol 29. issue 4. 2020-02-12. PMID:30582885. |
given the role of dopamine in the development of movement disorders, but also in motivation and reward, we investigated neurodegenerative pathology in dopaminergic circuitry in parkinson's disease (pd), pd with dementia (pdd) and dementia with lewy bodies (dlb) patients in relation to depressive symptoms. |
2020-02-12 |
2023-08-13 |
Not clear |
| Merijn Joling, Chris Vriend, Pieter G H M Raijmakers, Jessica J van der Zande, Afina W Lemstra, Henk W Berendse, Jan Booij, Odile A van den Heuve. Striatal DAT and extrastriatal SERT binding in early-stage Parkinson's disease and dementia with Lewy bodies, compared with healthy controls: An NeuroImage. Clinical. vol 22. 2020-01-17. PMID:30884365. |
striatal dat and extrastriatal sert binding in early-stage parkinson's disease and dementia with lewy bodies, compared with healthy controls: an parkinson's disease (pd) and dementia with lewy bodies (dlb) are thought to be part of a spectrum: both have a clinical profile including symptoms associated with dopaminergic and serotonergic loss, yet few imaging studies have focused on serotonergic neurodegeneration in both disorders. |
2020-01-17 |
2023-08-13 |
Not clear |
| Claudio Babiloni, Claudio Del Percio, Maria Teresa Pascarelli, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Marco Rizzo, Raffaele Ferri, Andrea Soricelli, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Salvetti, Virginia Cipollini, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Dag Aarsland, Lucilla Parnetti, Lucia Farotti, Moira Marizzoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Harald Hampel, Giovanni B Frisoni, Maria Francesca De Pandis, Laura Bonann. Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases. Neurobiology of aging. vol 77. 2019-12-06. PMID:30797169. |
it can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both ad and dlb, before a substantial dopaminergic derangement in the dementia stage of dlb. |
2019-12-06 |
2023-08-13 |
human |
| Michela Ferrucci, Francesca Biagioni, Giorgio Vivacqua, Carla Letizia Busceti, Alessia Bartalucci, Paola Soldani, Loredana D'Este, Lorenzo Fumagalli, Francesco Forna. The neurobiology of the spinal cord in experimental parkinsonism and Parkinson's disease. Archives italiennes de biologie. vol 151. issue 4. 2019-11-20. PMID:24873929. |
such an involvement is intriguing since the major degenerative disease of the spinal cord (amyotrophic lateral sclerosis) features the involvement of dopaminergic neurons of the substantia nigra pars compacta, while some environmental (parkinsonism, als, and dementia of guam) and genetic (kufor-rakeb syndrome) diseases are known to be characterized by mixed degeneration of pyramidal and extrapyramidal regions. |
2019-11-20 |
2023-08-13 |
Not clear |
| Madhavi Tripathi, Atin Kumar, Chandrasekhar Ba. Neuroimaging in Parkinsonian Disorders. Neurology India. vol 66. issue Supplement. 2019-09-17. PMID:29503329. |
while dopaminergic imaging is useful in the early stages of disease to differentiate the neurodegenerative versus non-degenerative causes of parkinsonism like essential tremors, it has also been used for the differential diagnosis of dementia with lewy bodies (dlb) from alzheimer's disease (ad), for inclusion of pd patients into clinical trials and for evaluating response to cell-replacement therapies in pd. |
2019-09-17 |
2023-08-13 |
Not clear |
| Tomoyuki Kawad. Validation in SPECT imaging on presynaptic dopaminergic deficit for dementia with Lewy bodies and degenerative Parkinsonism. Journal of the neurological sciences. vol 392. 2019-07-18. PMID:30055381. |
validation in spect imaging on presynaptic dopaminergic deficit for dementia with lewy bodies and degenerative parkinsonism. |
2019-07-18 |
2023-08-13 |
Not clear |
| Andrew Siderowf, Dag Aarsland, Brit Mollenhauer, Jennifer G Goldman, Bernard Ravin. Biomarkers for cognitive impairment in Lewy body disorders: Status and relevance for clinical trials. Movement disorders : official journal of the Movement Disorder Society. vol 33. issue 4. 2019-06-26. PMID:29624752. |
dopaminergic imaging is used for differential diagnosis of parkinsonian disorders versus tremor disorders without dopamingeric deficits, and also to differentiate dementia with lewy bodies from alzheimer's disease. |
2019-06-26 |
2023-08-13 |
Not clear |
| Nicolas Nicastro, Pierre R Burkhard, Valentina Garibott. Scan without evidence of dopaminergic deficit (SWEDD) in degenerative parkinsonism and dementia with Lewy bodies: A prospective study. Journal of the neurological sciences. vol 385. 2019-05-24. PMID:29406901. |
scan without evidence of dopaminergic deficit (swedd) in degenerative parkinsonism and dementia with lewy bodies: a prospective study. |
2019-05-24 |
2023-08-13 |
Not clear |
| Silke Frahm, Valeria Melis, David Horsley, Janet E Rickard, Gernot Riedel, Paula Fadda, Maria Scherma, Charles R Harrington, Claude M Wischik, Franz Theuring, Karima Schwa. Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease. Behavioural brain research. vol 339. 2018-08-07. PMID:29180135. |
since accumulation of α-syn aggregates in neurones and synapses and alterations in the dopaminergic tone are characteristics of pd, phenotypes reported for l62 present a good opportunity to further our understanding of motor dysfunction in pd and lewy body dementia. |
2018-08-07 |
2023-08-13 |
mouse |
| David Bäckström, Magdalena Eriksson Domellöf, Gabriel Granåsen, Jan Linder, Sofia Mayans, Eva Elgh, Susanna Jakobson Mo, Lars Forsgre. PITX3 genotype and risk of dementia in Parkinson's disease: A population-based study. Journal of the neurological sciences. vol 381. 2018-06-11. PMID:28991698. |
this study investigates whether a common polymorphism in the pitx3 gene (rs2281983), which is of importance for the function of dopaminergic neurons, affects the risk of developing dementia in pd and whether it affects dopamine transporter (dat) uptake. |
2018-06-11 |
2023-08-13 |
Not clear |
| Marina A Gruden, Tatiana V Davydova, Chao Wang, Victor B Narkevich, Valentina G Fomina, Vladimir S Kudrin, Ludmilla A Morozova-Roche, Robert D E Sewel. The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer's disease-like cognitive deficit. Behavioural brain research. vol 306. 2017-11-17. PMID:26965570. |
the data further suggests that amyloid species of s100a9 create deleterious effects principally on the dopaminergic system and this novel finding might be potentially exploited during dementia management through a neuroprotective strategy. |
2017-11-17 |
2023-08-13 |
mouse |
| Paromita Kundu, Manasi Das, Kalpalata Tripathy, Sanjeeb K Saho. Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease. ACS chemical neuroscience. vol 7. issue 12. 2017-10-20. PMID:27642670. |
parkinson's disease (pd) is the most widespread form of dementia where there is an age related degeneration of dopaminergic neurons in the substantia nigra region of the brain. |
2017-10-20 |
2023-08-13 |
mouse |
| Susanna Nuvoli, Angela Spanu, Giuseppe Madedd. Brain SPECT with Perfusion Radiopharmaceuticals and Dopaminergic System Radiocompounds in Dementia Disorders. Current Alzheimer research. vol 14. issue 2. 2017-10-10. PMID:27774875. |
brain spect with perfusion radiopharmaceuticals and dopaminergic system radiocompounds in dementia disorders. |
2017-10-10 |
2023-08-13 |
Not clear |
| Ismael Huertas, Silvia Jesús, Francisco Javier García-Gómez, José Antonio Lojo, Inmaculada Bernal-Bernal, Marta Bonilla-Toribio, Juan Francisco Martín-Rodriguez, David García-Solís, Pilar Gómez-Garre, Pablo Mi. Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease. PloS one. vol 12. issue 4. 2017-09-12. PMID:28399184. |
the degree of dopaminergic depletion was investigated with [123i]fp-cit spects and the presence of dementia was ascertained with a long-term review based on established criteria. |
2017-09-12 |
2023-08-13 |
Not clear |
| Sean J Colloby, Ruth A Cromarty, Luis R Peraza, Kristinn Johnsen, Gísli Jóhannesson, Laura Bonanni, Marco Onofrj, Robert Barber, John T O'Brien, John-Paul Taylo. Multimodal EEG-MRI in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies. Journal of psychiatric research. vol 78. 2017-08-29. PMID:27060340. |
differential diagnosis of alzheimer's disease (ad) and dementia with lewy bodies (dlb) remains challenging; currently the best discriminator is striatal dopaminergic imaging. |
2017-08-29 |
2023-08-13 |
human |
| Silvia P Caminiti, Marco Tettamanti, Arianna Sala, Luca Presotto, Sandro Iannaccone, Stefano F Cappa, Giuseppe Magnani, Daniela Peran. Metabolic connectomics targeting brain pathology in dementia with Lewy bodies. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 4. 2017-07-26. PMID:27306756. |
dementia with lewy bodies is characterized by α-synuclein accumulation and degeneration of dopaminergic and cholinergic pathways. |
2017-07-26 |
2023-08-13 |
Not clear |
| John T O'Brien, Wolfgang H Oertel, Ian G McKeith, Donald G Grosset, Zuzana Walker, Klaus Tatsch, Eduardo Tolosa, Paul F Sherwin, Igor D Grache. Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials. BMJ open. vol 4. issue 7. 2016-06-16. PMID:24993764. |
to pool clinical trials of similar design to assess overall sensitivity and specificity of ioflupane i123 injection (datscan or ioflupane ((123)i)) to detect or exclude a striatal dopaminergic deficit disorder (sddd), such as parkinsonian syndrome and dementia with lewy bodies. |
2016-06-16 |
2023-08-13 |
Not clear |